程茹,教授。1997-2006年于南京工业大学本硕博学习,2006.1获工学博士学位。2006-2007中科院南京土壤研究所博士后。2007年入职苏州大学任讲师,2012年受聘苏州大学副教授,2018年晋升为教授。2011-2012瑞士洛桑联邦理工访问学者;2013-2014美国康奈尔大学访问学者。发表论文90多篇,被引用8200多次,H-因子44;Web of Science高引用论文8篇。一篇论文获中国百篇最具影响国际学术论文奖,连续两年入选全球高被引科学家(Highly Cited Researcher,Clarivate Analytics)榜单。申请和授权多项专利。已完成多项国家、省和市级自然科学项目,现主持2项国自然面上项目。主要研究方向为智能聚合物纳米药物的研制及肿瘤的高效靶向治疗。
1997-2006年于南京工业大学本硕博学习,化学工程与工艺专业。2006.1获工学博士学位。
2006-2007中科院南京土壤研究所博士后。2007年入职苏州大学任讲师,2012年受聘苏州大学副教授,2018年晋升为教授。2011-2012瑞士洛桑联邦理工访问学者;2013-2014美国康奈尔大学访问学者。
主要研究方向为智能聚合物纳米药物的研制及肿瘤的高效靶向治疗。
《无机及分析化学》
《无机及分析化学实验》
《有机化学实验》
1. 国家自然科学基金面上项目,52073195,多功能维特克拉胶束用于CXCR4高表达的白血病干细胞的高效靶向化疗,2021/01-2024/12,58万元,完成中,主持
2. 国家自然科学基金面上项目,51873144,A6多肽导向多功能囊泡甲硫哒嗪药物用于乳腺癌干细胞的高效靶向化疗,2019/01-2022/12,59万元,完成中,主持
3. 国家自然科学基金面上项目,51373113,pH和还原双重生物响应氨基酸聚氨酯纳米药物载体的设计合成,2014/01-2017/12,85万元,已结题,主持
4. 江苏省自然科学基金面上项目,BK20131166,设计合成双重生物响应氨基酸聚氨酯纳米药物载体,2013/07-2016/6,10万元,已结题,主持
5. 苏州市科技计划项目,SYG201331,双重生物响应性氨基酸聚氨酯纳米药物载体的研究,2013/07-2015/6,10万元,已结题,主持
6. 国家自然科学基金青年项目,51103093,可生物还原降解聚乙二醇-聚(酯-氨酯)-聚乙二醇纳米抗癌药物载体的设计合成,2012/01-2014/12,26万元,已结题,主持
7. 江苏省教育厅项目,11KJB150013,还原敏感聚乙二醇-聚(酯-氨酯)纳米抗癌药物载体, 2011/09-2013/12,3万元,已结题,主持
部分论文:
Wang, X.; Cheng, R.; Zhong, Z., Facile Fabrication of Robust, Hyaluronic Acid-Surfaced and Disulfide-Crosslinked PLGA Nanoparticles for Tumor-Targeted and Reduction-Triggered Release of Docetaxel. Acta Biomater. 2021. DOI:10.1016/j.actbio.2021.02.044
Wang, H.; Wang, X.; Zhang, Y.; Cheng, R.; Yuan, J.; Zhong, Z., Systemic Delivery of NAC-1 siRNA by Neuropilin-Targeted Polymersomes Sensitizes Antiangiogenic Therapy of Metastatic Triple-Negative Breast Cancer. Biomacromolecules 2020, 21, 5119-5127.
Wang, X.; Cheng, R.; Cheng, L.; Zhong, Z., Lipoyl Ester Terminated Star PLGA as a Simple and Smart Material for Controlled Drug Delivery Application. Biomacromolecules 2018, 19, 1368-1373.
Gu, Z.; Wang, X.; Cheng, R.; Cheng, L.; Zhong, Z., Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma. Acta Biomater. 2018, 80, 288-295.
