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Biography

  • Department:International College of Pharmaceutical Innovation
  • Tel:0512-65886182
  • Gender:male
  • Email:xucc@suda.edu.cn
  • Post:
  • Office Location:ICPI BLDG Room 709
  • Graduate School:The Ohio State University
  • Address:Jiuyong West Rd. 1, Wujiang District, Suzhou
  • Degree:Ph.D.
  • PostCode:
  • Academic Credentials:
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Overview

Overview:Overview:

Education

Education:

Professional Experiences

Professional Experiences:

Professional Service

Professional Service:Professional Service:

Overview

Overview:Overview:

Professional Service

Professional Service:Professional Service:

Research

Research:

Teaching

Teaching:

Projects

Projects:

Publications

Publications:

n  Xu, C., Zhang, L., Wang, W.,   Tang, Y., Wang, Q., An, J., ... & Li, H. (2023). Improving the   Circularization Efficiency, Stability and Translatability of Circular RNA by   circDesign. bioRxiv, 2023-07.

n  Fan T#, Xu   C# (co-first author), Wu J#, Cai Y, Cao W,   Shen H, Zhang M, Zhu H, Yang J, Zhu Z, Ma X, Ren J, Huang L, Li Q, Tang Y, Yu   B, Chen C, Xu M, Wang Q, Xu Z, Chen F, Liang S, Zhong Z, Jamroze A, Tang DG,   Li H, Dong C. Lipopolyplex-formulated mRNA cancer vaccine elicits strong   neoantigen-specific T cell responses and antitumor activity. Sci Adv.  2024 Oct 11;10(41):eadn9961. doi: 10.1126/sciadv.adn9961.

n  Cui G, Shao Y, Wang J, Xu   C*, Jinping Zhang*, Zhiyuan Zhong*, Polymersome-mediated Cbl-b silencing   activates T cells against solid tumors.   Biomater. Sci., 2025, doi:10.1039/D5BM00001G

n  Xu C, Yin H, Yudhistira T, Li Z,   Binzel D,*Guo P*, Conversion of Chemical Drugs into Targeting Ligands on RNA   Nanoparticles and Assessing Payload Stoichiometry for Optimal Biodistribution   in Cancer Treatment. RNA NanoMed, 2024, (1) 109-123.doi:10.59566/ISRNN.2024.0101109.

n    Zhang,   H.#, Zhang, L.#, Lin, A. #,   Xu, C. # (co-first author), Li, Z., Liu, K., ... &   Huang, L. (2023). Algorithm for optimized mRNA design improves stability and   immunogenicity. Nature, 1-3.

n    Yi   Fang, Jing-Xin Li, Davone Duangdany, Yang Li, Xi-Lin Guo, Chanthala   Phamisith, Ming-Yun Shen, Bo Yu, Bin Luo, Yu-Zhu Wang, Si-Jun Liu, Fan-Fan   Zhao, Cong-Cong Xu, Xu-Hui Qiu, Rong-Juan Pei, Jie Wang, Haifa Shen,   Wu-Xiang Guan, Hang-Wen Li, Mayfong Mayxay, Safety, immunogenicity and   efficacy of a modified COVID-19 mRNA vaccine, SW-BIC-213, in healthy people   aged 18 years and above: interim report of a Phase 3 double-blinded,   randomized, parallel controlled clinical trial in Lao PDR (Laos). EClinicalMedicine.   2023 Dec 13;67:102372. doi: 10.1016/j.eclinm.2023.102372.

n    Carcache   PJ, Guo S, Li H, Zhang K, Xu C, Chiu W, Guo P. Regulation of   reversible conformational change, size switching, and immunomodulation of RNA   nanocubes. RNA. 2021 Sep 1;27(9):971-80.

n    Guo   S., Xu C., Yin H., Hill J., Pi F., Guo P. (2019). Tuning the size,   shape and structure of RNA nanoparticles for favorable cancer targeting and   immunostimulation. WIREs Nanomedicine and Nanobiotechnology,   2019 Aug 27:e1582. doi: 10.1002/wnan.1582

n  Xu, C.,   Zhang, K., Yin, H., Li, Z., Krasnoslobodtsev, A., Zheng, Z., Ji, Z., Guo, S.,   Li, S., Chiu, W. and Guo, P., 2020. 3D RNA nanocage for encapsulation and   shielding of hydrophobic biomolecules to improve the in vivo biodistribution.   Nano Research, 13(12), pp.3241-3247.

