朱珂，特聘教授，博士生导师，江苏省特聘教授，国家优秀青年科学基金（海外）获得者。获南开大学/美国Rush大学医学中心联合培养博士学位。2013年至2023年先后于美国Rush大学医学中心和德克萨斯大学医学部，任博士后研究员、讲师、助理教授（独立PI）。2024年7月起任职苏州大学基础医学院特聘教授。2024年12月起担任医学生物化学与分子生物学系系主任。

      朱珂教授是国际华人骨科学会（ICMRS）终身会员。近年来以第一作者/通讯作者在 Sci Transl Med (2023), Nat Metab (2023), J Clin Invest (2021), Nat Commun (2020) 等国际主流期刊发表论文多篇。2014年获美国骨矿协会青年研究员 Travel Grant，担任Nat Metab, J Clin Invest, J Clin Endocrinol Metab 等多个SCI杂志审稿专家，及 J Orthop Translat 编委会成员。受邀在美国骨矿协会年会（ASBMR）及美国肾脏协会年会（ASN）进行口头报告 (oral presentation)。

    发表论文：

   1. Zhu K, Mukherjee K, Wei C, Hayek SS, Gu C, Altintas MM, Sushrut WS, Korapi K, Reiser J, Sever S. The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. 2023; 15(714):eabq6492. 

2. Zhu K, Reiser J. XOR risk variants drive diabetic kidney disease. Nat Metab. 2023; 5(4):536-537.  

3. Zhu K, Reiser J. ALKBH1 reduces DNA N⁶-methyladenine to allow forvascular calcification in chronic kidney disease. J Clin Invest. 2021; 131(14):150966. 

4. Zhu K, Lai Y, Cao H, Bai X, Liu C, Yan Q, Ma L, Chen D, Kanaporis G, Wang J, Li L, Cheng T, Wang   Y, Wu C, Xiao G. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun. 2020; 11 (1): 484. 

5. Zhu K, Song P, Lai Y, Liu C, Xiao G. Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts. Gene. 2016, 594(1): 125-130. 

6. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol Chem. 2015, 290 (13): 8081-8094.

7. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res. 2013, 28(9): 1870-84. (封面文章；骨科领域Top杂志). 

8. Altintas MM, Agarwal S, Sudhini Y, Zhu K, Wei C, Reiser J. Pathogenesis of Focal Segmental Glomerulosclerosis and Related Disorders.Annu Rev Pathol. 2025; 20(1): 329-353.

9. Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Kumar VS, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, Staruschenko A, Reiser J. The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. Kidney Int. 2023: S0085-2538(23)00066-2.

10. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma- induced osteoclast formation and osteolysis. J Biol Chem. 2013, 288 (42): 30399-410.

11. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Deng W, Chen D, Yao Z,Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013, 9(8): 830-841.

12. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β- Catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013, 9(3): 256-266.

13. Yu S, Sharma R, Nie D, Jiao H, Im HJ, Lai Y, Zhao Z, Zhu K, Fan J, Chen D, Wang Q, Xiao G. ADAR1 ablation decreases bone mass by impairing osteoblast function in mice. Gene. 2013, 513(1): 101-10.

14. Wu C, Jiao H, Lai Y, Zheng W, Chen K, Qu H, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015; 6: 7531.

15. Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019; 129 (5): 1946-1959.

16. Wei C, Zhu K, Reiser J. Soluble Urokinase Receptor and Liver Disease. Clin Liver Dis (Hoboken). 2019; 14 (5): 163-166.

科研项目：

      1. 国家优秀青年科学基金（海外）

      2. 国家自然科学基金面上项目

      3. 江苏省特聘教授科研基金

      4. 苏州创新创业领军人才项目

      5. 苏州大学特聘教授启动资金

      6. 美国 NIH R01 

主要运用转录组学、蛋白质组学、疾病的人源化动物模型及AI等技术，鉴定疾病状态下血液和细胞水平的致病因子，并开展靶向治疗研究。主要研究方向：

1. 常见骨科疾病的致病机制及干预

2. 糖尿病及其并发症的致病因子和靶向治疗

3. 骨髓微环境对白血病发生的细胞调控及临床转化