Zhong, P.; Meng, H.; Qiu, J.; Zhang, J.; Sun, H.; Cheng, R.; Zhong, Z., alpha(v)beta(3) Integrin-targeted reduction-sensitive micellarmertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo. J. Controlled Release 2017, 259, 176-186.
Zhong, P.; Gu, X.; Cheng, R.; Deng, C.; Meng, F.; Zhong, Z., alpha(v)beta(3) integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo. Int. J. Nanomed. 2017, 12, 7913-7921.
Wu, K.; Cheng, R.; Zhang, J.; Meng, F.; Deng, C.; Zhong, Z., Micellar nanoformulation of lipophilized bortezomib: high drug loading, improved tolerability and targeted treatment of triple negative breast cancer. J. Mater. Chem.B 2017, 5, 5658-5667.
Zhong, P.; Zhang, J.; Deng, C.; Cheng, R.; Meng, F.; Zhong, Z., Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy. Biomacromolecules 2016, 17, 3602-3608.
Wang, X.; Zhang, J.; Cheng, R.; Meng, F.; Deng, C.; Zhong, Z., Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent. Biomacromolecules 2016, 17, 882-890.
Zhong, Y.; Zhang, J.; Cheng, R.; Deng, C.; Meng, F.; Xie, F.; Zhong, Z., Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+human breast tumor xenografts. J. Controlled Release 2015, 205, 144-154.
Lu, W.; Wang, X.; Cheng, R.; Deng, C.; Meng, F.; Zhong, Z., Biocompatible and bioreducible micelles fabricated from novel alpha-amino acid-based poly(disulfide urethane)s: design, synthesis and triggered doxorubicin release. Polym. Chem. 2015, 6, 6001-6010.
Huang, F.; Cheng, R.; Meng, F.; Deng, C.; Zhong, Z., Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release. Biomacromolecules 2015, 16, 2228-2236.
Cheng, R.; Meng, F.; Deng, C.; Zhong, Z., Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy. Nano Today 2015, 10, 656-670.
Cheng, R.; Meng, F.; Deng, C.; Klok, H.-A.; Zhong, Z., Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery. Biomaterials 2013, 34, 3647-3657.
Cheng, R.; Wang, X.; Chen, W.; Meng, F.; Deng, C.; Liu, H.; Zhong, Z., Biodegradable poly(epsilon-caprolactone)-g-poly(2-hydroxyethyl methacrylate) graft copolymer micelles as superior nano-carriers for smart doxorubicin release. J. Mater. Chem. 2012, 22, 11730-11738.
Cheng, R.; Meng, F.; Ma, S.; Xu, H.; Liu, H.; Jing, X.; Zhong, Z., Reduction and temperature dual-responsive crosslinked polymersomes for targeted intracellular protein delivery. J. Mater. Chem. 2011, 21, 19013-19020.
Cheng, R.; Feng, F.; Meng, F.; Deng, C.; Feijen, J.; Zhong, Z., Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J. Controlled Release 2011, 152, 2-12.
