学习概况：张乐帅博士，苏州大学生命科学学院教授、博士生导师，放射医学与辐射防护国家重点实验室成员。2002年获得华东理工大学生物化学学士学位；后由华东理工大学及中国科学院上海生化细胞所（李林院士组）联合培养，参与GPCR和Wnt细胞信号转导相关通路研究，于2005年获得华东理工大学分子生物学与生物化学硕士学位。同年赴美学习，于美国北卡州立大学（North Carolina State University）从事纳米材料的皮肤互作研究，包括其透皮吸收能力、纳米颗粒内吞能力及通路、对皮肤角质细胞及免疫细胞的功效及安全性评价等，2010年获比较生物医学（Comparative Biomedical Science）博士学位。
工作概况：2010年起，于美国食品药物管理局的药审中心（CDER/USFDA）开展抗糖药的胰腺副作用机制研究及纳米材料的毒性评估，协助建设心脏及血管体外研究平台，期间还经历了多轮药审培训。2012年于美国堪萨斯州立大学（Kansas State University）纳米技术创新中心聘为研究助理教授，从事纳米材料皮肤毒性与食品添加剂肝毒性研究。2014年受聘苏州大学，从事组织工程（细胞3D培养、细胞背包）、纳米/药物毒理学（临床前安全性）及肿瘤免疫学研究。
成果概况：已在纳米医学、毒理学等相关杂志发表SCI文章60余篇，论文引用1700余次，获国自然基金5项（面上4项、青年1项）。
社会服务：现为Toxicology and Industry Health副主编、Journal of Nanobiotechnology副主编。
产业服务：现持有美国资质认证毒理学家（DABT,2015-）、欧洲注册毒理学家（ERT,2018-）、英国注册毒理学家（UKRT,2018-）、中国毒理学会认证毒理学家（DCST,2021-）等国际毒理学家资质。承担诸多药械妆甲方及第三方的药物、医疗器械、化妆品、消费品的产品质量控制、安全性评价、风险评估工作。目前是苏州大学卫生与环境技术研究所（苏大检测）的首席科学家，负责毒理学评估团队的建设与运营。
1. 2025 – 至今，中国毒理学会医疗器械专委会委员
2. 2025 – 至今，中国毒理学会人工智能毒理学专委会委员
3. 2024 – 至今，华东理工大学美妆行业校友会理事
4. 2024 – 至今，中国毒理学会类器官与器官芯片专委会委员
5. 2023 – 至今，全国专业标准化技术委员会委员
6. 2023 – 至今，江苏省研究型医院学会类器官与器官芯片委员会委员
7. 2023 – 至今，中国毒理学会青年委员会常务委员
8. 2021 - 2023，学术期刊Toxicology Research and Applications编委
9. 2021 - 至今，学术期刊Journal of Nanobiotechnology副主编
10. 2021 - 至今，中国同位素与辐射行业协会委员
11. 2018 - 至今，苏州市器械不良反应监测专家库成员
12. 2018 - 至今，纳米药物审批政策推进专家组成员
13. 2018 - 至今，中国毒理学会中药毒理专委会青年委员
15. 2016 –至今，中国香料香精化妆品工业协会/化妆品科学技术学会会员
16. 2016 –至今，中国毒理学会会员
17. 2015 –至今，学术期刊Toxicology and Industrial Health 副主编
18. 2011 –2014，美国毒理学会教育委员会执行委员
19. 2011 –2012，美国毒理学会纳米毒理专业委员会执行委员
20. 2009 –2013，美国Sigma Xi 科学研究协会会员
21. 2007 –至今，美国毒理学会会员
组织工程学、肿瘤免疫学
新技术方法（NAMs）、类器官、体外与替代毒理学、药物毒理学
药事法规、医疗器械法规与标准、化妆品安评等转化法规研究
研究方向：本研究小组研究方向为基于生物医学工程方法的毒理学及肿瘤免疫学研究，方向涉及两大部分。一、体外替代方法——利用3D细胞培养技术（如细胞球）研究药物肝脏毒性，及基于肝病模型药物筛选、其它类器官的开发与模型验证。二、细胞背包技术——以高分子材料为基础的免疫细胞背包，通过背包载药或背包自身的力学性能，强化免疫细胞的能力，协同放化疗杀灭肿瘤。
发表成果：至今共发表文章60余篇（引用1700余次），其中SCI一作或通讯作者文章40余篇；申请批准专利10余份；部分工作被Science Daily等杂志和网站报道；主编专业书籍1本，参编英文书籍2本。主持国家自然科学基金面上在研项目（32171403）、教育部留学回国基金；国家自然科学基金面上项目（#31971319、#81373950、#31771104）与青年基金（#81401511）已结题。
学术职务：
2025 – 至今，中国毒理学会医疗器械专委会委员
2025 – 至今，中国毒理学会人工智能毒理学专委会委员
