个人简介
中文名：朱晨
苏州大学材料与化学化工学部，教授，博导，国家优青，江苏特聘教授。2003年厦门大学化学化工学院获学士学位。2008年中国科学院上海有机化学研究所获博士学位。2008年至2013年分别在日本东京学习院大学和美国德州大学西南医学研究中心进行博士后研究工作，2013年12月加入苏州大学，2014年入选江苏省特聘教授（考核优秀）和苏州市紧缺高层次人才。2015年获得美国化学会ACS Membership Award。2016年获得苏州市自然科学优秀学术论文一等奖。2017年获得国家自然科学基金优秀青年基金，同年获得ThiemeChemistry Journals Award。2018年获得江苏省教育教学与研究成果奖二等奖，苏州市自然科学优秀学术论文一等奖，苏州大学周氏教育科研奖，入选苏州市科教创新区高端人才集聚工程（科教骨干人才）。受邀担任《中国科学—化学》、《化学学报》、《高等学校化学学报》杂志编委。以通讯作者和第一作者发表学术论文70余篇，他引2000余次。在德国应用化学累计发表十余篇研究性论文并应邀发表个人 Author Profile。研究领域为自由基与过渡金属参与的惰性键官能化反应及其在药物分子和天然产物合成中的应用。
学习与工作经历
2013.12 苏州大学材料与化学化工学部，教授，博士生导师
2013.6-2013.11 美国德州大学西南医学研究中心，指导教授：Chuo Chen
2009.10-2013.5 美国德州大学西南医学研究中心，指导教授：J. R. Falck
2008.7-2009.9 日本东京学习院大学，美国德州大学西南医学研究中心进行博士后研究工作，指导教授：Takahiko Akiyama
2003.8-2008.7中国科学院上海有机化学研究所，获博士学位，指导教授：林国强
1999.8-2003.7 厦门大学，化学化工学院，获学士学位，指导教授：黄培强
Chen Zhu
Professor, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Email: chzhu@suda.edu.cn
Learning and Work Experience
Professional Experience
2013.12-current Professor, Soochow University, Suzhou, China
Education
2013.6-2013.11 Postdoctoral Fellow, The University of Texas Southwestern Medical Center, Dallas, Texas
Advisor: Chuo Chen
2009.10-2013.5 Postdoctoral Fellow, The University of Texas SouthwesternMedical Center, Dallas, Texas
Advisor: J. R. Falck
2008.7-2009.9 Postdoctoral Researcher, Gakushuin University, Tokyo, Japan
Advisor: Takahiko Akiyama
2003.8-2008.7 Ph. D. in Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China
Advisor: Guo-Qiang Lin
1999.8-2003.7 B. S. in Chemistry, Xiamen University, Xiamen, China
Advisor: Pei-Qiang Huang
https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.202010114
自由基与过渡金属参与的惰性键官能化反应及其在药物分子和天然产物合成中的应用.
自由基参与的远程官能团迁移反应研究
开环反应研究
扩环反应研究
Zhu Lab 留影
2021
2020
2019
教学工作
有机化学（研究生、本科生的实验及理论课程）
79. X. Wu, Z. Ma, T. Feng, C. Zhu* “Radical-mediated rearrangements: past, present, and future” Chem. Soc. Rev.2021, 50, 11577
https://pubs.rsc.org/en/content/articlelanding/2021/CS/D1CS00529D
78. Z. Cao, H. Zhang, X. Wu, Y. Li *, C. Zhu* “Radical heteroarylation of unactivated remote C(sp3)–H bonds via intramolecular heteroaryl migration” Org. Chem. Front. 2021, 50, 11577
https://pubs.rsc.org/en/Content/ArticleLanding/2021/QO/D1QO01209F#!divRelatedContent&articles
77. M. Ji, X. Wang, J. Liu, X. Wu, C. Zhu.* “Catalyst-free, radical-mediated intermolecular 1,2-arylheteroarylation of alkenes by cleaving inert C–C bond” Sci China Chem. 2021, 64, 1703
https://link.springer.com/article/10.1007%2Fs11426-021-1077-4
76. M. Ji, C. Chang, X. Wu, C. Zhu.* “Photocatalytic intermolecular carboarylation of alkenes by selective C–O bond cleavage of diarylethers” Chem. Commun. 2021, 57, 9240
https://pubs.rsc.org/en/Content/ArticleLanding/2021/CC/D1CC04038C
75. Y. Wei, H. Zhang, X. Wu, C. Zhu.* “Alkene Difunctionalization Triggered by a Stabilized Allenyl Radical: Concomitant Installation of Two Unsaturated C-C Bonds” Angew. Chem. Int. Ed. 2021, 60, 20215
https://onlinelibrary.wiley.com/doi/10.1002/anie.202106145
74. N. Tang, Y. Xu, T. Niu, S. Yang, H. Dong, X. Wu, C. Zhu.* “A Radical [3 + 2]-Cycloaddition Reaction for the Synthesis of Difluorocyclopentanones.” Org. Chem. Front. 2021, 8, 3118
https://pubs.rsc.org/en/content/articlelanding/2021/QO/D1QO00201E#!divAbstract
73. Y. Wei, Z. Chen, Z. Wu, Y. Xu, X. Wu, C. Zhu.* “Radical Carbosulfonylation of Propellane: Synthesis of Sulfonyl β-Ketobicyclo[1,1,1]pentanes.” Synthesis. 2021, 53, 3325
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1484-1028
72. J. Yu, H. Zhang, X. Wu, C. Zhu.* “Intermolecular Radical Fluoroalkylative Olefination of Unactivated Alkenes.” CCS Chem. 2021, 3, 1426
https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202100944
71. Z. Wu, Y. Xu, H. Zhang, X. Wu, C. Zhu.* “Radical-Mediated Sulfonyl Alkynylation, Allylation, and Cyanation of Propellane.” Chem. Commun. 2021, 57, 6066
https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC02249K#!divAbstract
70. H. Zhang, M. Wang, X. Wu, C. Zhu.* “Heterocyclization Reagents for Rapid Assembly of N-Fused Heteroarenes from Alkenes.” Angew. Chem. Int. Ed. 2021, 60, 3714. (Highlighted by Synfacts 2021, 60, 3714)
https://onlinelibrary.wiley.com/doi/10.1002/anie.202013089
69. T. Niu, S. Yang, X. Wu, C. Zhu.* “Remote C(sp3)–H Vinylation via Radical-Mediated Consecutive Fission of C–H and C–C Bonds.” Org. Chem. Front. 2020, 7, 2981.
https://pubs.rsc.org/en/content/articlelanding/2020/QO/D0QO00952K#!divAbstract
68. H. Zhang, M. Ji, Y. Wei, H. Chen, X. Wu, C. Zhu.* “Radical-Mediated Hetaryl Functionalization of Nonactivated Alkenes through Distal ipso-Migration of O- or S-Hetaryls.” Synlett 2021, 32, 401.
https://www.thiemeconnect.de/products/ejournals/abstract/10.1055/s-0040-1705968
67. Z. Wu, Y. Xu, X. Wu, C. Zhu.* “Synthesis of Selenoether and Thioether Functionalized Bicyclo[1.1.1]pentanes.” Tetrahedron 2020, 76, 131692.
https://www.sciencedirect.com/science/article/pii/S0040402020309054?via%3Dihub.
66. X. Shao, X. Wu, S. Wu, C. Zhu.* “Metal-Free Radical-Mediated C(sp3)-H Heteroarylation of Alkanes.” Org. Lett. 2020, 22, 7450.
https://pubs.acs.org/doi/10.1021/acs.orglett.0c02475
65. C. Zhu. “Author Profile.” Angew. Chem. Int. Ed. 2020, 59, 21279.
https://onlinelibrary.wiley.com/doi/10.1002/anie.202010114
64. H. Zhang, L. Kou, D. Chen, M. Ji, X. Bao,* X. Wu, C. Zhu.* “Radical-Mediated Distal Ipso-Migration of O/S Containing Heteroaryls and DFT Studies for Migratory Aptitude.” Org. Lett. 2020, 22, 5947.
https://pubs.acs.org/doi/10.1021/acs.orglett.0c02030.