1、参与《化工原理实验》教材的编写
南京大学出版社
ISBN 978-7-305-07977-1
2、作为第一作者撰写
RSC Smart Materials No. 2
Smart Materials for Drug Delivery: Volume 1,Chapter 8,Reduction-sensitive Nanosystems for Active Intracellular Drug Delivery
Edited by Carmen Alvarez-Lorenzo and Angel Concheiro
The Royal Society of Chemistry 2013
Published by the Royal Society of Chemistry, www.rsc.org
部分专利:
1.程茹;王秀秀;钟志远,胱胺二异氰酸酯单体、基于该单体的聚合物及其制备方法和应用,2015.12.18,中国,ZL 2015 1 o952367.8(已授权)
教学:
2015年获校第15届青年教师课堂教学竞赛一等奖
2011年获省本科优秀毕业论文优秀团队毕业设计奖
科研:
一篇论文获中国百篇最具影响国际学术论文奖(2013)
一篇论文获苏州市自然科学优秀学术论文二等奖(2012-2013)
连续两年入选全球高被引科学家(Highly Cited Researcher,Clarivate Analytics)榜单(2018,2019)
程茹,教授。1997-2006年于南京工业大学本硕博学习,2006.1获工学博士学位。2006-2007中科院南京土壤研究所博士后。2007年入职苏州大学任讲师,2012年受聘苏州大学副教授,2018年晋升为教授。2011-2012瑞士洛桑联邦理工访问学者;2013-2014美国康奈尔大学访问学者。发表论文90多篇,被引用8200多次,H-因子44;Web of Science高引用论文8篇。一篇论文获中国百篇最具影响国际学术论文奖,连续两年入选全球高被引科学家(Highly Cited Researcher,Clarivate Analytics)榜单。申请和授权多项专利。已完成多项国家、省和市级自然科学项目,现主持2项国自然面上项目。主要研究方向为智能聚合物纳米药物的研制及肿瘤的高效靶向治疗。
1997-2006年于南京工业大学本硕博学习,化学工程与工艺专业。2006.1获工学博士学位。
2006-2007中科院南京土壤研究所博士后。2007年入职苏州大学任讲师,2012年受聘苏州大学副教授,2018年晋升为教授。2011-2012瑞士洛桑联邦理工访问学者;2013-2014美国康奈尔大学访问学者。
主要研究方向为智能聚合物纳米药物的研制及肿瘤的高效靶向治疗。
《无机及分析化学》
《无机及分析化学实验》
《有机化学实验》
1. 国家自然科学基金面上项目,52073195,多功能维特克拉胶束用于CXCR4高表达的白血病干细胞的高效靶向化疗,2021/01-2024/12,58万元,完成中,主持
2. 国家自然科学基金面上项目,51873144,A6多肽导向多功能囊泡甲硫哒嗪药物用于乳腺癌干细胞的高效靶向化疗,2019/01-2022/12,59万元,完成中,主持
3. 国家自然科学基金面上项目,51373113,pH和还原双重生物响应氨基酸聚氨酯纳米药物载体的设计合成,2014/01-2017/12,85万元,已结题,主持
4. 江苏省自然科学基金面上项目,BK20131166,设计合成双重生物响应氨基酸聚氨酯纳米药物载体,2013/07-2016/6,10万元,已结题,主持
5. 苏州市科技计划项目,SYG201331,双重生物响应性氨基酸聚氨酯纳米药物载体的研究,2013/07-2015/6,10万元,已结题,主持
6. 国家自然科学基金青年项目,51103093,可生物还原降解聚乙二醇-聚(酯-氨酯)-聚乙二醇纳米抗癌药物载体的设计合成,2012/01-2014/12,26万元,已结题,主持
7. 江苏省教育厅项目,11KJB150013,还原敏感聚乙二醇-聚(酯-氨酯)纳米抗癌药物载体, 2011/09-2013/12,3万元,已结题,主持
部分论文:
Wang, X.; Cheng, R.; Zhong, Z., Facile Fabrication of Robust, Hyaluronic Acid-Surfaced and Disulfide-Crosslinked PLGA Nanoparticles for Tumor-Targeted and Reduction-Triggered Release of Docetaxel. Acta Biomater. 2021. DOI:10.1016/j.actbio.2021.02.044
Wang, H.; Wang, X.; Zhang, Y.; Cheng, R.; Yuan, J.; Zhong, Z., Systemic Delivery of NAC-1 siRNA by Neuropilin-Targeted Polymersomes Sensitizes Antiangiogenic Therapy of Metastatic Triple-Negative Breast Cancer. Biomacromolecules 2020, 21, 5119-5127.
Wang, X.; Cheng, R.; Cheng, L.; Zhong, Z., Lipoyl Ester Terminated Star PLGA as a Simple and Smart Material for Controlled Drug Delivery Application. Biomacromolecules 2018, 19, 1368-1373.
Gu, Z.; Wang, X.; Cheng, R.; Cheng, L.; Zhong, Z., Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma. Acta Biomater. 2018, 80, 288-295.
