教育背景
2020.09-2024.12：南京大学，物理学，博士（导师：马余强院士）
2017.09-2020.06：中国石油大学（华东），生物化工，硕士
2013.09-2017.06：河北农业大学，化学工程与工艺，学士
工作经历
2025.02-至今 苏州大学物理科学与技术学院/软凝聚态物理及交叉研究中心，助理研究员（丁泓铭教授团队）
研究领域
计算生物物理和统计物理交叉领域研究
研究方向
主要从事纳米-生物界面相互作用、生物大分子自组装和相分离等方面的理论模拟研究工作，重点关注界面相互作用的结合自由能计算和分子机制、纳米-生物界面作用的调控机制以及复杂环境下生物大分子的相行为和动力学机制。
研究成果
1. Zeng-Shuai Yan, Yu-Qiang Ma and Hong-Ming Ding. Unveiling the multicomponent phase separation through molecular dynamics simulation and graph theory. The Journal of Chemical Physics, 2024, 160(6): 064907.
2. Zeng-Shuai Yan, Xiao-Lei Li, Yu-Qiang Ma and Hong-Ming Ding. Effect of the graphene nanosheet on functions of the spike protein in open and closed states: comparison between SARS-CoV-2 wild type and the Omicron variant. Langmuir, 2022, 38(45): 13972-13982.
3. Zeng-Shuai Yan, Yao Xu, Hong-Ming Ding and Yu-Qiang Ma. Molecular insights into striking antibody evasion of SARS-CoV-2 Omicron variant. Chinese Physics Letters, 2022, 39(10): 108701.
4. Zeng-Shuai Yan, Ling-Zhi Li, Shi-Xin Li, Yan Xu and Tong-Tao Yue. Extracellular interactions between graphene nanosheets and E-cadherin. Environmental Science: Nano, 2021, 8(8): 2152-2164.
5. Zeng-Shuai Yan, Ze-Ming Wu, Shi-Xin Li, Xian-Ren Zhang, Xin Yi and Tong-Tao Yue. Curvature-mediated cooperative wrapping of multiple nanoparticles at the same and opposite membrane sides. Nanoscale, 2019, 11(42): 19751-19762.
6. Zeng-Shuai Yan, Shi-Xin Li, Zhen Luo, Yan Xu and Tong-Tao Yue. Membrane nanotube pearling restricted by confined polymers. Soft matter, 2018, 14(46): 9383-9392.
7. Xiao-Lei Li, Zeng-Shuai Yan, Yu-Qiang Ma and Hong-Ming Ding. Impact of Glycosylation of Apolipoprotein D on Its Interaction with Gold Nanoparticles: Insights from Molecular Dynamics Simulations. ACS Applied Materials & Interfaces, 2025, 17(3): 4490-4501
8. Xu, Yao, Zeng-Shuai Yan, Yu-Qiang Ma, and Hong-Ming Ding. Topology-and size-dependent binding of DNA nanostructures to the DNase I. International Journal of Biological Macromolecules, 2024, 257: 128703.
9. Chen, Chen, Zeng-Shuai Yan, Yu-Qiang Ma and Hong-Ming Ding. Effect of terahertz waves on the structure of the Aβ42 monomer, dimer, and protofibril: Insights from molecular dynamics simulations. ACS Chemical Neuroscience, 2023, 14(23): 4128-4138.
10. Li Ye, Zeng-Shuai Yan, Jian-Wei Xiao and Tong-Tao Yue. DNA-conjugated layered double hydroxides penetrating into a plasma membrane: Layer size, thickness and DNA grafting density matter. NanoImpact, 2020, 18: 100222.
11. Shi-Xin Li, Zeng-Shuai Yan, Fang Huang, Xian-Ren Zhang and Tong-Tao Yue. How a lipid bilayer membrane responds to an oscillating nanoparticle: Promoted membrane undulation and directional wave propagation. Colloids and Surfaces B: Biointerfaces, 2020, 187: 110651.
