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NAME：Chentao

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  • Gender：male
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Education

Education：

Ph. D. (2002-2005) Institute of Zoology, Chinese Academy of Sciences, China

Professional Experiences

Work Experience：

Professor (2019- ) School of public health, Soochow University, China

Associate professor (2013-2018) School of public health, Soochow University, China

Research fellow (2010-2012) Northern institute for cancer research, Newcastle University, UK

Research fellow (2007-2009) The School of Biosciences, University of Birmingham, UK



Overview

Resume：

Professional Service

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Research

Research Field：

Cardiac developmental toxicity of environmental chemicals

Investigate the molecular mechanisms of cardiac developmental toxicity of environmental chemicals using zebrafish embryos and human embryonic stem cells as model systems.


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Publications

Thesis：

1.      Liu T, Jiang B, Fu BQ, Shang CY, Feng HB, Chen T*, Jiang Y*. “PM2.5 Induces Cardiomyoblast Senescence via AhR-Mediated Oxidative Stress.” Antioxidants. 2024.

2.      Fu B#, Chen T#, Jiang B, Feng H, Zhu Z, Li M, Zhang G, Jiang Y*. 6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage. Environ Pollut. 2024 May 15;349:123872

3.      Chen J, Zhang M, Aniagu S, Jiang Y*, Chen T*. PM2.5 induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage. Environ Toxicol Pharmacol. 2024 March, 106:104393

4.      Jiang Y, Zhang M, Li J, Hu K, Chen T*. AHR/cyp1b1 signaling-mediated extrinsic apoptosis contributes to 6PPDQ-induced cardiac dysfunction in zebrafish embryos. Environ Pollut. 2024 Feb 2:345:123467.

5.      Zou H, Zhang M, Chen J, Aniagu S, Jiang Y, Chen T*. AHR-mediated DNA damage contributes to BaP-induced cardiac malformations in zebrafish. Sci Total Environ. 2024 Jan 1;906:167636.

6.      Jiang Y, Aniagu S, Chen T*. Current Techniques and Models for Assessing the Developmental Toxicity of Environmental Pollutants. J Vis Exp. 2023 Mar 3;(193). doi: 10.3791/64981.

7.      Wang J, Liu T, Wang J, Chen T*, Jiang Y. Genome-Wide Profiling of Transcriptome and DNA Methylome in Human Embryonic Stem Cells Exposed to Extractable Organic Matter from PM2.5. Toxics. 2023 Oct 6;11(10):840.

8.      Ji C, Tao Y, Li X, Wang J, Chen J, Aniagu S, Jiang Y, Chen T*. AHR-mediated m6A RNA methylation contributes to PM2.5-induced cardiac malformations in zebrafish larvae. J Hazard Mater. 2023 Sep 5;457:131749.

9.      Teng Z, Jiang B, Wang J, Liu T, Aniagu S, Zhu Z, Chen T*, Jiang Y. Regulation of Cx43 and its role in trichloroethylene-induced cardiac toxicity in H9C2 rat cardiomyocytes. Chemosphere. 2023 May;323:138249.

10.   Chen J, Zhang M, Zou H, Aniagu S, Jiang Y, Chen T*. PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development. Toxicology. 2023 Mar 15;487:153466.

11.   Jiang Y, Zhao X, Chen J, Aniagu S, Chen T*. PM2.5 induces cardiac malformations via PI3K/akt2/mTORC1 signaling pathway in zebrafish larvae. Environ Pollut. 2023 Apr 15;323:121306.

12.   Chen J, Zhang M, Zou H, Aniagu S, Jiang Y, Chen T*. Synergistic protective effects of folic acid and resveratrol against fine particulate matter-induced heart malformations in zebrafish embryos. Ecotoxicol Environ Saf. 2022 Aug;241:113825.

13.   Zhang M, Chen J, Jiang Y, Chen T*. Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress. Chemosphere. 2022 Nov;307(Pt 2):135962.

