个人简介

个人简介

2006-2010        B.S., Soochow University, School of Life Sciences

2010-2015        Ph.D., Soochow University, Institute of Functional Nano & Soft Materials (FUNSOM)

2015-2018        Postdoctoral Researcher, University of North Carolina at Chapel Hill & North Carolina State                             University, Dept. of Joint Department of Biomedical Engineering
2018-present    Professor, Soochow University, 
FUNSOM


研究领域

Welcome to the Prof. Chao Wang's Group in the FUNSOM at Soochow University! The overall goal of our BIE Lab (Laboratory for Biomaterial and ImmunoEngineering) is to integrate Biomaterials, Immunoengineering and Translational Medicine for the clinical applications. Our lab current research focuses include development of biomaterials for immunoengineering and immunotherapy, in order to develop effective novel immunotherapies for cancer, infectious diseases, autoimmune disorders and age-related disease. more>>

基本信息

头像

汪超  

职称:   教授

院部/部门:   功能纳米与软物质研究院

学历:   博士研究生

学位:   Ph.D.

毕业学校:   Soochow University

毕业专业:   化学生物学

联系方式

通讯地址:  

邮政编码:  

电子邮箱:   cwang(at)suda.edu.cn

联系电话:   0512-65880722

传真号码:  

办公地点:   功能纳米与软物质研究院 910-408A

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

科学研究

Biomaterials for Immunotherapy

The immune system is one of systemic barriers to the body’s defense against tumors. Emerging interest is moving on tilizing biomaterials for immunotherapy and immunoengineering of cancer therapy. Such biomaterial platform offers the remarkable ability to codelivery of multiple cargoes, control their release behavior, alter their kinetics and pharmacodynamic effects, and so on. In addition, well-designed functional biomaterials can alter the immune-related microenvironment, modulate the immune response, as well as reverse immunosuppressive tumor environment in the context of disease treatment.

Cell-based therapy

Various types of cells are promising drug carriers or living drugs themselves. Armed with the emerging techniques in materials science, molecular pharmaceutics and nanobiotechnology, cell engineering is an appealing therapeutic platform for the development of next-generation medications. We will study the enhanced therapy effects by the combination of functional cells and biomaterials. Generally, our biomaterials – based on micor/nanoparticles or scaffolds – will be engineered for switching using innovate and modern concepts in cell based therapy.


Immunity in Tumor Microenvironment

We will study the immune cells in the tumor microenvironment and the mechanisms of tumor to suppress the immune response. Understanding the mechanism by which the tumor microenvironment context is extremely important for the design of novel immunotherapies .


科研团队




Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

论文

Representative Publications (View All Publications)


2020

[36] Qin Fan, Qingle Ma, Jingyu Bai, Jialu Xu, Ziying Fei, Ziliang Dong, Atsushi Maruyama, Kam W. Leong, Zhuang Liu and Chao Wang*. An Implantable Blood Clot-based Immune Niche for Enhanced Cancer Vaccination. Science Advances, (2020) In press.

[35] Qingle Ma, Qin Fan, Jialu Xu, Jinyu Bai, Xiao Han, Ziliang Dong, Xiaozhong Zhou, Zhuang Liu, Zhen Gu* and Chao Wang*Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-derived Extracellular Vesicles. Matter, 3, 287 (2020). Link Highlight by Matter


[34] Lulu Cai#, Jialu Xu#, Zhenglin Yang, Rongsheng Tong, Ziliang Dong, Chao Wang* and Kam W. Leong*. Engineered Biomaterials for Cancer Immunotherapy. MedComm, Link. (Invited review)

[33] Xuanfang Zhou, Zhouqi Meng*, Jialin She, Yaojia Zhang, Xuan Yi, Hailin Zhou, Jing Zhong, Ziliang Dong, Xiao Han, Muchao Chen, Qin Fan, Kai Yang and Chao Wang* . Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy. Nano-Micro Letters, 12, 100 (2020).

[32] Yingjun Liu, Dongdong Sun, Qin Fan, Qingle Ma, Ziliang Dong, Weiwei Tao, Huiquan Tao, Zhuang Liu and Chao Wang*. The Enhanced Permeability and Retention Effect based Nanomedicine at the Site of Injury. Nano Research, 13, 564-569 (2020).


