1. 分子影像探针的设计及其活体生物成像的应用研究；
2. 开发基于共轭聚合物，智能自组装等多功能纳米材料在生物成像及诊疗一体化的应用研究；1. 激活探针设计及生物医学应用：针对生物蛋白酶，，等与生命活动相关的生物标志物设计激活探针，用于肿瘤等疾病的早期诊断；
2. 智能自组装纳米材料的开发及生物学应用：基于多种组装体系，开发一系列智能组装纳米体系，用于生物传感、载药及可控释放，组织工程等方面的应用研究；
3. 开发光学成像、光声成像、核素成像等多种分子影像技术及其在临床肿瘤早期诊断、皮肤瘢痕、药物毒性检测等转化医学的应用研究。
Publications:
[25]. Q. Miao and K. Pu*. Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics. Advanced Materials, 2018, 30, 1801778.
[24]. Q. Miao, D. C. Yeo, C. Wiraja, J. Zhang, X. Ning, C. Xu* and K. Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid. Angewandte Chemie International Edition, 2018, 57, 1256 –1260.
[23]. Q. Miao, C. Xie, X. Zhen, Y. Lyu, H. Duan, X. Liu, J. V. Jokerst and K. Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nature Biotechnology, 2017, 35, 1102.
[22]. Q. Miao, Y. Lyu, D. Ding and K. Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Advanced Materials, 2016, 28, 3662-3668.
[21]. Q. Miao and K. Pu*. Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjugate Chemistry, 2016, 27, 2808-2823.
[20]. C. Xie, X. Zhen, Q. Miao, Y. Lyu and K. Pu*. Self‐Assembled Semiconducting Polymer Nanoparticles for Ultrasensitive Near‐Infrared Afterglow Imaging of Metastatic Tumors. Advanced Materials, 2018, 30, 1801331.
[19]. P. Cheng, J. Zhang, J. Huang, Q. Miao, C. Xu and K. Pu*. Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis. Chemical Science, 2018, 9, 6340-6347.
[18]. J. Li, C. Xie, J. Huang, Y. Jiang, Q. Miao and K. Pu*. Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy. Angewandte Chemie International Edition, 2018, 57, 3995-3998.
[17]. C. Xie, Y. Lyu, X. Zhen, Q. Miao and K. Pu*. Activatable Semiconducting Oligomer Amphiphile for Near-Infrared Luminescence Imaging of Biothiols. ACS Applied Bio Materials, 2018, 1, 1147-1153.
[16]. X. Zhen, J. Zhang, J. Huang, C. Xie, Q. Miao and K. Pu*. Macrotheranostic Probe with Disease‐Activated Near‐Infrared Fluorescence, Photoacoustic, and Photothermal Signals for Imaging‐Guided Therapy. Angewandte Chemie International Edition, 2018, 57, 7804 –7808.
[15]. D. C. Yeo, C. Wiraja, Q. Miao, X. Ning, K. Pu* and C. Xu*. Anti-Scarring Drug Screening with Near-Infrared Molecular Probes Targeting Fibroblast Activation Protein-α. ACS Applied Bio Materials, 2018, 1, 2054-2061.
[14]. H. Zhu, Y. Fang, Q. Miao, X. Qi, D. Ding, P. Chen and K. Pu*. Regulating near-infrared photodynamic properties of semiconducting polymer nanotheranostics for optimized cancer therapy. ACS Nano, 2017, 11, 8998-9009.
[13]. Y. Lyu, Y. Fang, Q. Miao, X. Zhen, D. Ding and K. Pu*. Intraparticle molecular orbital engineering of semiconducting polymer nanoparticles as amplified theranostics for in vivo photoacoustic imaging and photothermal therapy. ACS Nano, 2016, 10, 4472-4481.
[12]. X. Zhen, C. Zhang, C. Xie, Q. Miao, K. L. Lim and K. Pu*. Intraparticle energy level alignment of semiconducting polymer nanoparticles to amplify chemiluminescence for ultrasensitive in vivo imaging of reactive oxygen species. ACS Nano, 2016, 10, 6400-6409.
[11]. Q. Miao, Z. Wu, Z. Hai, C. Tao, Q. Yuan, Y. Gong, Y. Guan, J. Jiang and G. Liang*. Bipyridine hydrogel for selective and visible detection and absorption of Cd2+. Nanoscale, 2015, 7, 2797-2804.
[10]. Q. Miao, C. Yin, M. Xie, Y. Luo, Z. Hai, Q. Yuan, J. Jiang and G. Liang*. Gathering nanorings via Fe2+–bipyridine coordination. Chemical Communications, 2015, 51, 11045-11047.