12. Shi-Xin Li, Zeng-Shuai Yan, Zhen Luo, Yan Xu, Fang Huang, Guo-Qing Hu, Xian-Ren Zhang, and Tong-Tao Yue. Directional and rotational motions of nanoparticles on plasma membranes as local probes of surface tension propagation. Langmuir, 2019, 35(15): 5333-5341.
13. Shi-Xin Li, Zeng-Shuai Yan, Zhen Luo, Yan Xu, Fang Huang, Xian-Ren Zhang, Xin Yi and Tong-Tao Yue. Mechanics of the formation, interaction, and evolution of membrane tubular structures. Biophysical journal, 2019, 116(5): 884-892.
14. Mei-Wen Cao, Yang Shen, Zeng-shuai Yan, Qiang Wei, Ti-Feng Jiao, Yu-Tan Shen, Yu-Chun Han, Yi-Lin Wang, Sheng-Jie Wang, Yong-Qing Xia and Tong-Tao Yue. Extraction-like removal of organic dyes from polluted water by the graphene oxide/PNIPAM composite system. Chemical Engineering Journal, 2021, 405:126647.
15. Shi-Xin Li, Ru-Jie Lv, Zeng-Shuai Yan, Fang Huang, Xian-Ren Zhang, Guang-Jin Chen and Tong-Tao Yue. Design of alanine-rich short peptides as a green alternative of gas hydrate inhibitors: dual methyl group docking for efficient adsorption on the surface of gas hydrates. ACS Sustainable Chemistry & Engineering, 2020, 8(10): 4256-4266.
16. Yan Xu, Shi-Xin Li, Zeng-Shuai Yan, Bao-Sheng Ge, Fang Huang and Tong-Tao Yue. Revealing cooperation between knotted conformation and dimerization in protein stabilization by molecular dynamics simulations. The journal of physical chemistry letters, 2019, 10(19): 5818-5822.
17. Yan Xu, Shi-Xin Li, Zeng-Shuai Yan, Zhen Luo, Hao Ren, Bao-Sheng Ge, Fang Huang and Tong-Tao Yue. Stabilizing effect of inherent knots on proteins revealed by molecular dynamics simulations. Biophysical journal, 2018, 115(9): 1681-1689.
教育背景
2020.09-2024.12：南京大学，物理学，博士（导师：马余强院士）
2017.09-2020.06：中国石油大学（华东），生物化工，硕士
2013.09-2017.06：河北农业大学，化学工程与工艺，学士
工作经历
2025.02-至今 苏州大学物理科学与技术学院/软凝聚态物理及交叉研究中心，助理研究员（丁泓铭教授团队）
研究领域
计算生物物理和统计物理交叉领域研究
研究方向
主要从事纳米-生物界面相互作用、生物大分子自组装和相分离等方面的理论模拟研究工作，重点关注界面相互作用的结合自由能计算和分子机制、纳米-生物界面作用的调控机制以及复杂环境下生物大分子的相行为和动力学机制。
研究成果
1. Zeng-Shuai Yan, Yu-Qiang Ma and Hong-Ming Ding. Unveiling the multicomponent phase separation through molecular dynamics simulation and graph theory. The Journal of Chemical Physics, 2024, 160(6): 064907.
2. Zeng-Shuai Yan, Xiao-Lei Li, Yu-Qiang Ma and Hong-Ming Ding. Effect of the graphene nanosheet on functions of the spike protein in open and closed states: comparison between SARS-CoV-2 wild type and the Omicron variant. Langmuir, 2022, 38(45): 13972-13982.
3. Zeng-Shuai Yan, Yao Xu, Hong-Ming Ding and Yu-Qiang Ma. Molecular insights into striking antibody evasion of SARS-CoV-2 Omicron variant. Chinese Physics Letters, 2022, 39(10): 108701.
4. Zeng-Shuai Yan, Ling-Zhi Li, Shi-Xin Li, Yan Xu and Tong-Tao Yue. Extracellular interactions between graphene nanosheets and E-cadherin. Environmental Science: Nano, 2021, 8(8): 2152-2164.
5. Zeng-Shuai Yan, Ze-Ming Wu, Shi-Xin Li, Xian-Ren Zhang, Xin Yi and Tong-Tao Yue. Curvature-mediated cooperative wrapping of multiple nanoparticles at the same and opposite membrane sides. Nanoscale, 2019, 11(42): 19751-19762.
