- 个人信息
- 科学研究
- 成果奖励
- 教学招生
个人信息
个人简介
个人简介 苏州大学医学部基础医学与生物科学学院,教授。近年来,以第一和通讯身份(含共同)在发表SCI论文10余篇。主持国家自然科学基金面上项目、国家自然科学基金青年基金项目、江苏省高校自然科学基金、以及苏州市自然科学基金。主要从事肿瘤免疫、感染免疫等研究。Cancer Letters、Journal of Immunology、Scienctific reports等杂志审稿人。 研究领域
肿瘤免疫、感染免疫 基本信息
![]() 职称:教授 院部/部门:医学部基础医学与生物科学学院 学历: 学位: 毕业学校: 毕业专业: 联系方式
通讯地址: 邮政编码: 电子邮箱:zhaolixiang@suda.edu.cn 联系电话:15262444830 传真号码: 办公地点:医学部基础医学与生物科学学院 科学研究
致力于通过肿瘤疫苗、溶瘤病毒等免疫治疗方法的研究,探索肿瘤进程与免疫系统的相互作用。 科研团队
论文
1. Xu X, Yi C, Yang X, Xu J, Sun Q, Liu Y, Zhao L. Tumor Cells Modified with Newcastle Disease Virus Expressing IL-24 as a Cancer Vaccine. Mol Ther Oncolytics. 2019. 14:213-221. (Corresponding author) 2. Xu Xiaojing, Jin Ziqi, Liu Yonghao, Gong Huanle, Sun Qing, Zhang Weidong, Zhao Lixiang*. Carbohydrate-based adjuvants activate tumor-specific Th1 and CD8+ T-cell responses and reduce the immunosuppressive activity of MDSCs. Cancer Letters. 2019. 440: 94~105. (Corresponding author) 3. Mei Yu, Zhao Lixiang#, Yonghao Liu, et al. Combining DNA Vaccine and AIDA-1 in Attenuated Salmonella Activates Tumor-Specific CD4(+) and CD8(+) T-cell Responses. Cancer Immunology Research. 2017. 5(6):503-514. (Equal contributor) 4. Xu Xiaojing, Mei Yu, Zhao Lixiang*. Newcastle disease virus co-expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy. Cancer Science. 2018.109(2): 279. (Corresponding author) 5. Zhao Lixiang, Mei Yu, Sun Qing, et al. Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response. The Journal of Immunology.2014. 193(2): 735-745. 6. Xu Xiaojing, Sun Qing, Yu Xiao,Zhao Lixiang*. Rescue of nonlytic Newcastle Disease Virus (NDV) expressing IL-15 for cancer immunotherapy. Virus Research. 2017. 233:35-41. 7. Xu Xiaojing, Chen Xiang, Gao Song, Zhao Lixiang*. Pathogenicity of FtsK mutant of avian pathogenic Escherichia coli 2016. 60(1): 13~18. (Corresponding author) 8. Sun Qing#, Zhao Lixiang#, Song Qingqing, et al. Hybrid- and complex-type N-glycans are notessential for Newcastle disease virus infection and fusion of host cells. Glycobiology. 2012. (Equal contributor) 9.Zhao L, Liu H. Newcastle disease virus: a promising agent for tumor immunotherapy. Clin Exp Pharmacol Physiol. 2012; 39(8): 725-30. 10. Zhao L, Gao S, Huan H,Xu X, Zhu X, Yang W, Gao Q, Liu X.Comparison of virulence factors and expression of specific genes between uropathogenic Escherichia coli and avian pathogenic E. coli in a murine urinary tract infection model and a chicken challenge model. Microbiology. 2009; 155: 1634-1644. 11. Zhao L, Chen X, Xu X, Song G, Liu X. Analysis of the AIDA-I gene sequence and prevalence in Escherichia coli isolates from pigs with post-weaning diarrhoea and oedema disease. The Veterinary Journal. 2009; 180:124-9. (II区) 12. Zhao L, Chen X, Zhu X. Prevalence of virulence factors and antimicrobial resistance of uropathogenic Escherichia coli in Jiangsu province (China). Urology. 2009; 74(3):702-7. 发明专利 1. 赵李祥,梅雨,刘海燕。以减毒沙门氏菌为载体的口服肿瘤疫苗的制备及其应用。专利号:CN201310600070.6 (授权时间:2015年) 2. 赵李祥,刘海燕,文丽君。一种重组新城疫病毒修饰的自体肿瘤疫苗的制备及其应用。专利号:CN201110188380.2(授权时间:2013年) 荣誉奖励
开授课程
承担本科生的教学课程:《免疫学》、《医学免疫学》、《Medical Immunology》、《细胞工程》、《基因工程原理与技术》。 招生信息
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1. 葡聚糖修饰的CpG作为瘤苗佐剂调节肿瘤微环境中MDSCs亚型并增强T细胞应答的作用及机制(国家自然科学基金面上项目 2019年-2022年 主持)