王盈 副教授

王盈，苏州大学基础医学与生物科学学院特聘副教授，硕士生导师。2013-2018年在美国弗吉尼亚大学获得分析化学博士学位，2018-2022年在瑞典哥德堡大学开展博士后研究工作。主要从事法医脑科学和毒物分析方面的研究。主要研究工作包括：（1）活体检测：在活体细胞中，通过优化电极和电压曲线以及电化学成像等方法对不同神经化学物质的释放进行选择性检测；（2）通过电化学分析方法研究神经系统病变的相关机理，主要针对活体脑组织中的神经化学物质的变化以及神经细胞囊泡中神经递质的释放过程和机理进行分析；（3）以电化学分析方法为技术手段研究相关毒品、药物、疾病对神经系统发育的影响。

    教育经历:

2013. 08 - 2018. 08，美国弗吉尼亚大学（University of Virginia)，分析化学，博士， 导师: B. Jill Venton 

2009. 08 - 2013. 05, 美国日内瓦学院（Geneva College)，化学，副修生物和数学， 学士

工作经历：

 2022. 05 - 至今，苏州大学，特聘副教授

2018. 09 - 2022. 04， 瑞典哥德堡大学（University of Gothenburg)，化学与生物分子系，博士后， 合作导师：Andrew G. Ewing

2012. 05 - 2012. 12， 美国匹兹堡大学工程学院（University of Pittsburgh Swanson School of Engineering)， 机械和材料工程系，科研助理

2011. 07 - 2011. 08， 美国匹兹堡大学医学院（Unversity of Pittsburgh School of Medicine)，药学和生物化学系，科研助理

2010. 05 - 2011. 06， 美国匹兹堡大学医学院（Unversity of Pittsburgh School of Medicine)，骨科整形系，科研助理

科研项目：

1. 江苏省青年科学基金，2023-2026，在研，主持

2. 苏州大学引进人才启动基金，2023-2025，在研，主持

3. 苏州大学医学院交叉种子基金， 2023-2026，在研，主持

代表性科研论文（第一作者和通讯作者）：

1. Lv, X., Liu, W., Zhou, X., Yang, Y., Zhao, W., Meng, L., ... & Wang, Y. (2025). Exosomes in Systemic Autoimmune Diseases: Recent Advances in Diagnostic Biomarkers and Therapeutic Applications. International Journal of Nanomedicine, 5137-5160.

2. Zhang, S., Yang, Y., Lv, X., Zhou, X., Zhao, W., M, L., ... & Wang, Y. (2024). Doxorubicin-induced cardiotoxicity through SIRT1 loss-potentiates overproduction of exosomes in cardiomyocytes. International Journal of Molecular Sciences. 

3. Zhang, S., Yang, Y., Lv, X., Zhou, X., Zhao, W., Meng, L., ... & Wang, Y. (2024). Exosome Cargo in Neurodegenerative Diseases: Leveraging Their Intercellular Communication Capabilities for Biomarker Discovery and Therapeutic Delivery. Brain Sciences, 14(11), 1049. 

4.  Zhang, S., Yang, Y., Lv, X., Liu, W., Zhu, S., Wang, Y., & Xu, H. (2023). Unraveling the Intricate Roles of Exosomes in Cardiovascular Diseases: A Comprehensive Review of Physiological Significance and Pathological Implications. International Journal of Molecular Sciences, 24(21), 15677.

5.  Wang, Y., Gu, C., & Ewing, G. Andrew. (2022). Single‐Vesicle Electrochemistry Following Repetitive Stimulation Reveals a Mechanism for Plasticity Changes with Iron Deficiency. Angewandte Chemie. 61(20), e202200716. 

6.  Wang, Y., Gu, C., Patel, B., & Ewing, G. Andrew. (2021). Nano-analysis reveals high fraction of serotonin release during exocytosis from a gut epithelium model cell. Angewandte Chemie. 133 (44): 23744-23748. 

7.  Wang, Y., Gu, C., & Ewing, G. Andrew. (2021). A multimodal electrochemical approach to measure the effect of zinc on vesicular content and exocytosis in a single cell model of ischemia. QRB discovery 2.

8.  Wang, Y., & Ewing, G. Andrew (2021). Electrochemical Quantification of Neurotransmitters in Single Live Cell Vesicles Show Exocytosis is Predominantly Partial. Chembiochem. 22.5 (2021): 807-813.

9.  Wang, Y., Copeland, J.,Shin. M., Chang, Y., & Venton, B. J. (2020). CD73 or CD39 deletion reveals different mechanisms of formation for spontaneous and mechanically-stimulated adenosine release and sex specific compensations in ATP degradation. ACS Chemical Neuroscience. 11(6): 919-928.

10.  Wang, Y. ^*, Shin, M. ^*, Borgus, J.R., & Venton, B. J. (2019). Electrochemistry at the synapse. Annual Review of Analytical Chemistry, volume 12. 12(1):297-321. 

11. Wang, Y., & Venton, B. J. (2019). Comparison of spontaneous and mechanically-stimulated adenosine release in mice. Neurochemistry International. 124: 46-50. 

12.Wang, Y., & Venton, B. J. (2019). Caffeine modulates spontaneous adenosine and oxygen changes during ischemia and  reperfusion.ACS Chemical Neuroscience. 10(4): 1941-1949. 

13. Wang, Y.^*, Ganesana, M.^*, Lee, S.^*, & Venton, B. J. (2017). Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separations, and Electrochemical Methods. Analytical Chemistry. 89 (1): 315-341.

