2006-2010 B.S., Soochow University, School of Life Sciences
2010-2015 Ph.D., Soochow University, Institute of Functional Nano & Soft Materials (FUNSOM)
2015-2018 Postdoctoral Researcher, University of North Carolina at Chapel Hill & North Carolina State University, Dept. of Joint Department of Biomedical Engineering
2018-present Professor, Soochow University, FUNSOM
Welcome to the Prof. Chao Wang's Group in the FUNSOM at Soochow University! The overall goal of our BIE Lab (Laboratory for Biomaterial and ImmunoEngineering, 生物材料与免疫工程实验室) is to integrate Biomaterials, Immunoengineering and Translational Medicine for the clinical applications. Our lab current research focuses include development of cell-derived biomaterials (细胞生物材料) for immunoengineering and immunotherapy, in order to develop effective novel immunotherapies for cancer, infectious diseases, autoimmune disorders and age-related disease. more>>
Biomaterials for Immunotherapy
The immune system is one of systemic barriers to the body’s defense against tumors. Emerging interest is moving on tilizing biomaterials for immunotherapy and immunoengineering of cancer therapy. Such biomaterial platform offers the remarkable ability to codelivery of multiple cargoes, control their release behavior, alter their kinetics and pharmacodynamic effects, and so on. In addition, well-designed functional biomaterials can alter the immune-related microenvironment, modulate the immune response, as well as reverse immunosuppressive tumor environment in the context of disease treatment.
Cell-based therapy
Various types of cells are promising drug carriers or living drugs themselves. Armed with the emerging techniques in materials science, molecular pharmaceutics and nanobiotechnology, cell engineering is an appealing therapeutic platform for the development of next-generation medications. We will study the enhanced therapy effects by the combination of functional cells and biomaterials. Generally, our biomaterials – based on micor/nanoparticles or scaffolds – will be engineered for switching using innovate and modern concepts in cell based therapy.
Immune microenvironment
The abnormal immune microenvironment is an essential component of a disease. Understanding the mechanism by which the immune microenvironment context is extremely important for the design of novel immunotherapies. we are also interested in how biomaterials such as nanoparticles interact with the immune system.
Gallery
2020 summer, Suzhou Amusement Land retreat
2019 spring, Qiandao Lake retreat
First/corresponding author papers (View All Publications)
2025
[84] Bo Tian#, Heng Wang#, Yue Zhang#, Jinmin Lv, Dongxiao Li, Chenmeng Zhou, Jialu Xu, Yichao Ni, Bingbing Wu, Mingchao Zhang, Huaxing Dai, Fang Xu, Jinyu Bai*, Chao Wang*, Xiaozhong Zhou*. Tryptophan-producing bacteria to mitigate osteoporosis and intestinal dysfunction, Bioactive Materials, 51, 293 (2025) Link
[83] Rong Sun, Huaxing Dai, Chenlu Yao, Heng Wang, Bingbing Wu, Xiaoyu Yu, Fang Xu, Chao Wang*. Artificial Tolerogenic Dendritic Cell-Derived Vesicles Prepared by High-Pressure Homogenization for Potent Immunotherapy of Type 1 Diabetes. ACS Nano, 19, 18214 (2025) Link
[82] Chenlu Yao, Qingle Ma, Heng Wang, Bingbing Wu, Huaxing Dai, Jialu Xu, Jinyu Bai, Fang Xu, Admire Dube, Chao Wang*. Targeting Myeloid Cells with Platelet-Derived Extracellular Vesicles to Overcome Resistance of Immune Checkpoint Blockade Therapy. Biomaterials, 123336 (2025) Link
[81] Chenmeng Zhou, Yue Zhang, Bo Tian, Yue Yu, Dongxiao Li, Bingbing Wu, Wenju Chang, Tongguo Shi, Fang Xu,* Jinyu Bai* and Chao Wang*. Bacteria-responsive cytoderm drug delivery systems. Biomaterials Science, 13, 2744 (2025) Link
[80] Yue Yu, Jintao Huang, Jialu Xu, Di Hu, Yue Zhang, Chenmeng Zhou, Tongguo Shi, Jian Shen*, Chao Wang*. Grifola Frondosa-Derived Nanoparticles Modulate Tumor-Associated Neutrophil Plasticity and Enhance Anti-Tumor Immunity. Advanced Functional Materials, 2424300 (2025) Link
[79] Heng Wang, Fang Xu, Chao Wang*. Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria. Seminars in Cancer Biology, 122, 58-70 (2025) (Invited Review) Link
[78] Bingbing Wu, Chenlu Yao, Heng Wang, Huaxing Dai, Bo Tian, Dongxiao Li, Jialu Xu, Haibo Cheng, Fang Xu*, Dongdong Sun*, Chao Wang*. Ellagic acid-protein nano-complex inhibits tumor growth by reducing the intratumor bacteria and inhibiting histamine production. Biomaterials, 317, 123078 (2025) Link
[77] Dongxiao Li, Yanhong Yang, Bo Tian, Chenmeng Zhou, Shuting Gu, Wenju Chang, Bingbing Wu, Dantong Dong, Fang Xu, Ziyang Yu, Ling Zhou, Chao Wang*, Hong Zhang*. Platelet-derived extracellular vesicles for endometrial regeneration towards efficient live birth. Nano Research, 18, 94907176 (2025) Link
[76] Jialu Xu, Jintao Huang, Yue Yu, Di Hu, Yue Zhang, Huaxing Dai, Li You, Fang Xu, Jian Shen*, Chao Wang*. Garlic-derived nanoparticles inhibit tumor by activating tumor-infiltrating γδT cells. Nano Research, 18, 94907145 (2025) Link
2024
[75] Heng Wang, Fang Xu*, Chenlu Yao, Huaxing Dai, Jialu Xu, Bingbing Wu, Bo Tian, Xiaolin Shi, Chao Wang*. Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+ T cell response. PNAS, 121 (52), e2412070121 (2024) Link
[74] Wenju Chang, Bo Tian, Qin Qin, Dongxiao Li, Yue Zhang, Chenmeng Zhou, Bingbing Wu, Mingchao Zhang, Huajian Shan, Yichao Ni, Qirong Dong*, Chao Wang*, Xiao-Zhong Zhou*, Jinyu Bai*. Receptor Activator of Nuclear Factor Kappa-B-Expressing Mesenchymal Stem Cells-Derived Extracellular Vesicles for Osteoporosis Therapy. ACS Nano, 18, 35368 (2024)Link
