个人信息
个人简介


2015年8月至今:                苏州大学心血管病研究所 副教授                         硕士研究生导师

2012年1月至2014年2月:  美国 North Carolina State University                      博士后助理研究员

2008年月至2011年6月:    武汉理工大学材料科学与工程学院                      工学博士

2009年10月至2011年6月:中国科学院苏州纳米技术与纳米仿生研究所      访问学生

2005年9月至2008年6月:  武汉理工大学材料科学与工程学院                       工学硕士

2006年10月至2007年9月:加拿大McMaster University                                    访问学者

2001年9月至2005年6月:  武汉理工大学化学工程学院                                   工学学士

基金

国家自然科学基金青年项目(21604059,22万,2017年1月到2019年12月)

  • 江苏省自然科学基金青年基金项目(BK20160321,20万,2016年7月到2019年6月)

  • 苏州市民生科技项目(sys2018026, 5万,2018年7月到2021年6月)

  • 江苏省高校自然科学研究面上项目(16KJB430029,3万,2016年9月到2018年8月)

  • 江苏省临床医学研究中心(30万,2016年3月到2018年6月)

  • 苏州大学科研启动经费(20万,2015年8月)


社会任职,荣誉奖励等

1. 现任Elsvier旗下Collid and interface science communication 杂志 Assitant editor;

2. 担任著名期刊Biomaterial,  Biomacromolecules, ACS Appl. Mater.Interfaces, Colloids Surf., B的审稿人;
3. 入选2016年度苏州市高等院校、科研院所紧缺高层次人才引进资助计划;

4. 20162017年度苏州市自然科学优秀学术论文二等奖;

5.2019年度江苏省科学技术奖一等奖11/11)。

研究领域
  • 具有生物功能性表面的设计与应用

  • 纳米纤维素在生物医用领域的应用

  • 免标记型生物传感器

  • 可注射型水凝胶用于心肌梗死修复

Education

  • Associate Professor, Institute for Cardiovascular Science of Soochow University. (08/2015-now)

  • Postdoctoral Fellow, North Carolina State University, USA (01/2012-02/2014, Advisor: Dr.Orlando J. Rojas)

  • Ph.D of Engineering, Wuhan University of Technology, (09/2008-06/2011, Advisor:Dr. Hong Chen)

  • Visiting Student, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (10/2009-06/2011, Advisor: Dr. Hongwei Ma)

  • Master of Engineering, Wuhan University of Technology (09/2005-06/2008, Advisor: Dr.Hong Chen

  • Visiting Scholar, McMaster University, Canada (10/2006-09/2007, Advisor: Dr. John L.Brash

  • Bachelor of Engineering, Wuhan University of Technology (09/2001-06/2005)

Funding

  • The National Natural Science Foundation of China (21604059, ¥220,000 01/2017 through 12/2019)

  • The Natural Science Foundation of Jiangsu Province (BK20160321, ¥200,000 07/2016 through 06/2019)

  • The Natural Science Foundation of the Jiangsu Higher Education Institutions of China (16KJB430029, ¥30,000 09/2016 through 08/2018)

  • Jiangsu Clinical Research Center for Cardiovascular Surgery (¥300,000 03/2016 through 06/2018)

  • Startup Funding from Soochow University (¥200,000 08/2015)


基本信息
头像




张燕霞

职称:副教授

院部/部门:苏州大学心血管病研究所

学历:博士

学位:博士

毕业学校:武汉理工大学

毕业专业:生物材料学

联系方式

通讯地址:人民路708号1号楼4楼

邮政编码:

电子邮箱:zhangyanxia@suda.edu.cn

联系电话:18012798116

传真号码:

办公地点:苏州大学心血管病研究所

科学研究

通过生物材料研发,实现心肌梗死修复及小口径血管替换的目的



科研团队

属于沈振亚教授科研团队一员

论文

入职苏大以后:

1.       Y. Zou, Y. Zhang*, Q. Yu*, H. Chen, Dual-function antibacterial surfaces to resist and kill bacteria: painting a picture with two brushes simultaneouslyJournal of Materials Science & Technology, DOI: 10.1016/J.JMST.2020.07.028

2.       Y. Wu, T. Chang, W. Chen, X. Wang, J. Li, Y. Chen, Y. Yu, Z. Shen, Q. Yu, Y. Zhang, Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction. Bioactive materials 2021, 6, 520-528.