14. Wang, Y., & Venton, B. J. (2017). Correlation of transient adenosine release and oxygen changes in the caudate‐putamen. Journal of Neurochemistry. 140(1): 13-23. 

其他论文：

1.  Gu, C., Wang, Y., Yeoman, M., Patel, B. A., & Ewing, A. (2024). Subsets of Nanometer Vesicles in the Fly Release Differential Fractions of Vesicular Serotonin Content during Exocytosis. Angewandte Chemie International Edition, e202409783. (SCI 1区top)

2.  Wang, Y. M., Zhang, Y. Y., Wang, Y., Cao, Q., & Zhang, M. (2024). Task-related brain activation associated with violence in patients           with schizophrenia: A meta-analysis. Asian journal of psychiatry, 97, 104080. (SCI 3区)

3.  Wang, Y.M., Wang, Y., Cao, Q. & Zhang, M. (2023). Aberrant brain structure in patients with schizophrenia and violence: a meta-analysis. Journal of psychiatric research. 164, 447-453.

4.  Han, F., Tu, Z., Zhu, Z., Liu, D., Meng, Q., Yu, Q., Wang, Y., Chen, J., Liu, T., Han, F. and Li, B. (2023). Targeting Endogenous Reactive Oxygen Species Removal and Regulating Regenerative Microenvironment at Annulus Fibrosus Defects Promote Tissue Repair. ACS nano, 17(8), pp.7645-7661. 

5.  Gao, Y., Wang, T., Cheng, Y., Wu, Y., Zhu, L., Gu, Z., Wu, Y., Cai, L., Zhang, Y., Gao, C., Li, L., Li, J., Wang, Z., Wang, Y., Wang, F., Luo, C., & Tao, L. (2023). Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury. Free Radical Biology and Medicine, 199, 97-112.

6. Gao, Y., Cai, L., Li, L.L., Zhang, Y.D, Li, J., Luo, C.L, Wang, Y., & Tao, L.Y. (2022).Emerging Effects of IL-33 on COVID-19. International Journal of Molecular Sciences, 23(21), p.13656. 

7. Xu H., Zheng L.X., Chen X.S., Pang Q.Y., Yan Y.N., Liu R., Guo H.M., Ren Z.Y., Yang Y., Gu Z.Y., Gao C., Gao Y., Luo C., Zhao Y., Wang Y., Wang T, Tao L.Y. (2022) Brain‐specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury. Brain Pathology, p.e13126.

8. Borgus, J., Wang, Y., & Venton, B.J. (2021). Spontaneous Adenosine and Dopamine Cotransmission in the Caudate-Putamen Is Regulated by Adenosine Receptors. ACS Chemical Neuroscience. 12(23), 4371-4379.

9. Puthongkham, P., Rocha, J., Borgus, J., Ganesana, M., Wang, Y., Chang, Y., Gahlmann, A., & Venton, B.J. (2020). Structural Similarity Image Analysis for Detection of Adenosine and Dopamine in Fast-Scan Cyclic Voltammetry Color Plots. Analytical Chemistry. 92(15): 10485-10494.

10. Chang, Y., Wang, Y., & Venton, B. J. (2020). A₁ and A_2A receptors modulate spontaneous adenosine but not mechanically-stimulated adenosine in the caudate. ACS Chemical Neuroscience. 11(20): 3377-3385.

11. Li, Q. Y., Luo, S. J., Wang, Y., & Wang, Q. M. (2019). Carbon based Polyimide Nanocomposites Thin Film Strain Sensors Fabricated by Ink-jet Printing Method. Sensors & Actuators: A. Physical. 300:111664.

12. Yang, C., Wang, Y., Jacobs, C. B., & Venton, B. J. (2017). O2 Plasma Etching and Anti-Static Gun Surface Modifications for CNT Yarn Microelectrode Improve Sensitivity and Anti-Fouling Properties. Analytical Chemistry. 89 (10): 5605-5611. 

13. Nguyen, M., Wang, Y., Ganesana, M., & Venton, B. J. (2017). Transient adenosine release is modulated by NMDA and GABA_Breceptors. ACS chemical neuroscience. 8(2): 376-385.

14. Borman, R., Wang, Y., Nguyen, M., Ganesana, M., Lee, S., & Venton, B. J. (2017). Automated Algorithm for Detection of Transient Adenosine Release. ACS chemical neuroscience. 8(2): 386-393.

15. Trikantzopoulos, E., Yang, C., Ganesana, M., Wang, Y., & Venton, B. J. (2016). Novel Carbon-Fiber Microelectrode batch fabrication using a 3D-printed mold and polyimide resin. Analyst. 141(18): 5256-5260.

16. Yang, C., Trikantzopoulos, E., Nguyen, M. D., Jacobs, C. B., Wang, Y., Mahjouri-Samani, M., & Venton, B. J. (2016). Laser treated carbon nanotube yarn microelectrodes for rapid and sensitive detection of dopamine in vivo. ACS Sensors, 1(5): 508-515.

17. Wang, Y., Wang, A. X., Wang, Y., Chyu, M. K., & Wang, Q. M. (2013). Fabrication and characterization of carbon nanotube–polyimide composite based high temperature flexible thin film piezoresistive strain sensor. Sensors and Actuators A: Physical, 199: 265-271.

18. Chen, Q., Sun, Y., Wang, Y., Cheng, H., & Wang, Q. M. (2013). ZnO nanowires–polyimide nanocomposite piezoresistive strain sensor. Sensors and actuators A: Physical, 190: 161-167. 

招生信息：

硕士研究生：法医学法医毒物分析方向（学术型，专业代码：100100 专业名称：基础医学）

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