2019

[31] 范亲,汪超*.纳米材料在肿瘤免疫治疗中的应用.中国科学-生命科学, (2019). DOI:10.1360/SSV-2019-0215 (Invited review)

[30] Lin Zhang, Jinhua Zhou, Lvzhong Hu, Xiao Han, Xinwei Zou, Qian Chen, Youguo Chen*, Zhuang Liu*, Chao Wang*. In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of  Cancer Recurrence after Surgery. Advanced Functional Materials, 1906922 (2019). 

[29] Baowen Qi, Chao Wang*, Jianxun Ding* and Wei Tao*. Applications of Nanobiotechnology in Pharmacology. Frontiers in Pharmacology, 10, 1451 (2019). (Editorial)

[28] Jinyu Bai,Yingzi Zhang, Qin Fan, Jialu Xu, Huajian Shan, Xiang Gao, Qinle Ma, Lei Sheng, Xin Zheng, Weinan Chen, Dazhuang Li, Mingchao Zhang, Yu Hao, Liangzhu Feng, Qian Chen, Xiaozhong Zhou* and Chao Wang*. Reactive Oxygen Species-Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disc Degeneration. Advanced Healthcare Materials, 1901186 (2019).

[27] Xiao Han, Rui Wang, Jun Xu, Qian Chen, Chao Liang, Jiawen Chen, Jiayue Zhao, Jiacheng Chu, Qin Fan, Edikan Archibong, Lixin Jiang*, Chao Wang*, Zhuang Liu*. In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence. Biomaterials, 119490 (2019). 

[26] Xiao Han#, Shufang Shen#, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu* and Chao Wang*. Red Blood Cell Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy. Science Advances, 5, eaaw6870 (2019).


[25] Xiao Han#, Jiawen Chen#, Jiacheng Chu, Chao Liang, Qingle Ma, Qin Fan, Zhuang Liu* and Chao Wang*. Platelets as Platforms for Inhibition of Tumor Recurrence Post-Physical Therapy by Delivery of anti-PD-L1 Checkpoint Antibody. Journal of Controlled Release, 304, 233-241(2019).


2018

[24] Xiaowen Liu, Chao Wang*, Zhuang Liu*. ProteinEngineered Biomaterials for CancerTheranostics. Advanced Healthcare Materials1800913(2018). (Review paper)

[23] Qin Fan, Zhipeng Chen,Chao Wang*, Zhuang Liu*. Toward Biomaterials for Enhancing Immune Checkpoint BlockadeTherapy. Advanced Functional Materials, 1802540 (2018). (Review paper)

[22] Xiao Han, Chao Wang*, Zhuang Liu *. Red Blood Cells as Smart Delivery Systems. Bioconjug Chem 29,852-860 (2018). (Review paper)

[21]Shuangjiang Yu#, Chao Wang#, Jicheng Yu, Jinqiang Wang, Yue Lu,Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He*, Xuesi Chen*, Zhen Gu*. Injectable Bioresponsive Gel Depot for Enhanced Immune CheckpointBlockade. Advanced Materials 1801527 (2018).

[20] Chao Wang#, Jinqiang Wang#, Xudong Zhang, Shuangjiang Yu, Di Wen, Quan Hu, Yanqi Ye, H.Bomba, X. Hu, Z. Liu. Gianpietro Dotti and Zhen Gu*. In situ formed reactiveoxygen species–responsive scaffold with gemcitabine and checkpoint inhibitorfor combination therapy. Science Translational Medicine 10,eaan3682 (2018).



2011-2017

[19] Chao Wang, Wujin Sun, Yanqi Ye, Hunter N Bomba, Zhen Gu*. Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs. Theranostics 7, 3504-3516 (2017). (Review paper)

[18] Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter N Bomba, Zhen Gu*. In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy. Nature Biomedical Engineering 1, 0011 (2017).

