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姓名：陈涛

学位：博士

直属机构：苏州医学院公共卫生学院

电子邮箱：tchen@suda.edu.cn

办公地址：402-2423

联系电话：65882273

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个人资料

  • 直属机构：苏州医学院公共卫生学院
  • 联系电话：65882273
  • 性别：男
  • 电子邮箱：tchen@suda.edu.cn
  • 专业技术职务：
  • 办公地址：402-2423
  • 毕业院校：中国科学院动物研究所
  • 通讯地址：
  • 学位：博士
  • 邮编：
  • 学历：博士
  • 传真：

教育经历

教育经历：
  • 博士研究生,2002.08.01 00:00:00-2005.09.01 00:00:00,中科院动物所,博士

工作经历

工作经历：
  • 2010-2012,英国纽卡斯尔大学,研究人员
  • 2007-2009,英国伯明翰大学,研究人员

个人简介

个人简介：

陈涛，苏州大学公共卫生学院教授,博士生导师。2005年中国科学院动物研究所生殖生物学国家重点实验室获博士学位，之后在英国伯明翰大学和纽卡斯尔大学进行研究工作，2012年入职苏州大学。长期致力于环境化学物致癌及发育毒性研究，近年来采用斑马鱼胚胎和人胚胎干细胞等模式生物研究大气PM2.5及三氯乙烯等环境化学物干扰心脏发育的分子机制。获得多项国家自然科学基金及省部级基金，担任《环境与职业医学》常务编委，Cardiovascular Toxicology副编委，以通讯作者在EHP、STOTEN、JHM、EP等期刊发表SCI论文80余篇。

社会职务

社会职务：

Associate Editor of Cardiovascular Toxicology.

Editor of Journal of Environmental & Occupational Medicine.

研究领域

研究领域：

１．环境化学物及新污染物的心脏发育毒性和毒理学机制

２．环境化学物的表观遗传毒性机制

开授课程

开授课程：
  • 1、卫生毒理学双语及全英文,本科生
  • 2、高级毒理学,研究生
  • 3、人口危机的背后,本科生
课程教学：

科研项目

科研项目：
  • 1、AHR调控RNA m6A甲基化介导大气PM2.5心脏发育毒性的机制研究,2020-,陈涛,国家自然科学基金,81972999
  • 2、白藜芦醇通过AhR和Rspo2/Wnt通路对大气PM2.5心脏发育毒性的保护机制研究,2018-,陈涛,国家自然科学基金,81741005

