医学博士，苏州大学病原生物学教授，博士生导师；中国微生物学会理事，江苏省微生物学会理事，江苏省免疫学会理事；教育部学位与研究生教育发展中心通讯评议专家，国家自然科学基金通讯评议专家；主持和主要参与10余项国家级和省部级科研项目，培养研究生30余名；长期承担临床医学5+3《病原生物学》和生物医学各专业《医学微生物学》教学工作；曾获得江苏省高校青蓝工程优秀青年骨干教师培养对象、苏州大学青年教师授课比赛一等奖、苏州大学生命科学英才奖、苏州大学周氏教育科研奖等奖项和荣誉称号。
近五年主持的代表性科研项目：
1. 国家自然科学基金面上项目（No. 32270187）沙门菌效应蛋白SopF调控宿主细胞PANoptosis加重感染的机制和宿主导向干预研究, 2023.1-2026.12
2. 国家自然科学基金面上项目（No. 319701322）沙门菌毒力基因spvC抑制GSDMD介导的吞噬细胞抗菌作用促进细菌播散的机制研究, 2020.1-2023.12
3. 国家自然科学基金面上项目（No. 81671976）沙门菌spvB基因介导巨噬细胞迟发性焦亡及其加重炎症损伤的信号通路研究, 2017. 1-2020.12
近五年以通讯作者发表的主要科研论文：
1. Zhou LT, Li YY, You JY, Wu CY, Zuo LL, Chen YL, Kang L, Zhou ZY, Huang R*, Wu SY*. Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D. Inflamm Res, 2024, 73:19-33.
2. Deng QF, Yang SD, Huang K, Zhu Y, Sun LQ, Cao Y, Dong KD, Li YY*, Wu SY*, Huang R*. NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38MAPK/MK2 phosphorylation in S. typhimurium infection. iScience, 2024, 27(4):109339.
3. Yuan HB, Zhou LT, Chen YL, You JY, Hu HY, Li YY, Huang R*, Wu SY*. Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection. Gut Microbes, 2023,15: 2180315.
4. Huang LL, Hu HY, Xu C, Zhou M, Li YY, Li YB, Wu SY*, Dong N*. Characterization of NDM-5-producing Escherichia coli strains isolated from pediatric patients with bloodstream infections in a Chinese hospital. Genes (Basel), 2023, 14(2): 520.
5. Deng QF, Yang SD, Sun LQ, Huang K, Dong KD, Zhu Y, Cao Y, Li YY, Wu SY*, Huang R*. A detrimental role of NLRP6 in host iron metabolism during Salmonella infection, Redox Biology, 2022, 49: 102217.
6. Dong KD, Zhu Y, Deng QF, Sun LQ, Yang SD, Huang K, Cao Y, Li YY, Wu SY*, Huang R*, Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells, Cell Death Discov, 2022, 8(1): 44.
7. Zhou LT, Li YY, Gao S, Yuan HB, Zuo LL, Wu CY, Huang R*, Wu SY*. Salmonella spvC gene inhibits autophagy of host cells and suppresses NLRP3 as well as NLRC4. Front Immunol, 2021,12:639019.
8. Wu CY, Zhou LT, Yuan HB, Wu SY*. Interconnections among major forms of regulated cell death. Apoptosis,2020, 25(9-10): 616-624.
9. Zuo LL, Zhou LT, Wu CY, Wang YL, Li YY, Huang R*, Wu SY*, Salmonella spvC gene inhibits pyroptosis and intestinal inflammation to aggravate systemic infection in mice, Front Microbiol, 2020, 11: 1-11.
10. Yang SD, Deng QF, Sun LQ, Dong KD, Li YY, Wu SY*, Huang R*. Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2. FASEB J, 2019, 33(12): 13450-13464.