Zhong, P.; Meng, H.; Qiu, J.; Zhang, J.; Sun, H.; Cheng, R.; Zhong, Z., alpha(v)beta(3) Integrin-targeted reduction-sensitive micellarmertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo. J. Controlled Release 2017, 259, 176-186.
Zhong, P.; Gu, X.; Cheng, R.; Deng, C.; Meng, F.; Zhong, Z., alpha(v)beta(3) integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo. Int. J. Nanomed. 2017, 12, 7913-7921.
Wu, K.; Cheng, R.; Zhang, J.; Meng, F.; Deng, C.; Zhong, Z., Micellar nanoformulation of lipophilized bortezomib: high drug loading, improved tolerability and targeted treatment of triple negative breast cancer. J. Mater. Chem.B 2017, 5, 5658-5667.
Zhong, P.; Zhang, J.; Deng, C.; Cheng, R.; Meng, F.; Zhong, Z., Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy. Biomacromolecules 2016, 17, 3602-3608.
Wang, X.; Zhang, J.; Cheng, R.; Meng, F.; Deng, C.; Zhong, Z., Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent. Biomacromolecules 2016, 17, 882-890.
Zhong, Y.; Zhang, J.; Cheng, R.; Deng, C.; Meng, F.; Xie, F.; Zhong, Z., Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+human breast tumor xenografts. J. Controlled Release 2015, 205, 144-154.
Lu, W.; Wang, X.; Cheng, R.; Deng, C.; Meng, F.; Zhong, Z., Biocompatible and bioreducible micelles fabricated from novel alpha-amino acid-based poly(disulfide urethane)s: design, synthesis and triggered doxorubicin release. Polym. Chem. 2015, 6, 6001-6010.
Huang, F.; Cheng, R.; Meng, F.; Deng, C.; Zhong, Z., Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release. Biomacromolecules 2015, 16, 2228-2236.
Cheng, R.; Meng, F.; Deng, C.; Zhong, Z., Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy. Nano Today 2015, 10, 656-670.
Cheng, R.; Meng, F.; Deng, C.; Klok, H.-A.; Zhong, Z., Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery. Biomaterials 2013, 34, 3647-3657.
Cheng, R.; Wang, X.; Chen, W.; Meng, F.; Deng, C.; Liu, H.; Zhong, Z., Biodegradable poly(epsilon-caprolactone)-g-poly(2-hydroxyethyl methacrylate) graft copolymer micelles as superior nano-carriers for smart doxorubicin release. J. Mater. Chem. 2012, 22, 11730-11738.
Cheng, R.; Meng, F.; Ma, S.; Xu, H.; Liu, H.; Jing, X.; Zhong, Z., Reduction and temperature dual-responsive crosslinked polymersomes for targeted intracellular protein delivery. J. Mater. Chem. 2011, 21, 19013-19020.
Cheng, R.; Feng, F.; Meng, F.; Deng, C.; Feijen, J.; Zhong, Z., Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J. Controlled Release 2011, 152, 2-12.
1、参与《化工原理实验》教材的编写
南京大学出版社
ISBN 978-7-305-07977-1
2、作为第一作者撰写
RSC Smart Materials No. 2
Smart Materials for Drug Delivery: Volume 1,Chapter 8,Reduction-sensitive Nanosystems for Active Intracellular Drug Delivery
Edited by Carmen Alvarez-Lorenzo and Angel Concheiro
The Royal Society of Chemistry 2013
Published by the Royal Society of Chemistry, www.rsc.org
部分专利:
1.程茹;王秀秀;钟志远,胱胺二异氰酸酯单体、基于该单体的聚合物及其制备方法和应用,2015.12.18,中国,ZL 2015 1 o952367.8(已授权)
教学:
2015年获校第15届青年教师课堂教学竞赛一等奖
2011年获省本科优秀毕业论文优秀团队毕业设计奖
科研:
一篇论文获中国百篇最具影响国际学术论文奖(2013)
一篇论文获苏州市自然科学优秀学术论文二等奖(2012-2013)
连续两年入选全球高被引科学家(Highly Cited Researcher,Clarivate Analytics)榜单(2018,2019)