Resume

I am a toxicologist with a focus on Mechanism and Prevention of Arsenic Poisoning, Biochemical and Molecular Toxicology, and The Mechanism of Chemical Carcinogenesis. I have been conducting the molecular mechanisms of the toxicities of environmental chemicals.Using cell lines and zebrafish embryos as model systems, and dissect the functions of signal pathways. I have raised the hypothesis that the metabolic process associated with the methylation of inorganic arsenicals, the subsequent metabolic sulfurization, and the chemical properties of their intermediate active metabolites play an important role in arsenic-induced redox homeostasis in cell transformation.


Research

Research statement


I am a toxicologist with a focus on Mechanism and Prevention of Arsenic Poisoning, Biochemical and Molecular Toxicology, and The Mechanism of Chemical Carcinogenesis. I have been conducting the molecular mechanisms of the toxicities of environmental chemicals.Using cell lines and zebrafish embryos as model systems, and dissect the functions of signal pathways. I have raised the hypothesis that the metabolic process associated with the methylation of inorganic arsenicals, the subsequent metabolic sulfurization, and the chemical properties of their intermediate active metabolites play an important role in arsenic-induced redox homeostasis in cell transformation.   



基本信息

头像

An Yan  

Career:   Professor

Organization:   Toxicology

Degree:   Dr

Academic Credentials:  

Graduate School:   Nihon University/Jilin University

Graduation Major:  

联系方式

Address:   199 Renai Rd, Suzhou Industrial Park Suzhou 215123, Jiangsu Province, China

PostCode:   215123

Email:   annine@suda.edu.cn

Tel:   +86-0512-65880910

Fax:  

Office Location:   402#2418

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

Scientific research

Scientific research team

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

Publications

Publication list

ISI Researcher ID: http://www.researcherid.com/rid/K-8337-2016

ORCID iD: https://orcid.org/0000-0003-2838-8169

Web of Science ResearcherID: K-8337-2016 ; M-9831-2019


Papers in ISI indexed journals (*corresponding author)


Year 2020

31. Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang; Yasuyo Shimoda; Shasha Tao; Koichi Kato; Jie Zhang**; Kenzo Yamanaka**Yan An**. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. Science of The Total Environment2020, 734: 143840. 

PMID: 33261869

DOI: 10.1016/j.scitotenv.2020.143840.

30. Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka**Yan An**. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety2020, 201: 110820. 

PMID: 32531574

DOI: 10.1016/j.ecoenv.2020.110820

29.Jiaoyuan Mao#; Qianlei Yang#; Makoto MiyazawaMotofumi Miura; Luna Wanga; Haixuan XiaaKoichi Kato; Kenzo Yamanaka**Yan An**. Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics. Journal of Trace Elements in Medicine and Biology. 2020, 61: 126544. 

       PMID: 32416464

DOI: 10.1016/j.jtemb.2020.126544

28.Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao; Yasuyo Shimoda; Xuerui Zhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang*; Kenzo Yamanaka*Yan An*. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes. Science of The Total Environment2020, 734: 139425. 

PMID: 32450402

DOI: 10.1016/j.scitotenv.2020.139425

Before 2019

27. Jing wu; Yiping Ni; Xiaojuan Wang; Qianlei Yang;Jiayuan Mao; Jian Tong; Jie Zhang*; Yan An**. Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells. Journal of Toxicology and Environmental Health-part A. 2019, DOI: 10.1080/15287394.2019.1686108.

DOI: 10.1080/15287394.2019.1686108

26. Jing Wu; Jie Zhang; Jihua Nie; Junchao Duan; Yanfeng Shi; Lin Feng; Xiaozhe Yang; Yan An*; Zhiwei Sun. The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicology Research. 2019. 

DOI: 10.1039/c9tx00112c

25. Qianlei Yang; Hanyi Deng; Haixuan XMengchuan Xu; Guotao Pan; Jiayuan Mao; Liqian Qin; Jie Zhang; Tom K Hei; Shasha Tao; Kenzo Yamanaka*Yan An*. High Nrf2 expression predicted poor prognosis in patients with lung cancer: A meta-analysis of cohort studies. Free Radical Research. 2019, 

DOI:10.1080/10715762.2019.1642472.

24. Qianlei Yang; Zhen Zhu; Luna Wang; Haixuan Xia; Xiaojuan Wang; Jing Wu; Koichi Kato; Heran Li; Jie Zhang*; Kenzo Yamanaka*Yan An*. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. Environmental Toxicology and Pharmacology. 2019, 69:66-71. 

DOI: 10.1016/j.etap.2019.04.001.