[73] Yue Zhang, Chenmeng Zhou, Bo Tian, Jialu Xu, Xiaoyu Wang, Huaxing Dai, Heng Wang, Fang Xu, Chao Wang*. 3D Printed Spiral Tube-like Cellulose Scaffold for Oral Delivery of Probiotics. Science Advances, 10, eadp3654 (2024) Link
[72] Jialu Xu, Yue Yu, Yue Zhang, Huaxing Dai, Qianyu Yang, Beilei Wang, Qingle Ma, Yitong Chen, Fang Xu, Xiaolin Shi, Zhuang Liu*, Chao Wang*. Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells, Nature Nanotechnology, 19, 1569–1578 (2024) Link
[71] Chenlu Yao, Hong Zhang* and Chao Wang*. Recent advances in therapeutic engineered extracellular vesicles. Nanoscale (2024) (Invited Review) Link
[70] Xiaoyu Wang, Yue Zhang, Anning Song, Heng Wang, Yi Wu, Wenju Chang, Bo Tian, Jialu Xu, Huaxing Dai, Qingle Ma, Chao Wang*, Xiaozhong Zhou*. A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing. Advanced Healthcare Materials, 2303017 (2024) Link
[69] Anning Song, Yuwei Wang, Jialu Xu, Xiaoyu Wang, Yi Wu, Heng Wang, Chenlu Yao, Huaxing Dai, Yue Zhang, Qi Wang*, Chao Wang*. Yeast Nanoparticle‐powered Tumor Photodynamic‐Immunotherapy. Nano Today, 54, 102109 (2024) Link
2023
[68] Yi Wu, Heng Wang, Anning Song, Xiaoyu Wang, Qingle Ma, Chenlu Yao, Jialu Xu, Huaxing Dai, Chao Wang*, Ting Lu*, and Fang Xu*, PD-L1-Expressing Extracellular Vesicles for the Treatment of Pneumonia. ACS Biomater. Sci. Eng. 9, 11, 6464–6471 (2023) Link
[67] Qingle Ma, Chenlu Yao, Yi Wu, Heng Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Yue Zhang, Fang Xu, Ting Lu, Jennifer K. Dowling, Chao Wang*. Neurological Disorders after Severe Pneumonia are Associated with Translocation of Endogenous Bacteria from The Lung to The Brain. Science Advances, 9, eadi0699 (2023) Link
[66] Qingle Ma, Chenlu Yao, Jialu Xu, Bo Tian, Yi Wu, Heng Wang, Qianyu Yang, Huaxing Dai, Yue Zhang, Fang Xu, Xiaolin Shi, Chao Wang*. Severe pneumonia induces immunosenescence of T cells in the lung of mice. Aging, 15, 7084 (2023) Link
[65] Bo Tian, Jinyu Bai, Lei Sheng, Hao Chen, Wenju Chang, Yue Zhang, Chenlu Yao, Chenmeng Zhou, Xiaoyu Wang, Huajian Shan, Qirong Dong*, Chao Wang*, Xiaozhong Zhou*. P7C3 Ameliorates Bone Loss by Inhibiting Osteoclast Differentiation and Promoting Osteogenesis. JBMR Plus, 7, e10811(2023) Link
[64] Chenlu Yao and Chao Wang*. Platelet-derived Extracellular Vesicles for Drug Delivery. Biomaterials Science, 11, 5758 (2023) (Invited Review) Link
[63] Huan He, Qiaozhen Qin, Fang Xu, Yitong Chen, Shuquan Rao, Chao Wang*, Xiaoxia Jiang*, Xiong Lu*, Chaoming Xie*. Oral Polyphenol-Armored Nanomedicine for Targeted Modulation of Gut Microbiota-Brain Interactions in Colitis. Science Advances, 9, eadf3887 (2023) Iink
[62] Qianyu Yang, Huaxing Dai, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Qingle Ma, Fang Xu, Haibo Chen, Dongdong Sun*, Chao Wang*. Nanoplastics Shape Adaptive Anticancer Immunity in the Colon in Mice. Nano Letters, 23, 3516 (2023) Link
[61] Qianyu Yang#, Huaxing Dai#, Ying Cheng#, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Fang Xu, Qingle Ma, Fang Lin* and Chao Wang*. Oral Feeding of Nanoplastics affects Brain function of Mice by Inducing Macrophage IL-1 signal in Intestine. Cell Reports, 42, 112346 (2023) Link [The Scientist]
[60] Mengying He, Mengyuan Wang, Tao Xu, Mengyao Zhang, Huaxing Dai, Chao Wang*, Dawei Ding*, Zhiyuan Zhong*. Reactive oxygen species-powered cancer immunotherapy: Current status and challenges. J Control Release, 356, 623 (2023) Link
[59] Yitong Chen, Yue Zhang, Beilei Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Fang Xu, Chao Wang*. Blood Clot Scaffold Load with Liposome Vaccine and siRNAs Targeting PD-L1 and TIM-3 for Effective DC Activation and Cancer Immunotherapy. ACS Nano, 17, 760 (2023) Link
[58] Huaxing Dai#, Qianyu Yang#, Rong Sun, Yue Zhang, Qingle Ma, Yifan Shen, Beilei Wang, Yitong Chen, Jialu Xu, Bo Tian, Fang Xu, Chao Wang*. Nanoparticle Accumulation in Liver May Induce Resistance to Immune Checkpoint Blockade Therapy. Nano Research, 16, 5237–5246 (2023) Link
2022
[57] Heng Wang#, Beilei Wang#, Jie Jiang#, Yi Wu, Anning Song, Xiaoyu Wang, Chenlu Yao, Huaxing Dai, Jialu Xu, Yue Zhang, Qingle Ma, Fang Xu, Ruibin Li, Chao Wang*. SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy. Molecules, 27, 8552 (2022) link
[56] Jialu Xu, Xin Ming*, Yuanzeng Min*, Chao Wang*. Emerging engineering approaches in cancer immunotherapy. Frontiers in Oncology, 12, 1009604 (2022) (Editorial) Link
[55] Yue Zhang, Chao Wang*. Recent advances in 3D printing hydrogel for topical drug delivery. MedComm - Biomaterials and Applications, 1, (2022) (Invited Review) Link
[54] Huaxing Dai, Qin Fan*, Chao Wang*. Recent applications of immunomodulatory biomaterials for disease immunotherapy. Exploration, 2, 20210157 (2022) (Invited Review) Link
[53] Huajian Shan#, Xuanfang Zhou#, Bo Tian, Chenyu Zhou, Xiang Gao, Chaowen Bai, Bingchen Shan, Yingzi Zhang, Shengxuan Sun, Dongdong Sun*, Qin Fan, Xiaozhong Zhou*, Chao Wang*, Jinyu Bai* Gold nanorods modified by endogenous protein with light-irradiation enhance bone repair via multiple osteogenic signal pathways. Biomaterials 284, 121482 (2022) Link