论文

论文：
  • 1、Fu B#, Chen T#, Jiang B, Feng H, Zhu Z, Li M, Zhang G, Jiang Y*. 6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage. Environ Pollut. 2024 May 15;349:123872
  • 2、Chen J, Zhang M, Aniagu S, Jiang Y*, Chen T*. PM2.5 induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage. Environ Toxicol Pharmacol. 2024 March, 106:104393
  • 3、Jiang Y, Zhang M, Li J, Hu K, Chen T*. AHR/cyp1b1 signaling-mediated extrinsic apoptosis contributes to 6PPDQ-induced cardiac dysfunction in zebrafish embryos. Environ Pollut. 2024 Feb 2:345:123467.
  • 4、Zou H, Zhang M, Chen J, Aniagu S, Jiang Y, Chen T*. AHR-mediated DNA damage contributes to BaP-induced cardiac malformations in zebrafish. Sci Total Environ. 2024 Jan 1;906:167636.
  • 5、Jiang Y, Aniagu S, Chen T*. Current Techniques and Models for Assessing the Developmental Toxicity of Environmental Pollutants. J Vis Exp. 2023 Mar 3;(193). doi: 10.3791/64981.
  • 6、Wang J, Liu T, Wang J, Chen T*, Jiang Y. Genome-Wide Profiling of Transcriptome and DNA Methylome in Human Embryonic Stem Cells Exposed to Extractable Organic Matter from PM2.5. Toxics. 2023 Oct 6;11(10):840.
  • 7、Ji C, Tao Y, Li X, Wang J, Chen J, Aniagu S, Jiang Y, Chen T*. AHR-mediated m6A RNA methylation contributes to PM2.5-induced cardiac malformations in zebrafish larvae. J Hazard Mater. 2023 Sep 5;457:131749.
  • 8、Teng Z, Jiang B, Wang J, Liu T, Aniagu S, Zhu Z, Chen T*, Jiang Y. Regulation of Cx43 and its role in trichloroethylene-induced cardiac toxicity in H9C2 rat cardiomyocytes. Chemosphere. 2023 May;323:138249.
  • 9、Chen J, Zhang M, Zou H, Aniagu S, Jiang Y, Chen T*. PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development. Toxicology. 2023 Mar 15;487:153466.
  • 10、Jiang Y, Zhao X, Chen J, Aniagu S, Chen T*. PM2.5 induces cardiac malformations via PI3K/akt2/mTORC1 signaling pathway in zebrafish larvae. Environ Pollut. 2023 Apr 15;323:121306.
  • 11、Chen J, Zhang M, Zou H, Aniagu S, Jiang Y, Chen T*. Synergistic protective effects of folic acid and resveratrol against fine particulate matter-induced heart malformations in zebrafish embryos. Ecotoxicol Environ Saf. 2022 Aug;241:113825.
  • 12、 Zhang M, Chen J, Jiang Y, Chen T*. Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress. Chemosphere. 2022 Nov;307(Pt 2):135962.
  • 13、Zhang H, Shan L, Aniagu S, Jiang Y, Chen T*. Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice. Food Chem Toxicol. 2022 Mar;161:112817
  • 14、Xia Y, Jiang B, Teng Z, Liu T, Wang J, Aniagu S, Zhang G, Chen T*, Jiang Y. Cx43 overexpression is involved in the hyper-proliferation effect of trichloroethylene on human embryonic stem cells. Toxicology. 2022 Jan 15;465:153065.
  • 15、Huang Y, Zhang J, Tao Y, Ji C, Aniagu S, Jiang Y*, Chen T*. AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol. Toxicology. 2021 Oct;462:152965.
  • 16、Huang Y, Tao Y, Cai C, Chen J, Ji C, Aniagu S, Jiang Y*, Chen T*. Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts. J Vis Exp. 2021 Feb 15;(168).
  • 17、Huang Y, Xia Y, Tao Y, Jin H, Ji C, Aniagu S, Chen T*, Jiang Y*. Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Toxicology 2021; 452: 152697.
  • 18、Ren F, Huang Y, Tao Y, Ji C, Aniagu S, Jiang Y*, Chen T*. Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist. Toxicol Appl Pharmacol. 2020 Jul 1;398:115029.
  • 19、Ren F, Wang J, Aniagu S, Li J, Jiang Y*, Chen T*，Effects of Trichloroethylene on the Expression of Long Intergenic Noncoding RNAs in B6C3F1 Mouse Liver. Chem Res Toxicol. 2020 Jan 27.
  • 20、Ren F, Ji C, Huang YJ, Aniagu S, Tong J, Jiang Y*, Chen T*, AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Sci Total Environ. 2020 Jun 1;719:135097.
  • 21、Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y*, Chen T*. AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. J Hazard Mater. 2020 Mar 5;385:121521.
  • 22、Jiang Y, Li J, Ren F, Ji C, Aniagu S, Chen T*.PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid, Environ Pollut. 2019 Dec;255(Pt 3):113331.
  • 23、Jiang Y, Zhou Z, Fei R, Zhou X, Wang J, Tao Y, Li J*, Chen T*. Role of miR-182-5p overexpression in trichloroethylene-induced abnormal cell cycle functions in human HepG2 cells. J Toxicol Environ Health A. 2019;82(16):920-927.
  • 24、Wang J, Yu XF, OUYang N, Luo QL, Zhao SY, Guan XF, Chen T*, Li JX*. Multi-platform analysis of methylation-regulated genes in human lung adenocarcinoma. J Toxicol Environ Health A. 2019 Jan 9:1-9.
  • 25、 Chen T#, Jin H, Wang H, Yao Y, Aniagu S, Tong J, Jiang Y*. Aryl hydrocarbon receptor mediates the cardiac developmental toxicity of EOM from PM2.5 in P19 embryonic carcinoma cells. Chemosphere. 2019 Feb;216:372-378.
  • 26、Yue C, Cheng Ji, H Zhang, L Zhang, Jian T, Jiang Y*, Chen T*. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways，Environ Toxicol，2017 Oct（Cover paper）
  • 27、Jiang Y, Chen JH, Yue C, Zhang H, Tong J, Li JX*, Chen T*. The role of miR-182-5p in hepatocarcinogenesis of trichloroethylene in mice. Toxicol Sci. 2016 Dec
  • 28、Zhang H, Yao YG, Chen Y, Yue C, Chen JH, Jiang Y*, Chen T*. Crosstalk between AhR and wnt/β-catenin signal pathwaysin the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Toxicology 2016 May
  • 29、Jiang Y, Wang D, Zhang G, Wang G, Tong J*, Chen T*. Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene. Environ Toxicol. 2015 Apr 6
  • 30、Chen T, Middleton FK, Falcon S, Reaper PM, Pollard JR, Curtin NJ. Development of pharmacodynamic biomarkers for ATR inhibitors. Mol Oncol. 2014 Oct 13. 
  • 31、Jiang Y, Chen JH, Tong J, Chen T*. Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. Plos One. 2014 Dec 30
  • 32、Chen T, Stephens P, Middleton F, Curtin NJ. Targeting the S and G2 Checkpoint to treat cancer. Drug Discov Today. 2011 Dec 14.
  • 33、Chen T, Williams T, Mally A, Hamberger C, Mirbahai L, Hickling K, Chipman JK*. Gene expression and epigenetic changes by furan in rat liver. Toxicology. 2011
  • 34、Chen T, Mally A, Ozden S, Chipman JK. Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation. Environ Health Perspect. 2010 Nov;118(11):1597-602.
  • 35、PFOS and PFOSA induce oxidative stress-mediated cardiac defects in zebrafish via PPARγ and AHR pathways, respectively,Sci Total Environ,Ma T,Jiang Y,Chen P,Chen T,951/175716

科技成果

软件著作 软件著作：
  • 1、Jiang Y, Dai YF, Chen T, Advances in Molecular Toxicology (Chapeter 2 Advances in TCE Toxicology)， Volume 11, Pages 51-79,2017,ELSIVER
 专利 专利：
  • 1、Method for measuring ATR inhibition mediated increases in DNA damage, 9791456 B2,美国发明专利

荣誉及奖励

荣誉及奖励：

招生信息

招生信息：

1，环境化学物干扰斑马鱼胚胎心脏发育分子机制

2，环境化学物影响胚胎干细胞心肌分化的机理

 招生信息1：