23. Jiting Liu; Li Zhang; Lixia Feng; Ming Xu; Yue Gao; Peng Zhou; Zhengmin Yu; Baoli Zhu; Yan An*; Hengdong Zhang*. Association Between Single Nucleotide Polymorphism (rs4252424) in TRPV5 Calcium Channel Gene and Lead Poisoning in Chinese Workers. Molecular Genetics & Genomic Medicine2019; e562. 

DOI10.1002/mgg3.562.

22. Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun, Wei Gong, Qiaoyun Zhang, Baoli ZhuYan An*. Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population. International Journal of Environmental Research and Public Health.2017, 14, 36.

DOI:10.3390/ijerph14010036

21. Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang; Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Jie Zhang; Yan An*. Total Arsenic and Speciation Analysis of Saliva and Urine Samples from Individuals Living in Chronic Arsenicosis Area in China. Environmental Health and Preventive Medicine.2017, 22:45.

DOI:10.1186/s12199-017-0652-5

20. Xing Liu; Bin Sun; Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan An*; Jian Tong. Synergistic Effect of Radon and Sodium Arsenite on DNA Damage in HBE Cells. Environmental Toxicology and Pharmacology. 2016,41: 127-131.

DOI: 10.1016/j.etap.2015.11.013

19. Dapeng Wang; Yuan Ma; Xu Yang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An*. Hypermethylation of Keap1 Gene Inactivates Its Function and Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced Human Keratinocyte Transformation. Free Radical Biology and Medicine.2015,89:209-219.

DOI10.1016/j.freeradbiomed.2015.07.153

18. Xu Yang; Dapeng Wang; Yuan Ma; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An*. Continuous Activation of Nrf2 and Its Target Antioxidant Enzymes Leads to Arsenite-Induced Malignant Transformation of Human Bronchial Epithelial Cells. Toxicology and Applied Pharmacology2015, 289:231-239. 

DOI: 10.1016/j.taap.2015.09.020

17. Zhen Zhu, Dapeng Wang,Yuan Ma, Xu Yang, Xiaojuan Wang, Hua Yin, Yan An*. Optimization of antioxidant silk fibroin peptide hydrolysis process. Advanced Materials Research.2015,1073-1076:1789-1792(EI).

16. Zhen Zhu, Hua Yin, Yan An*. Antioxidant activity of silk fibroin peptide hydrolyzed by pancreatin. Advanced Materials Research. 2015,1081:110-114(EI).

15. Dapeng Wang, Yasuyo Shimoda, Hidetoshi Kurosawa, Jian Liu, Xiguo Xu, Xing Liu, Huanyu Jin, Jian Tong, Kenzo Yamanaka, Yan An*. Excretion Patterns of Arsenic and Its Metabolites in Human Saliva and Urine After Ingestion of Chinese Seaweed. International Journal of Environmental Analytical Chemistry2015, 95(5):379-389.

DOI: 10.1080/03067319.2015.10368608

14. Huanyu Jin, Xing Liu, Hua Yin, Yan An*. The application of silk fibroin in tissue engineering and drug carrier area. Advanced Materials Research2013,634-6381120-1123(EI).

13. Huanyu Jin, Hua Yin,Yan An*. The effect of gamma ray on the thermo-mechanical property of silk fibroin. Thermal Science2013, 17(5): 1521-1522.

DOI: 102298/TSCI1305521J#

12. Huanyu Jin, Yu Liu, Xing Liu, Dapeng Wang, Jian Liu, Hua Yin, Yan An*. Study on biocompatibility of post-irradiated silk fibroin in vitro. Advanced Materials Research2012,535-537:2357-2360(EI).

11. Huanyu Jin, Yu Liu, Xing Liu, Dapeng Wang, Jian Liu,Hemei Zhang, Chunyan Zong, Hua Zhao, Xiaoqing Feng, Hua Yin, Yan An*. Effect of gamma irradiation on the biocompatibility and biodegradation of silk fibroin in vivo. Advanced Materials Research2012,535-537:2361-2364(EI).

10. Huanyu JinHua YinYu LiuYan An*. The effect of gamma ray on the mechanical and molecular structure changes of silk fibroin. Advanced Material Research2012,502: 269-272(EI).

9. Dapeng Wang, Sanxiang Wang, Zhenghui Wang, Liming Zhang, Jian Li, Jian Liu,   Xing Liu, Huanyu Jin, Chunling Fu, Yan An*. The arsenic concentration in saliva, urine and drinking water in endemic arsenicosis area in Shanyin county of Shanxi province, China. Applied Mechanics and Materials. 2012,140:465-468 (EI).

8. Dapeng Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunyan Ji, Chunling Fu,Yan An*. Comparison of the total arsenic between urine and saliva after consumption of seafood among volunteers.Conference on Environmental Pollution and Public Health. 2011, 271-273 (ISTP).

