Shao Changshun Professor

1. Redox regulation of cell fate decision

2. Role of immune cells in tissue regeneration and repair

3. DNA repair and cancer therapy 

Representative publications since 2018 (* Corresponding author)

1.Liu X, Zhao M, Sun X, Meng Z, Bai X, Gong Y, Xu L, Hao X, Yang T, Wei Z, Zhang X, Guo H, Li P, Liu Q, Gong Y, Shi Y, Shao C*. Autophagic Flux Unleashes GATA4-NF-κB Axis to Promote Antioxidant Defense-Dependent Survival of Colorectal Cancer Cells under Chronic Acidosis. Oxid Med Cell Longev. 2021 Dec 26;2021:8189485. doi: 10.1155/2021/8189485. PMID: 34987705; PMCID: PMC8720590.

2. Hao X, Bu W, Lv G, Xu L, Hou D, Wang J, Liu X, Yang T, Zhang X, Liu Q, Gong Y, Shao C*. Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress. Oncogene. 2021 Nov 12. doi: 10.1038/s41388-021-02105-9. Epub ahead of print. PMID: 34773075.

3. Zheng Z, Li YN, Jia S, Zhu M, Cao L, Tao M, Jiang J, Zhan S, Chen Y, Gao PJ, Hu W, Wang Y*, Shao C*, Shi Y*. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3. Nat Commun. 2021 Oct 27;12(1):6202. doi: 10.1038/s41467-021-26460-z. PMID: 34707103; PMCID: PMC8551331.

4. Hang Y, Ma X, Liu C, Li S, Zhang S, Feng R, Shang Q, Liu Q, Ding Z, Zhang X, Yu L, Lu Q*, Shao C*, Chen H*, Shi Y, He J, Kaplan DL. Blastocyst-Inspired Hydrogels to Maintain Undifferentiation of Mouse Embryonic Stem Cells. ACS Nano. 2021 Sep 28;15(9):14162-14173. doi: 10.1021/acsnano.0c10468. Epub 2021 Sep 13. PMID: 34516077.

5. Li X, Su X, Liu R, Pan Y, Fang J, Cao L, Feng C, Shang Q, Chen Y, Shao C*, Shi Y.* HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression. Oncogene. 2021 Mar;40(10):1836-1850. doi: 10.1038/s41388-020-01636-x. Epub 2021 Feb 9. PMID: 33564072; PMCID: PMC7946638.

6. Liu R, Li X, Ma H, Yang Q, Shang Q, Song L, Zheng Z, Zhang S, Pan Y, Huang P, Fang J, Li Y, Liu Z, Cao L, Feng C, Gong Z, Chen Y, Wang Y, Melino G, Shao C*, Shi Y*. Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy. Free Radic Biol Med. 2020 Dec;161:339-350. doi: 10.1016/j.freeradbiomed.2020.10.029. Epub 2020 Oct 24. PMID: 33122005.

7. Xu L, Wu T, Lu S, Hao X, Qin J, Wang J, Zhang X, Liu Q, Kong B, Gong Y, Liu Z, Shao C*. Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells. Redox Biol. 2020 Sep;36:101604. doi: 10.1016/j.redox.2020.101604. Epub 2020 Jun 8. PMID: 32554304; PMCID: PMC7303666.

8. Li X, Liu R, Su X, Pan Y, Han X*, Shao C*, Shi Y*. Harnessing tumor-associated macrophages as aids for cancer immunotherapy. Mol Cancer. 2019 Dec 5;18(1):177. doi: 10.1186/s12943-019-1102-3. PMID: 31805946; PMCID: PMC6894344.

9. Wei Z, Guo H*, Qin J, Lu S, Liu Q, Zhang X, Zou Y, Gong Y, Shao C*. Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence. Free Radic Biol Med. 2019 Jan;130:267-277. doi: 10.1016/j.freeradbiomed.2018.10.457. Epub 2018 Nov 2. PMID: 30391675.

10. Hou D, Liu Z, Xu X, Liu Q, Zhang X, Kong B, Wei JJ, Gong Y, Shao C*. Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. Redox Biol. 2018 Jul;17:99-111. doi: 10.1016/j.redox.2018.03.016. Epub 2018 Mar 30. PMID: 29684820; PMCID: PMC6006521.