姓名：何伟奇

何伟奇，剑桥-苏大基因组资源中心特聘教授、博士生导师、课题组长。江苏省杰出青年基金获得者，苏州大学仲英青年学者。主要从事肠道上皮稳态调控研究。主持国家自然科学基金3项，江苏省自然科学基金2项，Crohn's & Colitis Foundation基金1项。相关研究成果发表在Nat Med，Gastroenterology，CMGH，JBC等知名期刊。担任Gastroenterology，CMGH，Cell Death Dis等期刊审稿人。获2018-2019年度苏州市自然科学优秀学术论文一等奖，2020年度苏州大学周氏教育科研奖。

近期发表论文
Int J Mol Sci 2020, 21: 993

Nat Med 2019, 25: 690-700.

CMGH 2019, 7: 255-274

JoVE 2018, 140: e57032

课题组招聘信息

拟招聘1-2名博士后科研人员，应聘者请将个人简历包括学习工作经历、主要研究工作内容、代表论文论著、获得的奖励情况等发送至何老师邮箱：whe@suda.edu.cn

中国细胞生物学会节律分会委员会委员

江苏省细胞与发育生物学学会理事

1. 肠黏膜屏障紊乱及炎症性肠病的发生机制

2. 肠道和生物节律之间的相互作用机制

3. 炎症因子调控小肠干细胞增殖和分化的机制

研究团队

工作人员：李华善（2020-，博士后）

在读学生：盛建英（2018-，硕士研究生），王静（2018-，硕士研究生），高海婷（2019-，硕士研究生），李俊（2019-，硕士研究生），葛心瑶（2018-2020，本科生，2020-，硕士研究生），陆穆娇（2020-，硕士研究生）

已毕业学生：林倩（2014-2017，硕士），李华善（2015-2020，博士），蒋志慧（2016-2019，硕士），吴佳（2016-2019，硕士），徐绍芳（2017-2020，硕士），李般若（2016-2020，本科生），杨乙君（2016-2017，本科生），李仁晖（2016-2017，本科生），樊高（2017-2018，本科生），申方（2017-2018，本科生），哈力旦·艾尼（2018-2020，本科生），郑万坤（2018-2020，本科生）

已发表论文 (See in PubMed)

Selected Publications

2021

Li HS, Sheng JY, Wang J, Gao HT, Yu J, Ding GX, Ding N, He WQ, Zha JM, Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice. Drug Des Devel Ther. 2021 May 31;15:2309-2324.

2020

Zhu GJ, Gong S, Ma DB, Tao T, He WQ, Zhang L, Wang F, Qian XY, Zhou H, Fan C, Wang P, Chen X, Zhao W, Sun J, Chen H, Wang Y, Gao X, Zuo J, Zhu MS, Gao X, Wan G. Aldh inhibitor restores auditory function in a mouse model of human deafness. PLoS Genet. 2020 Sep 24;16(9):e1009040.

He WQ; Wang J; Sheng, JY; Zha JM; Graham WV; Turner JR Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis. Int. J. Mol. Sci.2020, 21, 993.

Zhao W, Wang P, He W, Tao T, Li H, Li Y, Jiang W, Sun J, Ge X, Chen X,Zheng Y, Wei L, Chen C, Wang Y, Li C, Chen H, Yao B, Tang W, Zhu M, MYPT1 Down-regulation by LPS-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease, Cell Mol Gastroenterol Hepatol. 2020. 9(2):345-347.

Li HS, Xu SF, Sheng JY, Jiang ZH, Wang J, Ding N, Wang T, Odenwald MA, Turner JR, He WQ, Xu H, Zha JM Quantification of Proliferative and Dead Cells in Enteroids. J Vis Exp. 2020. (155), e60501.

2019

Graham WV*, He WQ*, Marchiando AM, Zha JM, Gurminder S, Li HS, Biswas A, Jiang ZH, Choi W, Zuccola H, Wang YT, Griffith J, Wu J, Rosenberg H, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular diversion blocks specific MLCK functions to restore mucosal barriers. Nat Med. 2019. 25(4):690-700.

Juan-Min Zha; Hua-Shan Li; Qian Lin; Wei-Ting Kuo; Zhi-Hui Jiang; Pei-Yun Tsai; Ning Ding; Jia Wu; Shao-Fang Xu; Yi-Tang Wang; Jian Pan; Xiu-Min Zhou; Kai Chen; Min Tao; Matthew A. Odenwald; Atsushi Tamura; Sachiko Tsukita; Jerrold R. Turner; Wei-Qi He. Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. Cell Mol Gastroenterol Hepatol, 2019. 7(2): p. 255-274. 

2018

Li, B. R., Wu, J., Li, H. S., Jiang, Z. H., Zhou, X. M., Xu, C. H., Ding, N., Zha, J. M., He, W. Q. In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability. J Vis Exp. 2018. 140: e57032.

2017

Tsai P.Y., Zhang B., He W.Q., Zha J.M., Odenwald M.A., Singh G., Tamura A., Shen L., Sailer A., Yeruva S., Kuo W.T., Fu Y.X., Tsukita S., and Turner J.R., IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe, 2017. 21(6): p. 671-681e4.