[52] Huan He#, Ziying Fei#, Tailin Guo, Yue Hou, Da Li, Kefeng Wang, Fuzeng Ren, Kelong Fan, Daijun Zhou, Chaoming Xie*, Chao Wang*, Xiong Lu* Bioadhesive injectable hydrogel with phenolic carbon quantum dot supported Pd single atom nanozymes as a localized immunomodulation niche for cancer catalytic immunotherapy. Biomaterials, 280, 121272 (2022) Link
[51] Jialu Xu, Qingle Ma, Yue Zhang, Ziying Fei, Yifei Sun, Qin Fan, Bo Liu, Jinyu Bai, Yue Yu, Jianhong Chu*, Jingrun Chen*, Chao Wang*. Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth. Nature Communications, 13, 110 (2022) Link
[50] Huaxing Dai, Qin Fan, Ziying Fei, Qingle Ma, Qianyu Yang, Jiacheng Chu, Xuanfang Zhou, Yue Zhang, Ziliang Dong, Fang Xu, Beilei Wang, Rong Sun, Yifan Shen, Ruao Xie, Ruibin Li and Chao Wang*. Systemically Administered Silica Nanoparticles Result in Diminished T Cell Response in Lung. Nano Today 42, 101332 (2022) Link
[49] Qin Fan#, Huaxing Dai#, Jinyu Bai#, Jialu Xu, Qingle Ma, Ziying Fei, Xiaozhong Zhou*, Kam W. Leong*, Chao Wang*. Degradation-resistant Implanted Biomaterials Establish an Immunosuppressive Microenvironment that Induces T Cell Exhaustion by Recruiting Myeloid Cells. Fundamental Research 2, 648-658 (2022) Link
[48] Fang Xu, Ziying Fei, Huaxing Dai, Jialu Xu, Qin Fan, Shufang Shen, Yue Zhang, Qingle Ma, Jiacheng Chu, Fei Peng, Fangfang Zhou, Zhuang Liu, Chao Wang*. Mesenchymal Stem Cell-derived Extracellular Vesicles with High PD-L1 Expression for Autoimmune Diseases Treatment. Advanced Materials, 34, 2106265 (2022) Link
[47] Jiacheng Chu, Chenya Wang, Qingle Ma, Huaxing Dai, Jialu Xu, Edikan A. Ogunnaike, Fei Peng, Xiaolin Shi, Chao Wang*. Coupling PD-1+ Tumor-Infiltrating T Cells with anti-PD-1 Antibody Improve the Efficacy of Adoptive T-cell Therapy. Cytotherapy, 24, 291 (2022) Link
2021
[46] Hao Chen, Bo Tian, Xiyao Fang, Jinyu Bai, Qingle Ma, Yue Zhang, Jialu Xu, Beilei Wang, Qin Fan, Ziying Fei, Huaxing Dai, Huajian Shan, Xiang Gao, Qirong Dong, Chao Wang*, Xiaozhong Zhou*. Injectable Erythrocyte Gel Loaded with Bulleyaconitine A for the Treatment of Rheumatoid Arthritis, ACS Biomaterials Science & Engineering,7, 5706 (2021) Link
[45] Yue Zhang, Jialu Xu, Ziying Fei, Huaxing Dai, Qin Fan, Qianyu Yang, Yitong Chen, Beilei Wang, Chao Wang*. 3D Printing Scaffold Vaccine for Antitumor Immunity. Advanced Materials, 33, 2106768 (2021) Link
[44] Qingle Ma#, Jinyu Bai#, Jialu Xu, Huaxing Dai, Qin Fan, Ziying Fei, Jiacheng Chu, Chenlu Yao, Haoliang Shi, Xiaozhong Zhou*, Lin Bo*, Chao Wang*. Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles. Advanced NanoBiomed Research, 1, 2100071 (2021) Link
[43] Qingle Ma,‡ Chenlu Yao,‡ Haoliang Shi,‡ Jialu Xu, Huaxing Dai, Ziying Fei, Yi Wu, Ting Lu* and Chao Wang*. Targeted Delivery of Dexamethasone in Acute Pneumonia. Biomaterials Science, 9, 5569 (2021) Link
[42] Shufang Shen, Huaxing Dai, Ziying Fei, Yu Chai, Yu Hao, Qin Fan, Ziliang Dong, Yujie Zhu, Jialu Xu, Qingle Ma, Xiao Han, Ligeng Xu, Fei Peng, Zhuang Liu, Chao Wang*. Immunosuppressive Nanoparticles for Management of Immune-Related Adverse Events in Liver. ACS Nano, 5, 9111 (2021). Link
[41] Qin Fan, Jinyu Bai, Huajian Shan, Ziying Fei, Hao Chen, Jialu Xu, Qingle Ma, Xiaozhong Zhou* and Chao Wang*. Implantable Blood Clot Loaded with BMP-2 for Regulation of Osteoimmunology and Enhancement of Bone Repair. Bioactive Materials, 6, 4014 (2021). Link
[40] Yufen Xiao,Jun Chen*, Chao Wang*, Jianxun Ding*, Wei Tao*. Emerging Micro- and Nanotechnologies for Medical and Pharmacological Applications. Front Pharmacol, 12, 648749 (2021). (Editorial) Link
[39] Ziying Fei, Qin Fan*, Huaxing Dai, Xuanfang Zhou, Jialu Xu, Qingle Ma, Atsushi Maruyama*, Chao Wang*. Physiologically Triggered Injectable Red Blood Cell-Based Gel for Tumor Photoablation and Enhanced Cancer Immunotherapy. Biomaterials, 271, 120724 (2021). Link
[38] Qingle Ma, Qin Fan, Xiao Han, Ziliang Dong, Jialu Xu, Jinyu Bai, Weiwei Tao, Dongdong Sun* and Chao Wang*. Platelet-Derived Extracellular Vesicles to Target Plaque Inflammation for Effective Anti-atherosclerotic Therapy. Journal of Controlled Release, 329, 445 (2021). Link
[37] Jialu Xu and Chao Wang*. Cell-derived Vesicles for Delivery of Cancer Immunotherapy. Exploration of Medicine, 2, 39 (2021). (Invited Review) Link
2020
[36] Qin Fan, Qingle Ma, Jinyu Bai, Jialu Xu, Ziying Fei, Ziliang Dong, Atsushi Maruyama, Kam W. Leong, Zhuang Liu and Chao Wang*. An Implantable Blood Clot-based Immune Niche for Enhanced Cancer Vaccination. Science Advances, 6, eabb4639 (2020). Link[Biotechscope]
[35] Qingle Ma, Qin Fan, Jialu Xu, Jinyu Bai, Xiao Han, Ziliang Dong, Xiaozhong Zhou, Zhuang Liu, Zhen Gu* and Chao Wang*. Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-derived Extracellular Vesicles. Matter, 3, 287 (2020). LinkHighlight by [Matter]
[34] Lulu Cai#, Jialu Xu#, Zhenglin Yang, Rongsheng Tong, Ziliang Dong, Chao Wang* and Kam W. Leong*. Engineered Biomaterials for Cancer Immunotherapy. MedComm, 1, 35 (2020) Link (Invited review)
[33] Xuanfang Zhou, Zhouqi Meng*, Jialin She, Yaojia Zhang, Xuan Yi, Hailin Zhou, Jing Zhong, Ziliang Dong, Xiao Han, Muchao Chen, Qin Fan, Kai Yang and Chao Wang* . Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy. Nano-Micro Letters, 12, 100 (2020).
[32] Yingjun Liu, Dongdong Sun, Qin Fan, Qingle Ma, Ziliang Dong, Weiwei Tao, Huiquan Tao, Zhuang Liu and Chao Wang*. The Enhanced Permeability and Retention Effect based Nanomedicine at the Site of Injury. Nano Research 13, 564-569 (2020).