2024 – 至今，华东理工大学美妆行业校友会理事
2024 – 至今，中国毒理学会类器官与器官芯片专委会委员
2023 – 至今，全国专业标准化技术委员会委员
2023 – 至今，江苏省研究型医院学会类器官与器官芯片委员会委员
2023 – 至今，中国毒理学会青年委员会常务委员
2021 – 至今，中国同位素与辐射行业协会委员
2018 – 至今，苏州市器械不良反应监测专家库成员
2018 – 至今，纳米药物审批政策推进专家组成员
2018 – 至今，中国毒理学会中药毒理专委会青年委员
2016 – 至今，中国毒理学会纳米毒理专业委员会委员
期刊职务：
2021 – 至今，学术期刊Journal of Nanobiotechnology副主编
2015 – 至今，学术期刊Toxicology and Industrial Health 副主编
熟悉国内外的药械妆法规：
（1）涉及到早期研发、质量研究、工业生产、注册申报的法律法规，为企业、高校、政府的多个项目提供了咨询建议。
（2）药物ICH Q/M/S系列，熟练使用PDE、TTC、Cramer结合QSAR方法，为药物的安全性评价、API杂质、清洁残留、职业安全限值、单共线生产提供解决方案。
（3）OECD化学品安全指南、欧盟委员会SCCS化妆品成份安全指南及国内相关化妆品法规，委托开展化妆品的安全性评估（CPSR、CPSA）。
（4）医疗器械ISO10993/GB16886系列、MDR注册法规、医美产品法规，目前兼任苏州苏大卫生与环境技术研究所有限公司的首席科学家及毒理评估中心主任，致力于医疗器械生物学评价、E&L毒理学评估、注册申报相关的框架建设工作。
（5）熟悉纳米技术产品、体外与替代方法相关法规，并参与了国家药监局、中检院及多家标准委员会相关指南及标准的建设。近期开始涉及到电子烟、艺术消费品的法规。
1.Hali S, Kim K*, Zhang L*, Han DW* et al., Differentiation defect into GABAergic neurons in cerebral organoids from autism patients. CNS Neurosci Ther. 2025 Jun;31(6):e70449.
2.Cui J, Zhao G, Xie W, Yang Y, Fu X, Meng H, Liu H, Tan M, Chen D, Rong C, Wang Y, Wang Y*, Zhang L*. Exacerbated hepatotoxicity in in vivo and in vitro non-alcoholic fatty liver models by biomineralized copper sulfide nanoparticles. Biomater Adv. 2025 Mar;168:214117.
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15.Guo H, Yu H, Zu H, Cui J, Ding H, Xia Y, Chen D, Zeng Y, Wang Y, Wang Y, Zhang L*. Mechanistic study for drug induced cholestasis using batch-fabricated 3D spheroids developed by agarose-stamping method. Toxicol Lett. 2023;383:64-74.
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18.Hao P, Wang Y, Sun X, Wang J, Zhang L*. Derivation of the toxicological threshold of silicon element in the extractables and leachables from the pharmaceutical packaging and process components. Toxicol Ind Health. 2022;38(12):819-834.
19.Yang L, Afshari MJ, Ge J, Kou D, Chen L, Zhou D, Li C, Wu S, Zhang L, Zeng J, Zhong J, Stauber RH, Gao M. Functionalized Ultrasmall Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging of Tumor Hypoxia. Molecules. 2022;27(20):6929.