苏州工业园区特殊生物材料风险评估专家
教育部学位中心通讯评议专家
《微生物与感染》编委
感染与免疫
细菌致病的分子机制
细菌与宿主的互作
程序性细胞死亡与感染性疾病的发生
1. Wang L, Li Y, Liu Y, Zuo L, Li Y, Wu S*, Huang R*, Salmonella spv locus affects type I interferon response and the chemotaxis of neutrophils via suppressing autophagy. Fish Shellfish Immunol, 2019, 87, 721-729, 2019
3. He M, Xu W, Zhang L, Liu Z, Li Y, Wu S*, Niu H*,Identificationof novel immunoreactive proteins and delineation of a specific epitope of Anaplasma phagocytophilum, Microb Pathog, 125, 183-188, 2018
4. Li Y, Wang T, Gao S, Xu G, Niu H, Huang R, Wu S*, Salmonella plasmid virulence gene spvB enhances bacterial virulence by inhibiting autophagy in a zebrafish infection model, Fish Shellfish Immunol, 49, 252-259, 2016
5. Chu Y, Gao S, Wang T, Yan J, Xu G, Li Y, Niu H, Huang R*, Wu S*, A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells, Oncotarget, 7(7), 8295-8309, 2016
6. He M, Xie Y, Zhang R, Gao S, Xu, G, Li Y, Wu S*, Prevalence and antimicrobial resistance of Mycoplasmas and Chlamydiae in patients with genital tract infections in Shanghai, China, J Infect Chemother, 22(8), 548-552, 2016
7. Wang T, Chen T, Niu H, Li C, Xu C, Li Y, Huang R, Zhao J*, Wu S*, MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1, Int J Mol Med, 36(1), 93-102, 2015
8. Chu Y, Yang Y, Li Y, Ye Y, Yan J, Wang T, Wu S*, Huang R*, A Salmonellaenterica conjugative plasmid impairs autophagic flux in infected macrophages, Microbes Infect, 16(7), 553-561, 2014
9. Liu Z, Que F, Liao L, Zhou M, You L, Zhao Q, Li Y, Niu H, Wu S*, Huang R*, Study on the promotion of bacterial biofilm formation by a Salmonella conjugative plasmid and the underlying mechanism, PLoS One, 9(10), e109808, 2014
10.Wu S, Chu Y, Yang Y, Li Y, He P, Zheng Y, Zhang C, Liu Q, Han L, Huang R*. Inhibition of macrophage autophagy induced by Salmonella enterica serovar typhi plasmid, Front Biosci (Landmark Ed), 19, 490-503, 20141.Wu C, Zhou L, Yuan H, Wu S*. Interconnections among major forms of regulated cell death. Apoptosis, 25: 616-624, 202
2.Yang S, Deng Q, Sun L, Dong K, Li Y, Wu S*, Huang R*, Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2. FASEB J, 33(12):13450-13464, 2019
3. Wang L, Li Y, Liu Y, Zuo L, Li Y, Wu S*, Huang R*. Salmonella spv locus affects type I interferon response and the chemotaxis of neutrophils via suppressing autophagy. Fish Shellfish Immunol, 87, 721-729, 2019
4. Wang L, Yan J, Niu H, Huang R*, Wu S*, Autophagy and ubiquitination in Salmonella infection and the related inflammatory responses. Front Cell Infect Microb, 8(78), 1-14, 2018
5. Sun S, Zuo L, Liu P, Wang X, He M, Wu S*. The diagnostic performance of urine flow cytometer UF1000i for urinary tract infections. Clin Lab, 64, 1395-1401, 2018
6. Li Y, Wang T, Gao S, Xu G, Niu H, Huang R, Wu S*. Salmonella plasmid virulence gene spvB enhances bacterial virulence by inhibiting autophagy in a zebrafish infection model. Fish Shellfish Immunol, 49, 252-259, 2016
7. Chu Y, Gao S, Wang T, Yan J, Xu G, Li Y, Niu H, Huang R*, Wu S*. A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells. Oncotarget, 7(7), 8295-8309, 2016
8. He M, Xie Y, Zhang R, Gao S, Xu, G, Li Y, Wu S*. Prevalence and antimicrobial resistance of Mycoplasmas and Chlamydiae in patients with genital tract infections in Shanghai, China. J Infect Chemother, 22(8), 548-552, 2016
