个人简介

特聘教授,博士生导师

教育背景:

2002.9-2006.7 湖北大学生命科学学院化学生物学基地班,学士学位

2006.9-2012.7 中科院福建物质结构研究所生物化学与分子生物学专业,博士学位

博士生导师黄明东教授

工作经历:

2018.05-至今 苏州大学分子酶学研究所,特聘教授

2017.12-2018.04 清华大学生命科学学院,助理研究员

合作导师:李雪明教授

2012.11-2017.10 美国癌症研究所生物大分子晶体学实验室/阿贡国家实验室 博士后

博士后导师: Zbigniew Dauter


研究领域

1. 生物大分子的结构与功能研究
2. 蛋白质与核酸的相互作用研究
3. 晶体方法学的开发和应用


基本信息

头像

罗智璞  

职称:   教授

院部/部门:   医学部基础医学与生物科学学院

学历:  

学位:  

毕业学校:   中国科学院福建物质结构研究所

毕业专业:  

联系方式

通讯地址:  

邮政编码:  

电子邮箱:   luozhipu@suda.edu.cn

联系电话:   0512-65883528

传真号码:  

办公地点:   医学部

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

科学研究

科研团队

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

论文

已发表SCI论文31篇; 其中一作与共同一作15篇。

第一作者、共同第一作者(*)及通讯作者文章(#):

  • 15.    Heng, Z.,* Luo, Z.,*Li, X.M. #  Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction. (2019) Journal of Structural Biology. https://doi.org/10.1016/j.jsb.2019.02.004.

  • 14.    Luo, Z.*, Dauter, Z.#Crystal structure of Z-DNA with untypically coordinated Ca2+ ions (2017) Journal of Biological Inorganic Chemistry, DOI: https://doi.org/10.1007/s00775-017-1526-4. (IF=2.894)

  • 13.    Luo, Z.*, Kelleher, A., Darwiche, R., Hudspeth, E., Shittu, O., Krishnavajhala, A., Schneiter, R., Lopez, J.#, and Asojo, O.#Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated protein in the tick-mammalian transmission cycle of relapsing fever spirochetes. (2017) Scientific Reports, doi:10.1038/s41598-017-14959-9. (IF=4.259)

  • 12.    Luo, Z.*, Dauter, Z.#, Gilski, M. Four highly twinned structures of d(CGCGCG)2 extend the repertoire of pseudohexagonal crystal structures of Z-DNA. Acta Crystallographica Section D Biological Crystallography, 73, 940-951. (Cover paper) (IF=2.114)

  • 11.    Raroni, R.*, Luo, Z*., Darwiche, R., Hudspeth, E., Schneiter, R., Pereira, G., Mondego, J., Asojo, O.#(2017) Crystal Structure of MpPR-1i, a CAP protein from Moniliophthora perniciosa, the fungus that causes Witches' Broom Disease of Cacao. Scientific Reports, doi:10.1038/s41598-017-07887-1. (IF=4.259)

  • 10.    Luo, Z.*, Dauter, Z.#(2017) Embarras de richesses – it is not good to be too anomalous: accurate structure of selenourea, a chiral crystal of planar molecules. PLOS One, doi: 10.1371/journal.pone.0171740. (IF=2.806)

  • 9.    Shen, F.*,Luo, Z.*, Liu, H.,Wang, R.,Zhang, S., Gan, J., and Sheng, J.#(2017) Structural insights into RNA duplexes with multiple 2’-5’-linkages. Nucleic Acids Research, 45(6):3537-3546. (IF=10.162)

  • 8.    Luo, Z.*, #(2016) Selenourea: a convenient phasing vehicle for macromolecular X-ray crystal structures. Scientific Reports, 6, 37123; doi: 10.1038/srep37123. (First and corresponding author, IF=4.259)

  • 7.     Wang, R.*, Luo, Z.*, He, K., Delaney, MO., Chen, D., Sheng, J.#(2016) Base pairing and structural insights into the 5-formylcytosine in RNA duplex. Nucleic Acids Research, 44(10): 4968-4977 (IF=10.162)

  • 6.     Luo, Z.*, Dauter, Z.#(2016) Detection of twinning in macromolecular crystallography, Zeitschrift fuer Kristallographie, 231(10): 561-571 (IF=3.179)

  • 5.    Luo, Z.*, Dauter, Z.#(2015) Flexibility of Terminal Cytidines in Ca2+ Form B-DNA, The FASEB Journal 29 (1 Supplement), 710.15 (IF=5.498)

  • 4.     Luo, Z.*, Dauter, M., Dauter, Z.#(2014) Phosphates in Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution, Acta Crystallographica Section D Biological Crystallography 70, 1790-1800. (IF=2.114)

  • 3.    Luo, Z.*, Raj, K., Dauter, Z.#(2014) Weak data do not make a free lunch, but only a cheap meal, Acta Crystallographica Section D Biological Crystallography 70, 253-260. (IF=2.114)

  • 2.    Luo, Z.*, Shi, X., Hu, Q., Zhao, B., and Huang, M.#(2012) Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin, Chemical Research in Toxicology 25, 990-992. (IF=3.278)