[17] Chao Wang, Di Wen, Zhen Gu*. Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy. Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.7b00619 (2017). (Review paper)

[16] Chao Wang, Yanqi Ye, Zhen Gu*. Local delivery of checkpoints antibodies. Human Vaccines & Immunotherapeutics 13, 245-248 (2017). (Review paper)

[15] Chao Wang, Yanqi Ye, Quanyin Hu, Adriano Bellotti, Zhen Gu*. Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook. Advanced Materials 29, 201606036 (2017). (Review paper)

[14] Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jingqiang Wang, David S Lawrence, John B Buse, Zhen Gu*. Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials 29, 201606617 (2017).

[13] Chao Wang#, Yanqi Ye#, Gabrielle M Hochu, Hasan Sadeghifar, Zhen Gu*. Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-{PD}1 Antibody. Nano Letters 16, 2334-2340 (2016).

[12] Chao Wang#, Min Ye#, Liang Cheng, Rui Li, Wenwen Zhu, Zhen Shi, Chunhai Fan, Jinkang He, Jian Liu, Zhuang Liu*. Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials 54, 55-62 (2015).

[11] Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*. Multifunctional Theranostic Red Blood Cells For Magnetic-Field-Enhanced in vivo Combination Therapy of Cancer. Advanced Materials 26, 4794-4802 (2014).

[10] Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, Zhuang Liu*. Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-{CTLA}-4 Therapy to Inhibit Cancer Metastasis. Advanced Materials 26, 8154-8162 (2014).

[9] Liang Cheng#, Chao Wang#, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu*. Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control. Advanced Functional Materials 23, 272-280 (2013).

[8] Chao Wang, Liang Cheng, Yumeng Liu, Xiaojing Wang, Xinxing Ma, Zhaoyi Deng, Yonggang Li, Zhuang Liu*. Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light. Advanced Functional Materials 23, 3077-3086 (2013).

[7] Chao Wang, Liang Cheng, Zhuang Liu*. Upconversion Nanoparticles for Photodynamic Therapy and Other Cancer Therapeutics. Theranostics 3, 317-330 (2013). (Review paper)

[6] Chao Wang#, Huan Xu#, Chao Liang, Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li, Zhuang Liu*. Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect. ACS Nano 7, 6782-6795 (2013).

[5] Chao Wang, Liang Cheng, Huan Xu, Zhuang Liu*. Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles. Biomaterials 33, 4872-4881 (2012).

[4] Chao Wang, Xinxing Ma, Shuoqi Ye, Liang Cheng, Kai Yang, Liang Guo, Changhui Li, Yonggang Li, Zhuang Liu*. Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging. Advanced Functional Materials 22, 2363-2375 (2012).

[3] Chao Wang, Liang Cheng and Zhuang Liu*. Research Spotlight: Upconversion nanoparticles for potential cancer theranostics. Therapeutic Delivery 2, 1235-1239 (2011). (Review paper)

[2] Chao Wang, Huiquan Tao, Liang Cheng and Zhuang Liu*. Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials 32, 6145-6154 (2011).

[1] Chao Wang, Liang Cheng and Zhuang Liu*. Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. Biomaterials 32, 1110-1120  (2011).



Book chapter


[1] Shufang Shen and Chao Wang* (2020) Upconversion Fluorescent Nanoprobe for Highly Sensitive In Vivo Cell Tracking. Cell Tracking. Methods in Molecular Biology, vol 2126. Humana, New York, NY 




荣誉奖励

  • 1、科睿唯安“高被引科学家”名录,2018-2019
  • 2、江苏省特聘教授,2018
  • 3、教育部高等学校科学研究优秀成果自然科学奖二等奖(第四完成人),2014
  • 4、江苏省科学技术一等奖(第四完成人),2017
  • 5、Biomaterials Future Scientist Award,2017
  • 6、江苏省优秀博士论文,2016
  • 7、中国青少年科技创新奖,2014
  • 8、江苏省双创人才,2019
  • 9、江苏省“六大人才高峰”高层次人才,2019
Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

开授课程

  • 1、普通生物学,0,54

招生信息


课题组长期招聘博士后,待遇优厚,并可推荐海外名校继续深造,欢迎对相关方向有兴趣的同学前来咨询。如有兴趣,请联系cwang@suda.edu.cn。详见课题组网页:https://sites.google.com/view/the-wang-lab/


Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持