7. Chunyan Ji, Chunling Fu, Quanyong Xiang, Song Xu, Mingqing Zhu, Jian Liu, Dapeng Wang, Jie Zhang, Yan An*. Biomarkers of early vascular endothelial injury with low-arsenic exposure in drinking water of Jiangsu province. Conference on Environmental Pollution and Public Health2011, 364-366. (ISTP).

6. Huanyu Jin, Hua Yin,Yan An*. The application of radiation technology in the field of medical biomaterials. Advanced Material Research2011,287-290:1929-1932(EI).

5. Jian Liu, Sanxiang Wang, Zhenghui Wang, Dapeng Wang, Zhen Li, Xiaoping Wang, Xing Liu, Huanyu Jin, Yan An*. The Relationship between Arseninc Exposure and Skin Lesions in Endemic Arsenicosis Area of Shanxi Province, China. 2011 International Conference on Human Health and Biomedical Engineering.2011,7:1198-1200 (EI).

4.  Dapeng Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunyan Ji, Chunling Fu, Yan An*. Disposition of arsenic in saliva, blood and urine of Sprague-Dawley rats following repeated oral exposure to sodium arsenite. 2011 International Conference on Human Health and Biomedical Engineering2011,61156-1159(EI).

3.  Jian Liu, Sanxiang Wang, Zhenghui Wang, Dapeng Wang, Zhen Li, Xiaoping Wang, Xing Liu, Huanyu Jin, Yoko Endo, Ginji Endo, Kenzo Yamanaka, Yan An*. The level of aseninc in environmental media in endemic arsenism area of Shanxi province, China.Conference on Environmental Pollution and Public Health.2011, 301-304. (ISTP).

2.Yan An*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka*. Specific induction of oxidative stress in terminal bronchiolar Clara cells during dimethylarsenic-induced lung tumor promoting process in mice. Cancer Letters.2005, 230(1): 57-64.

DOI:10.1016/j.canlet.2004.12.029

1.  Yan An*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato, Masayuki Nakano, Shoji Okada, Kenzo Yamanaka*. Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China. Cancer Letters2004, 214(1): 11-18.

DOI:10.1016/j.canlet.2004.04.005


Honor

Honors and awards


2011

Third Prize for The study on Carcinogenic Mechanisms of Arsenics- Metabolic methylation of arsenic-induced oxidative stress

Science & Technology Advancement Award of Shandong province

2009

Poster award for A case-control study on         relationship between arsenic in drinking water and skin lesions in endemic arsenism area of Shanxi province, China

The 5th International Congress of Asia Society of ToxicologyASIATOX-V

2008


The introduction of a shortage talents of high-level personnel funded projects in Suzhou city

2008

The 8th Youth of Sciences & Technology award of Shandong provience,

2011

The National Outstanding Youth Scientists and Technicians Award for Carcinogenic Mechanisms of Arsenics- Metabolic methylation of arsenic-induced oxidative stress

The 2nd Session of National Chinese Youth Scholar Science and Technology Forum of Chinese Society of ToxicologyCST

2005

Import of foreign talent in Shandong province

Human Resources and Social Security Department of Shandong province

2000-

2005


Japanese Government (MONBUKAGAKUSHO: MEXT) Scholarship

2002

The 2nd class award for The Study on Judging Criterion of Public Nuisance Disease

National Defense Sciences & Technology Award,

2001

Excellent achievement award on Judging Criterion of Public Nuisance Disease

State Environmental Protection Administration of China

1999

The 3rd class award for The Morphometric Study of 131I-Induced Injury in Rat Thyroid

The 10th Conference of Shanxi Science & Technology

1999

Excellent achievement award on Carcinogenesis of Arsenic

The Organizing Committee of International Cooperative Symposium for Global Telemedicine Exchange of Excellent Studies on Oriental & Occidental Medicine,

1999

Awarded a grade of International Certificate of Excellent Papers forthe study on TheRetentionPatternof Radioiodine inRatThyroid and itsDoseEvaluation

World Network of Traditional Chinese Medicine U.K.

1998

The 2nd class awardfor The study on The Retention Pattern of Radioiodine in Rat Thyroid and its Dose Evaluation

The 2nd Development Conference of Sciences & Technology of Huazhong Area

1998

The 3rdclass award for The study onTheMorphometricStudy of 131I-Induced Injury inRatThyroid

Science & Technology Advancement Award of Ministry of Nucleus Industry of China

1996

The 2nd class award for The study onTheRetentionPattern of Radioiodine in RatThyroidand itsDose Evaluation

The 1st Conference of the Youth of Sciences & Technology of Shanxi


Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持

Teaching

Supervision

Copyright © 2011-2014苏州大学版权所有 苏州大学信息化建设与管理中心技术支持