个人简介
苏州大学药学院教授，国家海外高层次人才计划青年项目获得者，江苏省双创人才，姑苏创新领军人才。郑教授分别从美国约翰∙霍普金斯大学和美国麻省理工学院获得学士和博士学位，在新加坡科技研究局（A*STAR）从事研创工作后加盟苏州大学药学院。郑博士多年来在免疫学、生物科技和材料工程等的交叉领域研发了新型CAR-T细胞疗法、疫苗和其智能武装体系，高效治疗癌症和自身免疫性疾病。以通讯或第一作者在Nature Biotechnology、Advanced Materials、ACS Nano、Journal of Controlled Release等国际期刊发表成果，引用3800余次。已获中、美等国授权专利7项，其中转让生物医药公司3项，基于相关技术的公司产品在美国开展临床试验。
教育经历
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学士, 2006.09- 2009.05, 美国约翰霍普金斯大学, 学士
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博士, 2010.09- 2015.11, 生物工程, 美国麻省理工学院, 博士
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在职硕士, 2017.08- 2019.09, 商业分析(生物医药), 新加坡国立大学, 硕士
工作经历
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2015- 2017, 新加坡科技研究局 (A*STAR), 博士后
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2017- 2019, 新加坡科技研究局 (A*STAR), 科研员 (Research Scientist)
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2019- 至今, 苏州大学药学院, 教授
社会职务
中国抗癌协会纳米肿瘤学专业委员会委员 中国颗粒学会药物制剂与粒子设计专业委员会委员 江苏省药理学会青委会副主委 期刊Fundamental Research等青年编委 Adv Mater、Signal Transduction Targeted Ther、Adv Sci、J Exp Clin Canc Res等二十余本期刊审稿人
研究领域
结合免疫学、生物科技和材料工程，围绕癌症和自身免疫性疾病，研发新型CAR-T细胞疗法、癌症疫苗和相关智能药物递送体系。
社会职务
中国抗癌协会纳米肿瘤学专业委员会委员 中国颗粒学会药物制剂与粒子设计专业委员会委员 江苏省药理学会青委会副主委 期刊Fundamental Research等青年编委 Adv Mater、Signal Transduction Targeted Ther、Adv Sci、J Exp Clin Canc Res等二十余本期刊审稿人
论文
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1、Cell Surface-tethered Nucleic Acid Therapeutics Program Robust and Tumor-responsive Enhancement of Adoptive Cell Therapy, Advanced Materials, Mengqian Gao, Ying Liu, Lei Zhao, Jin Chen, Wenjun Wan, Yajun Wang#, Yiran Zheng#, 37, 2419969 (2025)
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2、In situ therapeutic vaccines for leukemia by chemo-nanoadjuvant therapy, Journal of Controlled Release, Peng Zhang, Guanhong Cui, Tanzhen Wang, Xiaofei Zhao, Tianhui Liu#, Yiran Zheng#, Zhiyuan Zhong#, 383, 113851 (2025)
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3、Systemic multifunctional nanovaccines for potent personalized immunotherapy of acute myeloid leukemia, Advanced Materials,Peng Zhang，Tianzhen Wang, Guihong Cui,Ruonan Ye,Wenjun Wan,Tianhui Liu#, Yiran Zheng#, Zhiyuan Zhong#,36, 2407189 (2024)
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4、Chemokine-based injectable navigation system for enhancing CAR-T cell therapy against solid tumors, Advanced Functional Materials, Wenjun Wan, Wenqing Han, Jin Chen, Yangjing Li, Yiran Zheng#, 34, 2401161 (2024)
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5、Paravertebrally‐injected multifunctional hydrogel for sustained anti‐inflammation and pain relief in lumbar disc herniation, Advanced Healthcare Materials, Wenhao Deng, Jin Chen, Xinli Wang, Qianliang Wang, Lei Zhao, Jun Yan#, Yiran Zheng#, 13, 2401227 (2024)
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6、Uplifting anti-tumor immunotherapy with lymph node-targeted and ratio-controlled co-delivery of tumor cell lysate and adjuvant, Advanced Healthcare Materials, Guihong Cui, Yinping Sun, Liping Qu, Yiran Zheng#, Zhiyuan Zhong#, 13, 2303690 (2024)
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7、Roadmap to next-generation cancer vaccines, Journal of Controlled Release, Yiran Zheng#, Zhiyuan Zhong#, 347, 308-313 (2022)
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8、Enhancing adoptive T cell therapy for solid tumor with cell-surface anchored immune checkpoint Inhibitor nanogels, Nanomedicine:NBM, Xingye Chen, Mengqian Gao, Shan An, Lei Zhao, Wenqing Han, Wenjun Wan, Jin Chen, Siqi Ma, Wenhua Cai, Yanni Cao, Dawei Ding, Yi Yan Yang, Lifang Cheng#, Yiran Zheng#, 45,102591 (2022)
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9、Immune Checkpoint Inhibitor‐Based Strategies for Synergistic Cancer Therapy, Advanced Healthcare Materials, M. He, T. Yang, Y. Wang, M. Wang, X. Chen, Dawei Ding#, Yiran Zheng#, Huabing Chen#, 10(9): 2002104 (2021)
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10、Cationic polymer synergizing with chemotherapeutics and re-purposing antibiotics against cancer cells, Biomaterials Science, Yiran Zheng#, J. Kng, C. Yang, J. L. Hedrick,, Yi Yan Yang#, 9, 2174-2182 (2021)
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11、Enhancing T-cell therapy through TCR signaling-responsive nanoparticle drug delivery, Nature Biotechnology, Li Tang, Yiran Zheng (co-first author), M. Melo, L. Mabardi, A. P. Castano, Y.Q. Xie, N. Li, S. B. Kudchodkar, H. C. Wong, E. K. Jeng, M. V. Maus, Darrell Irvine#, 36 (8), 707 (2018)
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12、Enhancing adoptive cell therapy of cancer through targeted delivery of small-molecule immunomodulators to internalizing or non-internalizing receptors, ACS Nano, Yiran Zheng, Li Tang, L. Mabardi, S. Kumari, Darrell Irvine#, 11(3):3089-3100 (2017)
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13、In vivo Targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes, Journal of Controlled Release, Yiran Zheng, M. T. Stephan, S. A. Gai, W. Abraham, A. Shearer, Darrell J. Irvine#, 172(2):426-35 (2013)
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14、Structure-based programming of lymph-node targeting in molecular vaccines, Nature, H. Liu, K. Moynihan, Y. Zheng, G. Szeto, A. Li, B. Huang, D. Egeren, C. Park, Darrell Irvine#, 507(7493): 519–522 (2014)
招生信息
欢迎博士后和研究生加入团队：针对实体肿瘤和自身免疫性疾病，共同研发新型免疫细胞制备及改造技术，开发针对免疫细胞的智能药物递送系统。 拟招人员专业背景：免疫学、细胞生物学、药剂学或生物材料。
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