9. Wang T, Chen T, Niu H, Li C, Xu C, Li Y, Huang R, Zhao J*, Wu S*. MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1. Int J Mol Med, 36(1), 93-102, 2015
10. Chu Y, Yang Y, Li Y, Ye Y, Yan J, Wang T, Wu S*, Huang R*. A Salmonellaenterica conjugative plasmid impairs autophagic flux in infected macrophages. Microbes Infect,16(7), 553-561, 201
11. Liu Z, Niu H, Wu S*, Huang R*. CsgD regulatory network in a bacterial trait-altering biofilm formation. Emerg Microbes Infect, 3(1), 1-5, 2014
12. Wu S, Chu Y, Yang Y, Li Y, He P, Zheng Y, Zhang C, Liu Q, Han L, Huang R. Inhibition of macrophage autophagy induced by Salmonella enterica serovar typhi plasmid. Front Biosci (Landmark Ed),19, 490-503, 2014
专业: 病原生物学
考生来源：医学或生物科学相关专业
医学博士，苏州大学病原生物学教授，博士生导师；中国微生物学会理事，江苏省微生物学会理事，江苏省免疫学会理事；教育部学位与研究生教育发展中心通讯评议专家，国家自然科学基金通讯评议专家；主持和主要参与10余项国家级和省部级科研项目，培养研究生30余名；长期承担临床医学5+3《病原生物学》和生物医学各专业《医学微生物学》教学工作；曾获得江苏省高校青蓝工程优秀青年骨干教师培养对象、苏州大学青年教师授课比赛一等奖、苏州大学生命科学英才奖、苏州大学周氏教育科研奖等奖项和荣誉称号。
近五年主持的代表性科研项目：
1. 国家自然科学基金面上项目（No. 32270187）沙门菌效应蛋白SopF调控宿主细胞PANoptosis加重感染的机制和宿主导向干预研究, 2023.1-2026.12
2. 国家自然科学基金面上项目（No. 319701322）沙门菌毒力基因spvC抑制GSDMD介导的吞噬细胞抗菌作用促进细菌播散的机制研究, 2020.1-2023.12
3. 国家自然科学基金面上项目（No. 81671976）沙门菌spvB基因介导巨噬细胞迟发性焦亡及其加重炎症损伤的信号通路研究, 2017. 1-2020.12
近五年以通讯作者发表的主要科研论文：
1. Zhou LT, Li YY, You JY, Wu CY, Zuo LL, Chen YL, Kang L, Zhou ZY, Huang R*, Wu SY*. Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D. Inflamm Res, 2024, 73:19-33.
2. Deng QF, Yang SD, Huang K, Zhu Y, Sun LQ, Cao Y, Dong KD, Li YY*, Wu SY*, Huang R*. NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38MAPK/MK2 phosphorylation in S. typhimurium infection. iScience, 2024, 27(4):109339.
3. Yuan HB, Zhou LT, Chen YL, You JY, Hu HY, Li YY, Huang R*, Wu SY*. Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection. Gut Microbes, 2023,15: 2180315.
4. Huang LL, Hu HY, Xu C, Zhou M, Li YY, Li YB, Wu SY*, Dong N*. Characterization of NDM-5-producing Escherichia coli strains isolated from pediatric patients with bloodstream infections in a Chinese hospital. Genes (Basel), 2023, 14(2): 520.
5. Deng QF, Yang SD, Sun LQ, Huang K, Dong KD, Zhu Y, Cao Y, Li YY, Wu SY*, Huang R*. A detrimental role of NLRP6 in host iron metabolism during Salmonella infection, Redox Biology, 2022, 49: 102217.
6. Dong KD, Zhu Y, Deng QF, Sun LQ, Yang SD, Huang K, Cao Y, Li YY, Wu SY*, Huang R*, Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells, Cell Death Discov, 2022, 8(1): 44.
7. Zhou LT, Li YY, Gao S, Yuan HB, Zuo LL, Wu CY, Huang R*, Wu SY*. Salmonella spvC gene inhibits autophagy of host cells and suppresses NLRP3 as well as NLRC4. Front Immunol, 2021,12:639019.
8. Wu CY, Zhou LT, Yuan HB, Wu SY*. Interconnections among major forms of regulated cell death. Apoptosis,2020, 25(9-10): 616-624.
9. Zuo LL, Zhou LT, Wu CY, Wang YL, Li YY, Huang R*, Wu SY*, Salmonella spvC gene inhibits pyroptosis and intestinal inflammation to aggravate systemic infection in mice, Front Microbiol, 2020, 11: 1-11.
10. Yang SD, Deng QF, Sun LQ, Dong KD, Li YY, Wu SY*, Huang R*. Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2. FASEB J, 2019, 33(12): 13450-13464.
