谢枫，苏州大学生物医学研究院 特聘教授，教育部青年长江学者。

谢枫博士致力于研究蛋白翻译后修饰、细胞信号转导、凝聚体及外泌体在肿瘤转移和肿瘤免疫中的分子机制以及治疗策略的研发。谢枫博士以第一或通讯作者（含共同）在Nature(2025), Cell (2024),Signal Transduction and Targeted Therapy(2025),

Nature Communications(2022, 2017a, 2017b), EMBO Journal (2022, 2017), Advanced Materials(2021), Signal Transduction and Targeted Therapy (2025), Advanced Science(2023, 2022, 2021, 2019),Cellular & Molecular Immunology (2022),Cell Death & Differentiation(2017), Cancer Communications (2022)等期刊上发表SCI论文23篇，总引用次数超过3800次，H-index为23。

主持国家自然科学基金3项（重大研究计划培育项目、面上项目和青年项目各1项）。获江苏省优秀青年基金（2024），姑苏创新创业领军人才（2021），江苏省双创博士（2021），苏州大学优秀青年学者（2020）和博士后创新人才支持计划（2017）等人才项目。获浙江省科学技术奖二等奖（2021），苏州市自然科学优秀学术一等奖（2017）。

发表论文（#第一作者，*通讯作者）

1. Xie F#*, Zhou X#, Ran Y, Li R, Zhou J, Wan S, Su P, Meng X, Yan H, Lu H, Ru H, Hu H, Mao Z*, Yang B*, Zhou F*, Zhang L*. Targeting FOXM1 condensates reduces breast tumor growth and metastasis. Nature. (2025)

2. Zong Z#, Xie F#, Wang S, Wu X, Zhang Z, Yang B, Zhou F*. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. Cell. (2024).

3. Zhou X#, Wu Y#, Zhu Z#, Lu C, Zhang C, Zeng L, Xie F*, Zhang L*, Zhou F*. Mucosal immune response in biology, disease prevention and treatment. Signal Transduction and Targeted Therapy. (2025).

4. Wan S#, Zhou X#, Xie F*, Zhou F*, Zhang L*. Ketogenic Diet and Cancer: Multidimensional Exploration and Research. SCIENCE CHINA Life Sciences. (2025).

5. Zhang M, Xie F*, Zhou F*. The impact of intestinal microbiota-derived metabolites on cancer and their potential application in tumor immunotherapy. MedComm-Future Medicine. (2024)

6. Peng Su#, Wu Y#, Xie F#, Zeng Q#, Chen L, Liu Z, Meng X*, Zhou F*, Zhang L*. A Review of Extracellular Vesicles in COVID-19 Diagnosis, Treatment, and Prevention. Advanced Science. (2023).

7. Xie F#, Zhou X#, Su P, Li H, Tu Y, Du J, Pan C, Wei X, Zheng M, Jin K, Miao L, Wang C, Meng X, Van Dam H, Ten dijke P, Zhang L*, Zhou F*. Breast Cancer Cell-derived Extracellular Vesicles Promote CD8+ T cell Exhaustion via TGF-β type II receptor Signalling. Nature Communications. (2022).

8. Wei X#, Xie F#, Zhou X#, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Role of pyroptosis in inflammation and cancer. Cellular & Molecular Immunology. (2022).

9. Xie F#, Zhou X#, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P*, Zhou F*, Zhang L*. USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII. EMBO Journal. (2022).

10. Xie Y#, Xie F#, Zhou X#, Zhang L#, Yang B, Huang J, Wang F, Yan H, Zeng L*,Zhang L*, Zhou F*. Microbiota in tumors: from understanding to application. Advanced Science. (2022).

11. Zhao L#, Zhou X#, Xie F#, Zhang L#, Yan H, Huang J, Zhang C*, Zhou F*, Chen J*, Zhang L*. Ferroptosis in cancer and cancer immunotherapy. Cancer Communications. (2022).

12. Xie F#, Su P#, Pan T#, Zhou X, Li H, Huang H, Wang A, Wang F, Huang J, Yan H, Zeng LH, Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. (2021).

13. Xie Y#, Xie F#, Zhang L#, Zhou X, Huang J, Wang F, Jin J, Zhang L*, Zeng L*, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science.(2021).

14. Zhou X#, Xie F#, Wang L#, Zhang L, Zhang S, Fang M,  Zhou F*. The function and clinical application of extracellular vesicles in innate immune regulation. Cellular & Molecular Immunology. (2020). 

15. Xie F#, Zhou X#, Fang M#, Li H, Su P, Tu Y, Zhang L, Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. (2019).

16. Xie F, Ling L, van Dam H, Zhou F*, Zhang L*. TGF-β signaling in cancer metastasis. Acta Biochim Biophys Sin. (2018).

17. Zhang Z#, Fan Y#, Xie F#, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L*. Breast cancer metastasis suppressor OTUD1 deubiquitylates SMAD7. Nature Communications. (2017).

18. Xie F#, Jin K#, Shao L#, Fan Y, Tu Y, Li Y, Yang B, van Dam H, Ten Dijke P, Weng H, Dooley S, Wang S, Jia J, Jin J, Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications.(2017).

19. Zhou F#, Xie F#, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L*, Ten Dijke P*. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO Journal. (2017).

20. Zhang L#*, Xie F#, Zhang J, Ten Dijke P, Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death & Differentiation. (2017).

