姓名：周飞

Fei Zhou received his Ph.D degreee in Biology from Model Animal Research Center of Nanjing University, China (2011). He then worked as a Senior Scientist in WuXi AppTec (2011-2013) and is now an associate professor of CAM-SU Genomic Resource Center, Soochow University. His research interests focus on base editing and the regulatory roles of circadian rhythm in cardiovascular system.

Selected Publications:

(#: first authors; *: corresponding authors)

一作或通讯作者论文：

[1]    Guo J#, Chen X#, Liu Z#, Sun H#, Zhou Y, Dai Y, Ma Y, He L, Qian X, Wang J, Zhang J, Zhu Y, Zhang J*, Shen B* and Zhou F*. DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome. Molecular Therapy – Nucleic Acids. 2022;27:73-80

[2]    Liu Z#, Dong Y#, Xu Y and Zhou F*. Chronotype distribution in the Chinese population. Brain Science Advances. 2020;6:81-91.

[3]    Wang X#, Liu Z#, Li G#, Dang L, Huang S, He L, Ma Y, Li C, Liu M, Yang G, Huang X, Zhou F* and Ma X*. Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation. Molecular Therapy. 2020;28:431-440

[4]    Jia K#, Lu Z#, Zhou F#, Xiong Z, Zhang R, Liu Z, Ma Y, He L, Li C, Zhu Z, Pan D* and Lian Z*. Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption. Protein & Cell. 2019;10:832-839.

[5]    Wang L#, Zhou F#, Zhang P#, Wang H, Qu Z, Jia P, Yao Z, Shen G, Li G, Zhao G, Li J, Mao Y, Xie Z, Xu W, Xu Y*, Xu Y*. Human Type H Vessels are a Sensitive Biomarker of Bone Mass. Cell Death & Disease. 2017;8, e2760

[6]    Chen W#, Xia J#, Hu P#, Zhou F#, Chen Y, Wu J, Lei W and Shen Z. Follistatin-like 1 protects cardiomyoblasts from injury induced by sodium nitroprusside through modulating Akt and Smad1/5/9 signaling. Biochemical and biophysical research communications. 2016;469:418-23.

[7]    Shen B#, Shang Z#, Wang B#, Zhang L#, Zhou F#, Li T, Chu M, Jiang H, Wang Y, Qiao T, Zhang J, Sun W, Kong X, He Y*. Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arteriosclerosis, thrombosis, and vascular biology. 2014;34:1221-1230

[8]    Zhou F#, Chang Z#, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z*, He Y*. Akt/protein kinase b is required for lymphatic network formation, remodeling, and valve development. The American journal of pathology. 2010;177:2124-2133

[9]    Zhang L#, Zhou F#, Han W#, Shen B, Luo J, Shibuya M, He Y*. Vegfr-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell research. 2010;20:1319-1331

其他论文

[10]Gan Y#, Zhang T#, Chen X, Cao W, Lin L, Du L, Wang Y, Zhou F, He X, He Y, Gan J, Sheng H, Sorokin L, Shi Y* and Wang Y*. Steroids Enable Mesenchymal Stromal Cells to Promote CD8(+) T Cell Proliferation Via VEGF-C. Adv Sci. 2021;8:2003712.

[11]Ma L#, Li W#, Zhang Y#, Qi L, Zhao Q, Li N, Lu Y, Zhang L, Zhou F, Wu Y, Yu H, He Y*, Wei B* and Wang H*. FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. Autophagy. 2021:1-16.

[12]Zheng Y#, Li B#, Pan D#, Cao J, Zhang J, Wang X, Li X, Hou W, Bao D, Ren L, Yang J, Wang S, Qiu Y, Zhou F, Liu Z, Zhu S, Zhang L, Qing T, Wang Y, Yu Y*, Wu J*, Hu X* and Shi L*. Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient. Breast Cancer Research. 2021;23:53.

[13]Zhang T*, Xie P*, Dong Y*, Liu Z, Zhou F, Pan D, Huang Z, Zhai Q, Gu Y, Wu Q, Tanaka N, Obata Y, Bradley A, Lelliott CJ, Sanger Institute Mouse Genetics P, Nutter LMJ, McKerlie C, Flenniken AM, Champy MF, Sorg T, Herault Y, Angelis MH, Durner VG, Mallon AM, Brown SDM, Meehan T, Parkinson HE, Smedley D, Lloyd KCK, Yan J, Gao X, Seong JK, Wang CL, Sedlacek R, Liu Y, Rozman J, Yang L and Xu Y#. High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genetics. 2020;16:e1008577.

[14]Chu M#, Li Taot#, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Ralf. HA and He Y*. Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.Elife. 2016;5.

[15]Holopainen T#, Huang H#, Chen C*, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K*, He Y*. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer research. 2009;69:4656-4664

基因编辑 Gene Editing

昼夜节律 Circadian Rhythm

血管/淋巴管生物学 Vascular Biology