- 个人信息
- 科学研究
- 成果奖励
- 教学招生
个人信息
个人简介
个人简介 B.S., Hunan Agricultural University, 1983 M.S., Sichuan Agricultural University, 1986 Ph.D., University of Edinburgh, United Kingdom, 1996 Postdoctoral Fellow, Medical College of Georgia, 1996 – 1998 Postdoctoral Associate, University of Ottawa, 1998 – 2001 Research Instructor, Vanderbilt University, 2002 – 2005 Assistant Professor, Cornell University, 2006-2014研究领域
The Long Lab studies: (1) transcriptional control of cell fate decisions of early pancreatic epithelial cells during mammalian embryonic development; (2) cellular and molecular mechanisms of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC); and (3) genetic factors and signaling pathways mediating cellular stress-induced neurodegeneration and cell death in the central nervous system (CNS). Our long-term goal has been to identifynovel therapeutic intervention targets and develop new strategies for more effective prevention and treatment of chronic human diseases, including diabetes mellitus, neurodegenerative diseases, virally and nonvirally induced liver cancers. 基本信息
![]() 职称:教授 院部/部门:教师主页校级站点 学历: 学位: 毕业学校: 毕业专业: 联系方式
通讯地址: 邮政编码: 电子邮箱:qmlong@suda.edu.cn 联系电话:051265883672 传真号码: 办公地点:医学部 科学研究
科研团队
论文
SELECTED PUBLICATIONS:
1. Sha, H.B., Sun, S.Y., Francisco, A.B., Ehrhardt, N., Xue, Z., Liu, L., Lawrence, P., Frits Mattijssen, F., Guber, R., Panhwar, M.S., Brenna, J.T., Hang Shi, H., Xue, B.Z., Sander Kersten, S., Bensadoun, A., *Péterfy, M., *Long, Q.M. and *Qi, L. (2014) The ER-associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism. Cell Metabolism;Sep 2; 20(3): 458-470. (*Co-senior author). 2. Sun, S. Shi, G., Han, X., Francisco, A.B., Ji, Y., Mendonca, N., Liu, X., Locasale, J.W., Simpson, K.W., Duhamel, G.E., Kersten, S., Yates, J.R. 3rd, *Long, Q.M. and *Qi, L. (2014) Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci USA. Jan 22. E582- 591. (*Co-corresponding author). signaling regulates proliferation of porcine satellite cells (PSCs). 2013; Cellular Signaling 25: 561–569. (*Co-corresponding author). 4. Francisco, A.B., Singh, R., Sha, H., Yan, X., Qi, L., Lei, X.G. and *Long, Q.M. Haploid insufficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) protein predisposes mice to high fat diet induced hyperglycemia. Journal of Biological Chemistry. 2011; 286 (24): 21231-21238. (*Corresponding author). 5. Francisco, A.B., Singh, R., Li, S., Vani, A., Yang, L., Munroe, R.J., Diaferia, G., Cardano, M., Biunno, I., Qi, L., Schimenti, J.C. and *Long, Q.M. Deficiency of Suppressor Enahncer Lin 12 1 Like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality. Journal of Biological Chemistry. 2010; 285 (18):13694-13703. (*Corresponding author). 6. Li, S., Francisco, A.B., Han, C., Pattabiraman, S., Foote, M.R., Giesy, S.L., Wang, C., Schimenti, J.C., Boisclair, Y.V. and *Long, Q.M. The full-length isoform of pleckstrin homology domain-interacting protein (PHIP) regulates postnatal growth independently of insulin-like growth factor 1. FEBS lett. 2010; 584:4121-4127. (*Corresponding author). 7. Li, S., Francisco, A. B., Munroe, R. J., Schimenti, J. C. and *Long, Q.M. SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells. BMC Developmental Biology. 2010; 10:19. (*Corresponding author). 8. Masui, T., Long, Q.M., Beres, T.M., Magnuson, M.A. and MacDonald, R.J. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes & Development. 2007; 21:2629-2643. 9. Long, Q.M., Huang, H., Shafizadeh, E. and Lin, S. Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nature Cell Biology. 2000; 2:549-552. 10. Wang, H., Long, Q.M., Scott, D.M., Sassa, S. and Lin. S. A zebrafish model for hepatoerythropoietic porphyria. Nature Genetics. 1998; 20 (3): 239-43. 11. Long, Q.M., Meng, A.M., Wang, H., Jessen, R.J., Farrell, M. and Lin, S. GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development. 1997; 124 (20): 4105-4111. 荣誉奖励
开授课程
The Science of Biology、实验动物学 招生信息
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