1.中国抗癌协会肿瘤标志专业委员会委员；

2.外泌体技术专家委员会委员；

3.江苏省免疫学会青年工作委员会委员。

谢枫，苏州大学生物医学研究院 特聘教授，教育部青年长江学者。

谢枫博士致力于研究蛋白翻译后修饰、细胞信号转导、凝聚体及外泌体在肿瘤转移和肿瘤免疫中的分子机制以及治疗策略的研发。谢枫博士以第一或通讯作者（含共同）在Nature(2025), Cell (2024),Signal Transduction and Targeted Therapy(2025),

Nature Communications(2022, 2017a, 2017b), EMBO Journal (2022, 2017), Advanced Materials(2021), Signal Transduction and Targeted Therapy (2025), Advanced Science(2023, 2022, 2021, 2019),Cellular & Molecular Immunology (2022),Cell Death & Differentiation(2017), Cancer Communications (2022)等期刊上发表SCI论文23篇，总引用次数超过3800次，H-index为23。

主持国家自然科学基金3项（重大研究计划培育项目、面上项目和青年项目各1项）。获江苏省优秀青年基金（2024），姑苏创新创业领军人才（2021），江苏省双创博士（2021），苏州大学优秀青年学者（2020）和博士后创新人才支持计划（2017）等人才项目。获浙江省科学技术奖二等奖（2021），苏州市自然科学优秀学术一等奖（2017）。

发表论文（#第一作者，*通讯作者）

1. Xie F#*, Zhou X#, Ran Y, Li R, Zhou J, Wan S, Su P, Meng X, Yan H, Lu H, Ru H, Hu H, Mao Z*, Yang B*, Zhou F*, Zhang L*. Targeting FOXM1 condensates reduces breast tumor growth and metastasis. Nature. (2025)

2. Zong Z#, Xie F#, Wang S, Wu X, Zhang Z, Yang B, Zhou F*. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. Cell. (2024).

3. Zhou X#, Wu Y#, Zhu Z#, Lu C, Zhang C, Zeng L, Xie F*, Zhang L*, Zhou F*. Mucosal immune response in biology, disease prevention and treatment. Signal Transduction and Targeted Therapy. (2025).

4. Wan S#, Zhou X#, Xie F*, Zhou F*, Zhang L*. Ketogenic Diet and Cancer: Multidimensional Exploration and Research. SCIENCE CHINA Life Sciences. (2025).

5. Zhang M, Xie F*, Zhou F*. The impact of intestinal microbiota-derived metabolites on cancer and their potential application in tumor immunotherapy. MedComm-Future Medicine. (2024)

6. Peng Su#, Wu Y#, Xie F#, Zeng Q#, Chen L, Liu Z, Meng X*, Zhou F*, Zhang L*. A Review of Extracellular Vesicles in COVID-19 Diagnosis, Treatment, and Prevention. Advanced Science. (2023).

7. Xie F#, Zhou X#, Su P, Li H, Tu Y, Du J, Pan C, Wei X, Zheng M, Jin K, Miao L, Wang C, Meng X, Van Dam H, Ten dijke P, Zhang L*, Zhou F*. Breast Cancer Cell-derived Extracellular Vesicles Promote CD8+ T cell Exhaustion via TGF-β type II receptor Signalling. Nature Communications. (2022).

8. Wei X#, Xie F#, Zhou X#, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Role of pyroptosis in inflammation and cancer. Cellular & Molecular Immunology. (2022).

9. Xie F#, Zhou X#, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P*, Zhou F*, Zhang L*. USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII. EMBO Journal. (2022).

10. Xie Y#, Xie F#, Zhou X#, Zhang L#, Yang B, Huang J, Wang F, Yan H, Zeng L*,Zhang L*, Zhou F*. Microbiota in tumors: from understanding to application. Advanced Science. (2022).

11. Zhao L#, Zhou X#, Xie F#, Zhang L#, Yan H, Huang J, Zhang C*, Zhou F*, Chen J*, Zhang L*. Ferroptosis in cancer and cancer immunotherapy. Cancer Communications. (2022).

12. Xie F#, Su P#, Pan T#, Zhou X, Li H, Huang H, Wang A, Wang F, Huang J, Yan H, Zeng LH, Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. (2021).

13. Xie Y#, Xie F#, Zhang L#, Zhou X, Huang J, Wang F, Jin J, Zhang L*, Zeng L*, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science.(2021).

14. Zhou X#, Xie F#, Wang L#, Zhang L, Zhang S, Fang M,  Zhou F*. The function and clinical application of extracellular vesicles in innate immune regulation. Cellular & Molecular Immunology. (2020). 

15. Xie F#, Zhou X#, Fang M#, Li H, Su P, Tu Y, Zhang L, Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. (2019).

16. Xie F, Ling L, van Dam H, Zhou F*, Zhang L*. TGF-β signaling in cancer metastasis. Acta Biochim Biophys Sin. (2018).

17. Zhang Z#, Fan Y#, Xie F#, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L*. Breast cancer metastasis suppressor OTUD1 deubiquitylates SMAD7. Nature Communications. (2017).

18. Xie F#, Jin K#, Shao L#, Fan Y, Tu Y, Li Y, Yang B, van Dam H, Ten Dijke P, Weng H, Dooley S, Wang S, Jia J, Jin J, Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications.(2017).

19. Zhou F#, Xie F#, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L*, Ten Dijke P*. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO Journal. (2017).

20. Zhang L#*, Xie F#, Zhang J, Ten Dijke P, Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death & Differentiation. (2017).

1.中国抗癌协会肿瘤标志专业委员会委员；

2.外泌体技术专家委员会委员；

3.江苏省免疫学会青年工作委员会委员。