2019
[31] 范亲, 汪超*.纳米材料在肿瘤免疫治疗中的应用.中国科学-生命科学, (2019). DOI:10.1360/SSV-2019-0215 (Invited review)
[30] Lin Zhang, Jinhua Zhou, Lvzhong Hu, Xiao Han, Xinwei Zou, Qian Chen, Youguo Chen*, Zhuang Liu*, Chao Wang*. In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of Cancer Recurrence after Surgery. Advanced Functional Materials, 30, 1906922 (2019).
[29] Baowen Qi, Chao Wang*, Jianxun Ding* and Wei Tao*. Applications of Nanobiotechnology in Pharmacology. Frontiers in Pharmacology, 10, 1451 (2019). (Editorial)
[28] Jinyu Bai,Yingzi Zhang, Qin Fan, Jialu Xu, Huajian Shan, Xiang Gao, Qinle Ma, Lei Sheng, Xin Zheng, Weinan Chen, Dazhuang Li, Mingchao Zhang, Yu Hao, Liangzhu Feng, Qian Chen, Xiaozhong Zhou* and Chao Wang*. Reactive Oxygen Species-Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disc Degeneration. Advanced Healthcare Materials, 9, 1901186 (2019).
[27] Xiao Han, Rui Wang, Jun Xu, Qian Chen, Chao Liang, Jiawen Chen, Jiayue Zhao, Jiacheng Chu, Qin Fan, Edikan Archibong, Lixin Jiang*, Chao Wang*, Zhuang Liu*. In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence. Biomaterials, 224, 119490 (2019).
[26] Xiao Han#, Shufang Shen#, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu* and Chao Wang*. Red Blood Cell Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy. Science Advances, 5, eaaw6870 (2019).
[25] Xiao Han#, Jiawen Chen#, Jiacheng Chu, Chao Liang, Qingle Ma, Qin Fan, Zhuang Liu* and Chao Wang*. Platelets as Platforms for Inhibition of Tumor Recurrence Post-Physical Therapy by Delivery of anti-PD-L1 Checkpoint Antibody. Journal of Controlled Release, 304, 233-241(2019).
2018
[24] Xiaowen Liu, Chao Wang*, Zhuang Liu*. Protein‐Engineered Biomaterials for CancerTheranostics. Advanced Healthcare Materials, 1800913(2018). (Review paper)
[23] Qin Fan, Zhipeng Chen,Chao Wang*, Zhuang Liu*. Toward Biomaterials for Enhancing Immune Checkpoint BlockadeTherapy. Advanced Functional Materials, 1802540 (2018). (Review paper)
[22] Xiao Han, Chao Wang*, Zhuang Liu *. Red Blood Cells as Smart Delivery Systems. Bioconjug Chem 29, 852-860 (2018). (Review paper)
[21]Shuangjiang Yu#, Chao Wang#, Jicheng Yu, Jinqiang Wang, Yue Lu,Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He*, Xuesi Chen*, Zhen Gu*. Injectable Bioresponsive Gel Depot for Enhanced Immune CheckpointBlockade. Advanced Materials 1801527 (2018).
[20] Chao Wang#, Jinqiang Wang#, Xudong Zhang, Shuangjiang Yu, Di Wen, Quan Hu, Yanqi Ye, H.Bomba, X. Hu, Z. Liu. Gianpietro Dotti and Zhen Gu*. In situ formed reactiveoxygen species–responsive scaffold with gemcitabine and checkpoint inhibitorfor combination therapy. Science Translational Medicine 10, eaan3682 (2018).
2011-2017
[19] Chao Wang, Wujin Sun, Yanqi Ye, Hunter N Bomba, Zhen Gu*. Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs. Theranostics 7, 3504-3516 (2017). (Review paper)
[18] Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter N Bomba, Zhen Gu*. In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy. Nature Biomedical Engineering 1, 0011 (2017).
[17] Chao Wang, Di Wen, Zhen Gu*. Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy. Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.7b00619 (2017). (Review paper)
[16] Chao Wang, Yanqi Ye, Zhen Gu*. Local delivery of checkpoints antibodies. Human Vaccines & Immunotherapeutics 13, 245-248 (2017). (Review paper)
[15] Chao Wang, Yanqi Ye, Quanyin Hu, Adriano Bellotti, Zhen Gu*. Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook. Advanced Materials 29, 201606036 (2017). (Review paper)
[14] Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jingqiang Wang, David S Lawrence, John B Buse, Zhen Gu*. Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials 29, 201606617 (2017).
[13] Chao Wang#, Yanqi Ye#, Gabrielle M Hochu, Hasan Sadeghifar, Zhen Gu*. Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-{PD}1 Antibody. Nano Letters 16, 2334-2340 (2016).
[12] Chao Wang#, Min Ye#, Liang Cheng, Rui Li, Wenwen Zhu, Zhen Shi, Chunhai Fan, Jinkang He, Jian Liu, Zhuang Liu*. Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials 54, 55-62 (2015).
[11] Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*. Multifunctional Theranostic Red Blood Cells For Magnetic-Field-Enhanced in vivo Combination Therapy of Cancer. Advanced Materials 26, 4794-4802 (2014).
[10] Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, Zhuang Liu*. Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-{CTLA}-4 Therapy to Inhibit Cancer Metastasis. Advanced Materials 26, 8154-8162 (2014).
[9] Liang Cheng#, Chao Wang#, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu*. Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control. Advanced Functional Materials 23, 272-280 (2013).
[8] Chao Wang, Liang Cheng, Yumeng Liu, Xiaojing Wang, Xinxing Ma, Zhaoyi Deng, Yonggang Li, Zhuang Liu*. Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light. Advanced Functional Materials 23, 3077-3086 (2013).
[7] Chao Wang, Liang Cheng, Zhuang Liu*. Upconversion Nanoparticles for Photodynamic Therapy and Other Cancer Therapeutics. Theranostics 3, 317-330 (2013). (Review paper)
[6] Chao Wang#, Huan Xu#, Chao Liang, Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li, Zhuang Liu*. Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect. ACS Nano 7, 6782-6795 (2013).
[5] Chao Wang, Liang Cheng, Huan Xu, Zhuang Liu*. Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles. Biomaterials 33, 4872-4881 (2012).
[4] Chao Wang, Xinxing Ma, Shuoqi Ye, Liang Cheng, Kai Yang, Liang Guo, Changhui Li, Yonggang Li, Zhuang Liu*. Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging. Advanced Functional Materials 22, 2363-2375 (2012).
[3] Chao Wang, Liang Cheng and Zhuang Liu*. Research Spotlight: Upconversion nanoparticles for potential cancer theranostics. Therapeutic Delivery 2, 1235-1239 (2011). (Review paper)
[2] Chao Wang, Huiquan Tao, Liang Cheng and Zhuang Liu*. Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials 32, 6145-6154 (2011).
[1] Chao Wang, Liang Cheng and Zhuang Liu*. Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. Biomaterials 32, 1110-1120 (2011).