[9]. Q. Miao, Q. Li, Q. Yuan, L. Li, Z. Hai, S. Liu and G. Liang*. Discriminative fluorescence sensing of biothiolsin vitro and in living cells. Analytical Chemistry, 2015, 87, 3460-3466.
[8]. Y. Liu#, Q. Miao#, P. Zou, L. Liu, X. Wang, L. An, X. Zhang, X. Qian, S. Luo and G. Liang*. Enzyme-Controlled Intracellular Self-Assembly of 18F Nanoparticles for Enhanced MicroPET Imaging of Tumor. Theranostics, 2015, 5, 1058.
[7]. B. Mei#, Q. Miao#, A. Tang and G. Liang*. Enzyme-instructed self-assembly of taxol promotes axonal branching. Nanoscale, 2015, 7, 15605-15608.
[6]. L. Dong, Q. Miao, Z. Hai, Y. Yuan and G. Liang*. Enzymatic hydrogelation-induced fluorescence turn-off for sensing alkaline phosphatase in vitro and in living cells. Analytical Chemistry, 2015, 87, 6475-6478.
[5]. Z. Hai, Y. Bao, Q. Miao, X. Yi and G. Liang*. Pyridine–biquinoline–metal complexes for sensing pyrophosphate and hydrogen sulfide in aqueous buffer and in cells. Analytical Chemistry, 2015, 87, 2678-2684.
[4]. X. Wang, Q. Miao, T. Song, Q. Yuan, J. Gao and G. Liang*. A fluorescent switch for sequentially and selectively sensing copper (II) and L-histidine in vitro and in living cells. Analyst, 2014, 139, 3360-3364.
[3]. Y. Yuan, S. Jiang, Q. Miao, J. Zhang, M. Wang, L. An, Q. Cao, Y. Guan, Q. Zhang and G. Liang*. Fluorescent switch for fast and selective detection of mercury (II) ions in vitro and in living cells and a simple device for its removal. Talanta, 2014, 125, 204-209.
[2]. L. Liu, Q. Miao and G. Liang*. Quantum dots as multifunctional materials for tumor imaging and therapy. Materials, 2013, 6, 483-499.
招生方向及招聘信息：
本课题组热忱欢迎有志从事科研工作的本科/硕士/博士研究生以及博士后（常年招收）到课题组学习工作。欢迎具有化学、材料、生物和医学背景的同学加盟。如有兴趣，请联系qqmiao@suda.edu.cn。诚挚欢迎各位加入我们课题组!1. 分子影像探针的设计及其活体生物成像的应用研究；
2. 开发基于共轭聚合物，智能自组装等多功能纳米材料在生物成像及诊疗一体化的应用研究；1. 激活探针设计及生物医学应用：针对生物蛋白酶，，等与生命活动相关的生物标志物设计激活探针，用于肿瘤等疾病的早期诊断；
2. 智能自组装纳米材料的开发及生物学应用：基于多种组装体系，开发一系列智能组装纳米体系，用于生物传感、载药及可控释放，组织工程等方面的应用研究；
3. 开发光学成像、光声成像、核素成像等多种分子影像技术及其在临床肿瘤早期诊断、皮肤瘢痕、药物毒性检测等转化医学的应用研究。
Publications:
[25]. Q. Miao and K. Pu*. Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics. Advanced Materials, 2018, 30, 1801778.
[24]. Q. Miao, D. C. Yeo, C. Wiraja, J. Zhang, X. Ning, C. Xu* and K. Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid. Angewandte Chemie International Edition, 2018, 57, 1256 –1260.
[23]. Q. Miao, C. Xie, X. Zhen, Y. Lyu, H. Duan, X. Liu, J. V. Jokerst and K. Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nature Biotechnology, 2017, 35, 1102.
[22]. Q. Miao, Y. Lyu, D. Ding and K. Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Advanced Materials, 2016, 28, 3662-3668.
[21]. Q. Miao and K. Pu*. Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjugate Chemistry, 2016, 27, 2808-2823.
[20]. C. Xie, X. Zhen, Q. Miao, Y. Lyu and K. Pu*. Self‐Assembled Semiconducting Polymer Nanoparticles for Ultrasensitive Near‐Infrared Afterglow Imaging of Metastatic Tumors. Advanced Materials, 2018, 30, 1801331.
[19]. P. Cheng, J. Zhang, J. Huang, Q. Miao, C. Xu and K. Pu*. Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis. Chemical Science, 2018, 9, 6340-6347.
[18]. J. Li, C. Xie, J. Huang, Y. Jiang, Q. Miao and K. Pu*. Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy. Angewandte Chemie International Edition, 2018, 57, 3995-3998.
[17]. C. Xie, Y. Lyu, X. Zhen, Q. Miao and K. Pu*. Activatable Semiconducting Oligomer Amphiphile for Near-Infrared Luminescence Imaging of Biothiols. ACS Applied Bio Materials, 2018, 1, 1147-1153.