63. X. Wu, C. Zhu.* “Radical-Mediated Remote Functional Group Migration.” Acc. Chem. Res. 2020, 53, 8, 1620.
https://pubs.acs.org/doi/10.1021/acs.accounts.0c00306
62. H. Zhang, M. Wang, X. Wu, C. Zhu.* “Radical-Mediated Bromoalkylation of [1.1.1] Propellane: Synthesis of Bromo-substituted Bicyclo[1.1.1]pentane (BCP) De-rivatives.” Chin. J. Org. Chem. 2020, 40, 3431.
http://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202005001
61. Z. Wu, Y. Xu, J. Liu, X. Wu, C. Zhu.* A “Practical Access to Fluoroalkylthio(seleno)Functionalizedbicyclo[1.1.1]pentanes.” Sci.China Chem. 2020, 63, 1025.
https://link.springer.com/article/10.1007%2Fs11426-020-9733-y
60. T. Niu, J. Liu, X.Wu, C. Zhu.* “Radical Heteroarylalkylation of Alkenes via Three‐Component Docking‐Migration Thioetheri-fication Cascade.” Chin. J. Chem. 2020, 38, 803.
https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202000088
59. J. Liu, S. Wu, J. Yu, C. Lu, Z. Wu, X. Wu, X.‐S. Xue, C. Zhu.* “Polarity Umpolung Strategy for the Radical Alkylation of Alkenes.” Angew. Chem. Int. Ed. 2020, 59, 8195. (Highlighted by Chin. J. Org. Chem.)
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915837
58. M. Wang, M. Li, S. Yang, X.-S. Xue,* X. Wu, C. Zhu.* “Radical-Mediated C-C Cleavage of Unstrained Cycloketone and DFTStudy for Unusual Regioselectivity.” Nat. Commun. 2020, 11, 672.
https://www.nature.com/articles/s41467-020-14435-5
57. M. Wang, H. Zhang, J. Liu, X. Wu, C. Zhu.* “Radical Monofluoroalkylative Alkynylation of Olefins by Docking-MigrationStrategy.” Angew. Chem. Int. Ed. 2019, 58, 17646.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201910514
56. N. Tang, X. Wu, C. Zhu.* “Practical, Metal-Free Remote Heteroarylation of Amides via Unactivated C(sp3)-HBondFunctionalization.” Chem. Sci. 2019, 10, 6915.
https://pubs.rsc.org/en/content/articlelanding/2019/SC/C9SC02564B#!divAbstract
55. H. Zhang, X. Wu, Y. Wei, C. Zhu.* “Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of FunctionalizedPolyenes.” Org. Lett. 2019, 21, 7568.
https://pubs.acs.org/doi/10.1021/acs.orglett.9b02838
54. S. Yang, X. Wu, S. Wu, C. Zhu.* “Regioselective Sulfonylvinylation of the Unactivated C(sp3)–H Bond via a C-Centered Radical-Mediated Hydrogen Atom Transfer (HAT) Process.” Org. Lett. 2019, 21, 4837.
https://pubs.acs.org/doi/10.1021/acs.orglett.9b01734
53. X. Wu, C. Zhu.* “Recent Advances in Alkoxy Radical-Promoted C-C and C-H Bond Functionalization Starting from FreeAlcohols.” Chem. Commun. 2019, 55, 9747.
https://pubs.rsc.org/en/Content/ArticleLanding/2019/CC/C9CC04785A#!divAbstract
52. S. Wu, X. Wu, Z. Wu, C. Zhu.* “Regioselective Introduction of Vinyl Trifluoromethylthioether to Remote Unactivated C(sp3)-HBonds via Radical Translocation Cascade.” Sci. China Chem. 2019, 62, 1507.
https://link.springer.com/article/10.1007%2Fs11426-019-9527-5
51. D. Chen, M. Ji, C. Zhu.* “Intramolecular Nitration-Aminocarbonylation of Unactivated Olefins: Metal-Free Synthesis of γ-Lactams.” Chem. Commun. 2019, 55, 7796.
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03736E#!divAbstract
50. N. Tang, X. Shao, M. Wang, X. Wu, C. Zhu.* “Sulfonyl Chlorides Mediated Alkynylation of Non-Activated Alkenes via Distal Alkynyl Group Migration.” Acta Chim. Sinica (化学学报) 2019, 77, 922.
http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A19050158
49. Y. Zhao, P. Wang, Y. Gao, C. Zhu,* W. Liu,* Y. Wang.* “Mechanistic Insights into Intermolecular Cyclization of Ring-Fused Benzocyclobutenols with Alkynes Catalyzed by [{Ir(OMe)COD}2].” Org. Chem. Front. 2019, 6, 791.
https://pubs.rsc.org/en/content/articlelanding/2019/QO/C8QO01371C#!divAbstract
48. M. Ji, Z. Wu, C. Zhu.* “Visible-Light-Induced Consecutive C-C Bond Fragmentation and Formation for the Synthesis of Elusive Unsymmetric 1,8-Dicarbonyl Compounds.” Chem. Commun. 2019, 55, 2368.
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC00378A#!divAbstract
47. M. Wang, L. Huan, C. Zhu.* “Cyanohydrin-Mediated Cyanation of Remote Unactivated C(sp3)-H Bonds.” Org. Lett. 2019, 21, 821.
https://pubs.acs.org/doi/10.1021/acs.orglett.8b04104
46. S. Wu, X. Wu, D. Wang, C. Zhu.* “Regioselective Vinylation of Remote Unactivated C(sp3)-H Bonds: Access to Complex Fluoroalkylated Alkenes.” Angew. Chem. Int. Ed. 2019, 58, 1499.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201812927
45. J. Yu, S. Yang, Z. Wu, C. Zhu.* “Annulation of Benzylic Alcohols with Alkynes for Rapid and Efficient Synthesis of Indenes and Spiroindenes.” Chin. J. Org. Chem.(有机化学) 2019, 39, 223.
http://www.ccspublishing.org.cn/article/doi/10.6023/cjoc201808009
44. X. Wu, C. Zhu.* “Recent Advances in Radical-Mediated C-C Bond Fragmentation of Non-Strained Molecules.” Chin. J. Chem. 2019, 37, 171.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.201800455
43. N. Tang, S. Yang, X. Wu, C. Zhu.* “Visible-Light-Induced Carbosulfonylation of Unactivated Alkenes via Remote Heteroaryl and Oximino Migration.” Tetrahedron 2019, 75, 1639.
https://www.sciencedirect.com/science/article/pii/S0040402018314686?via%3Dihub
42. D. Chen, M. Ji, Y. Yao,* C. Zhu* “Difunctionalization of Unactivated Alkenes through SCF3 Radical-Triggered Distal Functional Group Migration.” Acta Chim. Sinica (化学学报) 2018, 76, 951.
http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A18080313
41. J. Yu, Z. Wu, C. Zhu.* “Efficient Docking–Migration Strategy for Selective Radical Difluoromethylation of Alkenes.” Angew. Chem. Int. Ed. 2018, 57, 17156.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201811346
40. X. Wu, H. Zhang, N. Tang, Z. Wu, D. Wang, M. Ji, Y. Xu, M. Wang, C. Zhu.* “Metal-Free Alcohol-Directed Regioselective Heteroarylation of Remote Unactivated C(sp3)-H Bonds.” Nat. Commun. 2018, 9, 3343.
39. D. Chen, Z. Wu, Y. Yao,* C. Zhu.* “Phosphinoyl-Functionalization of Unactivated Alkenes through Phosphinoyl Radical-Triggered Distal Functional Group Migration.” Org. Chem.Front. 2018, 5, 2370.
https://pubs.rsc.org/en/content/articlelanding/2018/QO/C8QO00558C#!divAbstract
38. D. Wang, J. Mao, C. Zhu.* “Visible Light-Promoted Ring-Opening Functionalization of Unstrained Cycloalkanols via Inert C-C Bond Scission.” Chem. Sci. 2018, 9, 5805
https://pubs.rsc.org/en/content/articlelanding/2018/SC/C8SC01763H#!divAbstract
.