Book chapter
[1] Shufang Shen and Chao Wang* (2020) Upconversion Fluorescent Nanoprobe for Highly Sensitive In Vivo Cell Tracking. Cell Tracking. Methods in Molecular Biology, vol 2126. Humana, New York, NY
2006-2010 B.S., Soochow University, School of Life Sciences
2010-2015 Ph.D., Soochow University, Institute of Functional Nano & Soft Materials (FUNSOM)
2015-2018 Postdoctoral Researcher, University of North Carolina at Chapel Hill & North Carolina State University, Dept. of Joint Department of Biomedical Engineering
2018-present Professor, Soochow University, FUNSOM
Welcome to the Prof. Chao Wang's Group in the FUNSOM at Soochow University! The overall goal of our BIE Lab (Laboratory for Biomaterial and ImmunoEngineering, 生物材料与免疫工程实验室) is to integrate Biomaterials, Immunoengineering and Translational Medicine for the clinical applications. Our lab current research focuses include development of cell-derived biomaterials (细胞生物材料) for immunoengineering and immunotherapy, in order to develop effective novel immunotherapies for cancer, infectious diseases, autoimmune disorders and age-related disease. more>>
Biomaterials for Immunotherapy
The immune system is one of systemic barriers to the body’s defense against tumors. Emerging interest is moving on tilizing biomaterials for immunotherapy and immunoengineering of cancer therapy. Such biomaterial platform offers the remarkable ability to codelivery of multiple cargoes, control their release behavior, alter their kinetics and pharmacodynamic effects, and so on. In addition, well-designed functional biomaterials can alter the immune-related microenvironment, modulate the immune response, as well as reverse immunosuppressive tumor environment in the context of disease treatment.
Cell-based therapy
Various types of cells are promising drug carriers or living drugs themselves. Armed with the emerging techniques in materials science, molecular pharmaceutics and nanobiotechnology, cell engineering is an appealing therapeutic platform for the development of next-generation medications. We will study the enhanced therapy effects by the combination of functional cells and biomaterials. Generally, our biomaterials – based on micor/nanoparticles or scaffolds – will be engineered for switching using innovate and modern concepts in cell based therapy.
Immune microenvironment
The abnormal immune microenvironment is an essential component of a disease. Understanding the mechanism by which the immune microenvironment context is extremely important for the design of novel immunotherapies. we are also interested in how biomaterials such as nanoparticles interact with the immune system.
Gallery
2020 summer, Suzhou Amusement Land retreat
2019 spring, Qiandao Lake retreat
First/corresponding author papers (View All Publications)
2025
[84] Bo Tian#, Heng Wang#, Yue Zhang#, Jinmin Lv, Dongxiao Li, Chenmeng Zhou, Jialu Xu, Yichao Ni, Bingbing Wu, Mingchao Zhang, Huaxing Dai, Fang Xu, Jinyu Bai*, Chao Wang*, Xiaozhong Zhou*. Tryptophan-producing bacteria to mitigate osteoporosis and intestinal dysfunction, Bioactive Materials, 51, 293 (2025) Link
[83] Rong Sun, Huaxing Dai, Chenlu Yao, Heng Wang, Bingbing Wu, Xiaoyu Yu, Fang Xu, Chao Wang*. Artificial Tolerogenic Dendritic Cell-Derived Vesicles Prepared by High-Pressure Homogenization for Potent Immunotherapy of Type 1 Diabetes. ACS Nano, 19, 18214 (2025) Link
[82] Chenlu Yao, Qingle Ma, Heng Wang, Bingbing Wu, Huaxing Dai, Jialu Xu, Jinyu Bai, Fang Xu, Admire Dube, Chao Wang*. Targeting Myeloid Cells with Platelet-Derived Extracellular Vesicles to Overcome Resistance of Immune Checkpoint Blockade Therapy. Biomaterials, 123336 (2025) Link
[81] Chenmeng Zhou, Yue Zhang, Bo Tian, Yue Yu, Dongxiao Li, Bingbing Wu, Wenju Chang, Tongguo Shi, Fang Xu,* Jinyu Bai* and Chao Wang*. Bacteria-responsive cytoderm drug delivery systems. Biomaterials Science, 13, 2744 (2025) Link
[80] Yue Yu, Jintao Huang, Jialu Xu, Di Hu, Yue Zhang, Chenmeng Zhou, Tongguo Shi, Jian Shen*, Chao Wang*. Grifola Frondosa-Derived Nanoparticles Modulate Tumor-Associated Neutrophil Plasticity and Enhance Anti-Tumor Immunity. Advanced Functional Materials, 2424300 (2025) Link
[79] Heng Wang, Fang Xu, Chao Wang*. Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria. Seminars in Cancer Biology, 122, 58-70 (2025) (Invited Review) Link
[78] Bingbing Wu, Chenlu Yao, Heng Wang, Huaxing Dai, Bo Tian, Dongxiao Li, Jialu Xu, Haibo Cheng, Fang Xu*, Dongdong Sun*, Chao Wang*. Ellagic acid-protein nano-complex inhibits tumor growth by reducing the intratumor bacteria and inhibiting histamine production. Biomaterials, 317, 123078 (2025) Link
[77] Dongxiao Li, Yanhong Yang, Bo Tian, Chenmeng Zhou, Shuting Gu, Wenju Chang, Bingbing Wu, Dantong Dong, Fang Xu, Ziyang Yu, Ling Zhou, Chao Wang*, Hong Zhang*. Platelet-derived extracellular vesicles for endometrial regeneration towards efficient live birth. Nano Research, 18, 94907176 (2025) Link
[76] Jialu Xu, Jintao Huang, Yue Yu, Di Hu, Yue Zhang, Huaxing Dai, Li You, Fang Xu, Jian Shen*, Chao Wang*. Garlic-derived nanoparticles inhibit tumor by activating tumor-infiltrating γδT cells. Nano Research, 18, 94907145 (2025) Link
2024
[75] Heng Wang, Fang Xu*, Chenlu Yao, Huaxing Dai, Jialu Xu, Bingbing Wu, Bo Tian, Xiaolin Shi, Chao Wang*. Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+ T cell response. PNAS, 121 (52), e2412070121 (2024) Link
