个人信息
个人简介

吴华,研究员,博士生导师,苏州大学首批“仲英青年学者”,江苏省杰出青年基金获得者,中国医学装备人工智能联盟病理委员会委员,中国研究型医院学会超微与分子病理学专业委员会心血管疾病多学科协作学组委员等。20077月本科毕业于山东大学,2012年12月博士毕业于厦门大学,2011年-2012年在美国Sanford-Burnham医学研究所访学交流,2013年1月起就职于苏州大学医学部病理学与病理生理学系,历任副教授、副研究员,研究员。近些年,主要致力于消化系统肿瘤尤其结直肠癌、肝癌发生及转移相关机制研究迄今以第一/通讯作者在Journal of HepatologyHepatologyNature CommunicationsAutophagyCancer Research(3篇)等国际知名学术刊物发表SCI论文22篇;主持国家自然科学基金5项、江苏省自然科学基金3项。2010年度荣获教育部首届学术新人奖,2017年度荣获苏州大学周氏科研奖。




研究领域

消化系统肿瘤分子病理

基本信息
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吴华

职称:教授

院部/部门:医学部基础医学与生物科学学院

学历:博士研究生

学位:博士

毕业学校:厦门大学

毕业专业:

联系方式

通讯地址:

邮政编码:215123

电子邮箱:wuhua@suda.edu.cn

联系电话:

传真号码:

办公地点:苏州大学独墅湖校区仁爱路199号医学部基础医学与生物科学学院403-3329

科学研究
科研团队
论文

论文发表:

https://publons.com/researcher/3076578/hua-wu/

一、代表性学术成果

1Wu H*, Yang TY, Li Y, Ye W, Liu F, He XS, Wang JR, Gan WJ, Li XM, Zhang S, Zhao YY, Li JM*. TRAF6 promotes hepatocarcinogenesis by interacting with HDAC3 to enhance c-Myc gene expression and protein stability. Hepatology. 2019.第一作者/共同通讯作者IF: 14.971

2Wu H, Lu XX, Wang JR, Yang TY,Li XM, He XS,Li Y, Ye WL,Wu Y, Gan WJ, Guo PD, Li JM*. TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/β-catenin degradation and is targeted for GSK3B/GSK3β-mediated phosphorylation and degradation. Autophagy. 2019 Feb 26. (第一作者,IF: 11.059)

3Ye XH#, Wu H#, Sheng LY, Liu YX, Ye F, Wang M, Zhou H, Su Y, Zhang XK*, Oncogenic potential of truncated RXR during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling. Nature Communications. 2019 Apr 1;10(1):1463.(共同第一作者IF: 11.878

4Wu H#, Yao S#, Zhang S, Wang JR, Guo PD, Li XM, Gan WJ, Mei L, Gao TM*, Li JM*. Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis of hepatocellular carcinoma. Journal of Hepatology. 2017Jun;66(6):1193-1204.  (第一作者IF : 18.946

5Guo PD#, Lu XX#, Gan WJ#, Li XM#, He XS, Zhang S, Ji QH, Zhou F, Cao Y, Wang JR, Li JM*, Wu H*.RARγ downregulation contributes to colorectal tumorigenesis and metastasis by de-repressing the Hippo-Yap pathway. Cancer Research.2016 Jul 1;76(13):3813-25. (通讯作者IF:8.378

6Gan WJ#, Wang JR#, Zhu XL#, He XS, Guo PD, Zhang S, Li XM, Li JM*, Wu H*. RARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis. J Exp Clin Cancer Res. 2016 Oct 19;35(1):164. (通讯作者IF:5.646

7Wu H#, Li XM#, Wang JR, Gan WJ, Jiang FQ, Liu Y, Zhang XD, He XS, Zhao YY, Lu XX, Guo YB, Zhang XK*, Li JM*.NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis. Journal of pathology. 2016 Feb;238(3):457-69.(第一作者IF:5.942

8Xing C, Lu XX, Guo PD, Shen T, Zhang S, He XS, Gan WJ, Li XM, Wang JR, Zhao YY, Wu H*, Li JM*.Ubiquitin Specific Protease 4 (USP4)-mediated Deubiquitination and Stabilization of PRL-3 is Required for Potentiating Colorectal Oncogenesis.Cancer Research. 2016 Jan 1;76(1):83-95. (共同通讯作者IF : 8.378

9Yao S#, Zheng P#, Wu H#, Song L, Ying X, Xing C, Li Y, Xiao Z, Zhou X, Shen T, Chen L, Liu Y, Lai M, Mei L, Gao T*, Li J*.Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl mediated ubiquitination and down-regulation of EGFR. Journal of pathology. 2015 May;236(1):65-77.   (共同第一作者IF:5.942