3.       Y. Qu#, Y. Zhang#, Q. Yu*, H. Chen, Surface-Mediated Intracellular Delivery by Physical Membrane Disruption. ACS Appl. Mater. Interfaces 2020, 12(28) 31054–31078

4.       Y. Zou, Y. Zhang*, Q. Yu*, H. Chen, Photothermal bactericidal surfaces: killing bacteria using light instead of biocides. Biomaterials science (2020) https://doi.org/10.1039/d0bm00617c

5.       Y. Zheng, Y. Wu, Y. Zhou, J. Wu, X. Wang, Y. Qu, Y. Wang, Y. Zhang*, Q. Yu* (2020). Photothermally Activated Electrospun Nanofiber Mats for High-Efficiency Surface-Mediated Gene Transfection. ACS applied materials & interfaces. 2020 Feb 19;12(7):7905-7914

6.       P. Zhao#, W. J. Zhou#, Y. X. Zhang#, J. J. Li, Y. Zhao, L. H. Pan, Z. Y. Shen, W. Q. Chen, J. Hui. Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice. Journal of Cellular and Molecular Medicine. J Cell Mol Med. 2020;00:1–17.

7.       Shen, H, Cui, G, Li, Y, Ye, W, Sun, Y, Zhang, Z, Li, J, Xu, G, Zeng, X, Zhang, Y, Zhang, W, Huang, Z, Chen, W, Shen, Z., Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model. Stem Cell Res Ther 2019, 10 (1), 17.

8.       J. Feng, Y. Wu, W. Chen, J. Li, X. Wang, Y. Chen, Y. Yu*, Z. Shen* and Y. Zhang*. Sustained Release of Bioactive IGF-1 from a Silk Fibroin Microsphere-Based Injectable Alginate Hydrogel for the Treatment of Myocardial Infarction. J. Mater. Chem. B, 2020, 8, 308-315

9.       Y. Wang, T. Wei, Y. Qu, Y. Zhou, Y. Zheng, C. Huang, Y. Zhang, Q. Yu and H. Chen (2019). Smart, Photothermally Activated, Antibacterial Surfaces with Thermally Triggered Bacteria-Releasing Properties. ACS Appl. Mater. Interfaces 2020, 12, 19, 21283–21291

10.    Y. C. Qu, Y. J. Zheng, L. Y. Yu, Y. Zhou, Y. R. Wang, Y. X. Zhang, Q. Yu and H. Chen. A Universal Platform for High-Efficiency Engineering Living Cells: Integration of Cell Capture, Intracellular Delivery of Biomolecules, and Cell Harvesting Functions. Advanced Functional Materials. 2020, 30(3), 1906362

11.    Y. Q. Chen, J. F. Zuo, W. Q. Chen, Z. Y. Yang, Y. X. Zhang, F. Hua, L. B. Shao, J. J. Li, Y. H. Chen, Y. S. Yu, Z. Y. Shen. The enhanced effect and underlying mechanisms of mesenchymal stem cells with IL-33 overexpression on myocardial infarction. Stem Cell Research & Therapy 2019, 10(1). 10:295

12.    Liu Y, Xu C, Gu Y, Shen X, Zhang Y, Li B, Chen L, Polydopamine-modified poly(L-lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration. RSC Advances 2019, 9(21):11722-11736.

13.    Xiao Y#, Zhang Y#, Chen Y#, Li J#, Zhang Z, Sun Y, Shen H, Zhao Z, Huang Z, Zhang W, Chen W, Shen Z., Inhibition of microRNA-9-5p Protects against Cardiac Remodeling following Myocardial Infarction in Mice. Hum Gene Ther., 2019, 30(3): 286-301

14.    Tao, C.#, Zhang, Y.#, Li, B., Chen, L.* Hierarchical micro/submicrometer-scale structured scaffolds prepared via coaxial electrospinning for bone regeneration. J. Mater. Chem. B, 2017, 5(46), 9219-9228

15.    Sun, J.#, Zhang, Y.#, Li, B., Gu, Y.*, Chen, L.* Controlled release of BMP-2 from a collagen-mimetic peptide-modified silk fibroin-nanohydroxyapatite scaffold for bone regeneration. J. Mater. Chem. B, 2017, 5(44), 8770-8779

16.    Wang, Q.#, Zhang, Y.#, Li, B., Chen, L.* Controlled dual delivery of low doses of BMP-2 and VEGF in a silk fibroin–nanohydroxyapatite scaffold for vascularized bone regeneration. J. Mater. Chem. B, 2017, 5(33), 6963-6972.