  • 1.    Wang, Y.*, Luo, Z.*, Shi, X., Wang, H., Nie, L., and Huang, M.#(2011) A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin, Protein science 20, 2095-2101. (IF=2.523)


其它共同作者文章:

  • 16.    Jiangqing Dong, Ximing Du, Huan Wang, Jue Wang, Chang Lu, Xiang Chen, Zhiwen Zhu, Zhipu Luo, Li Yu, Andrew J. Brown, Hongyuan Yang & Jia-Wei Wu (2019). Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nature Communications. 10: 829

  • 15.    Liu, N., Zhang, J., Chen, Y., Liu, C., Zhang, X., Xu, K., Wen, J., Luo, Z., Chen, S., Gao, P., Jia, K., Liu, Z., Peng, H., Wang, H. (2019) Bioactive functionalized monolayer graphene for high resolution cryo-EM. Journal of the American Chemical Society. Feb 6. doi: 10.1021/jacs.8b13038

  • 14.    Jiang, L., Zhang, X., Zhou, Y., Chen, Y., Luo, Z., Li, J., Yuan, C., Huang, M. (2018) Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases. RSC Advances 8(49):28189-28197. (IF=2.936)

  • 13.    Li, Y., Zhao, C., Luo, F., Liu, Z., Gui, X., Luo, Z., Zhang, X., Li, D., Liu, C., Li. X. (2018) Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy. Cell Res. 28(9):897-903. (IF=15.606)

  • 12.    Liu, T., Liu, X., Wang, W., Luo, Z., Liu, M., Zou, S., Sissa, C., Painelli, A., Zhang, Y., Vengris, M. and Bondar, M.V. (2018) Systematic Molecular Engineering of a Series of Aniline-Based Squaraine Dyes and Their Structure-Related Properties. The Journal of Physical Chemistry C. 122 (7), 3994-4008. (IF=4.484)

  • 11.    Zhang, Z., Li, H., Luo, Z., Chang, S., Li, Z., Guan, M., Zhou, Z., Liu, M., Grossman, J., Ren, S. (2017) Molecular Assembly-Induced Charge Transfer for Programmable Functionalities, Chemistry of Materials29, 9851-9858

  • 10.    Yuan, C., Jürgensen, H.J., Engelholm, L.H., Li, R., Liu, M., Jiang, L., Luo, Z., Behrendt, N. and Huang, M. (2016) Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding. Biochem Journal. 473(15):2359-2368. (IF=3.797)

  • 9.    Xu, B., Luo, Z., Wilson, AJ., Chen, K., Gao, W., Yuan, G., Chopra, HD., Chen, X., Willets, KA., Dauter, Z., Ren, S. (2016) Multifunctional Charge-Transfer Single Crystals through Supramolecular Assembly, Advanced Materials, 28(26): 5322–5329 (IF=19.791)

  • 8.    Xu, B., Luo, Z., Gao, W., Wilson, A., He, C., Chen, C., Yuan, G., Dai, H., Rao, Y., Willets, K., Dauter, Z., Ren, S. (2016) Solution-Processed Molecular Opto-Ferroic Crystals, Chemistry of Materials 28, 2441–2448 (IF=9.466)

  • 7.    Xu, P., Xu, M., Jiang, L., Yang, Q., Luo, Z., Dauter, Z., Huang, M., Andreasen, P. (2015) Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold, Journal of Medicinal Chemistry 58, 8868-8876. (IF=6.259)

  • 6.    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., G?rdsvoll, H., de Lorenzi, V., Sidenius, N., Huang, M., Ploug. M.. (2015) Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation, Journal of Molecular Biology 427, 1389-1403. (IF=4.632)

  • 5.    Wang, Y., Yu, H., Shi, X., Luo, Z., Lin, D., Huang, M. (2013) Structural mechanism of ring-opening reaction of glucose by human serum albumin, Journal of biological Chemistry 288, 15980-15987. (IF=4.125)

  • 4.    Liu, Y., Chen, M., Luo, Z., Lin, J., Song L. (2013) Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride, Journal of Biomolecular Structure and Dynamics 10, 1160-1174. (IF=3.123)

  • 3.    Li, L., Luo, Z., Chen, Z., Chen, J., Zhou, S., Xu, P., Hu, P., Wang, J., Chen, N., Huang, J., Huang, M. (2012) Enhanced photodynamic efficacy of zinc phthalocyanine by conjugating to heptalysine, Bioconjugate Chemistry 23, 2168-2172. (IF=4.818)

  • 2.    Lin, Z., Jiang, L., Yuan, C., Jensen, J. K., Zhang, X., Luo, Z., Furie, B. C., Furie, B., Andreasen, P. A., and Huang, M. (2011) Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1, The Journal of Biological Chemistry 286, 7027-7032. (IF=4.125)

  • 1.    Chen, Z., Zhou, S., Chen, J., Deng, Y.,Luo, Z., Chen, H., Hamblin, M. R., and Huang, M. (2010) Pentalysine beta-carbonylphthalocyanine zinc: an effective tumor-targeting photosensitizer for photodynamic therapy, ChemMedChem 5, 890-898. (IF=3.225)


荣誉奖励

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

开授课程

招生信息

1,博士生:医学细胞与分子生物学(1001Z2)
2,硕士生:生化与分子生物学(071010)


Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持