14.   Zhang H, Shan L, Aniagu S, Jiang Y, Chen T*. Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice. Food Chem Toxicol. 2022 Mar;161:112817

15.   Xia Y, Jiang B, Teng Z, Liu T, Wang J, Aniagu S, Zhang G, Chen T*, Jiang Y. Cx43 overexpression is involved in the hyper-proliferation effect of trichloroethylene on human embryonic stem cells. Toxicology. 2022 Jan 15;465:153065.

16.   Huang Y, Zhang J, Tao Y, Ji C, Aniagu S, Jiang Y*, Chen T*. AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol. Toxicology. 2021 Oct;462:152965.

17.   Huang Y, Tao Y, Cai C, Chen J, Ji C, Aniagu S, Jiang Y*, Chen T*. Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts. J Vis Exp. 2021 Feb 15;(168).

18.   Huang Y, Xia Y, Tao Y, Jin H, Ji C, Aniagu S, Chen T*, Jiang Y*. Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Toxicology 2021; 452: 152697.

19.   Huang Y, Jiang B, Xia Y, Wang J, Ji C, Tong J, Chen T*, Jiang Y*. Downregulation of miR-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish. Chemosphere. 2020 Jul;251:126610.

20.   Ren F, Huang Y, Tao Y, Ji C, Aniagu S, Jiang Y*, Chen T*. Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist. Toxicol Appl Pharmacol. 2020 Jul 1;398:115029.

21.   Ren F, Wang J, Aniagu S, Li J, Jiang Y*, Chen T*，Effects of Trichloroethylene on the Expression of Long Intergenic Noncoding RNAs in B6C3F1 Mouse Liver. Chem Res Toxicol. 2020 Jan 27.

22.   Ren F, Ji C, Huang YJ, Aniagu S, Tong J, Jiang Y*, Chen T*, AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Sci Total Environ. 2020 Jun 1;719:135097.

23.   Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y*, Chen T*. AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. J Hazard Mater. 2020 Mar 5;385:121521.

24.   Jiang Y, Li J, Ren F, Ji C, Aniagu S, Chen T*.PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid, Environ Pollut. 2019 Dec;255(Pt 3):113331.

25.   Yu XF, Wang J, OUYang N, Guo S, Sun H, Tong J, Chen T*, Li J*, The role of miR-130a-3p and SPOCK1 in tobacco exposed bronchial epithelial BEAS-2B transformed cells: Comparison to A549 and H1299 lung cancer cell lines. J. Toxicol. Environ. Health Part A. 2019;82(15)  

26.   Jiang Y, Zhou Z, Fei R, Zhou X, Wang J, Tao Y, Li J*, Chen T*. Role of miR-182-5p overexpression in trichloroethylene-induced abnormal cell cycle functions in human HepG2 cells. J Toxicol Environ Health A. 2019;82(16):920-927.

27.   Wang J, Yu XF, OUYang N, Luo Q, Tong J, Chen T*, Li J*. Role of DNA methylation regulation of miR-130b expression in human lung cancer using bioinformatics analysis.J Toxicol Environ Health A. 2019;82(17):935-943.

28.   Wang J, Yu XF, Ouyang N, Zhao S, Yao H, Guan X, Tong J, Chen T*, Li JX*. MicroRNA and mRNA Interaction Network Regulates the Malignant Transformation of Human Bronchial Epithelial Cells Induced by Cigarette Smoke.Front Oncol. 2019 Oct 9;9:1029

29.   Wang J, Yu XF, OUYang N, Luo QL, Zhao SY, Guan XF, Chen T*, Li JX*. Multi-platform analysis of methylation-regulated genes in human lung adenocarcinoma. J Toxicol Environ Health A. 2019 Jan 9:1-9.

30.   Chen T#, Jin H, Wang H, Yao Y, Aniagu S, Tong J, Jiang Y*. Aryl hydrocarbon receptor mediates the cardiac developmental toxicity of EOM from PM2.5 in P19 embryonic carcinoma cells. Chemosphere. 2019 Feb;216:372-378.