17.    Tayeb, A. H.; Hubbe, M. A.; Zhang, Y.Rojas, O. J.* Effect of Lipoxygenase Oxidation on Surface Deposition of Unsaturated Fatty Acids. Langmuir, 2017, 33 (18), 4559-4566

18.    Xu, Y.#, Cui W.#, Zhang, Y.#, Zhou, P., Gu, Y., Shen, X., Li, B., Chen, L.* Hierarchical micro/nano-fibrous bioscaffolds for structural tissue regeneration. Adv. Healthcare Mater. 2017, 6 (13), 1601457.

19.   Zhang, Y.#*; Rojas, O. J.* Immunosensors for C-reactive protein based on ultrathin films of carboxylated cellulose nanofibrils. Biomacromolecules 2017, 18 (2), 526-534

20.   Shen, X.#;Zhang, Y.#; Gu, Y.; Xu, Y.; Liu, Y; Li, B.; Chen, L.* Sequential and sustained release of SDF-1 and BMP-2 from silk fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration. Biomaterials,2016,106, 205-216.

入职苏大以前:

1.       B.B. Langdon, R.B. Mirhossaini, J.N. Mabry, I. Sriram, A. Lajmi, Y. Zhang, et al., Single-molecule resolution of protein dynamics on polymeric membrane surfaces: the roles of spatial and population heterogeneity, ACS applied materials & interfaces 7 (2015) 3607-3617

2.       H. Bai, J. Xu, Y. Zhang, X. Liu, O.J. Rojas, Dynamics of cyclodimerization and viscoelasticity of photo   crosslinkable PVA, J. Polym. Sci., B: Polym. Phys. 53 (2015) 345-355.

3.       Zhang, Y.*; Carbonell, R. G.; Rojas, O. J.* Bioactive cellulose nanofibrils for specific human IgG binding. Biomacromolecules 2013,14(12), 4161-4168.

4.       Zhang, Y.*; Islam, N.; Carbonell, R. G.; Rojas, O. J.* Specificity and regenerability of short Peptide ligands supported on polymer layers for immunoglobulin g binding and detection. ACS Appl. Mater. Interfaces 2013,5(16), 8030-8037.

5.       Zhang, Y.; Nypelö, T.*; Salas, C.; Arboleda, J.; Hoeger, I. C.*; Rojas, O. J.* Cellulose nanofibrils: from strong materials to bioactive surfaces. J. Renew. Mater. 2013,1, 195-211.

6.       Zhang, Y.*; Islam, N.; Carbonell, R. G.; Rojas, O. J.* Specific binding of immunoglobulin G with bioactive short peptides supported on antifouling copolymer layers for detection in quartz crystal microgravimetry and surface plasmon resonance. Anal. Chem. 2013,85(2), 1106-1113.

 7.       Zhang, Y.; Lv, B. e.; Lu, Z.; He, J. a.; Zhang, S.; Chen, H.*; Ma, H.* Predicting Au-S bond breakage from the swelling behavior of surface tethered polyelectrolytes. Soft Matter 2011,7, 11496-11500.

8.       Yu, Q.; Li, X.; Zhang, Y.; Yuan, L.; Zhao, T.; Chen, H.* The synergistic effects of stimuli-responsive polymers with nano-structured surfaces: wettability and protein adsorption. RSC Adv. 2011, 1, 262-269.

9.       Zhang, Y.; He, J. A.; Zhu, Y.; Chen, H.; Ma, H.* Directly observed Au-S bond breakage due to swelling of the anchored polyelectrolyte. Chem. Commun. 2011,47, 1190-1192.

10.     Yu, Q.; Zhang, Y.; Wang, H.; Brash, J. L.; Chen, H.* Anti-fouling bioactive surfaces. Acta Biomater. 2011,7, 1550-1557.

11.     Yu, Q.; Chen, H.*; Zhang, Y.; Yuan, L.; Zhao, T.; Li, X.; Wang, H. pH-reversible, high-capacity binding of proteins on a substrate with nanostructure. Langmuir 2010, 26, 17812-17815.

12.     Zhang, Y.; Yu, Q.; Huang, H.*; Zhou, F.; Wu, Z.; Yuan, L.; Li, D.; Chen, H.* A surface decorated with diblock copolymer for biomolecular conjugation. Soft Matter2010, 6, 2616–2618.