[74] Wenju Chang, Bo Tian, Qin Qin, Dongxiao Li, Yue Zhang, Chenmeng Zhou, Bingbing Wu, Mingchao Zhang, Huajian Shan, Yichao Ni, Qirong Dong*, Chao Wang*, Xiao-Zhong Zhou*, Jinyu Bai*. Receptor Activator of Nuclear Factor Kappa-B-Expressing Mesenchymal Stem Cells-Derived Extracellular Vesicles for Osteoporosis Therapy. ACS Nano, 18, 35368 (2024)Link
[73] Yue Zhang, Chenmeng Zhou, Bo Tian, Jialu Xu, Xiaoyu Wang, Huaxing Dai, Heng Wang, Fang Xu, Chao Wang*. 3D Printed Spiral Tube-like Cellulose Scaffold for Oral Delivery of Probiotics. Science Advances, 10, eadp3654 (2024) Link
[72] Jialu Xu, Yue Yu, Yue Zhang, Huaxing Dai, Qianyu Yang, Beilei Wang, Qingle Ma, Yitong Chen, Fang Xu, Xiaolin Shi, Zhuang Liu*, Chao Wang*. Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells, Nature Nanotechnology, 19, 1569–1578 (2024) Link
[71] Chenlu Yao, Hong Zhang* and Chao Wang*. Recent advances in therapeutic engineered extracellular vesicles. Nanoscale (2024) (Invited Review) Link
[70] Xiaoyu Wang, Yue Zhang, Anning Song, Heng Wang, Yi Wu, Wenju Chang, Bo Tian, Jialu Xu, Huaxing Dai, Qingle Ma, Chao Wang*, Xiaozhong Zhou*. A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing. Advanced Healthcare Materials, 2303017 (2024) Link
[69] Anning Song, Yuwei Wang, Jialu Xu, Xiaoyu Wang, Yi Wu, Heng Wang, Chenlu Yao, Huaxing Dai, Yue Zhang, Qi Wang*, Chao Wang*. Yeast Nanoparticle‐powered Tumor Photodynamic‐Immunotherapy. Nano Today, 54, 102109 (2024) Link
2023
[68] Yi Wu, Heng Wang, Anning Song, Xiaoyu Wang, Qingle Ma, Chenlu Yao, Jialu Xu, Huaxing Dai, Chao Wang*, Ting Lu*, and Fang Xu*, PD-L1-Expressing Extracellular Vesicles for the Treatment of Pneumonia. ACS Biomater. Sci. Eng. 9, 11, 6464–6471 (2023) Link
[67] Qingle Ma, Chenlu Yao, Yi Wu, Heng Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Yue Zhang, Fang Xu, Ting Lu, Jennifer K. Dowling, Chao Wang*. Neurological Disorders after Severe Pneumonia are Associated with Translocation of Endogenous Bacteria from The Lung to The Brain. Science Advances, 9, eadi0699 (2023) Link
[66] Qingle Ma, Chenlu Yao, Jialu Xu, Bo Tian, Yi Wu, Heng Wang, Qianyu Yang, Huaxing Dai, Yue Zhang, Fang Xu, Xiaolin Shi, Chao Wang*. Severe pneumonia induces immunosenescence of T cells in the lung of mice. Aging, 15, 7084 (2023) Link
[65] Bo Tian, Jinyu Bai, Lei Sheng, Hao Chen, Wenju Chang, Yue Zhang, Chenlu Yao, Chenmeng Zhou, Xiaoyu Wang, Huajian Shan, Qirong Dong*, Chao Wang*, Xiaozhong Zhou*. P7C3 Ameliorates Bone Loss by Inhibiting Osteoclast Differentiation and Promoting Osteogenesis. JBMR Plus, 7, e10811(2023) Link
[64] Chenlu Yao and Chao Wang*. Platelet-derived Extracellular Vesicles for Drug Delivery. Biomaterials Science, 11, 5758 (2023) (Invited Review) Link
[63] Huan He, Qiaozhen Qin, Fang Xu, Yitong Chen, Shuquan Rao, Chao Wang*, Xiaoxia Jiang*, Xiong Lu*, Chaoming Xie*. Oral Polyphenol-Armored Nanomedicine for Targeted Modulation of Gut Microbiota-Brain Interactions in Colitis. Science Advances, 9, eadf3887 (2023) Iink
[62] Qianyu Yang, Huaxing Dai, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Qingle Ma, Fang Xu, Haibo Chen, Dongdong Sun*, Chao Wang*. Nanoplastics Shape Adaptive Anticancer Immunity in the Colon in Mice. Nano Letters, 23, 3516 (2023) Link
[61] Qianyu Yang#, Huaxing Dai#, Ying Cheng#, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Fang Xu, Qingle Ma, Fang Lin* and Chao Wang*. Oral Feeding of Nanoplastics affects Brain function of Mice by Inducing Macrophage IL-1 signal in Intestine. Cell Reports, 42, 112346 (2023) Link [The Scientist]
[60] Mengying He, Mengyuan Wang, Tao Xu, Mengyao Zhang, Huaxing Dai, Chao Wang*, Dawei Ding*, Zhiyuan Zhong*. Reactive oxygen species-powered cancer immunotherapy: Current status and challenges. J Control Release, 356, 623 (2023) Link
[59] Yitong Chen, Yue Zhang, Beilei Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Fang Xu, Chao Wang*. Blood Clot Scaffold Load with Liposome Vaccine and siRNAs Targeting PD-L1 and TIM-3 for Effective DC Activation and Cancer Immunotherapy. ACS Nano, 17, 760 (2023) Link
[58] Huaxing Dai#, Qianyu Yang#, Rong Sun, Yue Zhang, Qingle Ma, Yifan Shen, Beilei Wang, Yitong Chen, Jialu Xu, Bo Tian, Fang Xu, Chao Wang*. Nanoparticle Accumulation in Liver May Induce Resistance to Immune Checkpoint Blockade Therapy. Nano Research, 16, 5237–5246 (2023) Link
2022
[57] Heng Wang#, Beilei Wang#, Jie Jiang#, Yi Wu, Anning Song, Xiaoyu Wang, Chenlu Yao, Huaxing Dai, Jialu Xu, Yue Zhang, Qingle Ma, Fang Xu, Ruibin Li, Chao Wang*. SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy. Molecules, 27, 8552 (2022) link
[56] Jialu Xu, Xin Ming*, Yuanzeng Min*, Chao Wang*. Emerging engineering approaches in cancer immunotherapy. Frontiers in Oncology, 12, 1009604 (2022) (Editorial) Link
[55] Yue Zhang, Chao Wang*. Recent advances in 3D printing hydrogel for topical drug delivery. MedComm - Biomaterials and Applications, 1, (2022) (Invited Review) Link
[54] Huaxing Dai, Qin Fan*, Chao Wang*. Recent applications of immunomodulatory biomaterials for disease immunotherapy. Exploration, 2, 20210157 (2022) (Invited Review) Link
[53] Huajian Shan#, Xuanfang Zhou#, Bo Tian, Chenyu Zhou, Xiang Gao, Chaowen Bai, Bingchen Shan, Yingzi Zhang, Shengxuan Sun, Dongdong Sun*, Qin Fan, Xiaozhong Zhou*, Chao Wang*, Jinyu Bai* Gold nanorods modified by endogenous protein with light-irradiation enhance bone repair via multiple osteogenic signal pathways. Biomaterials 284, 121482 (2022) Link