20.Yu H, Guo H, Wang Y, Wang Y, Zhang L*. Bismuth nanomaterials as contrast agents for radiography and computed tomography imaging and their quality/safety considerations. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022;14(6):e1801.
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22.Gu J, Zhao G, Yu J, Xu P, Yan J, Jin Z, Chen S*, Wang Y, Zhang L, Wang Y*. Injectable pH-responsive hydrogel for combinatorial chemoimmunotherapy tailored to the tumor microenvironment. J Nanobiotechnology. 2022;20(1):372.
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27.Jiang T, Guo H, Xia YN, Liu Y, Chen D, Pang G, Feng Y, Yu H, Wu Y, Zhang S, Wang Y, Wang Y, Wen H*, Zhang L*. Hepatotoxicity of copper sulfide nanoparticles towards hepatocyte spheroids using a novel multi-concave agarose chip method. Nanomedicine (Lond). 2021;16(17):1487-1504.
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29.Zhang X, Jiang T, Chen D, Wang Q, Zhang L*. Three-dimensional liver models: state of the art and their application for hepatotoxicity evaluation. Crit Rev Toxicol. 2020;50(4):279-309. 二区，
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31.Wang J, Chen XY, Zhao Y, Yang Y, Wang W, Wu C, Yang B, Zhang Z, Zhang L, Liu Y, Du X, Li W, Qiu L, Jiang P, Mou XZ, Li YQ*. pH-Switchable Antimicrobial Nanofiber Networks of Hydrogel Eradicate Biofilm and Rescue Stalled Healing in Chronic Wounds. ACS Nano. 2019;13(10):11686-11697.
32.Yu H, Yang Y, Jiang T, Zhang X, Zhao Y, Pang G, Feng Y, Zhang S, Wang F, Wang Y, Wang Y*, Zhang L*. Effective Radiotherapy in Tumor Assisted by Ganoderma lucidum Polysaccharide-Conjugated Bismuth Sulfide Nanoparticles through Radiosensitization and Dendritic Cell Activation. ACS Appl Mater Interfaces. 2019;11(31):27536-27547.
33.Cao Y, Huang H, Chen L, Du H, Cui J, Zhang L*, Lee B, Cao Q*. 2019. Enhanced Lysosomal Escape of pH-Responsive PEI-Betaine Functionalized Carbon Nanotube for the Co-delivery of Survivin siRNA and Doxorubicin. ACS Applied Materials & Interfaces 11(10):9763-9776.
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36.Yan R, Chen J, Wang J, Rao J, Du X, Liu Y, Zhang L, Qiu L, Liu B, Zhao YD, Jiang P, Chen C, Li YQ. 2018. A NanoFlare-Based Strategy for In Situ Tumor Margin Demarcation and Neoadjuvant Gene/Photothermal Therapy. Small. e1802745.
37.Zhang L*, Monteiro-Riviere NA Toxicity Assessment of Six Titanium Dioxide Nanoparticles in Human Epidermal Keratinocytes. 2018. Cutaneous and Ocular Toxicology. 2018:1-29.
38.Song ZT, Zhang L, Fan LQ, Kong JW, Mao JH, Zhao J, Wang FJ. 2018. Enhanced anticancer effect of MAP30-S3 by cyclosproin A through endosomal escape. Anti-cancer Drugs 29(8):736-747.
39.Pang G, Wang F*, Zhang L*. 2018. Direct Killing or Immunoregulatory Effects of Natural Polysaccharides in Cancer Treatment. Carbohydrate Polymer 195: 243–256.
40.Liu Y, Yu H, Zhang X, Wang Y, Zhao J, Shi H, Li R, Wang Y*, Zhang L*. 2018. The Protective Role of Autophagy in Nephrotoxicity Induced by Bismuth Nanoparticles Through AMPK/mTOR Pathway. Nanotoxicology 6:1-16.
41.Zhang X, Yang L, Liu Y, Song Z, Zhao J, Chen D, Yu Huan, Li R, Wang Y, Yang K, Chen Y, Xia M, Zhang L*. 2018. Detection of Nanocarrier Potentiation on Drug Induced Phospholipidosis in Cultured Cells and Primary Hepatocyte Spheroids by High Content Imaging and Analysis. Toxicology and Applied Pharmacology 348: 54–66.