13.     Yu, Q.; Zhang, Y.; Chen, H.*; Wu, Z.; Huang, H.; Cheng, C. Protein adsorption on poly(N-isopropylacrylamide)-modified silicon surfaces: Effects of grafted layer thickness and protein size. Colloids Surf., B 2010, 76, 468-474.

14.     Yu, Q.; Zhang, Y.; Chen, H.*; Zhou, F.; Wu, Z.; Huang, H.; Brash, J. L. Protein adsorption and cell adhesion/detachment behavior on dual-responsive silicon surfaces modified with Poly(N-isopropylacrylamide)-block-polystyrene copolymer. Langmuir 2010, 26, 8582-8588.

15.     Chen, H.*; Zhang, Y.; Li, D.; Hu, X.; Wang, L.; McClung, W. G.; Brash, J. L. Surfaces having dual fibrinolytic and protein resistant properties by immobilization of lysine on polyurethane through a PEG spacer. J. Biomed. Mater. Res., Part A 2009,90, 940-946.

16.     Wu, Z.; Chen, H.*; Liu, X.; Zhang, Y.; Li, D.; Huang, H. Protein adsorption on poly(N-vinylpyrrolidone)-modified silicon surfaces prepared by surface-initiated atom transfer radical polymerization. Langmuir 2009,25, 2900-2906.

17.     Chen, H.*; Wang, L.; Zhang, Y.; Li, D.; McClung, W. G.; Brook, M. A.; Sheardown, H.; Brash, J. L. Fibrinolytic poly(dimethyl siloxane) surfaces. Macromol. Biosci. 2008,8, 863-870.

18.     Chen, H.*; Hu, X.; Zhang, Y.; Li, D.; Wu, Z.; Zhang, T. Effect of chain density and conformation on protein adsorption at PEG-grafted polyurethane surfaces. Colloids Surf., B 2008,61, 237-243.

19.     张燕霞; 于谦; 武照强; 周峰; 李鑫; 陈红*能够促进细胞黏附的生物活性表面的制备. 高分子学报2011,(6), 622-627.(英文摘要)

20.     张燕霞; 于谦; 周峰; 徐亚骏; 陈红*嵌段共聚物改性表面对蛋白质吸附和细胞黏附的调控. 科学通报2010,55, 2808-2814.

21.     于谦; 张燕霞; 徐亚骏; 陈红接枝层厚度对聚(N-异丙基丙烯酰胺)改性表面与蛋白质相互作用的影响. 材料导报2010,24, 25-28.

22.     于谦; 张燕霞; 李鑫; 徐亚骏; 陈红(N-异丙基丙烯酰胺)改性表面与血浆蛋白质的相互作用. 高分子学报2011,(5), 537-542.

23.     李鑫; 于谦; 张燕霞; 武照强; 陈红 pH响应性表面对蛋白质吸附的调控. 高分子学报2011,(8), 812-816. .(英文摘要)

24.     于谦; 张燕霞; 周峰; 李鑫; 陈红*(N-异丙基丙烯酰胺)-b-聚苯乙烯改性玻璃表面对细胞黏附/脱附的调控. 材料导报2011,25, 23-26.

25.     胡小洋; 张燕霞; 张弢; 于谦; 陈红*PEG为间隔基固定赖氨酸制备血液相容的聚氨酯材料. 高等学校化学学报2009,30, 613-617.

26.     胡小洋; 陈红*; 张燕霞; 王艺峰; 吴仲岿聚乙二醇及其衍生物改性生物医用材料表面的血液相容性. 高分子材料科学与工程2007,23, 127-131.

书章和专利

1.     陈红; 张燕霞; 于谦一种高密度固定生物功能分子的材料的制备方法CN 101810888 A

2.    一种细菌纤维素膜的脱水方法及人造血管及其制备方法;张燕霞,于谦,吴永,沈振亚,周霄楠;申请号:201910265404.6

3    吴永,冯建国,王晓宇,张燕霞,余云生,沈振亚;一种升主动脉瘤动物模型的制备方法;申请号:201910857231.7


荣誉奖励
开授课程

参与由特聘教授胡士军老师主讲的《干细胞生物学》中的《干细胞组织工程》

招生信息

招收化学、材料、医学方向硕士研究生。欢迎报考!