10Wang JR#, Gan WJ#, Li XM#, Zhao YY, Li Y, Lu XX,Li JM*,Wu H*.Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin. Carcinogenesis.2014 Nov;35(11):2474-84.    (通讯作者IF:4.004

11Wu H, Lin YY, Li WG, Sun Z, Gao WW, Zhang HP, Xie L, Jiang FQ, Qin B, Yan TD, Chen LQ, Zhao Y, Cao X, Wu Y, Lin BZ, Zhou H, Wong AS,, Zhang XK*, Zeng JZ*. Regulation of Nur77 Expression by b-catenin and Its Mitogenic Effect in Colon Cancer Cells. FASEB J. 2011 Jan;25(1):192-205.  (第一作者IF:5.391

12Yan TD#, Wu H#, Zhang HP#, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, LinYY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK*Zeng JZ*. Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma. Cancer Research. 2010 Mar 15;70(6):2285-95.  (共同第一作者IF:8.378


二、近些年发表的其他学术论文:

1Xu Y, Xu H, Li M, Wu H, Guo Y, Chen J, Shan J, Chen X, Shen J, Ma Q, Liu J, Wang M, Zhao W, Hong J, Qi Y, Yao C, Zhang Q, Yang Z, Qian C, Li J.KIAA1199 promotes sorafenib tolerance and the metastasis of hepatocellular carcinoma by activating the EGF/EGFR-dependent epithelial-mesenchymal transition program. Cancer Lett. 2019 Jul 10;454:78-89.

2He XS#, Guo LC#, Du MZ#, Huang S, Huang RP, Zhan SH, Gu DM, Liu WS, Wang XM, Wu H*, Gan WJ*. The Long Non-coding RNA NONHSAT062994 Inhibits Colorectal Cancer by Inactivating Akt Signaling. Oncotarget. 2017 Aug 2;8(40):68696-68706.  (通讯作者)

3Li XM#, Yang TY#, He XS#, Wang JR, Gan WJ, Zhang S, Li JM*, Wu H*. Orphan nuclear receptor Nur77 inhibits Poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20. Oncotarget. 2017 May 9;8(37):61025-61035.(通讯作者)

4Li XM#, Wang JR#, Shen T#, Gao SS, He XS, Li JN, Yang TY, Zhang S, Gan WJ, Li JM*Wu H*. Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression. PLoS One. 2017 Feb 7;12(2):e0171347.  (通讯作者)

5Li XM#, Zhang S#, He XS#, Guo PD, Lu XX, Wang JR, Li JM, Wu H*. Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice. J Inflamm (Lond). 2016 Feb 2;13:4.  (通讯作者)

6Li XM#, Lu XX#, Xu Q, Wang JR, Zhang S, Guo PD, Li JM, Wu H*. Nur77 deficiency leads to systemic inflammation in elderly mice. J Inflamm (Lond). 2015 Jun 26;12:40. (通讯作者)

7Sun Z, Cao X, Jiang MM, Qiu Y, Zhou H, Chen L, Qin B, Wu H, Jiang F, Chen J, Liu J, Dai Y, Chen HF, Hu QY, Wu Z, Zeng JZ, Yao XS, Zhang XK*.Inhibition ofβ-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77.Oncogene, 2012 May 24;31(21):2653-67 .

8Lu N, Liu J, Liu J, Zhang C, Jiang F, Wu H, Cao X, Yan T, Wang G, Zhou H, Lin BZ, Yan XM, Zhang XK*, Zeng JZ*. Antagonist Effect of Triptolide on AKT Activation by Truncated Retinoid X Receptor-alpha. PLOS One. 2012;7(4):e35722.

9Zhou H#, Liu W#, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li W-G, Lin B, Zhang H-P, Yu J, Luo S-P, Zeng J-Z, Duester G, Huang P-Q, ZhangXK*.NSAID Sulindac and Its Analogs Bind RXRalpha and Inhibit RXRalpha-dependent AKT Signaling. Cancer Cell , 2010 Jun 15;17(6):560-73.

10Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, Zeng JZ, Zhang XK.A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations.J Biol Chem. 2009 Jul 3;284(27):18503-14.








荣誉奖励
  • 1、2010年度入选教育部首届学术新人奖
  • 2、2017年度荣获苏州大学周氏科研奖
  • 3、2019年入选苏州大学“仲英青年学者”
  • 4、2019年度荣获江苏省杰出青年基金
开授课程

1、《高级病理学》研究生课程;
2、《医学科研方法学》本科生课程;
3、《医学专业英语》本科生课程;

招生信息

热忱欢迎有志从事肿瘤学研究的本科生、研究生到本课题组学习工作。招生方向为“病理学与病理生理学”