42.Chen D, Yang L, Chen X, Zhang X, Liu Y, Guo Z*, Zhang L*. 2018. Automated contour analysis of multi-cellular spheroids spreading through high content imaging. Physical Biology 24: 15:026006
43.Liu Y, Shen C, Zhang X, Yu H, Wang F, Wang Y*, Zhang L*. 2018. Exposure and Nephrotoxicity Concern of Bismuth with the Occurrence of Autophagy. Toxicology and Industrial Health 34:188–199
44.Yue C, Ji C, Zhang H, Zhang L, Tong J, Jiang Y, Chen T*. 2017. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways. Environmental Toxicology. 32:2316-2322.
45.Pei W, Tao L, Zhang L, Zhang S, Cao J, Jiao Y, Tong J* and Nie J*. 2017. Circular RNA profiles in mouse lung tissue induced by radon. Environmental Health and Preventive Medicine 22:36.
46.Li J, He X, Zou Y, Chen D, Yang L, Rao J, Chen H, Chan M CW, Guo Z*, Zhang L*, Chen C. 2017. Mitochondria-Targeted Platinum(II) Complex: Dual Inhibitory Activities on Tumor Cell Proliferation and Migration/Invasion via Intracellular Trafficking of β-catenin. Metallomics 9:726-733.
47.Liu Y, Zhuang J, Zhang X, Le C, Zhu N, Yang L, Wang Y, Chen T, Wang Y*, Zhang L* 2017. Autophagy Associated Cytotoxicity and Cellular Uptake Mechanisms of Bismuth Nanoparticles in Human Kidney Cells. Toxicology Letters 275: 39-48.
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52.Wang Y*, Zhu L, Wang Y, Li L, Lu Y, Shen L*, Zhang L*. 2016. Ultrasensitive GSH-Responsive Ditelluride-Containing Poly(ether-urethane) Nanoparticles for Controlled Drug Release. ACS Applied Materials & Interfaces 8: 35106–35113
53.Lv X, Chen D, Yang L, Zhu N, Li J, Zhao J, Hu Z, Wang F*,Zhang L*. 2016. Comparative Studies on the Immunoregulatory Effects of Three Polysaccharides Using High Content Imaging System. International Journal of Biological Macromolecules 86:28–42.
54.Xin L, Wang J, Zhang L, Che B, Dong G, Fan G, Cheng K. 2016. Development of HSPA1A promoter-driven luciferase reporter gene assays in human cells for assessing the oxidative damage induced by silver nanoparticles. Toxicology and Applied Pharmacology 304:9–17.
55.Zhang L, Koci J, Brett J, Riviere JE, Monteiro-Riviere NA. 2015. Safety Assessment of Potential Food Ingredients in Canine Hepatocytes. Food and Chemical Toxicology 78:105–15.
56.Rouse RL, Zhang L, Shea K, Zhou H, Xu L, Sharron S, Rosenzweig B, Zhang J. 2014. Extended Exenatide Administration Enhances Lipid Metabolism and Exacerbates Pancreatic Injury in Mice on a High Fat, High Carbohydrate Diet. PLOS ONE. 9(10):e109477
57.Tobin GA, Zhang J, Goodwin D, Stewart S, Xu L, Knapton A, González C, Bancos S, Zhang L, Lawton MP, Enerson BE, Weaver JL. 2014. The role of eNOS phosphorylation in causing drug-induced vascular injury. Toxicologic Pathology 42(4):709–24.
58.Zhang L, Shea KI, Xu L, Stewart S, Zhang J, Rouse RL. 2014. Autophagy in pancreatic acinar cells in caerulein treated mice: Immunolocalization of related proteins and their potential as markers of pancreatitis. Toxicologic Pathology 42, 435–457.
59.Zhang L, Monteiro-Riviere NA. 2013. Use of confocal microscopy for nanoparticle drug delivery through skin. Journal of Biomedical Optics. 18(6):061214
60.Zhang L, McMahon Tobin GA, Rouse RL. 2012. Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line. Toxicology and Applied Pharmacology 264: 274–283.
61.Zhang L, Bäumer W, Monteiro-Riviere NA. 2011. Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells. Nanomedicine. 6: 777–791.