31.   Yue C, Cheng Ji, H Zhang, L Zhang, Jian T, Jiang Y*, Chen T*. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways，Environ Toxicol，2017 Oct（Cover  paper）

32.   Jiang Y, Chen JH, Yue C, Zhang H, Tong J, Li JX*, Chen T*. The role of miR-182-5p in hepatocarcinogenesis of trichloroethylene in mice. Toxicol Sci. 2016 Dec

33.   Zhang H, Yao YG, Chen Y, Yue C, Chen JH, Jiang Y*, Chen T*. Crosstalk between AhR and wnt/β-catenin signal pathwaysin the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Toxicology 2016 May

34.   Jiang Y, Wang D, Zhang G, Wang G, Tong J*, Chen T*. Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene. Environ Toxicol. 2015 Apr 6

35.   Chen T, Middleton FK, Falcon S, Reaper PM, Pollard JR, Curtin NJ. Development of pharmacodynamic biomarkers for ATR inhibitors. Mol Oncol. 2014 Oct 13. 

36.   Jiang Y, Chen JH, Tong J, Chen T*. Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. Plos One. 2014 Dec 30

37.   Chen T, Stephens P, Middleton F, Curtin NJ. Targeting the S and G2 Checkpoint to treat cancer. Drug Discov Today. 2011 Dec 14.

38.   Chen T, Williams T, Mally A, Hamberger C, Mirbahai L, Hickling K, Chipman JK*. Gene expression and epigenetic changes by furan in rat liver. Toxicology. 2011

39.   Chen T, Mally A, Ozden S, Chipman JK. Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation. Environ Health Perspect. 2010 Nov;118(11):1597-602.

40.   Edwards GO, Jondhale S, Chen T, Chipman JK*. A quantitative inverse relationship between connexin32 expression and cell proliferation in a rat hepatoma cell line. Toxicology. 2008 Nov 20;253(1-3):46-52. 2008 Sep 3

41.   Chen T, Zhang YL, Jiang Y, Liu JH, Hou Y, Schatten H, Chen DY, Sun QY*. Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm but not by donor intrinsic property in cloned embryos. Mol Reprod Dev. 2006 Mar;73(3):313

42.   Jiang Y, Chen T, Wang K, Jiang MX, Liu SZ, Ouyang YC, Sun QY, Chen DY*. Different fates of donor mitochondrial DNA in bovine-rabbit and cloned bovine-rabbit reconstructed embryos during preimplantation development. Front Biosci. 2006 May 1;11:1425-32

43.   Zhang YL, Chen T, Jiang Y, Zhong ZS, Liu SZ, Hou Y, Schatten H, Chen DY, Sun QY*. Active demethylation of individual genes in intracytoplasmic sperm injection rabbit embryos. Mol Reprod Dev. 2005 Dec;72(4):530-3

44.   Chen T, Jiang Y, Zhang YL, Liu JH, Hou Y, Schatten H, Chen DY, Sun QY*. DNA hypomethylation of individual sequences in aborted cloned bovine fetuses. Front. Biosci. 2005, 10:3002-3008

45.   Jiang Y, Chen T, Nan CL, Ouyang YC, Sun QY, Chen DY*. In vitro culture and mtDNA fate of ibex-rabbit nuclear transfer embryos. Zygote. 2005 Aug;13(3):233-40

46.   Chen T, Zhang YL, Jiang Y, Liu SZ, Schatten H, Chen DY, Sun QY*. The DNA methylation events in normal and cloned rabbit embryos. FEBS Letters. 2004, 578

 

Books&Patents

Books Writings：

  • 1、Jiang Y, Dai YF, Chen T, Advances in Molecular Toxicology (Chapeter 2 Advances in TCE Toxicology)， Volume 11, Pages 51-79,2017,ELSIVER


 Patents Patent：

Method for measuring ATR inhibition mediated increases in DNA damage. European Patent EP2904406

Honors

Honor Reward：

Supervision

Enrollment：