[52] Huan He#, Ziying Fei#, Tailin Guo, Yue Hou, Da Li, Kefeng Wang, Fuzeng Ren, Kelong Fan, Daijun Zhou, Chaoming Xie*, Chao Wang*, Xiong Lu* Bioadhesive injectable hydrogel with phenolic carbon quantum dot supported Pd single atom nanozymes as a localized immunomodulation niche for cancer catalytic immunotherapy. Biomaterials, 280, 121272 (2022) Link
[51] Jialu Xu, Qingle Ma, Yue Zhang, Ziying Fei, Yifei Sun, Qin Fan, Bo Liu, Jinyu Bai, Yue Yu, Jianhong Chu*, Jingrun Chen*, Chao Wang*. Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth. Nature Communications, 13, 110 (2022) Link
[50] Huaxing Dai, Qin Fan, Ziying Fei, Qingle Ma, Qianyu Yang, Jiacheng Chu, Xuanfang Zhou, Yue Zhang, Ziliang Dong, Fang Xu, Beilei Wang, Rong Sun, Yifan Shen, Ruao Xie, Ruibin Li and Chao Wang*. Systemically Administered Silica Nanoparticles Result in Diminished T Cell Response in Lung. Nano Today 42, 101332 (2022) Link
[49] Qin Fan#, Huaxing Dai#, Jinyu Bai#, Jialu Xu, Qingle Ma, Ziying Fei, Xiaozhong Zhou*, Kam W. Leong*, Chao Wang*. Degradation-resistant Implanted Biomaterials Establish an Immunosuppressive Microenvironment that Induces T Cell Exhaustion by Recruiting Myeloid Cells. Fundamental Research 2, 648-658 (2022) Link
[48] Fang Xu, Ziying Fei, Huaxing Dai, Jialu Xu, Qin Fan, Shufang Shen, Yue Zhang, Qingle Ma, Jiacheng Chu, Fei Peng, Fangfang Zhou, Zhuang Liu, Chao Wang*. Mesenchymal Stem Cell-derived Extracellular Vesicles with High PD-L1 Expression for Autoimmune Diseases Treatment. Advanced Materials, 34, 2106265 (2022) Link
[47] Jiacheng Chu, Chenya Wang, Qingle Ma, Huaxing Dai, Jialu Xu, Edikan A. Ogunnaike, Fei Peng, Xiaolin Shi, Chao Wang*. Coupling PD-1+ Tumor-Infiltrating T Cells with anti-PD-1 Antibody Improve the Efficacy of Adoptive T-cell Therapy. Cytotherapy, 24, 291 (2022) Link
2021
[46] Hao Chen, Bo Tian, Xiyao Fang, Jinyu Bai, Qingle Ma, Yue Zhang, Jialu Xu, Beilei Wang, Qin Fan, Ziying Fei, Huaxing Dai, Huajian Shan, Xiang Gao, Qirong Dong, Chao Wang*, Xiaozhong Zhou*. Injectable Erythrocyte Gel Loaded with Bulleyaconitine A for the Treatment of Rheumatoid Arthritis, ACS Biomaterials Science & Engineering,7, 5706 (2021) Link
[45] Yue Zhang, Jialu Xu, Ziying Fei, Huaxing Dai, Qin Fan, Qianyu Yang, Yitong Chen, Beilei Wang, Chao Wang*. 3D Printing Scaffold Vaccine for Antitumor Immunity. Advanced Materials, 33, 2106768 (2021) Link
[44] Qingle Ma#, Jinyu Bai#, Jialu Xu, Huaxing Dai, Qin Fan, Ziying Fei, Jiacheng Chu, Chenlu Yao, Haoliang Shi, Xiaozhong Zhou*, Lin Bo*, Chao Wang*. Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles. Advanced NanoBiomed Research, 1, 2100071 (2021) Link
[43] Qingle Ma,‡ Chenlu Yao,‡ Haoliang Shi,‡ Jialu Xu, Huaxing Dai, Ziying Fei, Yi Wu, Ting Lu* and Chao Wang*. Targeted Delivery of Dexamethasone in Acute Pneumonia. Biomaterials Science, 9, 5569 (2021) Link
[42] Shufang Shen, Huaxing Dai, Ziying Fei, Yu Chai, Yu Hao, Qin Fan, Ziliang Dong, Yujie Zhu, Jialu Xu, Qingle Ma, Xiao Han, Ligeng Xu, Fei Peng, Zhuang Liu, Chao Wang*. Immunosuppressive Nanoparticles for Management of Immune-Related Adverse Events in Liver. ACS Nano, 5, 9111 (2021). Link
[41] Qin Fan, Jinyu Bai, Huajian Shan, Ziying Fei, Hao Chen, Jialu Xu, Qingle Ma, Xiaozhong Zhou* and Chao Wang*. Implantable Blood Clot Loaded with BMP-2 for Regulation of Osteoimmunology and Enhancement of Bone Repair. Bioactive Materials, 6, 4014 (2021). Link
[40] Yufen Xiao,Jun Chen*, Chao Wang*, Jianxun Ding*, Wei Tao*. Emerging Micro- and Nanotechnologies for Medical and Pharmacological Applications. Front Pharmacol, 12, 648749 (2021). (Editorial) Link
[39] Ziying Fei, Qin Fan*, Huaxing Dai, Xuanfang Zhou, Jialu Xu, Qingle Ma, Atsushi Maruyama*, Chao Wang*. Physiologically Triggered Injectable Red Blood Cell-Based Gel for Tumor Photoablation and Enhanced Cancer Immunotherapy. Biomaterials, 271, 120724 (2021). Link
[38] Qingle Ma, Qin Fan, Xiao Han, Ziliang Dong, Jialu Xu, Jinyu Bai, Weiwei Tao, Dongdong Sun* and Chao Wang*. Platelet-Derived Extracellular Vesicles to Target Plaque Inflammation for Effective Anti-atherosclerotic Therapy. Journal of Controlled Release, 329, 445 (2021). Link
[37] Jialu Xu and Chao Wang*. Cell-derived Vesicles for Delivery of Cancer Immunotherapy. Exploration of Medicine, 2, 39 (2021). (Invited Review) Link
2020
[36] Qin Fan, Qingle Ma, Jinyu Bai, Jialu Xu, Ziying Fei, Ziliang Dong, Atsushi Maruyama, Kam W. Leong, Zhuang Liu and Chao Wang*. An Implantable Blood Clot-based Immune Niche for Enhanced Cancer Vaccination. Science Advances, 6, eabb4639 (2020). Link[Biotechscope]
[35] Qingle Ma, Qin Fan, Jialu Xu, Jinyu Bai, Xiao Han, Ziliang Dong, Xiaozhong Zhou, Zhuang Liu, Zhen Gu* and Chao Wang*. Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-derived Extracellular Vesicles. Matter, 3, 287 (2020). LinkHighlight by [Matter]
[34] Lulu Cai#, Jialu Xu#, Zhenglin Yang, Rongsheng Tong, Ziliang Dong, Chao Wang* and Kam W. Leong*. Engineered Biomaterials for Cancer Immunotherapy. MedComm, 1, 35 (2020) Link (Invited review)
[33] Xuanfang Zhou, Zhouqi Meng*, Jialin She, Yaojia Zhang, Xuan Yi, Hailin Zhou, Jing Zhong, Ziliang Dong, Xiao Han, Muchao Chen, Qin Fan, Kai Yang and Chao Wang* . Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy. Nano-Micro Letters, 12, 100 (2020).
[32] Yingjun Liu, Dongdong Sun, Qin Fan, Qingle Ma, Ziliang Dong, Weiwei Tao, Huiquan Tao, Zhuang Liu and Chao Wang*. The Enhanced Permeability and Retention Effect based Nanomedicine at the Site of Injury. Nano Research 13, 564-569 (2020).
