张雪迪 副教授

张雪迪，苏州大学基础医学院青年特聘教授。2013年获吉林大学生命科学学院理学学士学位，2019年获清华大学生命科学学院生物学专业理学博士学位，2019年7月至2023年8月，在中科院分子细胞科学卓越创新中心从事博士后研究工作，2023年9月至2024年5月，在上海科技大学从事副研究员研究工作，先后在Developmental Cell、Nature Communications、Nucleic Acids Research、Open Biology等国际知名期刊上发表论文。

实验室的主要研究方向是基因编辑和表观遗传学。我们致力于开发高效的基因编辑新技术,应用于构建人源化疾病动物模型和临床细胞基因治疗。

代表性科研论文（#第一作者，*通讯作者）

1. Xuedi Zhang#, Ju Peng#, Menghua Wu#, Angyang Sun, Xiangyu Wu, Jie Zheng, Wangfei Shi, Guanjun Gao* (2023). Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility. Nature Communications. 14(1):2629. 

2. Weimin Zhang#, Xuedi Zhang#, ZhaoyuXue#, Yijie Li#, Qing Ma, Xiangle Ren, Jiaying Zhang, Songhua Yang, Lijuan Yang, Menghua Wu, Mengda Ren, Rongwen Xi, Zheng Wu, Ji-Long Liu, Erika Matunis, Junbiao Dai and Guanjun Gao* (2019). Probing the function of metazoan histones with a systematic library of H3 and H4 mutants. Developmental Cell. 48, 406-419 e405. 

3. Kaixuan Gao#, Xuedi Zhang#, Zhenwu Zhang, Xiangyu Wu, Yan Guo, Pengchong Fu, Angyang Sun, Ju Peng, Jie Zheng, Pengfei Yu, Tengfei Wang, Qinying Ye, Jingwei Jiang, Haopeng Wang, Chao-Po Lin, Guanjun Gao* (2022). Transcription-coupled Donor DNA Expression Increases Homologous Recombination for Efficient Genome Editing. Nucleic Acids Research. 2022 Oct 28. 50(19). (# co-first author). 

4. Xuedi Zhang, Xiangyu Wu, Ju Peng, Angyang Sun, Yan Guo, Pengchong Fu, Guanjun Gao* (2022). Cis- and Trans-Regulation by Histone H4 Basic Patch R17/R19 in Metazoan Development. Open Biology. 2022 Nov;12(11):220066. 

5. Ke Shui, Chenwei Wang, Xuedi Zhang, Shanshan Ma, Qinyu Li, Wanshan Ning, Weizhi Zhang, Miaomiao Chen, Di Peng, Hui Hu, Zheng Fang, Anyuan Guo, Guanjun Gao, Mingliang Ye, Luoying Zhang & Yu Xue (2023). Small-sample learning reveals propionylation in determining global protein homeostasis. Nature Communications. 2813 (2023). 

6. Menghua Wu; Xuedi Zhang; Wei Wei; Li Long; Sainan An; Guanjun Gao* (2020). CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Scientific Reports. 30 Apr 2020. 10(1)

7. Kejia Wen#, Lijuan Yang#, TuanlinXiong#, Chao Di, DanHui Ma, Menghua Wu, ZhaoyuXue, Xuedi Zhang, Li Long, Weimin Zhang, Jiaying Zhang, Xiaolin Bi, Junbiao Dai, Qiangfen Zhang, Zhi Lu, and Guanjun Gao* (2016). Critical roles of long noncoding RNAs in Drosophila spermatogenesis. Genome Research. 26, 1233-1244.

8. ZhaoyuXue., Menghua Wu, Kejia Wen, Mengda Ren, Li Long, Xuedi Zhang and Guanjun Gao* (2014). CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila. G3-Genes Genomes Genetics 4 (11): 2167-2173