苏州工业园区特殊生物材料风险评估专家
教育部学位中心通讯评议专家
《微生物与感染》编委
感染与免疫
细菌致病的分子机制
细菌与宿主的互作
程序性细胞死亡与感染性疾病的发生
1. Wang L, Li Y, Liu Y, Zuo L, Li Y, Wu S*, Huang R*, Salmonella spv locus affects type I interferon response and the chemotaxis of neutrophils via suppressing autophagy. Fish Shellfish Immunol, 2019, 87, 721-729, 2019
3. He M, Xu W, Zhang L, Liu Z, Li Y, Wu S*, Niu H*,Identificationof novel immunoreactive proteins and delineation of a specific epitope of Anaplasma phagocytophilum, Microb Pathog, 125, 183-188, 2018
4. Li Y, Wang T, Gao S, Xu G, Niu H, Huang R, Wu S*, Salmonella plasmid virulence gene spvB enhances bacterial virulence by inhibiting autophagy in a zebrafish infection model, Fish Shellfish Immunol, 49, 252-259, 2016
5. Chu Y, Gao S, Wang T, Yan J, Xu G, Li Y, Niu H, Huang R*, Wu S*, A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells, Oncotarget, 7(7), 8295-8309, 2016
6. He M, Xie Y, Zhang R, Gao S, Xu, G, Li Y, Wu S*, Prevalence and antimicrobial resistance of Mycoplasmas and Chlamydiae in patients with genital tract infections in Shanghai, China, J Infect Chemother, 22(8), 548-552, 2016
7. Wang T, Chen T, Niu H, Li C, Xu C, Li Y, Huang R, Zhao J*, Wu S*, MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1, Int J Mol Med, 36(1), 93-102, 2015
8. Chu Y, Yang Y, Li Y, Ye Y, Yan J, Wang T, Wu S*, Huang R*, A Salmonellaenterica conjugative plasmid impairs autophagic flux in infected macrophages, Microbes Infect, 16(7), 553-561, 2014
9. Liu Z, Que F, Liao L, Zhou M, You L, Zhao Q, Li Y, Niu H, Wu S*, Huang R*, Study on the promotion of bacterial biofilm formation by a Salmonella conjugative plasmid and the underlying mechanism, PLoS One, 9(10), e109808, 2014
10.Wu S, Chu Y, Yang Y, Li Y, He P, Zheng Y, Zhang C, Liu Q, Han L, Huang R*. Inhibition of macrophage autophagy induced by Salmonella enterica serovar typhi plasmid, Front Biosci (Landmark Ed), 19, 490-503, 20141.Wu C, Zhou L, Yuan H, Wu S*. Interconnections among major forms of regulated cell death. Apoptosis, 25: 616-624, 202
2.Yang S, Deng Q, Sun L, Dong K, Li Y, Wu S*, Huang R*, Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2. FASEB J, 33(12):13450-13464, 2019
3. Wang L, Li Y, Liu Y, Zuo L, Li Y, Wu S*, Huang R*. Salmonella spv locus affects type I interferon response and the chemotaxis of neutrophils via suppressing autophagy. Fish Shellfish Immunol, 87, 721-729, 2019
4. Wang L, Yan J, Niu H, Huang R*, Wu S*, Autophagy and ubiquitination in Salmonella infection and the related inflammatory responses. Front Cell Infect Microb, 8(78), 1-14, 2018
5. Sun S, Zuo L, Liu P, Wang X, He M, Wu S*. The diagnostic performance of urine flow cytometer UF1000i for urinary tract infections. Clin Lab, 64, 1395-1401, 2018
6. Li Y, Wang T, Gao S, Xu G, Niu H, Huang R, Wu S*. Salmonella plasmid virulence gene spvB enhances bacterial virulence by inhibiting autophagy in a zebrafish infection model. Fish Shellfish Immunol, 49, 252-259, 2016
7. Chu Y, Gao S, Wang T, Yan J, Xu G, Li Y, Niu H, Huang R*, Wu S*. A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells. Oncotarget, 7(7), 8295-8309, 2016
8. He M, Xie Y, Zhang R, Gao S, Xu, G, Li Y, Wu S*. Prevalence and antimicrobial resistance of Mycoplasmas and Chlamydiae in patients with genital tract infections in Shanghai, China. J Infect Chemother, 22(8), 548-552, 2016
9. Wang T, Chen T, Niu H, Li C, Xu C, Li Y, Huang R, Zhao J*, Wu S*. MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1. Int J Mol Med, 36(1), 93-102, 2015
10. Chu Y, Yang Y, Li Y, Ye Y, Yan J, Wang T, Wu S*, Huang R*. A Salmonellaenterica conjugative plasmid impairs autophagic flux in infected macrophages. Microbes Infect,16(7), 553-561, 201
11. Liu Z, Niu H, Wu S*, Huang R*. CsgD regulatory network in a bacterial trait-altering biofilm formation. Emerg Microbes Infect, 3(1), 1-5, 2014
12. Wu S, Chu Y, Yang Y, Li Y, He P, Zheng Y, Zhang C, Liu Q, Han L, Huang R. Inhibition of macrophage autophagy induced by Salmonella enterica serovar typhi plasmid. Front Biosci (Landmark Ed),19, 490-503, 2014
专业: 病原生物学
考生来源：医学或生物科学相关专业