[16]. X. Zhen, J. Zhang, J. Huang, C. Xie, Q. Miao and K. Pu*. Macrotheranostic Probe with Disease‐Activated Near‐Infrared Fluorescence, Photoacoustic, and Photothermal Signals for Imaging‐Guided Therapy. Angewandte Chemie International Edition, 2018, 57, 7804 –7808.
[15]. D. C. Yeo, C. Wiraja, Q. Miao, X. Ning, K. Pu* and C. Xu*. Anti-Scarring Drug Screening with Near-Infrared Molecular Probes Targeting Fibroblast Activation Protein-α. ACS Applied Bio Materials, 2018, 1, 2054-2061.
[14]. H. Zhu, Y. Fang, Q. Miao, X. Qi, D. Ding, P. Chen and K. Pu*. Regulating near-infrared photodynamic properties of semiconducting polymer nanotheranostics for optimized cancer therapy. ACS Nano, 2017, 11, 8998-9009.
[13]. Y. Lyu, Y. Fang, Q. Miao, X. Zhen, D. Ding and K. Pu*. Intraparticle molecular orbital engineering of semiconducting polymer nanoparticles as amplified theranostics for in vivo photoacoustic imaging and photothermal therapy. ACS Nano, 2016, 10, 4472-4481.
[12]. X. Zhen, C. Zhang, C. Xie, Q. Miao, K. L. Lim and K. Pu*. Intraparticle energy level alignment of semiconducting polymer nanoparticles to amplify chemiluminescence for ultrasensitive in vivo imaging of reactive oxygen species. ACS Nano, 2016, 10, 6400-6409.
[11]. Q. Miao, Z. Wu, Z. Hai, C. Tao, Q. Yuan, Y. Gong, Y. Guan, J. Jiang and G. Liang*. Bipyridine hydrogel for selective and visible detection and absorption of Cd2+. Nanoscale, 2015, 7, 2797-2804.
[10]. Q. Miao, C. Yin, M. Xie, Y. Luo, Z. Hai, Q. Yuan, J. Jiang and G. Liang*. Gathering nanorings via Fe2+–bipyridine coordination. Chemical Communications, 2015, 51, 11045-11047.
[9]. Q. Miao, Q. Li, Q. Yuan, L. Li, Z. Hai, S. Liu and G. Liang*. Discriminative fluorescence sensing of biothiolsin vitro and in living cells. Analytical Chemistry, 2015, 87, 3460-3466.
[8]. Y. Liu#, Q. Miao#, P. Zou, L. Liu, X. Wang, L. An, X. Zhang, X. Qian, S. Luo and G. Liang*. Enzyme-Controlled Intracellular Self-Assembly of 18F Nanoparticles for Enhanced MicroPET Imaging of Tumor. Theranostics, 2015, 5, 1058.
[7]. B. Mei#, Q. Miao#, A. Tang and G. Liang*. Enzyme-instructed self-assembly of taxol promotes axonal branching. Nanoscale, 2015, 7, 15605-15608.
[6]. L. Dong, Q. Miao, Z. Hai, Y. Yuan and G. Liang*. Enzymatic hydrogelation-induced fluorescence turn-off for sensing alkaline phosphatase in vitro and in living cells. Analytical Chemistry, 2015, 87, 6475-6478.
[5]. Z. Hai, Y. Bao, Q. Miao, X. Yi and G. Liang*. Pyridine–biquinoline–metal complexes for sensing pyrophosphate and hydrogen sulfide in aqueous buffer and in cells. Analytical Chemistry, 2015, 87, 2678-2684.
[4]. X. Wang, Q. Miao, T. Song, Q. Yuan, J. Gao and G. Liang*. A fluorescent switch for sequentially and selectively sensing copper (II) and L-histidine in vitro and in living cells. Analyst, 2014, 139, 3360-3364.
[3]. Y. Yuan, S. Jiang, Q. Miao, J. Zhang, M. Wang, L. An, Q. Cao, Y. Guan, Q. Zhang and G. Liang*. Fluorescent switch for fast and selective detection of mercury (II) ions in vitro and in living cells and a simple device for its removal. Talanta, 2014, 125, 204-209.
[2]. L. Liu, Q. Miao and G. Liang*. Quantum dots as multifunctional materials for tumor imaging and therapy. Materials, 2013, 6, 483-499.
招生方向及招聘信息：
本课题组热忱欢迎有志从事科研工作的本科/硕士/博士研究生以及博士后（常年招收）到课题组学习工作。欢迎具有化学、材料、生物和医学背景的同学加盟。如有兴趣，请联系qqmiao@suda.edu.cn。诚挚欢迎各位加入我们课题组!