62.Zhang L, Monteiro-Riviere NA. 2010. Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes. Toxicology In Vitro 24: 546–555.
63.Zhang L, Yang J, Barron AR, Monteiro-Riviere NA. 2009.Endocytic mechanisms and toxicity of a functionalized fullerene in human cells. Toxicology Letters 191: 149–157.
64.Zhang L, Monteiro-Riviere NA. 2009. Mechanisms of quantum dot nanoparticle cellular uptake. Toxicological Sciences. 110: 138–155.
65.Chen T, Li M, Ding Y, Zhang L, Xi Y, Pan WJ, Tao DL, Wang JY, Li L. 2009. Identification of zinc-finger bed domain containing 3 (Z
66.Monteiro-Riviere NA, Inman Al, Zhang L. 2009. Limitations and relative utility of screening assays to assess nanoparticle toxicity in a human cell line. Toxicology and Applied Pharmacology 234: 222–235.
67.Zhang L, Monteiro-Riviere NA. 2008. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacology and Physiology 21:166 –180.
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69.Zhang L, Zeng L, Barron AR, Monteiro-Riviere NA. 2007. Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes. International Journal of Toxicology 26:103–113.
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学习概况：张乐帅博士，苏州大学生命科学学院教授、博士生导师，放射医学与辐射防护国家重点实验室成员。2002年获得华东理工大学生物化学学士学位；后由华东理工大学及中国科学院上海生化细胞所（李林院士组）联合培养，参与GPCR和Wnt细胞信号转导相关通路研究，于2005年获得华东理工大学分子生物学与生物化学硕士学位。同年赴美学习，于美国北卡州立大学（North Carolina State University）从事纳米材料的皮肤互作研究，包括其透皮吸收能力、纳米颗粒内吞能力及通路、对皮肤角质细胞及免疫细胞的功效及安全性评价等，2010年获比较生物医学（Comparative Biomedical Science）博士学位。
工作概况：2010年起，于美国食品药物管理局的药审中心（CDER/USFDA）开展抗糖药的胰腺副作用机制研究及纳米材料的毒性评估，协助建设心脏及血管体外研究平台，期间还经历了多轮药审培训。2012年于美国堪萨斯州立大学（Kansas State University）纳米技术创新中心聘为研究助理教授，从事纳米材料皮肤毒性与食品添加剂肝毒性研究。2014年受聘苏州大学，从事组织工程（细胞3D培养、细胞背包）、纳米/药物毒理学（临床前安全性）及肿瘤免疫学研究。
成果概况：已在纳米医学、毒理学等相关杂志发表SCI文章60余篇，论文引用1700余次，获国自然基金5项（面上4项、青年1项）。
社会服务：现为Toxicology and Industry Health副主编、Journal of Nanobiotechnology副主编。
产业服务：现持有美国资质认证毒理学家（DABT,2015-）、欧洲注册毒理学家（ERT,2018-）、英国注册毒理学家（UKRT,2018-）、中国毒理学会认证毒理学家（DCST,2021-）等国际毒理学家资质。承担诸多药械妆甲方及第三方的药物、医疗器械、化妆品、消费品的产品质量控制、安全性评价、风险评估工作。目前是苏州大学卫生与环境技术研究所（苏大检测）的首席科学家，负责毒理学评估团队的建设与运营。
1. 2025 – 至今，中国毒理学会医疗器械专委会委员
2. 2025 – 至今，中国毒理学会人工智能毒理学专委会委员
3. 2024 – 至今，华东理工大学美妆行业校友会理事
4. 2024 – 至今，中国毒理学会类器官与器官芯片专委会委员
5. 2023 – 至今，全国专业标准化技术委员会委员