Li H.S., Lin Q., Wu J., Jiang Z.H., Zhao J.B., Pan J., He W.Q.#, and Zha J.M.#, Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development. Biomed Pharmacother, 2017. 92: p. 810-818.

2016

Zhang C.H., Wang P., Liu D.H., Chen C.P., Zhao W., Chen X., Chen C., He W.Q., Qiao Y.N., Tao T., Sun J., Peng Y.J., Lu P., Zheng K., Craige S.M., Lifshitz L.M., Keaney J.F., Jr., Fogarty K.E., ZhuGe R., and Zhu M.S., The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun, 2016. 7: p.11358.

Zha J.M., Li H.S., Wang Y.T., Lin Q., Tao M., and He W.Q., Characterization of isoform expression and subcellular distribution of MYPT1 in intestinal epithelial cells. Gene, 2016. 588(1): p. 1-6.

Gao N., Chang A.N., He W., Chen C.P., Qiao Y.N., Zhu M., Kamm K.E., and Stull J.T., Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle. J Physiol, 2016.594(12):p. 3209-25.

2015

Chen C.P., Chen X.,Qiao Y.N., Wang P., He W.Q., Zhang C.H., Zhao W., Gao Y.Q., Chen C., Tao T., Sun J., Wang Y., Gao N., Kamm K.E., Stull J.T., and Zhu M.S., In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol, 2015. 593(3): p.681-700.

2014

Tsai M.H., Chang A.N., Huang J., He W., Sweeney H.L., Zhu M., Kamm K.E., and Stull J.T., Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle. J Physiol, 2014. 592(14): p. 3031-51.

Qiao Y.N.*, He W.Q.*, Chen C.P., Zhang C.H., Zhao W., Wang P., Zhang L., Wu Y.Z., Yang X., Peng Y.J., Gao J.M., Kamm K.E., Stull J.T., and Zhu M.S., Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J Biol Chem, 2014. 289(32):p. 22512-23.

Chen C., Tao T., Wen C., He W.Q., Qiao Y.N., Gao Y.Q., Chen X., Wang P., Chen C.P., Zhao W., Chen H.Q., Ye A.P., Peng Y.J., and Zhu M.S., Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism. J Biol Chem, 2014. 289(41): p.28478-88.

2013

He W.Q., Qiao Y.N., Peng Y.J., Zha J.M., Zhang C.H., Chen C., Chen C.P., Wang P.,Yang X., Li C.J., Kamm K.E., Stull J.T., and Zhu M.S., Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1. Gastroenterology, 2013. 144(7):p. 1456-65, 1465 e1-5.

Gao N., Huang J., He W., Zhu M., Kamm K.E., and Stull J.T., Signaling through myosin light chain kinase in smooth muscles. J Biol Chem, 2013. 288(11): p.7596-605.

2012

Yu Y., Lv N., Lu Z., Zheng Y.Y., Zhang W.C., Chen C., Peng Y.J., He W.Q., Meng F.Q., Zhu M.S., and Chen H.Q., Deletion of myosin light chain kinase in endothelial cells has a minor effect on the lipopolysaccharide-induced increase in microvascular endothelium permeability in mice. FEBS J, 2012. 279(8): p. 1485-94.

2011

Zha J., Chen X., Li C., Zhu M., Ding G., and He W., One-step construction of lentiviral reporter using Red-mediated recombination. Mol Biotechnol, 2011. 49(3): p.278-82.

He W.Q., Qiao Y.N., Zhang C.H., Peng Y.J., Chen C., Wang P., Gao Y.Q., Chen C., Chen X., Tao T., Su X.H., Li C.J., Kamm K.E., Stull J.T., and Zhu M.S., Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. Am J Physiol Heart Circ Physiol, 2011. 301(2): p.H584-91.

2006 - 2010

Wang L., Guo D.C., Cao J., Gong L., Kamm K.E., Regalado E., Li L., Shete S., He W.Q., Zhu M.S., Offermanns S., Gilchrist D., Elefteriades J.,Stull J.T., and Milewicz D.M., Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet, 2010. 87(5): p. 701-7.

Peng Y.J.*, He W.Q.*, Tang J., Tao T., Chen C., GaoY.Q., Zhang W.C., He X.Y., Dai Y.Y., Zhu N.C., Lv N., Zhang C.H., Qiao Y.N.,Zhao L.P., Gao X., and Zhu M.S., Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem, 2010. 285(32): p. 24834-44.

He W.Q., Peng Y.J., Zhang W.C., Lv N., Tang J., Chen C., Zhang C.H., Gao S., Chen H.Q., Zhi G., Feil R., Kamm K.E., Stull J.T., Gao X., and Zhu M.S., Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology, 2008. 135(2): p. 610-20.

Yang C.X., Chen H.Q., Chen C., Yu W.P., Zhang W.C., Peng Y.J., He W.Q., Wei D.M., Gao X., and Zhu M.S.,Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase. Cell Res, 2006. 16(4):p. 367-76.

中国细胞生物学会节律分会委员会委员

江苏省细胞与发育生物学学会理事

The Science of Biology、Medical Genetics、医学生物前沿、实验动物学

拟每年招收博士研究生1人，硕士研究生1-2人，也欢迎本科生加入