2019
[31] 范亲, 汪超*.纳米材料在肿瘤免疫治疗中的应用.中国科学-生命科学, (2019). DOI:10.1360/SSV-2019-0215 (Invited review)
[30] Lin Zhang, Jinhua Zhou, Lvzhong Hu, Xiao Han, Xinwei Zou, Qian Chen, Youguo Chen*, Zhuang Liu*, Chao Wang*. In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of Cancer Recurrence after Surgery. Advanced Functional Materials, 30, 1906922 (2019).
[29] Baowen Qi, Chao Wang*, Jianxun Ding* and Wei Tao*. Applications of Nanobiotechnology in Pharmacology. Frontiers in Pharmacology, 10, 1451 (2019). (Editorial)
[28] Jinyu Bai,Yingzi Zhang, Qin Fan, Jialu Xu, Huajian Shan, Xiang Gao, Qinle Ma, Lei Sheng, Xin Zheng, Weinan Chen, Dazhuang Li, Mingchao Zhang, Yu Hao, Liangzhu Feng, Qian Chen, Xiaozhong Zhou* and Chao Wang*. Reactive Oxygen Species-Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disc Degeneration. Advanced Healthcare Materials, 9, 1901186 (2019).
[27] Xiao Han, Rui Wang, Jun Xu, Qian Chen, Chao Liang, Jiawen Chen, Jiayue Zhao, Jiacheng Chu, Qin Fan, Edikan Archibong, Lixin Jiang*, Chao Wang*, Zhuang Liu*. In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence. Biomaterials, 224, 119490 (2019).
[26] Xiao Han#, Shufang Shen#, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu* and Chao Wang*. Red Blood Cell Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy. Science Advances, 5, eaaw6870 (2019).
[25] Xiao Han#, Jiawen Chen#, Jiacheng Chu, Chao Liang, Qingle Ma, Qin Fan, Zhuang Liu* and Chao Wang*. Platelets as Platforms for Inhibition of Tumor Recurrence Post-Physical Therapy by Delivery of anti-PD-L1 Checkpoint Antibody. Journal of Controlled Release, 304, 233-241(2019).
2018
[24] Xiaowen Liu, Chao Wang*, Zhuang Liu*. Protein‐Engineered Biomaterials for CancerTheranostics. Advanced Healthcare Materials, 1800913(2018). (Review paper)
[23] Qin Fan, Zhipeng Chen,Chao Wang*, Zhuang Liu*. Toward Biomaterials for Enhancing Immune Checkpoint BlockadeTherapy. Advanced Functional Materials, 1802540 (2018). (Review paper)
[22] Xiao Han, Chao Wang*, Zhuang Liu *. Red Blood Cells as Smart Delivery Systems. Bioconjug Chem 29, 852-860 (2018). (Review paper)
[21]Shuangjiang Yu#, Chao Wang#, Jicheng Yu, Jinqiang Wang, Yue Lu,Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He*, Xuesi Chen*, Zhen Gu*. Injectable Bioresponsive Gel Depot for Enhanced Immune CheckpointBlockade. Advanced Materials 1801527 (2018).
[20] Chao Wang#, Jinqiang Wang#, Xudong Zhang, Shuangjiang Yu, Di Wen, Quan Hu, Yanqi Ye, H.Bomba, X. Hu, Z. Liu. Gianpietro Dotti and Zhen Gu*. In situ formed reactiveoxygen species–responsive scaffold with gemcitabine and checkpoint inhibitorfor combination therapy. Science Translational Medicine 10, eaan3682 (2018).
2011-2017
[19] Chao Wang, Wujin Sun, Yanqi Ye, Hunter N Bomba, Zhen Gu*. Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs. Theranostics 7, 3504-3516 (2017). (Review paper)
[18] Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter N Bomba, Zhen Gu*. In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy. Nature Biomedical Engineering 1, 0011 (2017).
[17] Chao Wang, Di Wen, Zhen Gu*. Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy. Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.7b00619 (2017). (Review paper)
[16] Chao Wang, Yanqi Ye, Zhen Gu*. Local delivery of checkpoints antibodies. Human Vaccines & Immunotherapeutics 13, 245-248 (2017). (Review paper)
[15] Chao Wang, Yanqi Ye, Quanyin Hu, Adriano Bellotti, Zhen Gu*. Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook. Advanced Materials 29, 201606036 (2017). (Review paper)
[14] Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jingqiang Wang, David S Lawrence, John B Buse, Zhen Gu*. Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials 29, 201606617 (2017).
[13] Chao Wang#, Yanqi Ye#, Gabrielle M Hochu, Hasan Sadeghifar, Zhen Gu*. Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-{PD}1 Antibody. Nano Letters 16, 2334-2340 (2016).
[12] Chao Wang#, Min Ye#, Liang Cheng, Rui Li, Wenwen Zhu, Zhen Shi, Chunhai Fan, Jinkang He, Jian Liu, Zhuang Liu*. Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials 54, 55-62 (2015).
[11] Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*. Multifunctional Theranostic Red Blood Cells For Magnetic-Field-Enhanced in vivo Combination Therapy of Cancer. Advanced Materials 26, 4794-4802 (2014).
[10] Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, Zhuang Liu*. Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-{CTLA}-4 Therapy to Inhibit Cancer Metastasis. Advanced Materials 26, 8154-8162 (2014).
[9] Liang Cheng#, Chao Wang#, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu*. Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control. Advanced Functional Materials 23, 272-280 (2013).
[8] Chao Wang, Liang Cheng, Yumeng Liu, Xiaojing Wang, Xinxing Ma, Zhaoyi Deng, Yonggang Li, Zhuang Liu*. Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light. Advanced Functional Materials 23, 3077-3086 (2013).
[7] Chao Wang, Liang Cheng, Zhuang Liu*. Upconversion Nanoparticles for Photodynamic Therapy and Other Cancer Therapeutics. Theranostics 3, 317-330 (2013). (Review paper)
[6] Chao Wang#, Huan Xu#, Chao Liang, Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li, Zhuang Liu*. Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect. ACS Nano 7, 6782-6795 (2013).
[5] Chao Wang, Liang Cheng, Huan Xu, Zhuang Liu*. Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles. Biomaterials 33, 4872-4881 (2012).
[4] Chao Wang, Xinxing Ma, Shuoqi Ye, Liang Cheng, Kai Yang, Liang Guo, Changhui Li, Yonggang Li, Zhuang Liu*. Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging. Advanced Functional Materials 22, 2363-2375 (2012).
[3] Chao Wang, Liang Cheng and Zhuang Liu*. Research Spotlight: Upconversion nanoparticles for potential cancer theranostics. Therapeutic Delivery 2, 1235-1239 (2011). (Review paper)
[2] Chao Wang, Huiquan Tao, Liang Cheng and Zhuang Liu*. Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials 32, 6145-6154 (2011).
[1] Chao Wang, Liang Cheng and Zhuang Liu*. Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. Biomaterials 32, 1110-1120 (2011).
Book chapter
[1] Shufang Shen and Chao Wang* (2020) Upconversion Fluorescent Nanoprobe for Highly Sensitive In Vivo Cell Tracking. Cell Tracking. Methods in Molecular Biology, vol 2126. Humana, New York, NY