韩忠

韩忠，男，1987年11月出生，北京科技大学本科，上海交通大学大学硕士，法国巴黎萨克雷大学博士，2017年9月至2023年2月先后在法国巴黎狄德罗大学、英国弗朗西斯克里克研究所、丹麦哥本哈根大学从事博士后研究，2023年2月至2025年6月在丹麦哥本哈根大学任助理教授，2025年8月至2026年5月在中山大学任“百人计划”副研究员，2026年6月加盟苏州大学，现为基础医学院生物化学与分子生物学系教授。

主要研究方向

围绕真核生物RNA聚合酶II（RNAPII）转录质量控制机制这一核心问题开展研究，系统解析细胞如何通过转录终止与延伸调控保障转录过程的准确性与稳定性，并进一步阐明这些机制紊乱对基因组稳定性及人类疾病发生发展的影响。

703号楼B114，欢迎学生老师来交流与合作。

联系方式：联系电话:13671966336、邮箱:hanzhong@suda.edu.cn

代表性论文

1) Zhong Han, Shiqing Fu, Jens Vilstrup Johansen, David Lopez Martinez, Jiangman Lou, Thierry Boissière, Dandan He, Daniel Blears, Anouk M Olthof, A Barbara Dirac-Svejstrup, Jesper Q Svejstrup. A role for human senataxin in contending with pausing and backtracking during transcript elongation. Mol Cell, 2025 Nov 20;85(22):4166-4182.e10.

2) Zhong Han, George A. Moore, Richard Mitter, David Lopez Martinez, Li Wan, A. Barbara Dirac Svejstrup, David S. Rueda, and Jesper Q. Svejstrup. DNA-directed termination of RNA Polymerase II transcription. Mol Cell, 2023 Sep 21,83(18):3253-3267.e7.

3) Zhong Han, Jesper Q. Svejstrup. Protocol to detect spontaneous termination of yeast RNAPII transcription in vitro. STAR Protoc, 2024 Oct 10,5(4):103369.

4) Zhong Han, Olga Jasnovidova, Nouhou Haidara, Agnieszka Tudek, Karel Kubicek, Domenico Libri, Richard Stefl, Odil Porrua. Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1, The EMBO Journal, 2020 Apr 1,39(7):e101548.

5) Zhong Han, Odil Porrua. Helicases as transcription termination factors: different solutions for a common problem, Transcription, 2018, 9(3): 152-158

6) Bronislava Leonaite*, Zhong Han*, Jerome Basquin, Fabien Bonneau, Domenico Libri, Odil Porrua, Elena Conti. Sen1 has unique structural features grafted on the architecture of the Upf1‐like helicase family, The EMBO Journal, 2017, 36(11): 1590-1604 (*: 共同第一作者 )

7) Zhong Han, Domenico Libri, Odil Porrua. Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination, Nucleic Acids Research, 2017, 45(3): 1355-1370

8) Shuang Wang, Zhong Han, Terence R Strick. Nucleic Acids Research,2024 Apr 12;52(6):3249-3261.

9) Diana Zatreanu, Zhong Han, Richard Mitter, Emanuela Tumini, Hannah Williams, Lea Gregersen, Barbara Dirac Svejstrup, Stefania Roma, Aengus Stewart, Andres Aguilera, Jesper Q Svejstrup. Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability, Molecular Cell, 2019, 76(1): 57-69.e9

10) Shuang Wang, Zhong Han, Domenico Libri, Odil Porrua, Terence R. Strick. Single-molecule characterization of extrinsic transcription termination by Sen1 helicase, Nature Communications, 2019, 10(1): 1545

11) Simona Cugusi, Richard Mitter, Gavin P Kelly, Jane Walker, Zhong Han, Paola Pisano, Michael Wierer, Aengus Stewart, Jesper Q Svejstrup. (2022) Heat shock induces premature transcript termination and reconfigures the human transcriptome. Mol Cell, 2022 Apr 21,82(8):1573-1588.e10.

12) Li Wan, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Aengus Stewart, Ambrosius P Snijders, Ramanujan S Hegde, Jesper Q Svejstrup. (2021) Translation stress and collided ribosomes are co-activators of cGAS. Mol Cell 2021 Jul 1,81(13):2808-2822.e10