37. M. Wang, Z. Wu, B. Zhang, C. Zhu.* “Azidoheteroarylation of Unactivated Olefins through Distal Heteroaryl Migration.” Org. Chem.Front. 2018, 5, 1896.
https://pubs.rsc.org/en/content/articlelanding/2018/QO/C8QO00301G#!divAbstract
36. M. Ji, J. Yu, C. Zhu.* “Cyanotrifluoromethylthiolation of Unactivated Dialkyl-Substituted Alkynes via Cyano Migration: Synthesis of Trifluoromethylthiolated Acrylonitrile.” Chem. Commun. 2018, 54, 6812.
https://pubs.rsc.org/en/content/articlelanding/2018/CC/C8CC01189C#!divAbstract
35. H. Zhang, X. Wu, Q. Zhao, C. Zhu.* “Copper-Catalyzed Heteroarylsilylation of Unactivated Olefins through Distal Heteroaryl Migration.” Chem. Asian J. 2018, 13, 2453.
https://onlinelibrary.wiley.com/doi/full/10.1002/asia.201800150
34. X. Wu, S. Wu, C. Zhu.* “Radical-Mediated Difunctionalization of Unactivated Alkenes through Distal Migration of Functional Groups.” Tetrahedron Lett. 2018, 59, 1328.
https://www.sciencedirect.com/science/article/pii/S0040403918302533?via%3Dihub
33. X. Wu, C. Zhu.* “Recent Advances in Ring-Opening Functionalization of Cycloalkanols by C-C σ-Bond Cleavage.” Chem. Rec. 2018, 18, 587.
https://onlinelibrary.wiley.com/doi/full/10.1002/tcr.201700090
32. X. Wu, M. Wang, L. Huan, D. Wang, J. Wang, C. Zhu.* “Tertiary-Alcohol-Directed Functionalization of Remote C(sp3)-H Bonds by Sequential Hydrogen Atom and Heteroaryl Migrations.” Angew. Chem. Int. Ed. 2018, 57, 1640.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201709025
31. J. Yu, D. Wang, Y. Xu, Z. Wu, C. Zhu.* “Distal Functional Group Migration for Visible-light Induced Carbo-difluoroalkylation/monofluoroalkylation of Unactivated Alkenes.” Adv. Synth. Catal. 2018, 360, 744.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201701229
30. W. Mao, C. Zhu.* “Rhodium-Catalyzed C-C Bond Olefination of Ring-Fused Benzocyclobutenols and Application in the Construction of Polycyclic Compounds.” Synlett. 2018, 29, 731.
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1590830
29. R. Ren, Z. Wu, L. Huan, C. Zhu.* “Synergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di- and Mono-Fluorinated Alkyl Nitriles.” Adv. Synth. Catal. 2017, 359, 3052.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201700591
28. W. Mao, C. Zhu.* “C-C Bond (Hetero)arylation of Ring-Fused Benzocyclobutenols and Application in the Assembly of Polycyclic Aromatic Hydrocarbons.” J. Org. Chem. 2017, 82, 9133.
https://pubs.acs.org/doi/10.1021/acs.joc.7b01727
27. M. Ji, Z. Wu, J. Yu, X. Wan,* C. Zhu.* “Cyanotrifluoromethylthiolation of Unactivated Olefins through Intramolecular Cyano Migration.” Adv. Synth. Catal. 2017, 359, 1959.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201700218
26. Y. Xu, Z. Wu, J. Jiang, Z. Ke, C. Zhu.* “Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins.” Angew. Chem. Int. Ed. 2017, 56, 4545.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201700413
25. W. Mao, C. Zhu.* “Efficient Synthesis of Multiply Substituted Butenolides from Keto Acids and Terminal Alkynes Promoted by Combined Acids.” Org. Chem. Front. 2017, 4, 1029.
https://pubs.rsc.org/en/content/articlelanding/2017/QO/C6QO00820H#!divAbstract
24. M. Wang, Z. Wu, C. Zhu.* “Ring-Opening Selenation of Cyclobutanols: Synthesis of γ-Selenylated Alkyl Ketones through C–C Bond Cleavage.” Org. Chem. Front. 2017, 4, 427.
https://pubs.rsc.org/en/content/articlelanding/2017/QO/C6QO00744A#!divAbstract
23. Z. Wu, D. Wang, Y. Liu, L. Huan, C. Zhu.* “Chemo- and Regioselective Distal Heteroaryl ipso-Migration: A General Protocol for Heteroarylation of Unactivated Alkenes.” J. Am. Chem. Soc. 2017, 139, 1388.
https://pubs.acs.org/doi/10.1021/jacs.6b11234
22. H. Yan, C. Zhu.* “Recent Advances in Radical-Mediated Fluorination through C–H and C–C Bond Cleavage.” Sci. China Chem. 2017, 60, 214.
https://link.springer.com/article/10.1007%2Fs11426-016-0399-5
21. L. Huan, C. Zhu.* “Manganese-Catalyzed Ring-Opening Chlorination of Cyclobutanols: Regiospecific Synthesis of γ-Chloroketones.” Org. Chem. Front. 2016, 3, 1467.
https://pubs.rsc.org/en/content/articlelanding/2016/QO/C6QO00443A#!divAbstract
20. Z. Wu, R. Ren, C. Zhu.* “Combination of a Cyano Migration Strategy and Alkene Difunctionalization: The Elusive Selective Azidocyanation of Unactivated Olefins.” Angew. Chem. Int. Ed. 2016, 55, 10821.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201605130
19. D. Wang, R. Ren, C. Zhu.* “Manganese-Promoted Ring-Opening Hydrazination of Cyclobutanols: Synthesis of Alkyl Hydrazines.” J. Org. Chem. 2016, 81, 8043.
https://pubs.acs.org/doi/10.1021/acs.joc.6b01433
18. R. Ren, Z. Wu, C. Zhu.* “Manganese-Catalyzed Regiospecific sp3 C–S Bond Formation through C–C Bond Cleavage of Cyclobutanols.” Chem. Commun. 2016, 52, 8160.
https://pubs.rsc.org/en/content/articlelanding/2016/CC/C6CC01843B#!divAbstract
17. W. Mao, C. Zhu.* “Synthesis of Highly Substituted γ-Hydroxybutenolides through the Annulation of Keto Acids with Alkynes and Subsequent Hydroxyl Transposition.” Chem. Commun. 2016, 52, 5269.
https://pubs.rsc.org/en/content/articlelanding/2016/CC/C6CC01554A#!divAbstract
16. R. Ren, C. Zhu.* “Radical-Mediated Ring-Opening Functionalization of Cyclobutanols: A Shortcut to γ-Substituted Ketones.” Synlett 2016, 27, 1139.
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0035-1561351
15. R. Ren, Z. Wu, Y. Xu, C. Zhu.* “C-C Bond-Forming Strategy by Manganese-Catalyzed Oxidative Ring-Opening Cyanation and Ethynylation of Cyclobutanol Derivatives.” Angew. Chem. Int. Ed. 2016, 55, 2866.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201510973
14. X. Fan, H. Zhao, J. Yu, X. Bao,* C. Zhu.* “Regiospecific Synthesis of Distally Chlorinated Ketones via C-C Bond Cleavage of Cycloalkanols.” Org. Chem. Front. 2016, 3, 227.
https://pubs.rsc.org/en/content/articlelanding/2016/QO/C5QO00368G#!divAbstract
13. H. Yan, C. Zhu.* “Ring Openings of tert-Cyclobutanols: New Strategy towards the Synthesis of γ-Substituted Ketones via C-C Bond Cleavage.” Prog. Chem. (化学进展) 2016, 28, 1.
http://manu56.magtech.com.cn/progchem/CN/abstract/abstract11664.shtml
12. J. Yu, H. Yan, C. Zhu* “Synthesis of Multiply Substituted Polycyclic Aromatic Hydrocarbons by Iridium-Catalyzed Annulation of Ring-Fused Benzocyclobutenol with Alkyne through C-C Bond Cleavage.” Angew. Chem. Int. Ed. 2016, 55, 1143.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201509973
11. X. Fan, H. Zhao, C. Zhu.* “Recent Advances in the Synthesis of Distal Fluorinated Ketones.” Acta Chim. Sinica (化学学报) 2015, 73, 979.
http://sioc-journal.cn/Jwk_hxxb/CN/abstract/abstract345211.shtml
10. W. Mao, C. Zhu.* “Synergistic Acid-Promoted Synthesis of Highly Substituted Butenolides via the Annulation of Keto Acids and Tertiary Alcohols.” Org. Lett. 2015, 17, 5710.
https://pubs.acs.org/doi/10.1021/acs.orglett.5b03026
9. R. Ren, H. Zhao, L. Huan, C. Zhu.* “Manganese-Catalyzed Oxidative Azidation of Cyclobutanols: Regiospecific Synthesis of Alkyl Azides by C-C Bond Cleavage.” Angew. Chem. Int. Ed. 2015, 54, 12692.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201506578
8. J. Yu, H. Zhao, S. Liang, X. Bao,* C. Zhu.* “A Facile and Regioselective Synthesis of 1-Tetralones via Silver-Catalyzed Ring Expansion.” Org. Biomol. Chem. 2015, 13, 7924.
https://pubs.rsc.org/en/content/articlelanding/2015/OB/C5OB01222H#!divAbstract
7. Z. Shen, Z. Xia, H. Zhao, J. Hu, X. Wan, Y. Lai,* C. Zhu,* W. Xie,* “Synthesis of Naked Amino-Pyrroloindoline via Direct Aminocyclization of Tryptamine.” Org. Biomol. Chem. 2015, 13, 5381.
https://pubs.rsc.org/en/content/articlelanding/2015/OB/C5OB00546A#!divAbstract
6. D. Shi, H.-T. Qin, C. Zhu,* F. Liu.* “Selectfluor–Bu4NI-Mediated C(sp3)–H Oxidation in Aqueous Media: Synthesis of Δ2-Isoxazolines from Oximes.” Eur. J. Org. Chem. 2015, 5084.
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201500780
5. H. Zhao, X. Fan, J. Yu, C. Zhu.* “Silver-Catalyzed Ring-Opening Strategy for the Synthesis of β- and γ-Fluorinated Ketones.” J. Am. Chem. Soc. 2015, 137, 3490.
https://pubs.acs.org/doi/10.1021/jacs.5b00939
4. C. Zhu, K. Saito, M. Yamanaka, T. Akiyama.* “Benzothiazoline: Versatile Hydrogen Donor for Organocatalytic Transfer Hydrogenation.” Acc. Chem. Res. 2015, 48, 388.
https://pubs.acs.org/doi/10.1021/ar500414x
3. K.-Y. Dong, H.-T. Qin, F. Liu,* C. Zhu.* “Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins.” Eur. J. Org. Chem. 2015, 1419.
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201403538
2. K.-Y. Dong, H.-T. Qin, X.-X. Bao, F. Liu,* C. Zhu.* “Oxime-Mediated Facile Access to 5-Methylisoxazoles and Applications in the Synthesis of Valdecoxib and Oxacillin.” Org. Lett. 2014, 16, 5266.
https://pubs.acs.org/doi/10.1021/ol502246t
1. C. Zhu,* J. R. Falck. “Transition Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives.” Adv. Synth. Catal. 2014, 356, 2395.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201400305
Before
22. J.-B. Xia, C. Zhu, C. Chen.* “Visible Light-Promoted Metal-Free sp3-C–H Fluorination.” Chem. Commun. 2014, 50, 11701.
21. C. Zhu, J.-B. Xia, C. Chen.* “A Simple Method for the Electrophilic Cyanation of Secondary Amines.” Org. Lett. 2014, 16, 247.
20. C. Zhu. J.-B. Xia, C. Chen.* “Vanadium-catalyzed Oxidative Strecker Reaction: α-C-H Cyanation of para-Methoxyphenyl (PMP)-protected Primary Amines.” Tetrahedron Lett. 2014, 55, 232.
19. J.-B. Xia, C. Zhu, C. Chen.* “Visible Light-Promoted Metal-Free C-H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination.” J. Am. Chem. Soc. 2013, 135, 17494-17500.
18. P. Bachu, C. Zhu, T. Akiyama.* “Molecular Iodine Catalyzed Transfer Hydrogenation: Reduction of Aldimines, Ketimines, and α-Imino Esters.” Tetrahedron Lett. 2013, 54, 3977.
17. C. Zhu, G. Li, D. H. Ess, J. R. Falck, L. Kurti.* “Elusive Metal-Free Primary Amination of Arylboronic Acids: Synthetic Studies and Mechanism by Density Functional Theory.” J. Am. Chem. Soc. 2012, 134, 18253. (Top 5 most read article in Nov. 2012; Highlighted in C& EN 2012, 90, 31; Highlighted in Angew. Chem. Int. Ed. 2013, 52, 5684; Highlighted by Organic Chemistry Portal)
16. C. Zhu,* J. R. Falck. “Rhodium Catalyzed Synthesis of Isoindolinones via C-H Activation of N-Benzoylsulfonamides.” Tetrahedron 2012, 68, 9192.
15. C. Zhu,* R. Wang, J. R. Falck. “Mild and Rapid Hydroxylation of Aryl/Heteroaryl Boronic Acids and Boronate Esters with N-Oxides.” Org. Lett. 2012, 14, 3494. (Highlighted by Organic Chemistry Portal)
14. C. Zhu,* R. Wang, J. R. Falck. “Amide-Directed Tandem C-C/C-N Bond Formation through C-H Activation.” Chem. Asian J. 2012, 7, 1502. (Focus Review, invited)
13. C. Zhu,* J. R. Falck. “Rhodium Catalyzed C-H Olefination of N-Benzoylsulfonamide with Internal Alkenes.” Chem. Commun. 2012, 48, 1674. (Top 10 most accessed article in Dec. 2011)
12. C. Zhu, T. Akiyama.* “Transfer Hydrogenation of Imines with Carboxyl-tailed Benzothiazoline as Readily Removable Hydrogen Donor.” Tetrahedron Lett. 2012, 53, 416.
11. C. Zhu,* J. R. Falck. “Benzothiazoline: The Surrogate of Hantzsch Ester.” ChemCatChem 2011, 3, 1850.
10. C. Zhu,* W. Xie, J. R. Falck. “Rhodium-Catalyzed Annulation ofN-Benzoylsulfonamide with Isocyanide through C-H Activation.” Chem. Eur. J. 2011, 17, 12591.
9. C. Zhu,* J. R. Falck. “Alternative Pathways for Heck Intermediates: Pd-catalyzed Oxy-arylation of Homoallylic Alcohols.” Angew. Chem. Int. Ed. 2011, 50, 6626.
8. C. Zhu,* J. R. Falck. “N-Acylsulfonamide Assisted Tandem C-H Olefination/ Annulation: Synthesis of Isoindolinones.” Org. Lett. 2011, 13, 1214.
7. C. Zhu, T. Akiyama.* “Brønsted Acid Catalyzed Reductive Amination with Benzothiazoline as a Highly Efficient Hydrogen Donor.” Synlett 2011, 1251. (Cluster, Invited)
6. C. Zhu, T. Akiyama.* “Enantioselective Organocatalytic Transfer Hydrogenation of α-Imino Esters by Utilization of Benzothiazoline as Highly Efficient Reducing Agent.” Adv. Synth. Catal. 2010, 352, 1846.
5. C. Zhu, T. Akiyama.* “One-Pot Tandem Approach for the Synthesis of Benzothiazoles from Benzyl Halides.” Synlett 2010, 2457. (Highlighted by Organic Chemistry Portal)
4. W.-Y. Lu, X.-W. Sun, C. Zhu, J.-H. Xu, G.-Q. Lin.* “Expanding the application scope of glycosidases using click chemistry.” Tetrahedron 2010, 66, 750.
3. C. Zhu, T. Akiyama.* “Benzothiazoline: Highly Efficient Reducing Agent for the Enantioselective Organocatalytic Transfer Hydrogenation of Ketimines.” Org. Lett. 2009, 11, 4180. (Highlighted by Synfacts 2009, 1282)
2. C. Zhu, Y. Shi, M.-H. Xu, G.-Q. Lin.* “An Efficient and Versatile Approach for Optical Resolution of C2-Symmetric Axially Chiral Biaryl Dials. Synthesis of Enantiopure Biaryl-Derived Cyclic trans-1,2-Diols.” Org. Lett. 2008, 10, 1243.
1. T. Tang, C. Zhu, P.-Q. Huang.* “A Flexible Approach to (S)-3-Amino-2-Pyrrolidinone Deritives.” Heterocycles, 2004, 64, 121.
1.博士后
有机化学专业或具有有机化学专业背景
2.博士研究生
有机化学专业
3.硕士研究生
热爱有机化学
欢迎各位同学报考苏州大学材化部朱晨课题组
个人简介
中文名：朱晨
苏州大学材料与化学化工学部，教授，博导，国家优青，江苏特聘教授。2003年厦门大学化学化工学院获学士学位。2008年中国科学院上海有机化学研究所获博士学位。2008年至2013年分别在日本东京学习院大学和美国德州大学西南医学研究中心进行博士后研究工作，2013年12月加入苏州大学，2014年入选江苏省特聘教授（考核优秀）和苏州市紧缺高层次人才。2015年获得美国化学会ACS Membership Award。2016年获得苏州市自然科学优秀学术论文一等奖。2017年获得国家自然科学基金优秀青年基金，同年获得ThiemeChemistry Journals Award。2018年获得江苏省教育教学与研究成果奖二等奖，苏州市自然科学优秀学术论文一等奖，苏州大学周氏教育科研奖，入选苏州市科教创新区高端人才集聚工程（科教骨干人才）。受邀担任《中国科学—化学》、《化学学报》、《高等学校化学学报》杂志编委。以通讯作者和第一作者发表学术论文70余篇，他引2000余次。在德国应用化学累计发表十余篇研究性论文并应邀发表个人 Author Profile。研究领域为自由基与过渡金属参与的惰性键官能化反应及其在药物分子和天然产物合成中的应用。
学习与工作经历
2013.12 苏州大学材料与化学化工学部，教授，博士生导师
2013.6-2013.11 美国德州大学西南医学研究中心，指导教授：Chuo Chen
2009.10-2013.5 美国德州大学西南医学研究中心，指导教授：J. R. Falck
2008.7-2009.9 日本东京学习院大学，美国德州大学西南医学研究中心进行博士后研究工作，指导教授：Takahiko Akiyama
2003.8-2008.7中国科学院上海有机化学研究所，获博士学位，指导教授：林国强
1999.8-2003.7 厦门大学，化学化工学院，获学士学位，指导教授：黄培强
Chen Zhu
Professor, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Email: chzhu@suda.edu.cn
Learning and Work Experience
Professional Experience
2013.12-current Professor, Soochow University, Suzhou, China
Education
2013.6-2013.11 Postdoctoral Fellow, The University of Texas Southwestern Medical Center, Dallas, Texas
Advisor: Chuo Chen
2009.10-2013.5 Postdoctoral Fellow, The University of Texas SouthwesternMedical Center, Dallas, Texas
Advisor: J. R. Falck
2008.7-2009.9 Postdoctoral Researcher, Gakushuin University, Tokyo, Japan
Advisor: Takahiko Akiyama
2003.8-2008.7 Ph. D. in Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China
Advisor: Guo-Qiang Lin
1999.8-2003.7 B. S. in Chemistry, Xiamen University, Xiamen, China
Advisor: Pei-Qiang Huang
https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.202010114
自由基与过渡金属参与的惰性键官能化反应及其在药物分子和天然产物合成中的应用.
自由基参与的远程官能团迁移反应研究
开环反应研究
扩环反应研究
Zhu Lab 留影
2021
2020
2019
教学工作
有机化学（研究生、本科生的实验及理论课程）
79. X. Wu, Z. Ma, T. Feng, C. Zhu* “Radical-mediated rearrangements: past, present, and future” Chem. Soc. Rev.2021, 50, 11577
https://pubs.rsc.org/en/content/articlelanding/2021/CS/D1CS00529D
78. Z. Cao, H. Zhang, X. Wu, Y. Li *, C. Zhu* “Radical heteroarylation of unactivated remote C(sp3)–H bonds via intramolecular heteroaryl migration” Org. Chem. Front. 2021, 50, 11577
https://pubs.rsc.org/en/Content/ArticleLanding/2021/QO/D1QO01209F#!divRelatedContent&articles
77. M. Ji, X. Wang, J. Liu, X. Wu, C. Zhu.* “Catalyst-free, radical-mediated intermolecular 1,2-arylheteroarylation of alkenes by cleaving inert C–C bond” Sci China Chem. 2021, 64, 1703
https://link.springer.com/article/10.1007%2Fs11426-021-1077-4
76. M. Ji, C. Chang, X. Wu, C. Zhu.* “Photocatalytic intermolecular carboarylation of alkenes by selective C–O bond cleavage of diarylethers” Chem. Commun. 2021, 57, 9240
https://pubs.rsc.org/en/Content/ArticleLanding/2021/CC/D1CC04038C
75. Y. Wei, H. Zhang, X. Wu, C. Zhu.* “Alkene Difunctionalization Triggered by a Stabilized Allenyl Radical: Concomitant Installation of Two Unsaturated C-C Bonds” Angew. Chem. Int. Ed. 2021, 60, 20215
https://onlinelibrary.wiley.com/doi/10.1002/anie.202106145
74. N. Tang, Y. Xu, T. Niu, S. Yang, H. Dong, X. Wu, C. Zhu.* “A Radical [3 + 2]-Cycloaddition Reaction for the Synthesis of Difluorocyclopentanones.” Org. Chem. Front. 2021, 8, 3118
https://pubs.rsc.org/en/content/articlelanding/2021/QO/D1QO00201E#!divAbstract
73. Y. Wei, Z. Chen, Z. Wu, Y. Xu, X. Wu, C. Zhu.* “Radical Carbosulfonylation of Propellane: Synthesis of Sulfonyl β-Ketobicyclo[1,1,1]pentanes.” Synthesis. 2021, 53, 3325
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1484-1028
72. J. Yu, H. Zhang, X. Wu, C. Zhu.* “Intermolecular Radical Fluoroalkylative Olefination of Unactivated Alkenes.” CCS Chem. 2021, 3, 1426
https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202100944
71. Z. Wu, Y. Xu, H. Zhang, X. Wu, C. Zhu.* “Radical-Mediated Sulfonyl Alkynylation, Allylation, and Cyanation of Propellane.” Chem. Commun. 2021, 57, 6066
https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC02249K#!divAbstract
70. H. Zhang, M. Wang, X. Wu, C. Zhu.* “Heterocyclization Reagents for Rapid Assembly of N-Fused Heteroarenes from Alkenes.” Angew. Chem. Int. Ed. 2021, 60, 3714. (Highlighted by Synfacts 2021, 60, 3714)
https://onlinelibrary.wiley.com/doi/10.1002/anie.202013089
69. T. Niu, S. Yang, X. Wu, C. Zhu.* “Remote C(sp3)–H Vinylation via Radical-Mediated Consecutive Fission of C–H and C–C Bonds.” Org. Chem. Front. 2020, 7, 2981.
https://pubs.rsc.org/en/content/articlelanding/2020/QO/D0QO00952K#!divAbstract
68. H. Zhang, M. Ji, Y. Wei, H. Chen, X. Wu, C. Zhu.* “Radical-Mediated Hetaryl Functionalization of Nonactivated Alkenes through Distal ipso-Migration of O- or S-Hetaryls.” Synlett 2021, 32, 401.
https://www.thiemeconnect.de/products/ejournals/abstract/10.1055/s-0040-1705968
67. Z. Wu, Y. Xu, X. Wu, C. Zhu.* “Synthesis of Selenoether and Thioether Functionalized Bicyclo[1.1.1]pentanes.” Tetrahedron 2020, 76, 131692.
https://www.sciencedirect.com/science/article/pii/S0040402020309054?via%3Dihub.
66. X. Shao, X. Wu, S. Wu, C. Zhu.* “Metal-Free Radical-Mediated C(sp3)-H Heteroarylation of Alkanes.” Org. Lett. 2020, 22, 7450.
https://pubs.acs.org/doi/10.1021/acs.orglett.0c02475
65. C. Zhu. “Author Profile.” Angew. Chem. Int. Ed. 2020, 59, 21279.
https://onlinelibrary.wiley.com/doi/10.1002/anie.202010114
64. H. Zhang, L. Kou, D. Chen, M. Ji, X. Bao,* X. Wu, C. Zhu.* “Radical-Mediated Distal Ipso-Migration of O/S Containing Heteroaryls and DFT Studies for Migratory Aptitude.” Org. Lett. 2020, 22, 5947.
https://pubs.acs.org/doi/10.1021/acs.orglett.0c02030.
63. X. Wu, C. Zhu.* “Radical-Mediated Remote Functional Group Migration.” Acc. Chem. Res. 2020, 53, 8, 1620.
https://pubs.acs.org/doi/10.1021/acs.accounts.0c00306
62. H. Zhang, M. Wang, X. Wu, C. Zhu.* “Radical-Mediated Bromoalkylation of [1.1.1] Propellane: Synthesis of Bromo-substituted Bicyclo[1.1.1]pentane (BCP) De-rivatives.” Chin. J. Org. Chem. 2020, 40, 3431.
http://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202005001
61. Z. Wu, Y. Xu, J. Liu, X. Wu, C. Zhu.* A “Practical Access to Fluoroalkylthio(seleno)Functionalizedbicyclo[1.1.1]pentanes.” Sci.China Chem. 2020, 63, 1025.
https://link.springer.com/article/10.1007%2Fs11426-020-9733-y
60. T. Niu, J. Liu, X.Wu, C. Zhu.* “Radical Heteroarylalkylation of Alkenes via Three‐Component Docking‐Migration Thioetheri-fication Cascade.” Chin. J. Chem. 2020, 38, 803.
https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202000088
59. J. Liu, S. Wu, J. Yu, C. Lu, Z. Wu, X. Wu, X.‐S. Xue, C. Zhu.* “Polarity Umpolung Strategy for the Radical Alkylation of Alkenes.” Angew. Chem. Int. Ed. 2020, 59, 8195. (Highlighted by Chin. J. Org. Chem.)
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915837
58. M. Wang, M. Li, S. Yang, X.-S. Xue,* X. Wu, C. Zhu.* “Radical-Mediated C-C Cleavage of Unstrained Cycloketone and DFTStudy for Unusual Regioselectivity.” Nat. Commun. 2020, 11, 672.
https://www.nature.com/articles/s41467-020-14435-5
57. M. Wang, H. Zhang, J. Liu, X. Wu, C. Zhu.* “Radical Monofluoroalkylative Alkynylation of Olefins by Docking-MigrationStrategy.” Angew. Chem. Int. Ed. 2019, 58, 17646.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201910514
56. N. Tang, X. Wu, C. Zhu.* “Practical, Metal-Free Remote Heteroarylation of Amides via Unactivated C(sp3)-HBondFunctionalization.” Chem. Sci. 2019, 10, 6915.
https://pubs.rsc.org/en/content/articlelanding/2019/SC/C9SC02564B#!divAbstract
55. H. Zhang, X. Wu, Y. Wei, C. Zhu.* “Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of FunctionalizedPolyenes.” Org. Lett. 2019, 21, 7568.
https://pubs.acs.org/doi/10.1021/acs.orglett.9b02838
54. S. Yang, X. Wu, S. Wu, C. Zhu.* “Regioselective Sulfonylvinylation of the Unactivated C(sp3)–H Bond via a C-Centered Radical-Mediated Hydrogen Atom Transfer (HAT) Process.” Org. Lett. 2019, 21, 4837.
https://pubs.acs.org/doi/10.1021/acs.orglett.9b01734
53. X. Wu, C. Zhu.* “Recent Advances in Alkoxy Radical-Promoted C-C and C-H Bond Functionalization Starting from FreeAlcohols.” Chem. Commun. 2019, 55, 9747.
https://pubs.rsc.org/en/Content/ArticleLanding/2019/CC/C9CC04785A#!divAbstract
52. S. Wu, X. Wu, Z. Wu, C. Zhu.* “Regioselective Introduction of Vinyl Trifluoromethylthioether to Remote Unactivated C(sp3)-HBonds via Radical Translocation Cascade.” Sci. China Chem. 2019, 62, 1507.
https://link.springer.com/article/10.1007%2Fs11426-019-9527-5
51. D. Chen, M. Ji, C. Zhu.* “Intramolecular Nitration-Aminocarbonylation of Unactivated Olefins: Metal-Free Synthesis of γ-Lactams.” Chem. Commun. 2019, 55, 7796.
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03736E#!divAbstract
50. N. Tang, X. Shao, M. Wang, X. Wu, C. Zhu.* “Sulfonyl Chlorides Mediated Alkynylation of Non-Activated Alkenes via Distal Alkynyl Group Migration.” Acta Chim. Sinica (化学学报) 2019, 77, 922.
http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A19050158
49. Y. Zhao, P. Wang, Y. Gao, C. Zhu,* W. Liu,* Y. Wang.* “Mechanistic Insights into Intermolecular Cyclization of Ring-Fused Benzocyclobutenols with Alkynes Catalyzed by [{Ir(OMe)COD}2].” Org. Chem. Front. 2019, 6, 791.
https://pubs.rsc.org/en/content/articlelanding/2019/QO/C8QO01371C#!divAbstract
48. M. Ji, Z. Wu, C. Zhu.* “Visible-Light-Induced Consecutive C-C Bond Fragmentation and Formation for the Synthesis of Elusive Unsymmetric 1,8-Dicarbonyl Compounds.” Chem. Commun. 2019, 55, 2368.
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC00378A#!divAbstract
47. M. Wang, L. Huan, C. Zhu.* “Cyanohydrin-Mediated Cyanation of Remote Unactivated C(sp3)-H Bonds.” Org. Lett. 2019, 21, 821.
https://pubs.acs.org/doi/10.1021/acs.orglett.8b04104
46. S. Wu, X. Wu, D. Wang, C. Zhu.* “Regioselective Vinylation of Remote Unactivated C(sp3)-H Bonds: Access to Complex Fluoroalkylated Alkenes.” Angew. Chem. Int. Ed. 2019, 58, 1499.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201812927
45. J. Yu, S. Yang, Z. Wu, C. Zhu.* “Annulation of Benzylic Alcohols with Alkynes for Rapid and Efficient Synthesis of Indenes and Spiroindenes.” Chin. J. Org. Chem.(有机化学) 2019, 39, 223.
http://www.ccspublishing.org.cn/article/doi/10.6023/cjoc201808009
44. X. Wu, C. Zhu.* “Recent Advances in Radical-Mediated C-C Bond Fragmentation of Non-Strained Molecules.” Chin. J. Chem. 2019, 37, 171.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.201800455
43. N. Tang, S. Yang, X. Wu, C. Zhu.* “Visible-Light-Induced Carbosulfonylation of Unactivated Alkenes via Remote Heteroaryl and Oximino Migration.” Tetrahedron 2019, 75, 1639.
https://www.sciencedirect.com/science/article/pii/S0040402018314686?via%3Dihub
42. D. Chen, M. Ji, Y. Yao,* C. Zhu* “Difunctionalization of Unactivated Alkenes through SCF3 Radical-Triggered Distal Functional Group Migration.” Acta Chim. Sinica (化学学报) 2018, 76, 951.
http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A18080313
41. J. Yu, Z. Wu, C. Zhu.* “Efficient Docking–Migration Strategy for Selective Radical Difluoromethylation of Alkenes.” Angew. Chem. Int. Ed. 2018, 57, 17156.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201811346
40. X. Wu, H. Zhang, N. Tang, Z. Wu, D. Wang, M. Ji, Y. Xu, M. Wang, C. Zhu.* “Metal-Free Alcohol-Directed Regioselective Heteroarylation of Remote Unactivated C(sp3)-H Bonds.” Nat. Commun. 2018, 9, 3343.
39. D. Chen, Z. Wu, Y. Yao,* C. Zhu.* “Phosphinoyl-Functionalization of Unactivated Alkenes through Phosphinoyl Radical-Triggered Distal Functional Group Migration.” Org. Chem.Front. 2018, 5, 2370.
https://pubs.rsc.org/en/content/articlelanding/2018/QO/C8QO00558C#!divAbstract
38. D. Wang, J. Mao, C. Zhu.* “Visible Light-Promoted Ring-Opening Functionalization of Unstrained Cycloalkanols via Inert C-C Bond Scission.” Chem. Sci. 2018, 9, 5805
https://pubs.rsc.org/en/content/articlelanding/2018/SC/C8SC01763H#!divAbstract
.
37. M. Wang, Z. Wu, B. Zhang, C. Zhu.* “Azidoheteroarylation of Unactivated Olefins through Distal Heteroaryl Migration.” Org. Chem.Front. 2018, 5, 1896.
https://pubs.rsc.org/en/content/articlelanding/2018/QO/C8QO00301G#!divAbstract
36. M. Ji, J. Yu, C. Zhu.* “Cyanotrifluoromethylthiolation of Unactivated Dialkyl-Substituted Alkynes via Cyano Migration: Synthesis of Trifluoromethylthiolated Acrylonitrile.” Chem. Commun. 2018, 54, 6812.
https://pubs.rsc.org/en/content/articlelanding/2018/CC/C8CC01189C#!divAbstract
35. H. Zhang, X. Wu, Q. Zhao, C. Zhu.* “Copper-Catalyzed Heteroarylsilylation of Unactivated Olefins through Distal Heteroaryl Migration.” Chem. Asian J. 2018, 13, 2453.
https://onlinelibrary.wiley.com/doi/full/10.1002/asia.201800150
34. X. Wu, S. Wu, C. Zhu.* “Radical-Mediated Difunctionalization of Unactivated Alkenes through Distal Migration of Functional Groups.” Tetrahedron Lett. 2018, 59, 1328.
https://www.sciencedirect.com/science/article/pii/S0040403918302533?via%3Dihub
33. X. Wu, C. Zhu.* “Recent Advances in Ring-Opening Functionalization of Cycloalkanols by C-C σ-Bond Cleavage.” Chem. Rec. 2018, 18, 587.
https://onlinelibrary.wiley.com/doi/full/10.1002/tcr.201700090
32. X. Wu, M. Wang, L. Huan, D. Wang, J. Wang, C. Zhu.* “Tertiary-Alcohol-Directed Functionalization of Remote C(sp3)-H Bonds by Sequential Hydrogen Atom and Heteroaryl Migrations.” Angew. Chem. Int. Ed. 2018, 57, 1640.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201709025
31. J. Yu, D. Wang, Y. Xu, Z. Wu, C. Zhu.* “Distal Functional Group Migration for Visible-light Induced Carbo-difluoroalkylation/monofluoroalkylation of Unactivated Alkenes.” Adv. Synth. Catal. 2018, 360, 744.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201701229
30. W. Mao, C. Zhu.* “Rhodium-Catalyzed C-C Bond Olefination of Ring-Fused Benzocyclobutenols and Application in the Construction of Polycyclic Compounds.” Synlett. 2018, 29, 731.
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1590830
29. R. Ren, Z. Wu, L. Huan, C. Zhu.* “Synergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di- and Mono-Fluorinated Alkyl Nitriles.” Adv. Synth. Catal. 2017, 359, 3052.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201700591
28. W. Mao, C. Zhu.* “C-C Bond (Hetero)arylation of Ring-Fused Benzocyclobutenols and Application in the Assembly of Polycyclic Aromatic Hydrocarbons.” J. Org. Chem. 2017, 82, 9133.
https://pubs.acs.org/doi/10.1021/acs.joc.7b01727
27. M. Ji, Z. Wu, J. Yu, X. Wan,* C. Zhu.* “Cyanotrifluoromethylthiolation of Unactivated Olefins through Intramolecular Cyano Migration.” Adv. Synth. Catal. 2017, 359, 1959.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201700218
26. Y. Xu, Z. Wu, J. Jiang, Z. Ke, C. Zhu.* “Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins.” Angew. Chem. Int. Ed. 2017, 56, 4545.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201700413
25. W. Mao, C. Zhu.* “Efficient Synthesis of Multiply Substituted Butenolides from Keto Acids and Terminal Alkynes Promoted by Combined Acids.” Org. Chem. Front. 2017, 4, 1029.
https://pubs.rsc.org/en/content/articlelanding/2017/QO/C6QO00820H#!divAbstract
24. M. Wang, Z. Wu, C. Zhu.* “Ring-Opening Selenation of Cyclobutanols: Synthesis of γ-Selenylated Alkyl Ketones through C–C Bond Cleavage.” Org. Chem. Front. 2017, 4, 427.
https://pubs.rsc.org/en/content/articlelanding/2017/QO/C6QO00744A#!divAbstract
23. Z. Wu, D. Wang, Y. Liu, L. Huan, C. Zhu.* “Chemo- and Regioselective Distal Heteroaryl ipso-Migration: A General Protocol for Heteroarylation of Unactivated Alkenes.” J. Am. Chem. Soc. 2017, 139, 1388.
https://pubs.acs.org/doi/10.1021/jacs.6b11234
22. H. Yan, C. Zhu.* “Recent Advances in Radical-Mediated Fluorination through C–H and C–C Bond Cleavage.” Sci. China Chem. 2017, 60, 214.
https://link.springer.com/article/10.1007%2Fs11426-016-0399-5
21. L. Huan, C. Zhu.* “Manganese-Catalyzed Ring-Opening Chlorination of Cyclobutanols: Regiospecific Synthesis of γ-Chloroketones.” Org. Chem. Front. 2016, 3, 1467.
https://pubs.rsc.org/en/content/articlelanding/2016/QO/C6QO00443A#!divAbstract
20. Z. Wu, R. Ren, C. Zhu.* “Combination of a Cyano Migration Strategy and Alkene Difunctionalization: The Elusive Selective Azidocyanation of Unactivated Olefins.” Angew. Chem. Int. Ed. 2016, 55, 10821.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201605130
19. D. Wang, R. Ren, C. Zhu.* “Manganese-Promoted Ring-Opening Hydrazination of Cyclobutanols: Synthesis of Alkyl Hydrazines.” J. Org. Chem. 2016, 81, 8043.
https://pubs.acs.org/doi/10.1021/acs.joc.6b01433
18. R. Ren, Z. Wu, C. Zhu.* “Manganese-Catalyzed Regiospecific sp3 C–S Bond Formation through C–C Bond Cleavage of Cyclobutanols.” Chem. Commun. 2016, 52, 8160.
https://pubs.rsc.org/en/content/articlelanding/2016/CC/C6CC01843B#!divAbstract
17. W. Mao, C. Zhu.* “Synthesis of Highly Substituted γ-Hydroxybutenolides through the Annulation of Keto Acids with Alkynes and Subsequent Hydroxyl Transposition.” Chem. Commun. 2016, 52, 5269.
https://pubs.rsc.org/en/content/articlelanding/2016/CC/C6CC01554A#!divAbstract
16. R. Ren, C. Zhu.* “Radical-Mediated Ring-Opening Functionalization of Cyclobutanols: A Shortcut to γ-Substituted Ketones.” Synlett 2016, 27, 1139.
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0035-1561351
15. R. Ren, Z. Wu, Y. Xu, C. Zhu.* “C-C Bond-Forming Strategy by Manganese-Catalyzed Oxidative Ring-Opening Cyanation and Ethynylation of Cyclobutanol Derivatives.” Angew. Chem. Int. Ed. 2016, 55, 2866.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201510973
14. X. Fan, H. Zhao, J. Yu, X. Bao,* C. Zhu.* “Regiospecific Synthesis of Distally Chlorinated Ketones via C-C Bond Cleavage of Cycloalkanols.” Org. Chem. Front. 2016, 3, 227.
https://pubs.rsc.org/en/content/articlelanding/2016/QO/C5QO00368G#!divAbstract
13. H. Yan, C. Zhu.* “Ring Openings of tert-Cyclobutanols: New Strategy towards the Synthesis of γ-Substituted Ketones via C-C Bond Cleavage.” Prog. Chem. (化学进展) 2016, 28, 1.
http://manu56.magtech.com.cn/progchem/CN/abstract/abstract11664.shtml
12. J. Yu, H. Yan, C. Zhu* “Synthesis of Multiply Substituted Polycyclic Aromatic Hydrocarbons by Iridium-Catalyzed Annulation of Ring-Fused Benzocyclobutenol with Alkyne through C-C Bond Cleavage.” Angew. Chem. Int. Ed. 2016, 55, 1143.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201509973
11. X. Fan, H. Zhao, C. Zhu.* “Recent Advances in the Synthesis of Distal Fluorinated Ketones.” Acta Chim. Sinica (化学学报) 2015, 73, 979.
http://sioc-journal.cn/Jwk_hxxb/CN/abstract/abstract345211.shtml
10. W. Mao, C. Zhu.* “Synergistic Acid-Promoted Synthesis of Highly Substituted Butenolides via the Annulation of Keto Acids and Tertiary Alcohols.” Org. Lett. 2015, 17, 5710.
https://pubs.acs.org/doi/10.1021/acs.orglett.5b03026
9. R. Ren, H. Zhao, L. Huan, C. Zhu.* “Manganese-Catalyzed Oxidative Azidation of Cyclobutanols: Regiospecific Synthesis of Alkyl Azides by C-C Bond Cleavage.” Angew. Chem. Int. Ed. 2015, 54, 12692.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201506578
8. J. Yu, H. Zhao, S. Liang, X. Bao,* C. Zhu.* “A Facile and Regioselective Synthesis of 1-Tetralones via Silver-Catalyzed Ring Expansion.” Org. Biomol. Chem. 2015, 13, 7924.
https://pubs.rsc.org/en/content/articlelanding/2015/OB/C5OB01222H#!divAbstract
7. Z. Shen, Z. Xia, H. Zhao, J. Hu, X. Wan, Y. Lai,* C. Zhu,* W. Xie,* “Synthesis of Naked Amino-Pyrroloindoline via Direct Aminocyclization of Tryptamine.” Org. Biomol. Chem. 2015, 13, 5381.
https://pubs.rsc.org/en/content/articlelanding/2015/OB/C5OB00546A#!divAbstract
6. D. Shi, H.-T. Qin, C. Zhu,* F. Liu.* “Selectfluor–Bu4NI-Mediated C(sp3)–H Oxidation in Aqueous Media: Synthesis of Δ2-Isoxazolines from Oximes.” Eur. J. Org. Chem. 2015, 5084.
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201500780
5. H. Zhao, X. Fan, J. Yu, C. Zhu.* “Silver-Catalyzed Ring-Opening Strategy for the Synthesis of β- and γ-Fluorinated Ketones.” J. Am. Chem. Soc. 2015, 137, 3490.
https://pubs.acs.org/doi/10.1021/jacs.5b00939
4. C. Zhu, K. Saito, M. Yamanaka, T. Akiyama.* “Benzothiazoline: Versatile Hydrogen Donor for Organocatalytic Transfer Hydrogenation.” Acc. Chem. Res. 2015, 48, 388.
https://pubs.acs.org/doi/10.1021/ar500414x
3. K.-Y. Dong, H.-T. Qin, F. Liu,* C. Zhu.* “Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins.” Eur. J. Org. Chem. 2015, 1419.
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201403538
2. K.-Y. Dong, H.-T. Qin, X.-X. Bao, F. Liu,* C. Zhu.* “Oxime-Mediated Facile Access to 5-Methylisoxazoles and Applications in the Synthesis of Valdecoxib and Oxacillin.” Org. Lett. 2014, 16, 5266.
https://pubs.acs.org/doi/10.1021/ol502246t
1. C. Zhu,* J. R. Falck. “Transition Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives.” Adv. Synth. Catal. 2014, 356, 2395.
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201400305
Before
22. J.-B. Xia, C. Zhu, C. Chen.* “Visible Light-Promoted Metal-Free sp3-C–H Fluorination.” Chem. Commun. 2014, 50, 11701.
21. C. Zhu, J.-B. Xia, C. Chen.* “A Simple Method for the Electrophilic Cyanation of Secondary Amines.” Org. Lett. 2014, 16, 247.
20. C. Zhu. J.-B. Xia, C. Chen.* “Vanadium-catalyzed Oxidative Strecker Reaction: α-C-H Cyanation of para-Methoxyphenyl (PMP)-protected Primary Amines.” Tetrahedron Lett. 2014, 55, 232.
19. J.-B. Xia, C. Zhu, C. Chen.* “Visible Light-Promoted Metal-Free C-H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination.” J. Am. Chem. Soc. 2013, 135, 17494-17500.
18. P. Bachu, C. Zhu, T. Akiyama.* “Molecular Iodine Catalyzed Transfer Hydrogenation: Reduction of Aldimines, Ketimines, and α-Imino Esters.” Tetrahedron Lett. 2013, 54, 3977.
17. C. Zhu, G. Li, D. H. Ess, J. R. Falck, L. Kurti.* “Elusive Metal-Free Primary Amination of Arylboronic Acids: Synthetic Studies and Mechanism by Density Functional Theory.” J. Am. Chem. Soc. 2012, 134, 18253. (Top 5 most read article in Nov. 2012; Highlighted in C& EN 2012, 90, 31; Highlighted in Angew. Chem. Int. Ed. 2013, 52, 5684; Highlighted by Organic Chemistry Portal)
16. C. Zhu,* J. R. Falck. “Rhodium Catalyzed Synthesis of Isoindolinones via C-H Activation of N-Benzoylsulfonamides.” Tetrahedron 2012, 68, 9192.
15. C. Zhu,* R. Wang, J. R. Falck. “Mild and Rapid Hydroxylation of Aryl/Heteroaryl Boronic Acids and Boronate Esters with N-Oxides.” Org. Lett. 2012, 14, 3494. (Highlighted by Organic Chemistry Portal)
14. C. Zhu,* R. Wang, J. R. Falck. “Amide-Directed Tandem C-C/C-N Bond Formation through C-H Activation.” Chem. Asian J. 2012, 7, 1502. (Focus Review, invited)
13. C. Zhu,* J. R. Falck. “Rhodium Catalyzed C-H Olefination of N-Benzoylsulfonamide with Internal Alkenes.” Chem. Commun. 2012, 48, 1674. (Top 10 most accessed article in Dec. 2011)
12. C. Zhu, T. Akiyama.* “Transfer Hydrogenation of Imines with Carboxyl-tailed Benzothiazoline as Readily Removable Hydrogen Donor.” Tetrahedron Lett. 2012, 53, 416.
11. C. Zhu,* J. R. Falck. “Benzothiazoline: The Surrogate of Hantzsch Ester.” ChemCatChem 2011, 3, 1850.
10. C. Zhu,* W. Xie, J. R. Falck. “Rhodium-Catalyzed Annulation ofN-Benzoylsulfonamide with Isocyanide through C-H Activation.” Chem. Eur. J. 2011, 17, 12591.
9. C. Zhu,* J. R. Falck. “Alternative Pathways for Heck Intermediates: Pd-catalyzed Oxy-arylation of Homoallylic Alcohols.” Angew. Chem. Int. Ed. 2011, 50, 6626.
8. C. Zhu,* J. R. Falck. “N-Acylsulfonamide Assisted Tandem C-H Olefination/ Annulation: Synthesis of Isoindolinones.” Org. Lett. 2011, 13, 1214.
7. C. Zhu, T. Akiyama.* “Brønsted Acid Catalyzed Reductive Amination with Benzothiazoline as a Highly Efficient Hydrogen Donor.” Synlett 2011, 1251. (Cluster, Invited)
6. C. Zhu, T. Akiyama.* “Enantioselective Organocatalytic Transfer Hydrogenation of α-Imino Esters by Utilization of Benzothiazoline as Highly Efficient Reducing Agent.” Adv. Synth. Catal. 2010, 352, 1846.
5. C. Zhu, T. Akiyama.* “One-Pot Tandem Approach for the Synthesis of Benzothiazoles from Benzyl Halides.” Synlett 2010, 2457. (Highlighted by Organic Chemistry Portal)
4. W.-Y. Lu, X.-W. Sun, C. Zhu, J.-H. Xu, G.-Q. Lin.* “Expanding the application scope of glycosidases using click chemistry.” Tetrahedron 2010, 66, 750.
3. C. Zhu, T. Akiyama.* “Benzothiazoline: Highly Efficient Reducing Agent for the Enantioselective Organocatalytic Transfer Hydrogenation of Ketimines.” Org. Lett. 2009, 11, 4180. (Highlighted by Synfacts 2009, 1282)
2. C. Zhu, Y. Shi, M.-H. Xu, G.-Q. Lin.* “An Efficient and Versatile Approach for Optical Resolution of C2-Symmetric Axially Chiral Biaryl Dials. Synthesis of Enantiopure Biaryl-Derived Cyclic trans-1,2-Diols.” Org. Lett. 2008, 10, 1243.
1. T. Tang, C. Zhu, P.-Q. Huang.* “A Flexible Approach to (S)-3-Amino-2-Pyrrolidinone Deritives.” Heterocycles, 2004, 64, 121.
1.博士后
有机化学专业或具有有机化学专业背景
2.博士研究生
有机化学专业
3.硕士研究生
热爱有机化学
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