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姓名：李玉梅

学位：理学博士学位

毕业院校：北京大学

电子邮箱：ymli12@suda.edu.cn

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个人简介

李玉梅，特聘教授，博士生导师，江苏省特聘教授。2019年博士毕业于北京大学，后赴美国加州大学尔湾分校进行博士后研究，具有生物学、信息学和统计学的交叉背景。曾获美国George E. Hewitt医学研究基金会博士后奖学金资助。于2023年2月加盟苏州大学基础医学院，成立医学基因组与表观基因组学课题组。


李玉梅教授主要采用生物信息学方法结合高通量、多组学数据开展生物医学研究，一系列研究成果发表在PNAS, Molecular Cell, Circulation Research, Genome Biology, Genome Medicine等国际高水平杂志上。


实验室主页：https://liymlab.github.io/


在研项目：

1. 国家自然科学基金青年科学基金项目，2025-2027，主持

2. 江苏省自然科学基金青年基金项目，2024-2027，主持

3. 江苏特聘教授，2023-2026，主持

4. 苏州大学海外高层次人才引进启动经费，2023-2026，主持


代表性论文 (全部论文详见Google Scholar)：

  • 预印本（preprints）

1. Junpeng Zhou, Keyao Zhu, Xiaoqian Huang, Jinqi Yuan, Yumei Li. cfDNAanalyzer: a comprehensive toolkit for analyzing cell-free DNA genomic sequencing data in liquid biopsy. bioRxiv. 2025 (https://doi.org/10.1101/2025.06.09.658767)

2. Yixuan Wang, Jiayi Li, Jingqi Li, Shen Yang, Yuhan Huang, Xinyuan Liu, Yimin Fan, Irwin King, Yumei Li, Yu Li. cfDecon: Accurate and Interpretable methylation-based cell type deconvolution for cell-free DNA. bioRxiv. 2024 (https://doi.org/10.1101/2025.02.11.637663)

  • 已发表

1. Tongyue Sun*, Jinqi Yuan*, Yacheng Zhu, Jingqi Li, Shen Yang, Junpeng Zhou, Xinzhou Ge, Susu Qu, Wei Li, Jingyi Jessica Li, Yumei Li. Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA. Genome Biology. 2024 (https://doi.org/10.1186/s13059-024-03456-8)

2. Xinzhou Ge*, Yumei Li*, Wei Li and Jingyi Jessica Li. Response to Neglecting normalization impact in semi-synthetic RNA-seq data simulation generates artificial false positives and Winsorization greatly reduces false positives by popular differential expression methods when analyzing human population samples. Genome Biology. 2024 (https://doi.org/10.1186/s13059-024-03232-8)

3. Yumei Li*, Jianfeng Xu*, Chaorong Chen*, Zhenhai Lu*, Desen Wan, Diange Li, Jason S. Li, Allison J. Sorg, Curt C. Roberts, Shivani Mahajan, Maxime A. Gallant, Itai Pinkoviezky, Ya Cui, David J. Taggart, Wei Li. Multimodal Epigenetic Sequencing Analysis (MESA) of Cell-free DNA for Non-invasive Colorectal Cancer Detection. Genome Medicine. 2024 (https://doi.org/10.1186/s13073-023-01280-6)

4. Yumei Li*, Xinzhou Ge*, Fanglue Peng, Wei Li, Jingyi Jessica Li. Exaggerated false positives by popular differential expression methods when analyzing human population samples. Genome Biology. 2022 (https://doi.org/10.1186/s13059-022-02648-4)

5. Deepanwita Sengupta*, Liyong Zeng*, Yumei Li*, Simone Hausmann, Debopam Ghosh, Gang Yuan, Thuyen N Nguyen, Ruitu Lyu, Marcello Caporicci, Ana Morales Benitez, Garry L Coles, Vladlena Kharchenko, Iwona Czaban, Dulat Azhibek, Wolfgang Fischle, Mariusz Jaremko, Ignacio I Wistuba, Julien Sage, Łukasz Jaremko, Wei Li, Pawel K Mazur, Or Gozani. NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. Molecular Cell. 2021 (https://doi.org/10.1016/j.molcel.2021.08.034)

6. Yumei Li*, Qing Sunny Shen*, Qi Peng*, Wanqiu Ding, Jie Zhang, Xiaoming Zhong, Ni A An, Mingjun Ji, Wei-Zhen Zhou, Chuan-Yun Li. Polyadenylation- related isoform switching in human evolution revealed by full-length transcript structure. Briefings in Bioinformatics. 2021 (https://doi.org/10.1093/bib/bbab157)

7. Yumei Li*, Shanshan Ai*, Xianhong Yu*, Chen Li, Xin Li, Yanzhu Yue, Yusheng Wei, Chuan-Yun Li, and Aibin He. Replication-independent histone turnover underlines the epigenetic homeostasis in adult heart. Circulation Research. 2019 (https://doi.org/10.1161/circresaha.118.314366)

8. Yumei Li*, Chen Li*, Shuxian Li, Qi Peng, Ni A. An, Aibin He, and Chuan-Yun Li. Human exonization through differential nucleosome occupancy. PNAS. 2018 (https://doi.org/10.1073/pnas.1802561115)

9. Shanshan Ai*, Xianhong Yu*, Yumei Li*, Yong Peng, Chen Li, Yanzhu Yue, Ge Tao, Chuan-Yun Li, William T. Pu, and Aibin He. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circulation Research. 2017 (https://doi.org/10.1161/circresaha.117.311212)


教育经历

工作经历

社会职务

研究领域

医学基因组与表观基因组学课题组主要通过运用和开发生物信息学方法，结合高通量组学数据，研究核小体相关的表观遗传调控在基础生命过程和疾病发生发展中的功能，以期理解生命过程的基本调控规律和发现其潜在的临床应用价值。


主要研究方向包括：

（1）核小体相关的表观遗传调控在基础生物学过程和疾病发生发展中的功能研究；（2）基于血液等体液游离DNA的疾病无创诊断方法的开发；（3）多组学数据的处理和分析算法的评估和开发。



社会职务

开授课程

科研项目

论文

  • 1、Exaggerated false positives by popular differential expression methods when analyzing human population samples,Genome Biology,2022,Yumei Li,Xinzhou Ge et al.
  • 2、NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis,Molecular Cell,2021,Deepanwita Sengupta, Liyong Zeng, Yumei Li et al.
  • 3、Polyadenylation-related isoform switching in human evolution revealed by full-length transcript structure,Briefings in Bioinformatics,2021,Yumei Li, Qing Sunny Shen, Qi Peng et al.
  • 4、Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart,Circulation Research,2019,Yumei Li, Shanshan Ai, Xianhong Yu et al.
  • 5、Human exonization through differential nucleosome occupancy,PNAS,2018,Yumei Li, Chen Li et al.
  • 6、Divergent Requirements for EZH1 in Heart Development Versus Regeneration,Circulation Research,2017,Shanshan Ai, Xianhong Yu, Yumei Li et al.

科技成果

软件著作 专利

荣誉及奖励

招生信息

生物学、生物信息学。

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