6. 2023 – 至今，江苏省研究型医院学会类器官与器官芯片委员会委员
7. 2023 – 至今，中国毒理学会青年委员会常务委员
8. 2021 - 2023，学术期刊Toxicology Research and Applications编委
9. 2021 - 至今，学术期刊Journal of Nanobiotechnology副主编
10. 2021 - 至今，中国同位素与辐射行业协会委员
11. 2018 - 至今，苏州市器械不良反应监测专家库成员
12. 2018 - 至今，纳米药物审批政策推进专家组成员
13. 2018 - 至今，中国毒理学会中药毒理专委会青年委员
15. 2016 –至今，中国香料香精化妆品工业协会/化妆品科学技术学会会员
16. 2016 –至今，中国毒理学会会员
17. 2015 –至今，学术期刊Toxicology and Industrial Health 副主编
18. 2011 –2014，美国毒理学会教育委员会执行委员
19. 2011 –2012，美国毒理学会纳米毒理专业委员会执行委员
20. 2009 –2013，美国Sigma Xi 科学研究协会会员
21. 2007 –至今，美国毒理学会会员
组织工程学、肿瘤免疫学
新技术方法（NAMs）、类器官、体外与替代毒理学、药物毒理学
药事法规、医疗器械法规与标准、化妆品安评等转化法规研究
研究方向：本研究小组研究方向为基于生物医学工程方法的毒理学及肿瘤免疫学研究，方向涉及两大部分。一、体外替代方法——利用3D细胞培养技术（如细胞球）研究药物肝脏毒性，及基于肝病模型药物筛选、其它类器官的开发与模型验证。二、细胞背包技术——以高分子材料为基础的免疫细胞背包，通过背包载药或背包自身的力学性能，强化免疫细胞的能力，协同放化疗杀灭肿瘤。
发表成果：至今共发表文章60余篇（引用1700余次），其中SCI一作或通讯作者文章40余篇；申请批准专利10余份；部分工作被Science Daily等杂志和网站报道；主编专业书籍1本，参编英文书籍2本。主持国家自然科学基金面上在研项目（32171403）、教育部留学回国基金；国家自然科学基金面上项目（#31971319、#81373950、#31771104）与青年基金（#81401511）已结题。
学术职务：
2025 – 至今，中国毒理学会医疗器械专委会委员
2025 – 至今，中国毒理学会人工智能毒理学专委会委员
2024 – 至今，华东理工大学美妆行业校友会理事
2024 – 至今，中国毒理学会类器官与器官芯片专委会委员
2023 – 至今，全国专业标准化技术委员会委员
2023 – 至今，江苏省研究型医院学会类器官与器官芯片委员会委员
2023 – 至今，中国毒理学会青年委员会常务委员
2021 – 至今，中国同位素与辐射行业协会委员
2018 – 至今，苏州市器械不良反应监测专家库成员
2018 – 至今，纳米药物审批政策推进专家组成员
2018 – 至今，中国毒理学会中药毒理专委会青年委员
2016 – 至今，中国毒理学会纳米毒理专业委员会委员
期刊职务：
2021 – 至今，学术期刊Journal of Nanobiotechnology副主编
2015 – 至今，学术期刊Toxicology and Industrial Health 副主编
熟悉国内外的药械妆法规：
（1）涉及到早期研发、质量研究、工业生产、注册申报的法律法规，为企业、高校、政府的多个项目提供了咨询建议。
（2）药物ICH Q/M/S系列，熟练使用PDE、TTC、Cramer结合QSAR方法，为药物的安全性评价、API杂质、清洁残留、职业安全限值、单共线生产提供解决方案。
（3）OECD化学品安全指南、欧盟委员会SCCS化妆品成份安全指南及国内相关化妆品法规，委托开展化妆品的安全性评估（CPSR、CPSA）。
（4）医疗器械ISO10993/GB16886系列、MDR注册法规、医美产品法规，目前兼任苏州苏大卫生与环境技术研究所有限公司的首席科学家及毒理评估中心主任，致力于医疗器械生物学评价、E&L毒理学评估、注册申报相关的框架建设工作。
（5）熟悉纳米技术产品、体外与替代方法相关法规，并参与了国家药监局、中检院及多家标准委员会相关指南及标准的建设。近期开始涉及到电子烟、艺术消费品的法规。
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56.Rouse RL, Zhang L, Shea K, Zhou H, Xu L, Sharron S, Rosenzweig B, Zhang J. 2014. Extended Exenatide Administration Enhances Lipid Metabolism and Exacerbates Pancreatic Injury in Mice on a High Fat, High Carbohydrate Diet. PLOS ONE. 9(10):e109477
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