Education

2009 - 2013, Hunan University (Changsha City, CN), Major: BioTechnology, Bsc

2013 - 2016, Hunan University (Changsha City, CN), Major: Biology, Msc

2016 - 2021, Maastricht University (The Netherlands), Major: Biochemistry, PhD

Work Experience

2021 - 2022, PostDoc, University of North Carolina at Chapel Hill, Blood Research Center (Mentor: prof Nigel Mackman)

2023 - current, Associate Professor, Soochow University, Cyrus Tang Hematology Center

Reseach interest and major findings

(1) Innovations of assays for hemostasis research.

    Developed novel assays that can directly measure thrombin generation (TG) in whole blood samples of human and mice. 

(J Thromb Haemost 2020, 18(6): 1291-1301.; Blood Advances 2022, Doi: 10.1182/bloodadvances.2022008720.)

(2) Novel mechanisms of coagulation.

    Studied the differential effects of platelets and erythrocytes on different phases of coagulation: the presence of platelets was essential for a fast onset of TG the initiation-amplification phase and propogation phase of thrombin generation.  

(J Thromb Haemost 2020, 18(6): 1291-1301.)

    The presence of erythrocytes greatly enhanced the sensitivity of TG assays for mice FIX deficiency, suggesting of role of erythrocytes in regulating FIX function.

 (Blood Advances 2022, Doi: 10.1182/bloodadvances.2022008720.)

    TG assay results was used as an intermediate phenotype in GWAS study, resulting in the identification of a role of kallikrein on regulating protein C pathway anticoagulant function.

 (J Thromb Haemost 2022, 20(1): 48-57.)

Publications:

https://www.ncbi.nlm.nih.gov/myncbi/1DmJPibOhxvkY/bibliography/public/

https://orcid.org/my-orcid?orcid=0000-0002-0948-8191

1.SP Grover, T Kawano, J Wan, P Tanratana, Z Polai, YJ Shim, O Snir, et al. C1 inhibitor deficiency enhances contact pathway mediated activation of coagulation and venous thrombosis. Blood. 2023; DOI: 10.1182/blood.2022018849

2.J Wan, P Tanratana, M Roest, A Gruber, R Pawlinski, AS Wolberg, N Mackman and SP Grover. A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation. Blood Adv. 2022; Doi: 10.1182/bloodadvances.2022008720

3.J Wan, N Vadaq, J Konings, M Jaeger, V Kumar, B de Laat, L Joosten, et al. Kallikrein augments the anticoagulant function of the protein C system in thrombin generation. J Thromb Haemost. 2022; 20: 48-57.

4.GS Temba#, N Vadaq#, J Wan, V Kullaya, D Huskens, T Pecht, M Jaeger, et al. Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors. J Thromb Haemost. 2022; 20: 1089-105.

5.L Li, M Roest, Y Sang, JA Remijn, R Fijnheer, K Smit, D Huskens, et al. Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile. Front Cardiovasc Med. 2022; 9: 919495.

6.S Huang, Wvd Heijden, IJ Reuling, J Wan, Q Yan, PGd Groot, AJVd Ven, et al. Functional changes in platelets and coagulation during asexual and sexual parasitemia in a controlled human malaria infection. PLoS One. 2022; Accepted

7.J Wan^*, J Konings, B de Laat, TM Hackeng and M Roest. Added Value of Blood Cells in Thrombin Generation Testing. Thromb Haemost. 2021; 121: 1574-87.

8.L Li^#, J Wan^#, X Wen, Q Guo, H Jiang, J Wang, Y Ren and K Wang. Identification of a New DNA Aptamer by Tissue-SELEX for Cancer Recognition and Imaging. Anal Chem. 2021; 93: 7369-77.

9.WA van der Heijden, J Wan, L Van de Wijer, M Jaeger, MG Netea, AJ van der Ven, PG de Groot, et al. Plasmatic Coagulation Capacity Correlates With Inflammation and Abacavir Use During Chronic HIV Infection. J Acquir Immune Defic Syndr. 2021; 87: 711-9.

10.J Wan, LN Roberts, W Hendrix, J Konings, TW Ow, L Rabinowich, O Barbouti, et al. Whole blood thrombin generation profiles of patients with cirrhosis explored with a near patient assay. J Thromb Haemost. 2020; 18: 834-43.

11.J Wan, J Konings, Q Yan, H Kelchtermans, R Kremers, B de Laat and M Roest. A novel assay for studying the involvement of blood cells in whole blood thrombin generation. J Thromb Haemost. 2020; 18: 1291-301.

12.Z Huang, Q Xie, Q Guo, K Wang, X Meng, B Yuan, J Wan and Y Chen. DNA aptamer selected for specific recognition of prostate cancer cells and clinical tissues. Chin Chem Lett. 2017; 28: 1252-7.

13.B Yuan, Y Zhou, Q Guo, K Wang, X Yang, X Meng, J Wan, et al. A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET. Chem Commun. 2016; 52: 1590-3.

14.J Wan^#, L Ye^#, X Yang, Q Guo, K Wang, Z Huang, Y Tan, et al. Cell-SELEX based selection and optimization of DNA aptamers for specific recognition of human cholangiocarcinoma QBC-939 cells. Analyst. 2015; 140: 5992-7.

15.Q Xie, Y Tan, Q Guo, K Wang, B Yuan, J Wan and X Zhao. A fluorescent aptasensor for sensitive detection of human hepatocellular carcinoma SMMC-7721 cells based on graphene oxide. Analytical Methods. 2014; 6: 6809-14.

16.Q Guo, X Zhao, Q Xie, K Wang, J Wan, B Yuan and Y Tan. Label-free Fluorescence Signal Amplifying Detection of DNA Based on Hairpin Probe and Exo III. Chemical Journal of Chinese Universities -Chinese Edition. 2014; 35: 1646-51.