6. Zeng-Shuai Yan, Shi-Xin Li, Zhen Luo, Yan Xu and Tong-Tao Yue. Membrane nanotube pearling restricted by confined polymers. Soft matter, 2018, 14(46): 9383-9392.
7. Xiao-Lei Li, Zeng-Shuai Yan, Yu-Qiang Ma and Hong-Ming Ding. Impact of Glycosylation of Apolipoprotein D on Its Interaction with Gold Nanoparticles: Insights from Molecular Dynamics Simulations. ACS Applied Materials & Interfaces, 2025, 17(3): 4490-4501
8. Xu, Yao, Zeng-Shuai Yan, Yu-Qiang Ma, and Hong-Ming Ding. Topology-and size-dependent binding of DNA nanostructures to the DNase I. International Journal of Biological Macromolecules, 2024, 257: 128703.
9. Chen, Chen, Zeng-Shuai Yan, Yu-Qiang Ma and Hong-Ming Ding. Effect of terahertz waves on the structure of the Aβ42 monomer, dimer, and protofibril: Insights from molecular dynamics simulations. ACS Chemical Neuroscience, 2023, 14(23): 4128-4138.
10. Li Ye, Zeng-Shuai Yan, Jian-Wei Xiao and Tong-Tao Yue. DNA-conjugated layered double hydroxides penetrating into a plasma membrane: Layer size, thickness and DNA grafting density matter. NanoImpact, 2020, 18: 100222.
11. Shi-Xin Li, Zeng-Shuai Yan, Fang Huang, Xian-Ren Zhang and Tong-Tao Yue. How a lipid bilayer membrane responds to an oscillating nanoparticle: Promoted membrane undulation and directional wave propagation. Colloids and Surfaces B: Biointerfaces, 2020, 187: 110651.
12. Shi-Xin Li, Zeng-Shuai Yan, Zhen Luo, Yan Xu, Fang Huang, Guo-Qing Hu, Xian-Ren Zhang, and Tong-Tao Yue. Directional and rotational motions of nanoparticles on plasma membranes as local probes of surface tension propagation. Langmuir, 2019, 35(15): 5333-5341.
13. Shi-Xin Li, Zeng-Shuai Yan, Zhen Luo, Yan Xu, Fang Huang, Xian-Ren Zhang, Xin Yi and Tong-Tao Yue. Mechanics of the formation, interaction, and evolution of membrane tubular structures. Biophysical journal, 2019, 116(5): 884-892.
14. Mei-Wen Cao, Yang Shen, Zeng-shuai Yan, Qiang Wei, Ti-Feng Jiao, Yu-Tan Shen, Yu-Chun Han, Yi-Lin Wang, Sheng-Jie Wang, Yong-Qing Xia and Tong-Tao Yue. Extraction-like removal of organic dyes from polluted water by the graphene oxide/PNIPAM composite system. Chemical Engineering Journal, 2021, 405:126647.
15. Shi-Xin Li, Ru-Jie Lv, Zeng-Shuai Yan, Fang Huang, Xian-Ren Zhang, Guang-Jin Chen and Tong-Tao Yue. Design of alanine-rich short peptides as a green alternative of gas hydrate inhibitors: dual methyl group docking for efficient adsorption on the surface of gas hydrates. ACS Sustainable Chemistry & Engineering, 2020, 8(10): 4256-4266.
16. Yan Xu, Shi-Xin Li, Zeng-Shuai Yan, Bao-Sheng Ge, Fang Huang and Tong-Tao Yue. Revealing cooperation between knotted conformation and dimerization in protein stabilization by molecular dynamics simulations. The journal of physical chemistry letters, 2019, 10(19): 5818-5822.
17. Yan Xu, Shi-Xin Li, Zeng-Shuai Yan, Zhen Luo, Hao Ren, Bao-Sheng Ge, Fang Huang and Tong-Tao Yue. Stabilizing effect of inherent knots on proteins revealed by molecular dynamics simulations. Biophysical journal, 2018, 115(9): 1681-1689.