个人信息
个人简介
个人简介
 

B.S., Hunan Agricultural University, 1983

M.S., Sichuan Agricultural University, 1986

Ph.D., University of Edinburgh, United Kingdom, 1996

Postdoctoral Fellow, Medical College of Georgia, 1996 – 1998

Postdoctoral Associate, University of Ottawa, 1998 – 2001

Research Instructor, Vanderbilt University, 2002 – 2005

Assistant Professor, Cornell University, 2006-2014


研究领域

The Long Lab studies:  (1) transcriptional control of cell fate decisions of early pancreatic epithelial cells during mammalian  embryonic development;  (2) cellular and molecular mechanisms of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC);  and (3) genetic factors and signaling pathways mediating cellular stress-induced neurodegeneration and cell death in the central nervous system (CNS).  Our long-term goal has been to identifynovel therapeutic intervention targets and develop new strategies for more effective prevention and treatment of chronic human diseases, including diabetes mellitus, neurodegenerative diseases, virally and nonvirally induced liver cancers.

基本信息
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龙乔明

职称:教授

院部/部门:剑桥-苏大基因组资源中心

学历:

学位:

毕业学校:

毕业专业:

联系方式

通讯地址:

邮政编码:

电子邮箱:qmlong@suda.edu.cn

联系电话:051265883672

传真号码:

办公地点:医学部

科学研究
科研团队
论文

SELECTED PUBLICATIONS:

  

1.   Sha, H.B.,  Sun, S.Y., Francisco, A.B., Ehrhardt,  N., Xue, Z., Liu, L., Lawrence, P., Frits

      Mattijssen, F., Guber, R., Panhwar, M.S.,  Brenna, J.T., Hang Shi, H., Xue, B.Z., Sander

      Kersten, S., Bensadoun,  A., *Péterfy, M., *Long, Q.M. and *Qi, L. (2014) The ER-associated

      Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism. 

      Cell MetabolismSep 2; 20(3): 458-470. (*Co-senior author).

2.   Sun, S. Shi, G., Han, X., Francisco, A.B., Ji, Y., Mendonca, N., Liu, X., Locasale, J.W.,

      Simpson, K.W., Duhamel, G.E., Kersten, S., Yates, J.R. 3rd*Long, Q.M. and *Qi, L. (2014)  

      Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation,

      endoplasmic reticulum homeostasis, and survival.  Proc Natl Acad Sci USA. Jan 22. E582-

      591. (*Co-corresponding author).
 3.   Qin, L.L, Xu, J., Wu, Z.F., Zhang, Z., Li, J.Q., *Wang, C. and *Long, Q.M. Notch1-mediated

      signaling regulates proliferation of porcine satellite cells (PSCs). 2013; Cellular Signaling

      25: 561569. (*Co-corresponding author).

4.   Francisco, A.B., Singh, R., Sha, H., Yan, X., Qi, L., Lei, X.G. and *Long, Q.M.    Haploid

      insufficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) protein predisposes mice to

      high fat diet induced hyperglycemia.   Journal of Biological Chemistry. 2011; 286 (24):

      21231-21238.  (*Corresponding author).

5.   Francisco, A.B., Singh, R., Li, S., Vani, A., Yang, L., Munroe, R.J., Diaferia, G., Cardano, M.,

      Biunno, I., Qi, L., Schimenti, J.C. and *Long, Q.M. Deficiency of Suppressor Enahncer Lin

      12 1 Like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic

      lethality.  Journal of Biological Chemistry. 2010; 285 (18):13694-13703. (*Corresponding

      author).

6.   Li, S., Francisco, A.B., Han, C., Pattabiraman, S., Foote, M.R., Giesy, S.L., Wang, C.,

      Schimenti, J.C., Boisclair, Y.V. and *Long, Q.M.  The full-length isoform of pleckstrin 

      homology domain-interacting protein (PHIP) regulates postnatal growth independently of

      insulin-like growth factor 1.  FEBS lett2010; 584:4121-4127. (*Corresponding author).

7.   Li, S., Francisco, A. B., Munroe, R. J., Schimenti, J. C. and *Long, Q.M.   SEL1L deficiency

      impairs growth and differentiation of pancreatic epithelial cells.  BMC Developmental Biology.

      2010; 10:19.  (*Corresponding author).

8.   Masui, T., Long, Q.M.Beres, T.M., Magnuson, M.A. and MacDonald, R.J.  Early pancreatic

      development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.

      Genes & Development2007; 21:2629-2643.

9.   Long, Q.M., Huang, H., Shafizadeh, E. and Lin, S.  Stimulation of erythropoiesis by inhibiting

      a new hematopoietic death receptor in transgenic zebrafish.  Nature Cell Biology. 2000;

      2:549-552.

10. Wang, H., Long, Q.M., Scott, D.M., Sassa, S. and Lin. S.  zebrafish model for

      hepatoerythropoietic porphyriaNature Genetics1998; 20 (3): 239-43.

11. Long, Q.M., Meng, A.M., Wang, H., Jessen, R.J., Farrell, M. and Lin, S.  GATA-1 expression

      pattern can be recapitulated in living transgenic zebrafish using GFP reporter

      gene. Development. 1997; 124  (20): 4105-4111.


荣誉奖励
开授课程

The Science of Biology、实验动物学

招生信息