师资队伍

苏州大学生物医学研究院副教授，硕士生导师。入选江苏省优秀青年基金（2025），苏州医学院“可园”高层次人才支持计划（2025）和国家博士后创新人才支持计划（2021）等人才项目。代通博士致力于研究蛋白翻译后修饰和固有免疫响应的动态调控机制，以第一作者（含共同）在Nature Structural & Molecular Biology (2023)、Nature Cell Biology (2021)、Cell Host & Microbe (2018)、Nature Immunology (2018)、Signal Transduction and Targeted Therapy (2021a, b, 2020a, b)、Cellular & Molecular Immunology (2021)和Advanced Science (2020)等期刊上发表SCI论文10篇，论文总引用次数超过1800次，H index=15。主持国家自然科学基金重大研究计划培育项目、面上项目和青年项目各1项。


发表论文（#第一作者）

1. Dai, T.#, Zhang, L.#, Ran, Y.#, Zhang, M., Yang, B., Lu, H., Lin, S., Zhang, L., and Zhou, F. (2023). MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation. Nat Struct Mol Biol, 30(6), 785–799.

2. Wang, S.#, Dai, T.#, Qin, Z.#, Pan, T.#, Chu, F., Lou, L., Zhang, L., Yang, B., Huang, H., Lu, H., and Zhou, F. (2021). Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity. Nat Cell Biol, 23(7), 718-732.

3. Dai, T.#, Wu, L.#, Wang, S., Wang, J., Xie, F., Zhang, Z., Fang, X., Li, J., Fang, P., Li, F., et al. (2018 Dec). FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection. Cell Host Microbe, 24(6), 776-790.e5.

4. Gao, L.#, Wang, L.#, Dai, T.#, Jin, K.#, Zhang, Z.#, Wang, S., Xie, F., Fang, P., Yang, B., Huang, H., et al. (2018). Tumor-derived exosomes antagonize innate antiviral immunity. Nat Immunol, 19(3), 233-245.

5. Wang, B.#, Zhang, L.#, Dai, T.#, Qin, Z.#, Lu, H., Zhang, L., and Zhou, F. (2021). Liquid–liquid phase separation in human health and diseases. Signal Transduct Target Ther, 6(1), 290.

6. Dong, Y.#, Dai, T.#, Wei, Y.#, Zhang, L., Zheng, M., and Zhou, F. (2020). A systematic review of SARS-CoV-2 vaccine candidates. Signal Transduct Target Ther, 5(1), 237.

7. Dong, Y.#, Dai, T.#, Wang, B.#, Zhang, L.#, Zeng, L.H., Huang, J., Yan, H., Zhang, L., and Zhou, F. (2021). The way of SARS-CoV-2 vaccine development: success and challenges. Signal Transduct Target Ther, 6(1), 387.

8. Wang, B.#, Dai, T.#, Sun, W.#, Wei, Y.#, Ren, J., Zhang, L., Zhang, M., and Zhou, F. (2021). Protein N-myristoylation: functions and mechanisms in control of innate immunity. Cell Mol Immunol, 18(4), 878-888.

9. Dong, Y.#, Dai, T.#, Liu, J.#, Zhang, L., and Zhou, F. (2020). Coronavirus in Continuous Flux: From SARS-CoV to SARS-CoV-2. Adv Sci, 7(20), 2001474.

10. Cheng, Z.#, Dai, T.#, He, X.#, Zhang, Z., Xie, F., Wang, S., Zhang, L., and Zhou, F. (2020). The interactions between cGAS-STING pathway and pathogens. Signal Transduct Target Ther, 5(1), 91.


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