严文颖，博士，副教授。2008年和2013年分别于苏州大学获得信息与计算科学理学学士和系统生物学理学博士学位，期间于2011年到2012年间国家公派访问芬兰奥卢大学。2013年至2016年间苏州大学附属第一医院从事博士后研究。2016年起入职苏州大学。目前在Briefings in Bioinformatics、Journal of Chemical Information and Modeling、Clinical and Translational Medicine、Journal of Translational Medicine、Journal of Experimental & Clinical Cancer Research等信息学和转化医学相关的 SCI 杂志上发表论文50余篇，其中第一和通讯作者论文28篇，获得授权发明专利5项，软件著作权6项，以第一副主编的身份参与撰写专著及教材2本。主持完成国家自然科学基金青年项目1 项、参与完成国家自然科学基金项目5项，作为骨干参与完成江苏省重点研发计划（社会发展）项目1项。目前为中国生物信息学学会转化信息学与数据共享安全专委会委员、江苏省医学会医学信息学分会委员。
生物信息学、系统生物学、医学信息学
主要从事生物医学多模态数据的融合分析并基于此构建人工智能模型，特别是多尺度生物网络模型的构建、分析与应用，尝试从分子、细胞、表型等刻画并预测癌症（特别是胃癌）的发生发展，为理解癌症的演变机制、生物标志物的识别、癌症的诊疗等提供理论指导。
科研项目==============================================================================================================================
国家自然科学基金青年基金，基于氨基酸接触能网络的蛋白质结合位点分析，19万，2017-2019，主持
江苏省重点研发计划，基于人工智能算法的胃癌早期诊断及发展预警模型的构建及应用，200万，2020-2023，骨干
1、生物信息学算法，2019年至今
2、生物信息学导论，2021年至今
3、Biopython，2019年
二、研究生课程
1、医学生物信息学，2022年至今
2、R语言基础，2019年
3、Python/Biopython编程，2019年
三、教材及专著
1、沈百荣、黄健主编，严文颖、郭天南、陈佳佳、邓成副主编《蛋白质组信息学》，2023，科学出版社，ISBN：9787030765185，科学出版社“十四五”普通高等教育本科规划教材
2、沈百荣主编，严文颖、张文宇、钱福良、林宇鑫副主编，《深度测序数据的生物信息学分析及实例》，2017，科学出版社，ISBN：9787030545800
l Yang Yang, Zixuan Zheng, Yuyang Xu, Huifang Wei, Wenying Yan, BioGSF: a graph-driven semantic feature integration framework for biomedical relation extraction. Briefings in Bioinformatics, 2025, 26(1):bbaf025.(中科院大类二区，通讯作者)
l Hubo Yang, Xuefeng Zhang, Zongming Jia, He Wang, Jixiang Wu, Xuedong Wei, Yuhua Huang, Wenying Yan, Yuxin Lin. Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives. Journal of Translational Medicine, 2025, 23(1):166 (中科院大类二区，通讯作者)
l Yang Yang, Yuwei Lu, Zixuan Zheng, Hao Wu, Yuxin Lin, Fuliang Qian, Wenying Yan. MKG-GC: A multi-task learning-based knowledge graph construction framework with personalized application to gastric cancer. Computational and Structural Biotechnology Journal, 2024, 23:1339–1347. (中科院大类二区，通讯作者)
l Jiayu Wang , Huan Zhang, Juntao Li, Xiangyu Ni, Wenying Yan, Yueqiu Chen, Tongguo Shi. Exosome-derived proteins in gastric cancer progression, drug resistance, and immune response. Cellular Molecular Biology Letters, 2024, 29(1) (中科院大类一区，共同通讯作者）
l Wenying Yan; Wentao Hu; Yidan Song; Xingyi Liu; Ziyun Zhou; Wanshi Li; Zhifei Cao; Weiwei Pei; Guangming Zhou; Guang Hu. Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation. Molecular Therapy - Nucleic Acids, 2024, 35(3): 102260 (中科院大类二区，第一作者）
l Jiahao Kuang; Zhihong Zhao; Yang Yang; Wenying Yan. PON-Tm: A sequence-based method for prediction of missense mutation effects on protein thermal stability changes. International Journal of Molecular Sciences, 2024, 25(15): 8379 (中科院大类二区，通讯作者）
l Wenying Yan; Yuqi Chen; Guang Hu; Tongguo Shi; Xingyi Liu; Juntao Li; Linqing Sun; Fuliang Qian; Weichang Chen. MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey. Journal of Translational Medicine, 2023, 21(1) (中科院大类二区，第一作者&共同通讯)
l Yuqi Chen; Wenying Yan; Kexi Yang; Yiting Qian; Yanjun Chen; Ruoqin Wang; Jinghan Zhu; Yuxin He; Hongya Wu; Guangbo Zhang; Tongguo Shi; Weichang Chen. Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer. Journal of Experimental & Clinical Cancer Research, 2023, 42(1) (中科院大类一区，并列第一作者)
l Xingyi Liu; Bin Yang; Xinpeng Huang; Wenying Yan; Yujuan Zhang; Guang Hu. Identifying lymph node metastasis-related factors in breast cancer using differential modular and mutational structural analysis. Interdisciplinary Sciences: Computational Life Sciences, 2023, (中科院大类三区，共同通讯作者)
l Yang Yang; Yuwei Lu; Wenying Yan. A comprehensive review on knowledge graphs for complex diseases. Briefings in Bioinformatics, 2023, 24(1) (中科院大类二区，通讯作者)
l Lianjie Zeng; Yitan Lu; Wenying Yan; Yang Yang. A protein co-conservation network model characterizes mutation effects on SARS-CoV-2 spike protein. International Journal of Molecular Sciences, 2023, 24(4): 3255 (中科院大类二区，共同通讯作者)
l Jianjun Zhao; Wenying Yan; Yang Yang. DeepTP: A deep learning model for thermophilic protein prediction. International Journal of Molecular Sciences, 2023, 24(3): 2217 (中科院大类二区，共同通讯作者)
l Wanshi Li, Yongduo Yu, Guangming Zhou, Guang Hu, Bingyan Li, Hong Ma, Wenying Yan, Hailong Pei. Large-scale ORF screening based on LC-MS to discover novel lncRNA-encoded peptides responding to ionizing radiation and microgravity. Computational and Structural Biotechnology Journal. 2023, 21: 5201-5211. (中科院大类二区，共同通讯作者)
l Wenying Yan; Guang Hu. Structural biology meets biomolecular networks: The post-alphafold era. Current Bioinformatics, 2022, 17(6). (中科院大类四区，第一作者)
l Fan Wang; Shuqing Han; Ji Yang; Wenying Yan; Guang Hu .knowledge-guided “community network” analysis reveals the functional modules and candidate targets in non-small-cell lung cancer. Cells, 2021, 10(2): 402. (中科院大类二区，共同通讯作者)
l Ji Yang; Hongchun Li; Fan Wang; Fei Xiao; Wenying Yan; Guang Hu. Network-based target prioritization and drug candidate identification for multiple sclerosis: From analyzing “omics data” to druggability simulations. ACS Chemical Neuroscience, 2021, 12(5): 917-929. (中科院大类二区，共同通讯作者)
l Yipeng Du; Xiaoting Li; Wenying Yan; Zhaohua Zeng; Dunzheng Han; Hong Ouyang; Xiudi Pan; Bihui Luo; Bohua Zhou; Qiang Fu; Dongfeng Lu; Zheng Huang; Zhiliang Li. Deciphering the in vivo dynamic proteomics of mesenchymal stem cells in critical limb ischemia. Frontiers in Cell and Developmental Biology, 2021, 9 (中科院大类二区，并列第一作者)
l Yuqi Chen; Huang Feng; Yanlin Wu; Ruoqin Wang; Zhaoji Li; Jiajia Chen; Wenying Yan; Weichang Chen. Evaluation of plasma exosomal microRNAs as circulating biomarkers for progression and metastasis of gastric cancer. Clinical and Translational Medicine, 2020, 10(6). (中科院大类一区，共同通讯作者)
l Wenying Yan; Xingyi Liu; Yibo Wang; Shuqing Han; Fan Wang; Xin Liu; Fei Xiao; Guang Hu. Identifying drug targets in pancreatic ductal adenocarcinoma through machine learning, analyzing biomolecular networks, and structural modeling. Frontiers in Pharmacology, 2020, 11: 0-534. (中科院大类二区，第一作者)
l Wenying Yan; Chunjiang Yu; Jiajia Chen; Jianhong Zhou; Bairong Shen. ANCA: A web server for amino acid networks construction and analysis. Frontiers in Molecular Biosciences, 2020, 7: 582702. (中科院大类二区，第一作者)
l Xiujun Duan; Lihua Wang; Guobo Sun; Wenying Yan; Yang Yang. Understanding the cross-talk between host and virus in poultry from the perspectives of microRNA. Poultry Science, 2020, 99(4): 1838-1846. (中科院大类二区，共同通讯作者)
l Wenying Yan; Guang Hu; Zhongjie Liang; Jianhong Zhou; Yang Yang; Jiajia Chen; Bairong Shen. Node-Weighted amino acid network strategy for characterization and identification of protein functional residues. Journal of Chemical Information and Modeling, 2018, 58(9): 2024-2032. (中科院大类二区，第一作者，
JCIM封面论文)
l Wenying Yan; Daqing Zhang; Chen Shen; Zhongjie Liang; Guang Hu. Recent Advances on the Network Models in Target-based Drug Discovery.Current Topics in Medicinal Chemistry, 2018, 18(13): 1031-1043.(中科院大类四区，第一作者)
l Wenying Yan; Guang Hu; Bairong Shen. Network analysis of protein structures: the comparison of three topologies.. Current Bioinformatics, 2016, 11(4): 480-489. (中科院大类三区，第一作者)
l Wenying Yan; Laijun Qian; Jiajia Chen; Weichang Chen; Bairong Shen. Comparison of prognostic microrna biomarkers in blood and tissues for gastric cancer.Journal of Cancer, 2016, 7(1): 95-106. (中科院大类三区，第一作者)
l Wenying Yan, Wenjin Xue, Jiajia Chen, Guang Hu. Biological networks for cancer candidate biomarkers discovery. Cancer Informatics. 2016;15:1-7. (大类二区，第一作者)
l Wenying Yan; Maomin Sun; Guang Hu; Jianhong Zhou; Wenyu Zhang; Jiajia Chen; Biao Chen; Bairong Shen. Amino acid contact energy networks impact protein structure and evolution.Journal of Theoretical Biology, 2014, 355: 95-104. (中科院大类三区，第一作者)
l Wenying Yan; Jianhong Zhou; Maomin Sun; Jiajia Chen; Guang Hu; Bairong Shen. The construction of an amino acid network for understanding protein structure and function.Amino Acids, 2014, 46(6): 1419-1439. (中科院大类三区，第一作者)
l Jianhong Zhou; Wenying Yan; Guang Hu; Bairong Shen. SVR_CAF: an integrated score function for detecting native protein structures among decoys. Proteins, 2014, 82(4): 556-564. (中科院大类三区，并列第一作者)
l Jianhong Zhou; Wenying Yan; Guang Hu; Bairong Shen. Amino acid network for the discrimination of native protein structures from decoys. Current Protein and Peptide Science, 2014, 15(6): 522-528. (中科院大类三区，并列第一作者)
专业名称：医学系统生物学；专业代码：1001J6；
欢迎生物信息学、系统生物学、医学信息学、计算机等相关专业，特别是对人工智能+大健康感兴趣的考生报考。
咨询：wyyan@suda.edu.cn
严文颖，博士，副教授。2008年和2013年分别于苏州大学获得信息与计算科学理学学士和系统生物学理学博士学位，期间于2011年到2012年间国家公派访问芬兰奥卢大学。2013年至2016年间苏州大学附属第一医院从事博士后研究。2016年起入职苏州大学。目前在Briefings in Bioinformatics、Journal of Chemical Information and Modeling、Clinical and Translational Medicine、Journal of Translational Medicine、Journal of Experimental & Clinical Cancer Research等信息学和转化医学相关的 SCI 杂志上发表论文50余篇，其中第一和通讯作者论文28篇，获得授权发明专利5项，软件著作权6项，以第一副主编的身份参与撰写专著及教材2本。主持完成国家自然科学基金青年项目1 项、参与完成国家自然科学基金项目5项，作为骨干参与完成江苏省重点研发计划（社会发展）项目1项。目前为中国生物信息学学会转化信息学与数据共享安全专委会委员、江苏省医学会医学信息学分会委员。
生物信息学、系统生物学、医学信息学
主要从事生物医学多模态数据的融合分析并基于此构建人工智能模型，特别是多尺度生物网络模型的构建、分析与应用，尝试从分子、细胞、表型等刻画并预测癌症（特别是胃癌）的发生发展，为理解癌症的演变机制、生物标志物的识别、癌症的诊疗等提供理论指导。
科研项目==============================================================================================================================
国家自然科学基金青年基金，基于氨基酸接触能网络的蛋白质结合位点分析，19万，2017-2019，主持
江苏省重点研发计划，基于人工智能算法的胃癌早期诊断及发展预警模型的构建及应用，200万，2020-2023，骨干
1、生物信息学算法，2019年至今
2、生物信息学导论，2021年至今
3、Biopython，2019年
二、研究生课程
1、医学生物信息学，2022年至今
2、R语言基础，2019年
3、Python/Biopython编程，2019年
三、教材及专著
1、沈百荣、黄健主编，严文颖、郭天南、陈佳佳、邓成副主编《蛋白质组信息学》，2023，科学出版社，ISBN：9787030765185，科学出版社“十四五”普通高等教育本科规划教材
2、沈百荣主编，严文颖、张文宇、钱福良、林宇鑫副主编，《深度测序数据的生物信息学分析及实例》，2017，科学出版社，ISBN：9787030545800
l Yang Yang, Zixuan Zheng, Yuyang Xu, Huifang Wei, Wenying Yan, BioGSF: a graph-driven semantic feature integration framework for biomedical relation extraction. Briefings in Bioinformatics, 2025, 26(1):bbaf025.(中科院大类二区，通讯作者)
l Hubo Yang, Xuefeng Zhang, Zongming Jia, He Wang, Jixiang Wu, Xuedong Wei, Yuhua Huang, Wenying Yan, Yuxin Lin. Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives. Journal of Translational Medicine, 2025, 23(1):166 (中科院大类二区，通讯作者)
l Yang Yang, Yuwei Lu, Zixuan Zheng, Hao Wu, Yuxin Lin, Fuliang Qian, Wenying Yan. MKG-GC: A multi-task learning-based knowledge graph construction framework with personalized application to gastric cancer. Computational and Structural Biotechnology Journal, 2024, 23:1339–1347. (中科院大类二区，通讯作者)
l Jiayu Wang , Huan Zhang, Juntao Li, Xiangyu Ni, Wenying Yan, Yueqiu Chen, Tongguo Shi. Exosome-derived proteins in gastric cancer progression, drug resistance, and immune response. Cellular Molecular Biology Letters, 2024, 29(1) (中科院大类一区，共同通讯作者）
l Wenying Yan; Wentao Hu; Yidan Song; Xingyi Liu; Ziyun Zhou; Wanshi Li; Zhifei Cao; Weiwei Pei; Guangming Zhou; Guang Hu. Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation. Molecular Therapy - Nucleic Acids, 2024, 35(3): 102260 (中科院大类二区，第一作者）
l Jiahao Kuang; Zhihong Zhao; Yang Yang; Wenying Yan. PON-Tm: A sequence-based method for prediction of missense mutation effects on protein thermal stability changes. International Journal of Molecular Sciences, 2024, 25(15): 8379 (中科院大类二区，通讯作者）
l Wenying Yan; Yuqi Chen; Guang Hu; Tongguo Shi; Xingyi Liu; Juntao Li; Linqing Sun; Fuliang Qian; Weichang Chen. MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey. Journal of Translational Medicine, 2023, 21(1) (中科院大类二区，第一作者&共同通讯)
l Yuqi Chen; Wenying Yan; Kexi Yang; Yiting Qian; Yanjun Chen; Ruoqin Wang; Jinghan Zhu; Yuxin He; Hongya Wu; Guangbo Zhang; Tongguo Shi; Weichang Chen. Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer. Journal of Experimental & Clinical Cancer Research, 2023, 42(1) (中科院大类一区，并列第一作者)
l Xingyi Liu; Bin Yang; Xinpeng Huang; Wenying Yan; Yujuan Zhang; Guang Hu. Identifying lymph node metastasis-related factors in breast cancer using differential modular and mutational structural analysis. Interdisciplinary Sciences: Computational Life Sciences, 2023, (中科院大类三区，共同通讯作者)
l Yang Yang; Yuwei Lu; Wenying Yan. A comprehensive review on knowledge graphs for complex diseases. Briefings in Bioinformatics, 2023, 24(1) (中科院大类二区，通讯作者)
l Lianjie Zeng; Yitan Lu; Wenying Yan; Yang Yang. A protein co-conservation network model characterizes mutation effects on SARS-CoV-2 spike protein. International Journal of Molecular Sciences, 2023, 24(4): 3255 (中科院大类二区，共同通讯作者)
l Jianjun Zhao; Wenying Yan; Yang Yang. DeepTP: A deep learning model for thermophilic protein prediction. International Journal of Molecular Sciences, 2023, 24(3): 2217 (中科院大类二区，共同通讯作者)
l Wanshi Li, Yongduo Yu, Guangming Zhou, Guang Hu, Bingyan Li, Hong Ma, Wenying Yan, Hailong Pei. Large-scale ORF screening based on LC-MS to discover novel lncRNA-encoded peptides responding to ionizing radiation and microgravity. Computational and Structural Biotechnology Journal. 2023, 21: 5201-5211. (中科院大类二区，共同通讯作者)
l Wenying Yan; Guang Hu. Structural biology meets biomolecular networks: The post-alphafold era. Current Bioinformatics, 2022, 17(6). (中科院大类四区，第一作者)
l Fan Wang; Shuqing Han; Ji Yang; Wenying Yan; Guang Hu .knowledge-guided “community network” analysis reveals the functional modules and candidate targets in non-small-cell lung cancer. Cells, 2021, 10(2): 402. (中科院大类二区，共同通讯作者)
l Ji Yang; Hongchun Li; Fan Wang; Fei Xiao; Wenying Yan; Guang Hu. Network-based target prioritization and drug candidate identification for multiple sclerosis: From analyzing “omics data” to druggability simulations. ACS Chemical Neuroscience, 2021, 12(5): 917-929. (中科院大类二区，共同通讯作者)
l Yipeng Du; Xiaoting Li; Wenying Yan; Zhaohua Zeng; Dunzheng Han; Hong Ouyang; Xiudi Pan; Bihui Luo; Bohua Zhou; Qiang Fu; Dongfeng Lu; Zheng Huang; Zhiliang Li. Deciphering the in vivo dynamic proteomics of mesenchymal stem cells in critical limb ischemia. Frontiers in Cell and Developmental Biology, 2021, 9 (中科院大类二区，并列第一作者)
l Yuqi Chen; Huang Feng; Yanlin Wu; Ruoqin Wang; Zhaoji Li; Jiajia Chen; Wenying Yan; Weichang Chen. Evaluation of plasma exosomal microRNAs as circulating biomarkers for progression and metastasis of gastric cancer. Clinical and Translational Medicine, 2020, 10(6). (中科院大类一区，共同通讯作者)
l Wenying Yan; Xingyi Liu; Yibo Wang; Shuqing Han; Fan Wang; Xin Liu; Fei Xiao; Guang Hu. Identifying drug targets in pancreatic ductal adenocarcinoma through machine learning, analyzing biomolecular networks, and structural modeling. Frontiers in Pharmacology, 2020, 11: 0-534. (中科院大类二区，第一作者)
l Wenying Yan; Chunjiang Yu; Jiajia Chen; Jianhong Zhou; Bairong Shen. ANCA: A web server for amino acid networks construction and analysis. Frontiers in Molecular Biosciences, 2020, 7: 582702. (中科院大类二区，第一作者)
l Xiujun Duan; Lihua Wang; Guobo Sun; Wenying Yan; Yang Yang. Understanding the cross-talk between host and virus in poultry from the perspectives of microRNA. Poultry Science, 2020, 99(4): 1838-1846. (中科院大类二区，共同通讯作者)
l Wenying Yan; Guang Hu; Zhongjie Liang; Jianhong Zhou; Yang Yang; Jiajia Chen; Bairong Shen. Node-Weighted amino acid network strategy for characterization and identification of protein functional residues. Journal of Chemical Information and Modeling, 2018, 58(9): 2024-2032. (中科院大类二区，第一作者，JCIM封面论文)
l Wenying Yan; Daqing Zhang; Chen Shen; Zhongjie Liang; Guang Hu. Recent Advances on the Network Models in Target-based Drug Discovery.Current Topics in Medicinal Chemistry, 2018, 18(13): 1031-1043.(中科院大类四区，第一作者)
l Wenying Yan; Guang Hu; Bairong Shen. Network analysis of protein structures: the comparison of three topologies.. Current Bioinformatics, 2016, 11(4): 480-489. (中科院大类三区，第一作者)
l Wenying Yan; Laijun Qian; Jiajia Chen; Weichang Chen; Bairong Shen. Comparison of prognostic microrna biomarkers in blood and tissues for gastric cancer.Journal of Cancer, 2016, 7(1): 95-106. (中科院大类三区，第一作者)
l Wenying Yan, Wenjin Xue, Jiajia Chen, Guang Hu. Biological networks for cancer candidate biomarkers discovery. Cancer Informatics. 2016;15:1-7. (大类二区，第一作者)
l Wenying Yan; Maomin Sun; Guang Hu; Jianhong Zhou; Wenyu Zhang; Jiajia Chen; Biao Chen; Bairong Shen. Amino acid contact energy networks impact protein structure and evolution.Journal of Theoretical Biology, 2014, 355: 95-104. (中科院大类三区，第一作者)
l Wenying Yan; Jianhong Zhou; Maomin Sun; Jiajia Chen; Guang Hu; Bairong Shen. The construction of an amino acid network for understanding protein structure and function.Amino Acids, 2014, 46(6): 1419-1439. (中科院大类三区，第一作者)
l Jianhong Zhou; Wenying Yan; Guang Hu; Bairong Shen. SVR_CAF: an integrated score function for detecting native protein structures among decoys. Proteins, 2014, 82(4): 556-564. (中科院大类三区，并列第一作者)
l Jianhong Zhou; Wenying Yan; Guang Hu; Bairong Shen. Amino acid network for the discrimination of native protein structures from decoys. Current Protein and Peptide Science, 2014, 15(6): 522-528. (中科院大类三区，并列第一作者)
专业名称：医学系统生物学；专业代码：1001J6；
欢迎生物信息学、系统生物学、医学信息学、计算机等相关专业，特别是对人工智能+大健康感兴趣的考生报考。
咨询：wyyan@suda.edu.cn
