医学博士，苏州大学病原生物学教授，博士生导师；中国微生物学会理事，江苏省微生物学会理事，江苏省免疫学会理事；教育部学位与研究生教育发展中心通讯评议专家，国家自然科学基金通讯评议专家；主持和主要参与10余项国家级和省部级科研项目，培养研究生30余名；长期承担临床医学5+3《病原生物学》和生物医学各专业《医学微生物学》教学工作；曾获得江苏省高校青蓝工程优秀青年骨干教师培养对象、苏州大学青年教师授课比赛一等奖、苏州大学生命科学英才奖、苏州大学周氏教育科研奖等奖项和荣誉称号。
近五年主持的代表性科研项目：
1. 国家自然科学基金面上项目（No. 32270187）沙门菌效应蛋白SopF调控宿主细胞PANoptosis加重感染的机制和宿主导向干预研究, 2023.1-2026.12
2. 国家自然科学基金面上项目（No. 319701322）沙门菌毒力基因spvC抑制GSDMD介导的吞噬细胞抗菌作用促进细菌播散的机制研究, 2020.1-2023.12
3. 国家自然科学基金面上项目（No. 81671976）沙门菌spvB基因介导巨噬细胞迟发性焦亡及其加重炎症损伤的信号通路研究, 2017. 1-2020.12
近五年以通讯作者发表的主要科研论文：
1. Zhou LT, Li YY, You JY, Wu CY, Zuo LL, Chen YL, Kang L, Zhou ZY, Huang R*, Wu SY*. Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D. Inflamm Res, 2024, 73:19-33.
2. Deng QF, Yang SD, Huang K, Zhu Y, Sun LQ, Cao Y, Dong KD, Li YY*, Wu SY*, Huang R*. NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38MAPK/MK2 phosphorylation in S. typhimurium infection. iScience, 2024, 27(4):109339.
3. Yuan HB, Zhou LT, Chen YL, You JY, Hu HY, Li YY, Huang R*, Wu SY*. Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection. Gut Microbes, 2023,15: 2180315.
4. Huang LL, Hu HY, Xu C, Zhou M, Li YY, Li YB, Wu SY*, Dong N*. Characterization of NDM-5-producing Escherichia coli strains isolated from pediatric patients with bloodstream infections in a Chinese hospital. Genes (Basel), 2023, 14(2): 520.
5. Deng QF, Yang SD, Sun LQ, Huang K, Dong KD, Zhu Y, Cao Y, Li YY, Wu SY*, Huang R*. A detrimental role of NLRP6 in host iron metabolism during Salmonella infection, Redox Biology, 2022, 49: 102217.
6. Dong KD, Zhu Y, Deng QF, Sun LQ, Yang SD, Huang K, Cao Y, Li YY, Wu SY*, Huang R*, Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells, Cell Death Discov, 2022, 8(1): 44.
7. Zhou LT, Li YY, Gao S, Yuan HB, Zuo LL, Wu CY, Huang R*, Wu SY*. Salmonella spvC gene inhibits autophagy of host cells and suppresses NLRP3 as well as NLRC4. Front Immunol, 2021,12:639019.
8. Wu CY, Zhou LT, Yuan HB, Wu SY*. Interconnections among major forms of regulated cell death. Apoptosis,2020, 25(9-10): 616-624.
9. Zuo LL, Zhou LT, Wu CY, Wang YL, Li YY, Huang R*, Wu SY*, Salmonella spvC gene inhibits pyroptosis and intestinal inflammation to aggravate systemic infection in mice, Front Microbiol, 2020, 11: 1-11.
10. Yang SD, Deng QF, Sun LQ, Dong KD, Li YY, Wu SY*, Huang R*. Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2. FASEB J, 2019, 33(12): 13450-13464.