n    Xu C., Yin H., Lingren H., Li Z., Guo P. 2022. Controlling the   Multivalency of Methotrexate on RNA Nanoparticles for Optimized Cancer   Targeting and Therapeutic Effect, Under Submission.

n    Xu   C., Wang   H., Yin H., Sechi M., Li Z., Kumar K., Tweedle M., Knopp M., Guo P. 2022.   Small Molecule Conjugated RNA Nanoparticles for PET Imaging-guided Prostate   Cancer Therapy, Under Submission.

n    Ghimire   C, Wang H, Li H, Vieweger M, Xu C, Guo P. RNA nanoparticles as rubber   for compelling vessel extravasation to enhance tumor targeting and for fast   renal excretion to reduce toxicity. ACS Nano. 2020 Sep   9;14(10):13180-91.

n    Li   H., Wang S., Ji Z., Xu C., Shlyakhtenko L.S. and Guo P., Construction   of RNA nanotubes. 2019. Nano Research12(8),   pp.1952-1958.

n    Zheng   Z, Li Z, Xu C, Guo B, Guo P. Folate-displaying exosome mediated   cytosolic delivery of siRNA avoiding endosome trapping. J Control   Release. 2019 Aug 22;. doi: 10.1016/j.jconrel.2019.08.021.

n    Yin   H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D. Delivery of Anti-miRNA   for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting   Stem Cell Marker CD133. Mol Ther. 2019 Jul 3;27(7):1252-1261.   doi: 10.1016/j.ymthe.2019.04.018.

n    Xu   Y, Pang L, Wang H, Xu C, Shah H, Guo P, Shu D, Qian SY. Specific   delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with   dihomo-γ-linolenic acid for colon cancer suppression. Redox Biol.   2019 Feb;21:101085. doi: 10.1016/j.redox.2018.101085.

n    Xu   C, Li H,   Zhang K, Binzel DW, Yin H, Chiu W, Guo P. Photo-controlled release of   paclitaxel and model drugs from RNA pyramids. Nano Res. 2019   Jan;12(1):41-48. doi: 10.1007/s12274-018-2174-x.

n    Xu   C, Haque   F, Jasinski DL, Binzel DW, Shu D, Guo P. Favorable biodistribution, specific   targeting and conditional endosomal escape of RNA nanoparticles in cancer   therapy. Cancer Lett. 2018 Feb 1;414:57-70. doi:   10.1016/j.canlet.2017.09.043.

n    Li   W, Yang X, He L, Wang K, Wang Q, Huang J, Liu J, Wu B, Xu C.   Self-Assembled DNA Nanocentipede as Multivalent Drug Carrier for Targeted   Delivery. ACS Appl Mater Interfaces. 2016 Oct   5;8(39):25733-25740. doi: 10.1021/acsami.6b08210.


Books&Patents

Books Books:

n  Haque F, Xu C,   Jasinski DL, Li H, Guo P. (Contributed   equally) Using Planar Phi29 pRNA Three-Way Junction to Control Size and Shape   of RNA Nanoparticles for Biodistribution Profiling in Mice. Methods Mol   Biol. 2017;1632:359-380. doi: 10.1007/978-1-4939-7138-1_23.

n    Guo   S, Xu C, Yin H, Guo P, Hill J, and Pi F. 2022. Tuning the Size, Shape,   and Structure of RNA Nanoparticles for Favorable Cancer Targeting and   Immunostimulation. RNA Nanotechnology and Therapeutics,   pp.543-562.


Patents Patents:

n  徐聪聪;唐钰莹;胡群;王纬云;李航文;一种新型环状RNA   及其制备方法以及治疗苯丙酮尿症的环状RNA   药物,申请号:2023103518562

n    方熠;王海丽;徐聪聪;王纬云;李航文;水痘-带状疱疹RNA   疫苗,申请号:202310351636X

n    羊小海;李文山;何磊良;王青;王柯敏;黄晋;刘剑波;吴斌;徐聪聪;靶向载体,靶向药物及靶向药物的应用,靶向探针及靶向探针的应用,CN106267219B2019

n    Peixuan Guo; Daniel Jasinski; Hui Li; Emil   Khisamutdinov; Congcong Xu; Self-assembled 3D RNA Cage Nanoparticles,   PCT/US2017/032001

n    Peixuan Guo; Satheesh Ellipilli; Hongzhi   Wang; Congcong Xu; Xin Li; RNA Nanoparticle for Liver Cancer   Treatment, 2020, PCT/US2020/065621


Honors

Honors:

Supervision

Supervision: