安艳(1969.09-),女,回族,中共党员,辽宁省营口市人,研究员、博士生导师
1.学历
2002.04–2005.03 日本大学药学部博士研究生
1998.09–2001.07 吉林大学白求恩医学院博士研究生
1993.09–1996.07 中国辐射防护研究院环境医学研究所硕士研究生
1988.09–1993.07 山西医学院预防医学系 大学本科
2.工作经历和任职情况
2018.03 – 至今 日本大学药学部上席客员研究员
2008.07–至今 苏州大学医学部公共卫生学院 研究员 (2008.07起博导)
2005.04–2008.06 山东省医学科学院放射医学研究所研究员 (2005.07起硕导)
2002.04–2005.03 日本大学药学部日本文部科学省资助国费留学生
2000.09–2002.03 日本大学药学部外国人研究员
1998.09–1998.12 日本国放射线医学综合研究所日本科技厅科技交流访问学者
1996.08–2005.03 中国辐射防护研究院环境医学研究所助理研究员
3.社会兼职
[1] 教育部科研基金和科技奖励评审专家
[2] 教育部学位论文评审专家
[3] 教育部留学回国人员科研启动基金评审专家
[4] 科技部国际科技合作计划评审专家
[5] 中国博士后基金评审专家
[6] 山东省、江西省科技攻关计划项目评审专家
[7] 山东省、四川省、河北省、江西省科学技术奖励评审专家
[8]天津市、重庆市、浙江省、广东省、河北省自然科学基金评审专家
[9] 广东省高层次人才评审专家
[10] 2020- 江苏省预防医学会职业健康专业委员会 常委
[11] 2019- 亚洲砷与健康研究联盟 理事
[12] 2018- 苏州市伊斯兰教协会 副会长
[13] 2018- 江苏省毒理学会 监事
[14] 2017-中国生物物理学会自由基生物学与自由基医学分会 理事
[15] 2015- 江苏省毒理学会基础毒理学专业委员会 副主委
[16] 2015- 江苏省毒理学会 理事
[17] 2014- 中国环境诱变剂学会活性氧生物学效应专业委员会 委员
[19] 1996- 中国毒理学会 会员
[20] Chemico-Biological Interactions 审稿人(2021-)
[21] Biomedical and Environmental Sciences 审稿人(2021-)
[21]《环境化学》 审稿人(2021-)
[22] Environmental Toxicology 审稿人(2020-)
[23] Environmental Toxicology and Pharmacology 审稿人(2020-)
[24] Environmental Pollution 审稿人(2019-)
[25]《中华地方病学杂志》 编委(2016-)
[26] Toxicology Research 审稿人(2015-)
[27]《国外医学 医学地理学分册》 常务编委(2010-)
教育部科研基金和科技奖励评审专家
教育部学位论文评审专家
教育部留学回国人员科研启动基金评审专家
科技部国际科技合作计划评审专家
中国博士后基金会评审专家
山东省、江西省科技攻关计划项目评审专家
天津市、重庆市、浙江省、广东省、河北省自然科学基金评审专家
广东省高层次人才评审专家
2020- 江苏省预防医学会职业健康专业委员会 常委
2020- 中国环境诱变剂学会环境与神经退行性疾病专业委员会 委员
2019- 中华预防医学会卫生毒理学分会 委员
2019- 亚洲砷与健康研究联盟 理事
2018- 苏州市伊斯兰教协会 副会长
2018- 江苏省毒理学会 监事
2017- 中国生物物理学会自由基生物学与自由基医学分会 委员
2015- 江苏省毒理学会基础毒理学专业委员会 副主委
2015- 江苏省毒理学会 理事
2014- 中国环境诱变剂学会活性氧生物学效应专业委员会 委员
中国毒理学会会员
中国环境科学学会会员
Chemico-Biological Interactions 审稿人(2021-)
Biomedical and Environmental Sciences 审稿人(2021-)
《环境化学》审稿人(2021-)
Environmental Toxicology 审稿人(2020-)
Environmental Toxicology and Pharmacology 审稿人(2020-)
Environmental Pollution 审稿人(2019-)
《中华地方病学杂志》编委(2016-)
Toxicology Research 审稿人(2015-)
《国外医学 医学地理学分册》常务编委(2010-)
1. 环境毒理学
2. 职业毒理学
3. 放射医学/放射毒理学
诚邀对科研感兴趣的本科生、研究生(硕士、博士)和博士后加入我们课题组!
1. 博士后
公共卫生与预防医学博士后流动站化学致癌氧化还原调控方向
2. 学术型博士研究生招生专业(只招非定向脱产考生)
[1] 卫生毒理学(环境毒理学、职业毒理学方向)
3.学术型硕士研究生招生专业(只招非定向脱产考生)
[1] 卫生毒理学
4.专业硕士(只招非定向脱产考生)
[1] 公共卫生学(MPH)
截止2024年共毕业博士和硕士36名,历届招生情况:
朱小乐,2024级 学硕
贾浩奇,2023级 学硕
樊 越,2023级MPH(全日制)
赵 鑫,2023级MPH(全日制)
张梓瑶,2023级MPH(非全)
朱原慧,2022级 博士
陆 慧,2022级 学硕
王 榕,2022级MPH(全日制)
陈樱樱,2022级MPH(全日制)
陈志成,2022级MPH(全日制)
杨乾磊,2021级 博后
黄海茹,2021级 学硕
韩俊宇,2021级 MPH(全日制)
彭晓琨,2021级 MPH(全日制)
景 楠,2020级 学硕
张晓云,2020级 学硕
丁 洁,2020级 MPH(全日制)
严 鋭,2019级 博士
孔 齐,2019级 学硕
魏园杰,2019级 学硕
武 婧,2018级 博后
杨乾磊,2018级 博士
夏海璇,2018级 学硕
王鲁娜,2018级 MPH(全日制)
朱雪睿,2017级 MPH(全日制)
毛佳渊,2017级 学硕
刘纪廷,2016级 MPH(全日制)
严 鋭,2016级 学硕
倪一平,2015级 学硕;
李春春,2014级 硕士;
邓晗依,2014级 硕士;张恒东,2013级 博士;
王小娟,2013级 硕士;王大朋,2012级 博士;
马 园,2012级 硕士;许熙国,2011级 硕士;
莫岳妹,2011级 MPH;金洹宇,2010级 硕士;
刘 星,2010级 硕士;王大朋,2009级 硕士;
刘 建,2009级 硕士;李 贞,2006级 硕士;
近五年主持项目
1. 国家自然科学基金面上项目“砷致细胞恶性转化过程中转录因子Nrf2的作用及调控机制(No.81573173)”,2016.01-2019.12,主持。
2. 国家自然科学基金国际(地区)合作交流项目-合作交流NSFC—JSPS(中日)“砷致细胞恶性转化过程中二甲基化胂对转录因子Nrf2的作用研究(No.8171101410)”,2018.04-2021.03,主持。
3. 国家自然科学基金面上项目“砷致细胞恶性转化过程中-凋亡的调控机制No.81872646)”, 2019.01-2022.12,主
持。
4. 国家自然科学基金国际(地区)合作交流项目-出国(境)参加双(多)边会议NSFC—JSPS(中日),“无机
砷硫化甲基化代谢的毒理学意义 (No.82381240027)”,2023.04-2024.03,主持。
杨乾磊,讲师
严 鋭,2019级 博士
陈樱樱,2022级 专硕
贾浩奇,2023级 学硕
樊 越,2023级 专硕
赵 鑫,2023级 专硕
张梓瑶,2023级 专硕
朱小乐,2024级 学硕
封云霄,2025级 学硕
崔灵嫣,2025级 专硕
蔡嘉祎,2025级 专硕
承担教学任务
1. 研究生基础课程:卫生毒理学
2. 研究生选修课程:高级毒理学
3. 预防医学专业课:卫生毒理学(双语和全英文教学)
4. 全校公共选修课:环境与健康同行
5. 全校公共选修课:纳米世界
6. 新生研讨课:One Health—健康的新机遇
7. 新生研讨课:纳米世界漫谈
8. 新生研讨课:由毒至药:砷的两面性
1. 近年发表的主要论文(*通讯作者):
Publication list
ISI Researcher ID: http://www.researcherid.com/rid/K-8337-2016
ORCID iD https://orcid.org/0000-0003-2838-8169
Papers in ISI indexed journals
Year 2026
Xiumei Yang#; Xianmei Zhang#;Guojun Jian;Yuanhui Zhu;Hangyu Chen;Xiaoxi Mu;Jie Li;Bijin Zhu;Hui Lu;Yan An*;Tingxu Jin*. Environmental standard limit fluoride exposure prioritizes neurotoxicity over osteotoxicity in larval zebrafish: A benchmark dose analysis. Aquatic Toxicology. 2026,293,107749.
PMID: 41687530
DOI: 10.1016/j.aquatox.2026.107749
Qianlei Yang#; Xingrun Li#; Qi Kong#; Ting Zhang; Haixuan Xia; Rui Yan; Xiaoyun Zhang; Hui Lu; Zhuorong Du; Chen Zhao; Bohan Xu; Koichi Kato; Xiaoyan Zhong*; Yan An*. Mitophagy Dynamics Mediating Oxidative to Reductive Stress Shift for Potentiating Arsenite-induced Malignant Transformation Potential in Human Keratinocytes. Journal of Hazardous Materials. 2026,504,141315. (Top Journal)
PMID: 41653749
DOI: 10.1016/j.jhazmat.2026.141315
Haoqi Jia#; Nan Jing#; Zhaomin Zhong#; Xiaole Zhu; Tongbo Jin; Qianlei Yang; Yuanjie Wei; Yuanhui Zhu; Tingxu Jin; Lan Lan; Ying Mei; Huai Hu; Yufei Guo; Xiaoya Fu; Jiahe Yao; Chongke Zhong*; Yan An*. Association of Arsenic Exposure with Adverse Birth Outcomes: A Meta-Analysis and a benchmark dose analysis. Environmental Research. 2026, 291:123538.
PMID: 41386450
DOI: 10.1016/j.envres.2025.123538
Year 2025
Rujin Wang#;Xingrun Li#;Yuanjie Wei#; Tingxu Jin; Yuanhui Zhu; Ting Zhang; Rui Yan; Heran Li; Koichi Kato; Runa A; Qianlei Yang*; Yan An*. Impacts of arsenic exposure in drinking water on pigment disorders: A meta-analysis and a Bayesian benchmark concentration analysis. Journal of Trace Elements in Medicine and Biology.2025. 92, 127744.
中科院3区,JCR Q2.
IF= 3.3 (ISSN1878-3252).
PMID: 40946386
DOI: 10.1016/j.jtemb.2025.127744
Hao Wu#; Xiting Liao#; Wusixian Huang#; Huai Hu; Lan Lan; Qianlei Yang*; Yan An*. Examining the Prognostic and Clinicopathological Significance of GPX4 in Human Cancers: A Meta-analysis. Free Radical Research. 2025,1-11.
中科院3区,JCR Q2.
IF=3.6(ISSN1071-5762).
PMID: 40034003
DOI: 10.1080/10715762.2025.2475153
Year 2024
Tingxu Jin*, Xiumei Yang #, Yuanhui Zhu, Cheng Yan, Rui Yan, Qianlei Yang, Hairu Huang, Yan An*. Analysis of acute and short
term fluoride toxicity in zebrafish embryo and sac-fry stages based on Bayesian model averaging. Toxics. 2024,12(12):902.
IF=3.9(ISSN2305-6304).
PMID: 39771117
Qianlei Yang#; Ting Zhang#; Jian Liu#; Hui Lu; Chen Zhao; Chunchun Li; Koichi Kato; Dapeng Wang*; Yan An*. Sustained high expression of NRF2 inhibits cell apoptosis in arsenite-transformed human keratinocytes.Food and Chemical Toxicology.2024, 191:114875.
PMID: 39033872
DOI: 10.1016/j.fct.2024.114875
Yuanhui Zhu#; Qianlei Yang;#; Jie Gu; Zhicheng Chen; Nan Jing; Tingxu Jin; Jiayuan Lin; Xin Wang; Jingwen Hu; Guixiang Ji*; Yan An*. ‘Environmental standard limit concentration’ arsenic exposure is associated with anxiety, depression and autism-like changes in early-life stage zebrafish. Journal of Hazardous Material. 2024,469:133953.(Top Journal)
PMID: 38461670
DOI: 10.1016/j.jhazmat.2024.133953
Tingxu Jin#; Tongtong Huang#; Tianxue Zhang; Quan Li; Cheng Yan; Qian Wang; Xiufang Chen; Jing Zhou; Yitong Sun; Wenqing Bo; Ziqi Luo; Haodong Li; Yan An*. A Bayesian Benchmark Concentration Analysis for Urinary Fluoride and Intelligence in Adults in Guizhou, China. Science of The Total Environment. 2024:171326.(Top Journal)
PMID: 38460703
DOI: 10.1016/j.scitotenv.2024.171326
Before 2023
Qianlei Yang#; Yan Rui#; Jie Zhang#; Ting Zhang Aojun Ye; Xinghua Qiao; Koichi Kato;Chang Chen; Yan AN. Reductive Stress Induced by NRF2/G6PD through Glucose Metabolic Reprogramming Promotes to Malignant Transformation in Arsenite-Exposed Human Keratinocytes. Science of The Total Environment. 2023,896: 165207.(Top Journal)
PMID: 37391132
DOI: 10.1016/j.scitotenv.2023.165207
Rui Yan#; Jie Ding#;Xiaoyun Zhang; Tingxu Jin; Shudi Shi; Xirui Wang; Yu Zheng; Heran Li; Hengdong Zhang;
Yan AN. Lead acetate induces cartilage defects and bone loss in zebrafish embryos by disrupting the GH/IGF-1
axis.Ecotoxicology and Environmental Safety. 2023, 253:114666.(Top Journal)
PMID: 36812871
DOI: 10.1016/j.ecoenv.2023.114666
Qianlei Yang #; Rui Yan #; Yuemei Mo#; Haixuan Xia; Hanyi Deng; Xiaojuan Wang; Chunchun Li; Koichi Kato;
Hengdong Zhang; Tingxu Jing; Jie Zhang; Yan AN.The Potential Key Role of the NRF2/NQO1 Pathway in
the Health Effects of Arsenic Pollution on SCC. International Journal of Environmental Research and Public
Health. 2022, 19(13): 8118.
PMID: 35805773
Rui Yan#; Jie Ding#; Yuanjie Wei; Qianlei Yang; Xiaoyun Zhang; Hairu Huang; Zhuoyue Shi; Yue Feng; Heran Li;
Hengdong Zhang; Wenjun Ding; Yan AN. Melatonin prevents NaAsO2-induced developmental cardio-
toxicity in zebrafish through regulating oxidative stress and apoptosis. Antioxidants. 2022, 11(7): 1301.(Top Journal)
PMID: 35883792
Jie Ding; Rui Yan; Luna Wang; Qianlei Yang; Xiaoyun Zhang; Nan Jing; Yuanjie Wei; Hengdong Zhang; Yan AN. Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae. JoVE-Journal of Visualized Experiments.2021, 178: e63251.
PMID: 35037650
DOI: 10.3791/63251
Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang; Yasuyo Shimoda; Shasha Tao; Koichi Kato; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. Science of The Total Environment. 2021, 756: 143840. (Top Journal)
PMID: 33261869
DOI: 10.1016/j.scitotenv.2020.143840
Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 201: 110820. (Top Journal)
PMID: 32531574
DOI: 10.1016/j.ecoenv.2020.110820
Jiaoyuan Mao#; Qianlei Yang#; Makoto Miyazawa; Motofumi Miura; Luna Wanga; Haixuan Xiaa; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics. Journal of Trace Elements in Medicine and Biology. 2020, 61: 126544.
PMID: 32416464
DOI: 10.1016/j.jtemb.2020.126544
Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao; Yasuyo Shimoda; Xuerui Zhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang*; Kenzo Yamanaka*; Yan AN*. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes. Science of The Total Environment. 2020, 734: 139425. (Top Journal)
PMID: 32450402
DOI: 10.1016/j.scitotenv.2020.139425
Jing Wu#, Jie Zhang#, Jihua Nie#, Junchao Duan, Yanfeng Shi, Lin Feng, Xiaozhe Yang, Yan AN*, Zhiwei Sun*. The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicology Research. 2019, 8(5):731-740.
PMID: 31588350
DOI: 10.1039/c9tx00112c
Qianlei Yang#; Hanyi Deng#; Haixuan Xia#; Mengchuan Xu; Guotao Pan; Jiayuan Mao; Shasha Tao; Kenzo Yamanaka*; Yan AN*. High Nrf2 expression predicted poor prognosis in patients with lung cancer: A meta-analysis of cohort studies. Free Radical Research. 2019, 1-9.
PMID: 31298052
DOI:10.1080/10715762.2019.1642472
Qianlei Yang#; Zhen Zhu#; Luna Wang; Haixuan Xia; Xiaojuan Wang; Jing Wu; Koichi Kato; Heran Li; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. Environmental Toxicology and Pharmacology. 2019, 69:66-71.
PMID: 30959417
DOI:10.1016/j.etap.2019.04.001
Jing wu; Yiping Ni; Xiaojuan Wang; Qianlei Yang;Jiayuan Mao; Jian Tong; Jie Zhang*; Yan AN*. Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells. Journal of Toxicology and Environmental Health-part A.2019,82(18):990-996.
PMID: 31679505
DOI:10.1080/15287394.2019.1686108.
Jiting Liu; Li Zhang; Lixia Feng; Ming Xu; Yue Gao; Peng Zhou; Zhengmin Yu; Baoli Zhu; Yan AN*; Hengdong Zhang*. Association Between Single Nucleotide Polymorphism (rs4252424) in TRPV5 Calcium Channel Gene and Lead Poisoning in Chinese Workers. Molecular Genetics & Genomic Medicine. 2019; e562. https://doi. org/10.1002/mgg3.562 .
Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun,Wei Gong, Qiaoyun Zhang, Baoli Zhu, Yan An*. Association between Polymorphism of Exportin-5 andSusceptibility to Lead Poisoning in a Chinese Population. International Journal of Environmental Research and Public Health.2017, 14, 36.
Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang;Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; KenzoYamanaka; Jie Zhang*; Yan An*. Total Arsenic andSpeciation Analysis of Saliva and Urine Samples from Individuals Living inChronic Arsenicosis Area in China. EnvironmentalHealth and Preventive Medicine. 2017,22:45.
Xing Liu; Bin Sun;Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan AN*; Jian Tong*. Synergistic Effect of Radon and SodiumArsenite on DNA Damage in HBE Cells. EnvironmentalToxicology and Pharmacology. 2016,41: 127-131.
DOI:10.1016/j.etap.2015.11.013
Dapeng Wang; Yuan Ma; XuYang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; ChunchunLi; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan AN*. Hypermethylation of Keap1 Gene Inactivates Its Functionand Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced HumanKeratinocyte Transformation. Free RadicalBiology and Medicine. 2015, 89:209-219.(Top Journal)
DOI:10.1016/j.freeradbiomed.2015.07.153
Xu Yang, Dapeng Wang, Yuan Ma, Xiguo Xu, Yingying Zhao, Zhen Zhu, Xiaojuan Wang, Hanyi Deng, ChunchunLi, Fenfang Gao, Jian Tong, Kenzo Yamanaka, Yan AN*. Continuous Activation of Nrf2 and Its Target AntioxidantEnzymes Leads to Arsenite-Induced Malignant Transformation of Human BronchialEpithelial Cells. Toxicology and AppliedPharmacology. 2015, 289:231-239. (Top Journal)
DOI:10.1016/j.taap.2015.09.020
Huanyu Jin, Hua Yin,Yan AN*. The effect of gamma ray on thethermo-mechanical property of silk fibroin. ThermalScience. 2013, 17(5): 1521-1522.
Yan AN*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka*. Specific induction of oxidative stress in terminal bronchiolar Clara cellsduring dimethylarsenic-induced lung tumor promoting process in mice. Cancer Letters.2005,230(1): 57-64.(Top Journal)
DOI:10.1016/j.canlet.2004.12.029
Yan AN*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato,Masayuki Nakano, Shoji Okada, Kenzo Yamanaka*. Immunohistochemical analysis ofoxidative DNA damage in arsenic-related human skin samples fromarsenic-contaminated area of China. CancerLetters. 2004, 214(1): 11-18.(Top Journal)
DOI:10.1016/j.canlet.2004.04.005
2. 专利
发明专利
【1】Dimethylarsinous acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/088303】【Patent No.:US 12,461,090 B2】已授权
【2】Dimethylmonothioarsinic acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/077088】【US 2023-0159910 A1】
【3】二甲基亚胂酸谷氨酰胺复合物及其制备方法和应用【ZL2025107374530】已授权
【4】有机砷化合物DMMTAV及其制备方法和在制备治疗皮肤炎症药物中的应用【ZL2025107893937】已授权
【5】一种线粒体自噬抑制剂在制备治疗砷至细胞恶性转化的疾病药物中的应用【ZL2022107802224】已授权
【6】硫代二甲基胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021101095403】已授权
【7】二甲基亚胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021103053231】已授权
已转让(化)实用新型专利
【1】一种衣物脱水拧干装置【ZL2019218655379】
【2】一种细胞培养用孔位标记发光板【2025201550619】
3. 主(参)编著作
[1] 参编:《环境毒理学基础》,人民卫生出版社,2024年6月 第四版(ISBN 978-7-04-062198-3).
[2] 参编:《环境毒理学基础》,人民卫生出版社,2018年11月 第三版(ISBN 978-7-04-050623-5).
[3] 参编:《毒理学基础》,人民卫生出版社,2017年8月 第七版(ISBN 978-7-117-24633-0).
[4] 参编:《现代环境毒理学》,中国环境出版社,2015年12月 第一版(ISBN 978-7-5111-2381-7 ).
[5] 参编: 《毒理学试验方法与技术》,人民卫生出版社,2018年3月 第四版(ISBN 978-7-117-27879-9)
[6]主编:《国家污染物环境健康风险名录.生物分册》,中国环境出版社,2013年12月 第一次印刷(36万字, ISBN 978-7-5111-1678-9).
安艳(1969.09-),女,回族,中共党员,辽宁省营口市人,研究员、博士生导师
1.学历
2002.04–2005.03 日本大学药学部博士研究生
1998.09–2001.07 吉林大学白求恩医学院博士研究生
1993.09–1996.07 中国辐射防护研究院环境医学研究所硕士研究生
1988.09–1993.07 山西医学院预防医学系 大学本科
2.工作经历和任职情况
2018.03 – 至今 日本大学药学部上席客员研究员
2008.07–至今 苏州大学医学部公共卫生学院 研究员 (2008.07起博导)
2005.04–2008.06 山东省医学科学院放射医学研究所研究员 (2005.07起硕导)
2002.04–2005.03 日本大学药学部日本文部科学省资助国费留学生
2000.09–2002.03 日本大学药学部外国人研究员
1998.09–1998.12 日本国放射线医学综合研究所日本科技厅科技交流访问学者
1996.08–2005.03 中国辐射防护研究院环境医学研究所助理研究员
3.社会兼职
[1] 教育部科研基金和科技奖励评审专家
[2] 教育部学位论文评审专家
[3] 教育部留学回国人员科研启动基金评审专家
[4] 科技部国际科技合作计划评审专家
[5] 中国博士后基金评审专家
[6] 山东省、江西省科技攻关计划项目评审专家
[7] 山东省、四川省、河北省、江西省科学技术奖励评审专家
[8]天津市、重庆市、浙江省、广东省、河北省自然科学基金评审专家
[9] 广东省高层次人才评审专家
[10] 2020- 江苏省预防医学会职业健康专业委员会 常委
[11] 2019- 亚洲砷与健康研究联盟 理事
[12] 2018- 苏州市伊斯兰教协会 副会长
[13] 2018- 江苏省毒理学会 监事
[14] 2017-中国生物物理学会自由基生物学与自由基医学分会 理事
[15] 2015- 江苏省毒理学会基础毒理学专业委员会 副主委
[16] 2015- 江苏省毒理学会 理事
[17] 2014- 中国环境诱变剂学会活性氧生物学效应专业委员会 委员
[19] 1996- 中国毒理学会 会员
[20] Chemico-Biological Interactions 审稿人(2021-)
[21] Biomedical and Environmental Sciences 审稿人(2021-)
[21]《环境化学》 审稿人(2021-)
[22] Environmental Toxicology 审稿人(2020-)
[23] Environmental Toxicology and Pharmacology 审稿人(2020-)
[24] Environmental Pollution 审稿人(2019-)
[25]《中华地方病学杂志》 编委(2016-)
[26] Toxicology Research 审稿人(2015-)
[27]《国外医学 医学地理学分册》 常务编委(2010-)
教育部科研基金和科技奖励评审专家
教育部学位论文评审专家
教育部留学回国人员科研启动基金评审专家
科技部国际科技合作计划评审专家
中国博士后基金会评审专家
山东省、江西省科技攻关计划项目评审专家
天津市、重庆市、浙江省、广东省、河北省自然科学基金评审专家
广东省高层次人才评审专家
2020- 江苏省预防医学会职业健康专业委员会 常委
2020- 中国环境诱变剂学会环境与神经退行性疾病专业委员会 委员
2019- 中华预防医学会卫生毒理学分会 委员
2019- 亚洲砷与健康研究联盟 理事
2018- 苏州市伊斯兰教协会 副会长
2018- 江苏省毒理学会 监事
2017- 中国生物物理学会自由基生物学与自由基医学分会 委员
2015- 江苏省毒理学会基础毒理学专业委员会 副主委
2015- 江苏省毒理学会 理事
2014- 中国环境诱变剂学会活性氧生物学效应专业委员会 委员
中国毒理学会会员
中国环境科学学会会员
Chemico-Biological Interactions 审稿人(2021-)
Biomedical and Environmental Sciences 审稿人(2021-)
《环境化学》审稿人(2021-)
Environmental Toxicology 审稿人(2020-)
Environmental Toxicology and Pharmacology 审稿人(2020-)
Environmental Pollution 审稿人(2019-)
《中华地方病学杂志》编委(2016-)
Toxicology Research 审稿人(2015-)
《国外医学 医学地理学分册》常务编委(2010-)
1. 环境毒理学
2. 职业毒理学
3. 放射医学/放射毒理学
诚邀对科研感兴趣的本科生、研究生(硕士、博士)和博士后加入我们课题组!
1. 博士后
公共卫生与预防医学博士后流动站化学致癌氧化还原调控方向
2. 学术型博士研究生招生专业(只招非定向脱产考生)
[1] 卫生毒理学(环境毒理学、职业毒理学方向)
3.学术型硕士研究生招生专业(只招非定向脱产考生)
[1] 卫生毒理学
4.专业硕士(只招非定向脱产考生)
[1] 公共卫生学(MPH)
截止2024年共毕业博士和硕士36名,历届招生情况:
朱小乐,2024级 学硕
贾浩奇,2023级 学硕
樊 越,2023级MPH(全日制)
赵 鑫,2023级MPH(全日制)
张梓瑶,2023级MPH(非全)
朱原慧,2022级 博士
陆 慧,2022级 学硕
王 榕,2022级MPH(全日制)
陈樱樱,2022级MPH(全日制)
陈志成,2022级MPH(全日制)
杨乾磊,2021级 博后
黄海茹,2021级 学硕
韩俊宇,2021级 MPH(全日制)
彭晓琨,2021级 MPH(全日制)
景 楠,2020级 学硕
张晓云,2020级 学硕
丁 洁,2020级 MPH(全日制)
严 鋭,2019级 博士
孔 齐,2019级 学硕
魏园杰,2019级 学硕
武 婧,2018级 博后
杨乾磊,2018级 博士
夏海璇,2018级 学硕
王鲁娜,2018级 MPH(全日制)
朱雪睿,2017级 MPH(全日制)
毛佳渊,2017级 学硕
刘纪廷,2016级 MPH(全日制)
严 鋭,2016级 学硕
倪一平,2015级 学硕;
李春春,2014级 硕士;
邓晗依,2014级 硕士;张恒东,2013级 博士;
王小娟,2013级 硕士;王大朋,2012级 博士;
马 园,2012级 硕士;许熙国,2011级 硕士;
莫岳妹,2011级 MPH;金洹宇,2010级 硕士;
刘 星,2010级 硕士;王大朋,2009级 硕士;
刘 建,2009级 硕士;李 贞,2006级 硕士;
近五年主持项目
1. 国家自然科学基金面上项目“砷致细胞恶性转化过程中转录因子Nrf2的作用及调控机制(No.81573173)”,2016.01-2019.12,主持。
2. 国家自然科学基金国际(地区)合作交流项目-合作交流NSFC—JSPS(中日)“砷致细胞恶性转化过程中二甲基化胂对转录因子Nrf2的作用研究(No.8171101410)”,2018.04-2021.03,主持。
3. 国家自然科学基金面上项目“砷致细胞恶性转化过程中-凋亡的调控机制No.81872646)”, 2019.01-2022.12,主
持。
4. 国家自然科学基金国际(地区)合作交流项目-出国(境)参加双(多)边会议NSFC—JSPS(中日),“无机
砷硫化甲基化代谢的毒理学意义 (No.82381240027)”,2023.04-2024.03,主持。
杨乾磊,讲师
严 鋭,2019级 博士
陈樱樱,2022级 专硕
贾浩奇,2023级 学硕
樊 越,2023级 专硕
赵 鑫,2023级 专硕
张梓瑶,2023级 专硕
朱小乐,2024级 学硕
封云霄,2025级 学硕
崔灵嫣,2025级 专硕
蔡嘉祎,2025级 专硕
承担教学任务
1. 研究生基础课程:卫生毒理学
2. 研究生选修课程:高级毒理学
3. 预防医学专业课:卫生毒理学(双语和全英文教学)
4. 全校公共选修课:环境与健康同行
5. 全校公共选修课:纳米世界
6. 新生研讨课:One Health—健康的新机遇
7. 新生研讨课:纳米世界漫谈
8. 新生研讨课:由毒至药:砷的两面性
1. 近年发表的主要论文(*通讯作者):
Publication list
ISI Researcher ID: http://www.researcherid.com/rid/K-8337-2016
ORCID iD https://orcid.org/0000-0003-2838-8169
Papers in ISI indexed journals
Year 2026
Xiumei Yang#; Xianmei Zhang#;Guojun Jian;Yuanhui Zhu;Hangyu Chen;Xiaoxi Mu;Jie Li;Bijin Zhu;Hui Lu;Yan An*;Tingxu Jin*. Environmental standard limit fluoride exposure prioritizes neurotoxicity over osteotoxicity in larval zebrafish: A benchmark dose analysis. Aquatic Toxicology. 2026,293,107749.
PMID: 41687530
DOI: 10.1016/j.aquatox.2026.107749
Qianlei Yang#; Xingrun Li#; Qi Kong#; Ting Zhang; Haixuan Xia; Rui Yan; Xiaoyun Zhang; Hui Lu; Zhuorong Du; Chen Zhao; Bohan Xu; Koichi Kato; Xiaoyan Zhong*; Yan An*. Mitophagy Dynamics Mediating Oxidative to Reductive Stress Shift for Potentiating Arsenite-induced Malignant Transformation Potential in Human Keratinocytes. Journal of Hazardous Materials. 2026,504,141315. (Top Journal)
PMID: 41653749
DOI: 10.1016/j.jhazmat.2026.141315
Haoqi Jia#; Nan Jing#; Zhaomin Zhong#; Xiaole Zhu; Tongbo Jin; Qianlei Yang; Yuanjie Wei; Yuanhui Zhu; Tingxu Jin; Lan Lan; Ying Mei; Huai Hu; Yufei Guo; Xiaoya Fu; Jiahe Yao; Chongke Zhong*; Yan An*. Association of Arsenic Exposure with Adverse Birth Outcomes: A Meta-Analysis and a benchmark dose analysis. Environmental Research. 2026, 291:123538.
PMID: 41386450
DOI: 10.1016/j.envres.2025.123538
Year 2025
Rujin Wang#;Xingrun Li#;Yuanjie Wei#; Tingxu Jin; Yuanhui Zhu; Ting Zhang; Rui Yan; Heran Li; Koichi Kato; Runa A; Qianlei Yang*; Yan An*. Impacts of arsenic exposure in drinking water on pigment disorders: A meta-analysis and a Bayesian benchmark concentration analysis. Journal of Trace Elements in Medicine and Biology.2025. 92, 127744.
中科院3区,JCR Q2.
IF= 3.3 (ISSN1878-3252).
PMID: 40946386
DOI: 10.1016/j.jtemb.2025.127744
Hao Wu#; Xiting Liao#; Wusixian Huang#; Huai Hu; Lan Lan; Qianlei Yang*; Yan An*. Examining the Prognostic and Clinicopathological Significance of GPX4 in Human Cancers: A Meta-analysis. Free Radical Research. 2025,1-11.
中科院3区,JCR Q2.
IF=3.6(ISSN1071-5762).
PMID: 40034003
DOI: 10.1080/10715762.2025.2475153
Year 2024
Tingxu Jin*, Xiumei Yang #, Yuanhui Zhu, Cheng Yan, Rui Yan, Qianlei Yang, Hairu Huang, Yan An*. Analysis of acute and short
term fluoride toxicity in zebrafish embryo and sac-fry stages based on Bayesian model averaging. Toxics. 2024,12(12):902.
IF=3.9(ISSN2305-6304).
PMID: 39771117
Qianlei Yang#; Ting Zhang#; Jian Liu#; Hui Lu; Chen Zhao; Chunchun Li; Koichi Kato; Dapeng Wang*; Yan An*. Sustained high expression of NRF2 inhibits cell apoptosis in arsenite-transformed human keratinocytes.Food and Chemical Toxicology.2024, 191:114875.
PMID: 39033872
DOI: 10.1016/j.fct.2024.114875
Yuanhui Zhu#; Qianlei Yang;#; Jie Gu; Zhicheng Chen; Nan Jing; Tingxu Jin; Jiayuan Lin; Xin Wang; Jingwen Hu; Guixiang Ji*; Yan An*. ‘Environmental standard limit concentration’ arsenic exposure is associated with anxiety, depression and autism-like changes in early-life stage zebrafish. Journal of Hazardous Material. 2024,469:133953.(Top Journal)
PMID: 38461670
DOI: 10.1016/j.jhazmat.2024.133953
Tingxu Jin#; Tongtong Huang#; Tianxue Zhang; Quan Li; Cheng Yan; Qian Wang; Xiufang Chen; Jing Zhou; Yitong Sun; Wenqing Bo; Ziqi Luo; Haodong Li; Yan An*. A Bayesian Benchmark Concentration Analysis for Urinary Fluoride and Intelligence in Adults in Guizhou, China. Science of The Total Environment. 2024:171326.(Top Journal)
PMID: 38460703
DOI: 10.1016/j.scitotenv.2024.171326
Before 2023
Qianlei Yang#; Yan Rui#; Jie Zhang#; Ting Zhang Aojun Ye; Xinghua Qiao; Koichi Kato;Chang Chen; Yan AN. Reductive Stress Induced by NRF2/G6PD through Glucose Metabolic Reprogramming Promotes to Malignant Transformation in Arsenite-Exposed Human Keratinocytes. Science of The Total Environment. 2023,896: 165207.(Top Journal)
PMID: 37391132
DOI: 10.1016/j.scitotenv.2023.165207
Rui Yan#; Jie Ding#;Xiaoyun Zhang; Tingxu Jin; Shudi Shi; Xirui Wang; Yu Zheng; Heran Li; Hengdong Zhang;
Yan AN. Lead acetate induces cartilage defects and bone loss in zebrafish embryos by disrupting the GH/IGF-1
axis.Ecotoxicology and Environmental Safety. 2023, 253:114666.(Top Journal)
PMID: 36812871
DOI: 10.1016/j.ecoenv.2023.114666
Qianlei Yang #; Rui Yan #; Yuemei Mo#; Haixuan Xia; Hanyi Deng; Xiaojuan Wang; Chunchun Li; Koichi Kato;
Hengdong Zhang; Tingxu Jing; Jie Zhang; Yan AN.The Potential Key Role of the NRF2/NQO1 Pathway in
the Health Effects of Arsenic Pollution on SCC. International Journal of Environmental Research and Public
Health. 2022, 19(13): 8118.
PMID: 35805773
Rui Yan#; Jie Ding#; Yuanjie Wei; Qianlei Yang; Xiaoyun Zhang; Hairu Huang; Zhuoyue Shi; Yue Feng; Heran Li;
Hengdong Zhang; Wenjun Ding; Yan AN. Melatonin prevents NaAsO2-induced developmental cardio-
toxicity in zebrafish through regulating oxidative stress and apoptosis. Antioxidants. 2022, 11(7): 1301.(Top Journal)
PMID: 35883792
Jie Ding; Rui Yan; Luna Wang; Qianlei Yang; Xiaoyun Zhang; Nan Jing; Yuanjie Wei; Hengdong Zhang; Yan AN. Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae. JoVE-Journal of Visualized Experiments.2021, 178: e63251.
PMID: 35037650
DOI: 10.3791/63251
Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang; Yasuyo Shimoda; Shasha Tao; Koichi Kato; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. Science of The Total Environment. 2021, 756: 143840. (Top Journal)
PMID: 33261869
DOI: 10.1016/j.scitotenv.2020.143840
Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 201: 110820. (Top Journal)
PMID: 32531574
DOI: 10.1016/j.ecoenv.2020.110820
Jiaoyuan Mao#; Qianlei Yang#; Makoto Miyazawa; Motofumi Miura; Luna Wanga; Haixuan Xiaa; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics. Journal of Trace Elements in Medicine and Biology. 2020, 61: 126544.
PMID: 32416464
DOI: 10.1016/j.jtemb.2020.126544
Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao; Yasuyo Shimoda; Xuerui Zhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang*; Kenzo Yamanaka*; Yan AN*. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes. Science of The Total Environment. 2020, 734: 139425. (Top Journal)
PMID: 32450402
DOI: 10.1016/j.scitotenv.2020.139425
Jing Wu#, Jie Zhang#, Jihua Nie#, Junchao Duan, Yanfeng Shi, Lin Feng, Xiaozhe Yang, Yan AN*, Zhiwei Sun*. The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicology Research. 2019, 8(5):731-740.
PMID: 31588350
DOI: 10.1039/c9tx00112c
Qianlei Yang#; Hanyi Deng#; Haixuan Xia#; Mengchuan Xu; Guotao Pan; Jiayuan Mao; Shasha Tao; Kenzo Yamanaka*; Yan AN*. High Nrf2 expression predicted poor prognosis in patients with lung cancer: A meta-analysis of cohort studies. Free Radical Research. 2019, 1-9.
PMID: 31298052
DOI:10.1080/10715762.2019.1642472
Qianlei Yang#; Zhen Zhu#; Luna Wang; Haixuan Xia; Xiaojuan Wang; Jing Wu; Koichi Kato; Heran Li; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. Environmental Toxicology and Pharmacology. 2019, 69:66-71.
PMID: 30959417
DOI:10.1016/j.etap.2019.04.001
Jing wu; Yiping Ni; Xiaojuan Wang; Qianlei Yang;Jiayuan Mao; Jian Tong; Jie Zhang*; Yan AN*. Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells. Journal of Toxicology and Environmental Health-part A.2019,82(18):990-996.
PMID: 31679505
DOI:10.1080/15287394.2019.1686108.
Jiting Liu; Li Zhang; Lixia Feng; Ming Xu; Yue Gao; Peng Zhou; Zhengmin Yu; Baoli Zhu; Yan AN*; Hengdong Zhang*. Association Between Single Nucleotide Polymorphism (rs4252424) in TRPV5 Calcium Channel Gene and Lead Poisoning in Chinese Workers. Molecular Genetics & Genomic Medicine. 2019; e562. https://doi. org/10.1002/mgg3.562 .
Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun,Wei Gong, Qiaoyun Zhang, Baoli Zhu, Yan An*. Association between Polymorphism of Exportin-5 andSusceptibility to Lead Poisoning in a Chinese Population. International Journal of Environmental Research and Public Health.2017, 14, 36.
Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang;Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; KenzoYamanaka; Jie Zhang*; Yan An*. Total Arsenic andSpeciation Analysis of Saliva and Urine Samples from Individuals Living inChronic Arsenicosis Area in China. EnvironmentalHealth and Preventive Medicine. 2017,22:45.
Xing Liu; Bin Sun;Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan AN*; Jian Tong*. Synergistic Effect of Radon and SodiumArsenite on DNA Damage in HBE Cells. EnvironmentalToxicology and Pharmacology. 2016,41: 127-131.
DOI:10.1016/j.etap.2015.11.013
Dapeng Wang; Yuan Ma; XuYang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; ChunchunLi; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan AN*. Hypermethylation of Keap1 Gene Inactivates Its Functionand Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced HumanKeratinocyte Transformation. Free RadicalBiology and Medicine. 2015, 89:209-219.(Top Journal)
DOI:10.1016/j.freeradbiomed.2015.07.153
Xu Yang, Dapeng Wang, Yuan Ma, Xiguo Xu, Yingying Zhao, Zhen Zhu, Xiaojuan Wang, Hanyi Deng, ChunchunLi, Fenfang Gao, Jian Tong, Kenzo Yamanaka, Yan AN*. Continuous Activation of Nrf2 and Its Target AntioxidantEnzymes Leads to Arsenite-Induced Malignant Transformation of Human BronchialEpithelial Cells. Toxicology and AppliedPharmacology. 2015, 289:231-239. (Top Journal)
DOI:10.1016/j.taap.2015.09.020
Huanyu Jin, Hua Yin,Yan AN*. The effect of gamma ray on thethermo-mechanical property of silk fibroin. ThermalScience. 2013, 17(5): 1521-1522.
Yan AN*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka*. Specific induction of oxidative stress in terminal bronchiolar Clara cellsduring dimethylarsenic-induced lung tumor promoting process in mice. Cancer Letters.2005,230(1): 57-64.(Top Journal)
DOI:10.1016/j.canlet.2004.12.029
Yan AN*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato,Masayuki Nakano, Shoji Okada, Kenzo Yamanaka*. Immunohistochemical analysis ofoxidative DNA damage in arsenic-related human skin samples fromarsenic-contaminated area of China. CancerLetters. 2004, 214(1): 11-18.(Top Journal)
DOI:10.1016/j.canlet.2004.04.005
2. 专利
发明专利
【1】Dimethylarsinous acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/088303】【Patent No.:US 12,461,090 B2】已授权
【2】Dimethylmonothioarsinic acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/077088】【US 2023-0159910 A1】
【3】二甲基亚胂酸谷氨酰胺复合物及其制备方法和应用【ZL2025107374530】已授权
【4】有机砷化合物DMMTAV及其制备方法和在制备治疗皮肤炎症药物中的应用【ZL2025107893937】已授权
【5】一种线粒体自噬抑制剂在制备治疗砷至细胞恶性转化的疾病药物中的应用【ZL2022107802224】已授权
【6】硫代二甲基胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021101095403】已授权
【7】二甲基亚胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021103053231】已授权
已转让(化)实用新型专利
【1】一种衣物脱水拧干装置【ZL2019218655379】
【2】一种细胞培养用孔位标记发光板【2025201550619】
3. 主(参)编著作
[1] 参编:《环境毒理学基础》,人民卫生出版社,2024年6月 第四版(ISBN 978-7-04-062198-3).
[2] 参编:《环境毒理学基础》,人民卫生出版社,2018年11月 第三版(ISBN 978-7-04-050623-5).
[3] 参编:《毒理学基础》,人民卫生出版社,2017年8月 第七版(ISBN 978-7-117-24633-0).
[4] 参编:《现代环境毒理学》,中国环境出版社,2015年12月 第一版(ISBN 978-7-5111-2381-7 ).
[5] 参编: 《毒理学试验方法与技术》,人民卫生出版社,2018年3月 第四版(ISBN 978-7-117-27879-9)
[6]主编:《国家污染物环境健康风险名录.生物分册》,中国环境出版社,2013年12月 第一次印刷(36万字, ISBN 978-7-5111-1678-9).
